Empirical likelihood for mixed-effects error-in-variables model

This paper mainly introduces the method of empirical likelihood and its applications on two different models. We discuss the empirical likelihood inference on fixed-effect parameter in mixed-effects model with error-in-variables. We first consider a linear mixed-effects model with measurement errors in both fixed and random effects. We construct the empirical likelihood confidence regions for the fixed-effects parameters and the mean parameters of random-effects. The limiting distribution of the empirical log likelihood ratio at the true parameter is X2p＋q, where p, q are dimension of fixed and random effects respectively. Then we discuss empirical likelihood inference in a semi-linear error-in-variable mixed-effects model. Under certain conditions, it is shown that the empirical log likelihood ratio at the true parameter also converges to X2p＋q. Simulations illustrate that the proposed confidence region has a coverage probability more closer to the nominal level than normal approximation based confidence region.     

半参数线性混合效应模型的联合变量选择

多数基于线性混合效应模型的变量选择方法分阶段对固定效应和随机效应进行选择,方法繁琐、易产生模型偏差,且大部分非参数和半参数的线性混合效应模型只涉及非参数部分的光滑度或者固定效应的选择,并未涉及非参变量或随机效应的选择。本文用B样条函数逼近非参数函数部分,从而把半参数线性混合效应模型转化为带逼近误差的线性混合效应模型。对随机效应的协方差矩阵采用改进的乔里斯基分解并重新参数化线性混合效应模型,接着对该模型的极大似然函数施加集群ALASSO惩罚和ALASSO惩罚两类惩罚,该法能实现非参数变量、固定效应和随机效应的联合变量选择,基于该法得出的估计量也满足相合性、稀疏性和Oracle性质。文章最后做了个数值模拟,模拟结果表明,本文提出的估计方法在变量选择的准确性、参数估计的精度两个方面均表现较好。     

A general framework for frequentist model averaging In Celebration of Professor Lincheng Zhao's 75th Birthday

Model selection strategies have been routinely employed to determine a model for data analysis in statistics, and further study and inference then often proceed as though the selected model were the true model that were known a priori. Model averaging approaches, on the other hand, try to combine estimators for a set of candidate models. Specifically, instead of deciding which model is the 'right' one, a model averaging approach suggests to fit a set of candidate models and average over the estimators using data adaptive weights.In this paper we establish a general frequentist model averaging framework that does not set any restrictions on the set of candidate models. It broaden, the scope of the existing methodologies under the frequentist model averaging development. Assuming the data is from an unknown model, we derive the model averaging estimator and study its limiting distributions and related predictions while taking possible modeling biases into account.We propose a set of optimal weights to combine the individual estimators so that the expected mean squared error of the average estimator is minimized. Simulation studies are conducted to compare the performance of the estimator with that of the existing methods. The results show the benefits of the proposed approach over traditional model selection approaches as well as existing model averaging methods.     

线性测量误差模型的平均估计

频率模型平均估计近年来受到了较大的关注,但对有测量误差的观测数据尚未见到任何研究.文章主要考虑了线性测量误差模型的平均估计问题,导出了模型平均估计的渐近分布,基于Hjort和Claeskens(2003)的思想构造了一个覆盖真实参数的概率趋于预定水平的置信区间,并证明了该置信区间与基于全模型正态逼近所构造的置信区间的渐近等价性.模拟结果表明当协变量存在测量误差时,模型平均估计能明显增加点估计的效率.     

Strong model dependence in statistical analysis: goodness of fit is not enough for model choice

Most statistical methods are based on models, but most practical applications ignore the fact that the results depend on the model as well as on the data. This paper examines the size of this model dependence, and finds that there can be very considerable variation between the results of fitting different models to the same data, even if the models being considered are restricted to those which give an acceptable fit to the data. Under reasonable regularity conditions, we show that different empirically acceptable models can give rise to non-overlapping confidence intervals for the same parameter. Application papers need to recognize that the validity of conventional statistical results rests on the assumption that the underlying model is known to be correct, and that this is a much stronger requirement than merely confirming that the model gives a good fit to the data. The problem of model dependence is only partially resolved by using formal methods of model selection or model averaging.

