A nonlinear AIDS epidemic model with screening and time delay

A nonlinear mathematical model to study the effect of time delay in the recruitment of infected persons on the transmission dynamics of HIV/AIDS is proposed and analyzed. In modeling the dynamics, the population is divided into four subclasses: the susceptibles, the HIV positives or infectives that do not know they are infected, the HIV positives that know they are infected and the AIDS patients. Susceptibles are assumed to become infected via sexual contacts with (both types of) infectives. The model is analyzed using stability theory of delay differential equations. Both the disease-free and the endemic equilibria are found and their stability is investigated. It is shown that the introduction of time delay in the model has a destabilizing effect on the system and periodic solutions can arise by Hopf bifurcation. Numerical simulations are also carried out to investigate the influence of key parameters on the spread of the disease, to support the analytical conclusion and to illustrate possible behavioral scenario of the model.     

Stability and bifurcation in a non-kolmogorov type prey-predator system with time delay

The purpose of this paper is to study a non-Kolmogrov type prey-predator system. First, we investigate the linear stability of the model by analyzing the associated characteristic equation of the linearized system. Second, we show that the system exhibits the Hopf bifurcation. The stability and direction of the Hopf bifurcation are determined by applying the norm form theory and center manifold theorem. Finally, numerical simulations are performed to illustrate the obtained results.     

Hopf bifurcation in a two-competitor, one-prey system with time delay

In this paper, we consider a delayed two-competitor/one-prey system in which both two competitors exhibit Holling II functional response. By choosing the time delay as a bifurcation parameter, it is found that the Hopf bifurcation occurs when the delay passes through a certain critical value. Numerical simulations are performed to illustrate the analytical results.     

Dynamics of a discrete food-limited population model with time delay

In this paper, we consider a discrete food-limited population model with time delay. Firstly, the stability of the equilibrium of the system is investigated by analyzing the characteristic equation. By choosing the time delay as a bifurcation parameter, we prove that Neimark-Sacker bifurcations occur when the delay passes a sequence of critical values. Then the explicit algorithm for determining the direction of the Neimark-Sacker bifurcations and the stability of the bifurcating periodic solutions are derived. Finally, some numerical simulations are given to verify the theoretical analysis.     

Properties of stability and Hopf bifurcation for a HIV infection model with time delay

In this paper, we consider the classical mathematical model with saturation response of the infection rate and time delay. By stability analysis we obtain sufficient conditions for the global stability of the infection-free steady state and the permanence of the infected steady state. Numerical simulations are carried out to explain the mathematical conclusions.     

Global dynamics of a discretized SIRS epidemic model with time delay

We derive a discretized SIRS epidemic model with time delay by applying a nonstandard finite difference scheme. Sufficient conditions for the global dynamics of the solution are obtained by improvements in discretization and applying proofs for continuous epidemic models. These conditions for our discretized model are the same as for the original continuous model.     

Dynamics of a discretized SIR epidemic model with pulse vaccination and time delay

We derive a discretized SIR epidemic model with pulse vaccination and time delay from the original continuous model. The sufficient conditions for global attractivity of an infection-free periodic solution and permanence of our model are obtained. Improving discretization, our results are corresponding to those in the original continuous model.     

Stochastically perturbed vector-borne disease models with direct transmission

In this paper we study a stochastic epidemic model of vector-borne diseases with direct mode of transmission and its delay modification. More precisely, we extend the deterministic epidemic models by introducing random perturbations around the endemic equilibrium state. By using suitable Lyapunov functions and functionals, we obtain stability conditions for the considered models and study the effect of the delay on the stability of the endemic equilibrium. Finally, numerical simulations for the stochastic model of malaria disease transmission are presented to illustrate our mathematical findings.     

一类具有时滞的病菌-免疫力模型的定性研究

考虑病菌的一种信息交流机制,建立一类病菌与免疫系统竞争的时滞传染病模型.分析正平衡点的存在性、渐近稳定性、Hopf分歧的存在性.特别的,研究了无病平衡点E0 在奇异条件(R0=1)下的稳定性.数值模拟验证了所得理论结果.     

Stability and Hopf bifurcation in a diffusive logistic population model with nonlocal delay effect

A reaction-diffusion model with logistic type growth, nonlocal delay effect and Dirichlet boundary condition is considered, and combined effect of the time delay and nonlocal spatial dispersal provides a more realistic way of modeling the complex spatiotemporal behavior. The stability of the positive spatially nonhomogeneous positive equilibrium and associated Hopf bifurcation are investigated for the case of near equilibrium bifurcation point and the case of spatially homogeneous dispersal kernel.     