     

The OWA-based consensus operator under linguistic representation models using position indexes

When using linguistic approaches to solve decision problems, we need linguistic representation models. The symbolic model, the 2-tuple fuzzy linguistic representation model and the continuous linguistic model are three existing linguistic representation models based on position indexes. Together with these three linguistic models, the corresponding ordered weighted averaging operators, such as the linguistic ordered weighted averaging operator, the 2-tuple ordered weighted averaging operator and the extended ordered weighted averaging operator, have been developed, respectively. In this paper, we analyze the internal relationship among these operators, and propose a consensus operator under the continuous linguistic model (or the 2-tuple fuzzy linguistic representation model). The proposed consensus operator is based on the use of the ordered weighted averaging operator and the deviation measures. Some desired properties of the consensus operator are also presented. In particular, the consensus operator provides an alternative consensus model for group decision making. This consensus model preserves the original preference information given by the decision makers as much as possible, and supports consensus process automatically, without moderator.     

Use of the Probability Integral Transformation to Fit Nonlinear Mixed-Effects Models With Nonnormal Random Effects

This article describes a simple computational method for obtaining the maximum likelihood estimates (MLE) in nonlinear mixed-effects models when the random effects are assumed to have a nonnormal distribution. Many computer programs for fitting nonlinear mixed-effects models, such as PROC NLMIXED in SAS, require that the random effects have a normal distribution. However, there is often interest in either fitting models with nonnormal random effects or assessing the sensitivity of inferences to departures from the normality assumption for the random effects. When the random effects are assumed to have a nonnormal distribution, we show how the probability integral transform can be used, in conjunction with standard statistical software for fitting nonlinear mixed-effects models (e.g., PROC NLMIXED in SAS), to obtain the MLEs. Specifically, the probability integral transform is used to transform a normal random effect to a nonnormal random effect. The method is illustrated using a gamma frailty model for clustered survival data and a beta-binomial model for clustered binary data. Finally, the results of a simulation study, examining the impact of misspecification of the distribution of the random effects, are presented.     

Bayesian Variable and Transformation Selection in Linear Regression

This article suggests a method for variable and transformation selection based on posterior probabilities. Our approach allows for consideration of all possible combinations of untransformed and transformed predictors along with transformed and untransformed versions of the response. To transform the predictors in the model, we use a change-point model, or “change-point transformation,” which can yield more interpretable models and transformations than the standard Box–Tidwell approach. We also address the problem of model uncertainty in the selection of models. By averaging over models, we account for the uncertainty inherent in inference based on a single model chosen from the set of models under consideration. We use a Markov chain Monte Carlo model composition (MC³) method which allows us to average over linear regression models when the space of models under consideration is very large. This considers the selection of variables and transformations at the same time. In an example, we show that model averaging improves predictive performance as compared with any single model that might reasonably be selected, both in terms of overall predictive score and of the coverage of prediction intervals. Software to apply the proposed methodology is available via StatLib.     

Bayesian inference on partially linear mixed-effects joint models for longitudinal data with multiple features

The relationship between viral load and CD4 cell count is one of the interesting questions in AIDS research. Statistical models are powerful tools for clarifying this important problem. Partially linear mixed-effects (PLME) model which accounts for the unknown function of time effect is one of the important models for this purpose. Meanwhile, the mixed-effects modeling approach is suitable for the longitudinal data analysis. However, the complex process of data collection in clinical trials has made it impossible to rely on one particular model to address the issues. Asymmetric distribution, measurement error and left censoring are features commonly arisen in longitudinal studies. It is crucial to take into account these features in the modeling process to achieve reliable estimation and valid conclusion. In this article, we establish a joint model that accounts for all these features in the framework of PLME models. A Bayesian inferential procedure is proposed to estimate parameters in the joint model. A real data example is analyzed to demonstrate the proposed modeling approach for inference and the results are reported by comparing various scenarios-based models.     

Model selection bias and Freedman’s paradox

In situations where limited knowledge of a system exists and the ratio of data points to variables is small, variable selection methods can often be misleading. Freedman (Am Stat 37:152–155, 1983) demonstrated how common it is to select completely unrelated variables as highly “significant” when the number of data points is similar in magnitude to the number of variables. A new type of model averaging estimator based on model selection with Akaike’s AIC is used with linear regression to investigate the problems of likely inclusion of spurious effects and model selection bias, the bias introduced while using the data to select a single seemingly “best” model from a (often large) set of models employing many predictor variables. The new model averaging estimator helps reduce these problems and provides confidence interval coverage at the nominal level while traditional stepwise selection has poor inferential properties.     

Robust Model Averaging Method Based on LOF Algorithm

Model averaging is a good alternative to model selection, which can deal with the uncertainty from model selection process and make full use of the information from various candidate models. However, most of the existing model averaging criteria do not consider the influence of outliers on the estimation procedures. The purpose of this paper is to develop a robust model averaging approach based on the local outlier factor (LOF) algorithm which can downweight the outliers in the covariates. Asymptotic optimality of the proposed robust model averaging estimator is derived under some regularity conditions. Further, we prove the consistency of the LOF-based weight estimator tending to the theoretically optimal weight vector. Numerical studies including Monte Carlo simulations and a real data example are provided to illustrate our proposed methodology.     

Comparison of the Bayesian and Randomised Decision Tree Ensembles within an Uncertainty Envelope Technique

Multiple Classifier Systems (MCSs) allow evaluation of the uncertainty of classification outcomes that is of crucial importance for safety critical applications. The uncertainty of classification is determined by a trade-off between the amount of data available for training, the classifier diversity and the required performance. The interpretability of MCSs can also give useful information for experts responsible for making reliable classifications. For this reason Decision Trees (DTs) seem to be attractive classification models for experts. The required diversity of MCSs exploiting such classification models can be achieved by using two techniques, the Bayesian model averaging and the randomised DT ensemble. Both techniques have revealed promising results when applied to real-world problems. In this paper we experimentally compare the classification uncertainty of the Bayesian model averaging with a restarting strategy and the randomised DT ensemble on a synthetic dataset and some domain problems commonly used in the machine learning community. To make the Bayesian DT averaging feasible, we use a Markov Chain Monte Carlo technique. The classification uncertainty is evaluated within an Uncertainty Envelope technique dealing with the class posterior distribution and a given confidence probability. Exploring a full posterior distribution, this technique produces realistic estimates which can be easily interpreted in statistical terms. In our experiments we found out that the Bayesian DTs are superior to the randomised DT ensembles within the Uncertainty Envelope technique.     

Forecasting seasonal time series data: a Bayesian model averaging approach

A flexible Bayesian periodic autoregressive model is used for the prediction of quarterly and monthly time series data. As the unknown autoregressive lag order, the occurrence of structural breaks and their respective break dates are common sources of uncertainty these are treated as random quantities within the Bayesian framework. Since no analytical expressions for the corresponding marginal posterior predictive distributions exist a Markov Chain Monte Carlo approach based on data augmentation is proposed. Its performance is demonstrated in Monte Carlo experiments. Instead of resorting to a model selection approach by choosing a particular candidate model for prediction, a forecasting approach based on Bayesian model averaging is used in order to account for model uncertainty and to improve forecasting accuracy. For model diagnosis a Bayesian sign test is introduced to compare the predictive accuracy of different forecasting models in terms of statistical significance. In an empirical application, using monthly unemployment rates of Germany, the performance of the model averaging prediction approach is compared to those of model selected Bayesian and classical (non)periodic time series models.     

Transformation-based model averaged tail area inference

In parameter estimation, it is not a good choice to select a “best model” by some criterion when there is model uncertainty. Model averaging is commonly used under this circumstance. In this paper, transformation-based model averaged tail area is proposed to construct confidence interval, which is an extension of model averaged tail area method in the literature. The transformation-based model averaged tail area method can be used for general parametric models and even non-parametric models. Also, it asymptotically has a simple formula when a certain transformation function is applied. Simulation studies are carried out to examine the performance of our method and compare with existing methods. A real data set is also analyzed to illustrate the methods.     

Spatial Localization for Nonlinear Dynamical Stochastic Models for Excitable Media

Nonlinear dynamical stochastic models are ubiquitous in different areas. Their statistical properties are often of great interest, but are also very challenging to compute. Many excitable media models belong to such types of complex systems with large state dimensions and the associated covariance matrices have localized structures. In this article, a mathematical framework to understand the spatial localization for a large class of stochastically coupled nonlinear systems in high dimensions is developed. Rigorous \linebreak mathematical analysis shows that the local effect from the diffusion results in an exponential decay of the components in the covariance matrix as a function of the distance while the global effect due to the mean field interaction synchronizes different components and contributes to a global covariance. The analysis is based on a comparison with an appropriate linear surrogate model, of which the covariance propagation can be computed explicitly. Two important applications of these theoretical results are discussed. They are the spatial averaging strategy for efficiently sampling the covariance matrix and the localization technique in data assimilation. Test examples of a linear model and a stochastically coupled FitzHugh-Nagumo model for excitable media are adopted to validate the theoretical results. The latter is also used for a systematical study of the spatial averaging strategy in efficiently sampling the covariance matrix in different dynamical regimes.     