Stability and bifurcation analysis of a nutrient-phytoplankton model with time delay

We proposed a nutrient-phytoplankton interaction model with a discrete and distributed time delay to provide a better understanding of phytoplankton growth dynamics and nutrient-phytoplankton oscillations induced by delay. Standard linear analysis indicated that delay can induce instability of a positive equilibrium via Hopf bifurcation. We derived the conditions guaranteeing the existence of Hopf bifurcation and tracked its direction and the stability of the bifurcating periodic solutions. We also obtained the sufficient conditions for the global asymptotic stability of the unique positive steady state. Numerical analysis in the fully nonlinear regime showed that the stability of the positive equilibrium is sensitive to changes in delay values under select conditions. Numerical results were consistent with results predicted by linear analysis.     

Hopf bifurcation analysis of a general non-linear differential equation with delay

This work represents Hopf bifurcation analysis of a general non-linear differential equation involving time delay. A special form of this equation is the Hutchinson–Wright equation which is a mile stone in the mathematical modeling of population dynamics and mathematical biology. Taking the delay parameter as a bifurcation parameter, Hopf bifurcation analysis is studied by following the theory in the book by Hazzard et al. By analyzing the associated characteristic polynomial, we determine necessary conditions for the linear stability and Hopf bifurcation. In addition to this analysis, the direction of bifurcation, the stability and the period of a periodic solution to this equation are evaluated at a bifurcation value by using the Poincaré normal form and the center manifold theorem. Finally, the theoretical results are supported by numerical simulations.     

Stability switch and Hopf bifurcation for a diffusive prey-predator system with delay

The increasing time delay usually destabilizes any dynamical system. In this paper we give an example that in some special cases the opposite effect can be experienced if the time delay is sufficiently great. We investigate the effect of both the parameter in the time delay kernel and diffusion coefficient on the stability of the positive steady state for a diffusive prey-predator system with delay. We obtain the condition of the occurrence of the stability switches of the positive steady state.     

Bifurcation analysis of a modified Holling-Tanner predator-prey model with time delay

In this paper, a modified Holling-Tanner predator-prey model with time delay is considered. By regarding the delay as the bifurcation parameter, the local asymptotic stability of the positive equilibrium is investigated. Meanwhile, we find that the system can also undergo a Hopf bifurcation of nonconstant periodic solution at the positive equilibrium when the delay crosses through a sequence of critical values. In particular, we study the direction of Hopf bifurcation and the stability of bifurcated periodic solutions, an explicit algorithm is given by applying the normal form theory and the center manifold reduction for functional differential equations. Finally, numerical simulations supporting the theoretical analysis are also included.     

Analysis of a bacteria-immunity model with delay quorum sensing

A bacteria-immunity model with bacterial quorum sensing is formulated, which describes the competition between bacteria and immune cells. A distributed delay is introduced to characterize the time in which bacteria receive signal molecules and then combat with immune cells. In this paper, we focus on a subsystem of the bacteria-immunity model, analyze the stability of the equilibrium points, discuss the existence and stability of periodic solutions bifurcated from the positive equilibrium point, and finally investigate the stability of the nonhyperbolic equilibrium point by the center manifold theorem.     

Complex dynamics in a prey predator system with multiple delays

The complex dynamics is explored in a prey predator system with multiple delays. Holling type-II functional response is assumed for prey dynamics. The predator dynamics is governed by modified Leslie-Gower scheme. The existence of periodic solutions via Hopf-bifurcation with respect to both delays are established. An algorithm is developed for drawing two-parametric bifurcation diagram with respect to two delays. The domain of stability with respect to τ₁ and τ₂ is thus obtained. The complex dynamical behavior of the system outside the domain of stability is evident from the exhaustive numerical simulation. Direction and stability of periodic solutions are also determined using normal form theory and center manifold argument.     

Permanence and extinction for a nonautonomous SIRS epidemic model with time delay

In this paper, a nonautonomous SIRS epidemic model with time delay is studied. We introduce some new threshold values _R∗$R_{\ast }$ and R^∗$R^{\ast }$ and further obtain the disease will be permanent when _R∗>1$R_{\ast }>1$ and the disease extinct when R^∗<1$R^{\ast }<1$. Using the method of Liapunov functional, some sufficient conditions are derived for the global attractivity of the system. The known results are extended.     

Hopf bifurcation analysis of a predator-prey system with Holling type IV functional response and time delay

This paper is concerned with a predator-prey system with Holling type IV functional response and time delay. Our aim is to investigate how the time delay affects the dynamics of the predator-prey system. By choosing the delay as a bifurcation parameter, the local asymptotic stability of the positive equilibrium and existence of local Hopf bifurcations are analyzed. Based on the normal form and the center manifold theory, the formulaes for determining the properties of Hopf bifurcation of the predator-prey system are derived. Finally, to support these theoretical results, some numerical simulations are given to illustrate the results.     

一类具有时滞的病菌-免疫力模型的Hopf分歧

考虑病菌的一种信息交流机制,建立一类病菌与免疫系统竞争的时滞传染病模型.分析正平衡点的存在性、渐近稳定性、Hopf分歧的存在性及方向.运用计算机数值模拟验证所得理论结果,为传染病的控制和预防提供了理论基础和数值依据.