Model Choice and Diagnostics for Linear Mixed-Effects Models Using Statistics on Street Corners

The complexity of linear mixed-effects (LME) models means that traditional diagnostics are rendered less effective. This is due to a breakdown of asymptotic results, boundary issues, and visible patterns in residual plots that are introduced by the model fitting process. Some of these issues are well known and adjustments have been proposed. Working with LME models typically requires that the analyst keeps track of all the special circumstances that may arise. In this article, we illustrate a simpler but generally applicable approach to diagnosing LME models. We explain how to use new visual inference methods for these purposes. The approach provides a unified framework for diagnosing LME fits and for model selection. We illustrate the use of this approach on several commonly available datasets. A large-scale Amazon Turk study was used to validate the methods. R code is provided for the analyses. Supplementary materials for this article are available online.     

Approximations to the Log-Likelihood Function in the Nonlinear Mixed-Effects Model

Abstract

Nonlinear mixed-effects models have received a great deal of attention in the statistical literature in recent years because of the flexibility they offer in handling the unbalanced repeated-measures data that arise in different areas of investigation, such as pharmacokinetics and economics. Several different methods for estimating the parameters in nonlinear mixed-effects model have been proposed. We concentrate here on two of them—maximum likelihood and restricted maximum likelihood. A rather complex numerical issue for (restricted) maximum likelihood estimation in nonlinear mixed-effects models is the evaluation of the log-likelihood function of the data, because it involves the evaluation of a multiple integral that, in most cases, does not have a closed-form expression. We consider here four different approximations to the log-likelihood, comparing their computational and statistical properties. We conclude that the linear mixed-effects (LME) approximation suggested by Lindstrom and Bates, the Laplacian approximation, and Gaussian quadrature centered at the conditional modes of the random effects are quite accurate and computationally efficient. Gaussian quadrature centered at the expected value of the random effects is quite inaccurate for a smaller number of abscissas and computationally inefficient for a larger number of abscissas. Importance sampling is accurate, but quite inefficient computationally.     

纵向数据下半参数混合效应模型的估计

考虑纵向数据下一类半参数混合效应模型.应用核权函数法以及矩估计法给出了总体效应和个体效应的估计.在一般的条件下,证明了总体效应估计的渐近正态性,并给出该估计的置信区域.对总体效应和个体效应的估计进行了模拟研究,模拟显示估计效果较好.     

Sampling Schemes for Bayesian Variable Selection in Generalized Linear Models

Bayesian approaches to prediction and the assessment of predictive uncertainty in generalized linear models are often based on averaging predictions over different models, and this requires methods for accounting for model uncertainty. When there are linear dependencies among potential predictor variables in a generalized linear model, existing Markov chain Monte Carlo algorithms for sampling from the posterior distribution on the model and parameter space in Bayesian variable selection problems may not work well. This article describes a sampling algorithm based on the Swendsen-Wang algorithm for the Ising model, and which works well when the predictors are far from orthogonality. In problems of variable selection for generalized linear models we can index different models by a binary parameter vector, where each binary variable indicates whether or not a given predictor variable is included in the model. The posterior distribution on the model is a distribution on this collection of binary strings, and by thinking of this posterior distribution as a binary spatial field we apply a sampling scheme inspired by the Swendsen-Wang algorithm for the Ising model in order to sample from the model posterior distribution. The algorithm we describe extends a similar algorithm for variable selection problems in linear models. The benefits of the algorithm are demonstrated for both real and simulated data.     

Selecting mixed-effects models based on a generalized information criterion

The generalized information criterion (GIC) proposed by Rao and Wu [A strongly consistent procedure for model selection in a regression problem, Biometrika 76 (1989) 369-374] is a generalization of Akaike's information criterion (AIC) and the Bayesian information criterion (BIC). In this paper, we extend the GIC to select linear mixed-effects models that are widely applied in analyzing longitudinal data. The procedure for selecting fixed effects and random effects based on the extended GIC is provided. The asymptotic behavior of the extended GIC method for selecting fixed effects is studied. We prove that, under mild conditions, the selection procedure is asymptotically loss efficient regardless of the existence of a true model and consistent if a true model exists. A simulation study is carried out to empirically evaluate the performance of the extended GIC procedure. The results from the simulation show that if the signal-to-noise ratio is moderate or high, the percentages of choosing the correct fixed effects by the GIC procedure are close to one for finite samples, while the procedure performs relatively poorly when it is used to select random effects.