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Matthew M. CummingsRonald W. Clawson Jr. Sriganesh B. SharmaRachel A. Byerly Novruz G. AkhmedovBjörn C.G. Söderberg 《Tetrahedron》2011,67(26):4753-4757
An expedient synthesis of the alkaloid salviadione, the only to date isolated naturally occurring 1H-benzo[def]carbazole is described. The key step in the synthesis is a palladium-catalyzed, carbon monoxide-mediated reductive N-heterocyclization of a nitroarene with an adjacent alkene. 相似文献
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The six-membered heterocyclic subunit of homophthalimides can be obtained by a direct, hitherto unprecedented, radical cyclisation onto an aromatic ring starting from a xanthate precursor. 相似文献
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Rose KG Jaber DM Jaber DA Gondo CA Hamilton DG 《The Journal of organic chemistry》2008,73(10):3950-3953
Heating of the solid ammonium salts obtained from treatment of mellitic acid with 3 equiv of a primary amine yields trisubstituted mellitic triimides via dehydration and imide ring closure. This surprisingly simple synthetic approach is amenable to incorporation of alkyl, aryl, and amino acid ester substituents, thereby opening broad access to a family of C(3)-symmetric organic electron acceptors. 相似文献
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Condensation of carboxylic acid esters with organodilithium reagents derived from N-trimethylsilyl-o-toluidine or N-trimethylsilyl-o-ethyl aniline affords substituted indoles. 相似文献
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Andrew Bach Xinglong Jiang Joseph Mckenna Kapa Prasad Oljan Repic Wen‐Chung Shieh 《Journal of heterocyclic chemistry》2004,41(4):637-640
An efficient approach has been developed for the synthesis of an isofervenulin analogue 1 employing a one‐pot condensation‐substitution reaction of a chlorocarboethoxytriazine (electrophile) with a urea (nucleophile). The resulting cyclization reaction resulted in the synthesis of a pyrimido‐heterocycle in good yield in either acidic or basic media. The former was assisted by utilizing trimethylsilyl chloride. 相似文献
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The readily available and enantiomerically pure trienes 12 undergo a thermally induced intramolecular Diels-Alder reaction to give the corresponding mixture of compounds 13 and 14. This mixture has been elaborated to an advanced intermediate associated with Nicolaou's recently reported total synthesis of the natural enantiomeric form of the antibiotic platencin (2). 相似文献
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A simple and efficient total synthesis of ellipticine was developed via the Suzuki-Miyaura coupling of sterically sensitive 2-hydroxybenzeneboronic acid with a multifunctional aryl halide using Pd(OAc)2 as a catalyst and Cu(OAc)2·H2O as an additive in DMSO/H2O as a key step followed by double N-arylation and cyclization. 相似文献
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An expedient synthesis of quinolactacin A2 from N-methylisatoic anhydride and N-Boc-(2S,3S)-isoleucine has been achieved. The key step involves the Friedländer-type annulation of isatoic anhydride and β-ketoester derived from isoleucine. 相似文献
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George Bashiardes Imad Safir Francis Barbot Joelle Laduranty 《Tetrahedron letters》2004,45(7):1567-1570
A general and rapid synthesis of new families of pyrrolizines and indolizines in good overall yields via an intramolecular [3+2] cycloaddition reaction is described. Diversity of substitutions can be achieved by the appropriate choice of readily available starting materials. The experimental procedures are straightforward and are performed under neutral conditions. New syntheses are also described for the preparation of N-propargylic 2-amino-benzaldehydes and S-propargylic 2-thiobenzaldehydes. 相似文献
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Caroline L. Nesbitt 《Tetrahedron letters》2009,50(46):6318-3666
Single enantiomer 2,5-disubstituted-3-oxygenated tetrahydrofurans are synthesized in as little as four steps from a commercially available epoxide. The key steps are homoallylic alcohol epoxidation, palladium-catalysed alkoxy-carbonylation-lactonisation and Mitsunobu inversion. The protocol is applied to the formal total syntheses of (+)-kumausallene, (6S,7S,9R,10R)-6,9-epoxynonadec-18-ene-7,10-diol and the core of lytophilippine A. 相似文献
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An expedient synthesis of the antibiotic natural product centrolobine is reported, the key step being the one pot, multi-component construction of a tetrahydropyran-4-one via a ‘revisited’ Maitland-Japp reaction. 相似文献
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Ramana CV Baquer SM Gonnade RG Gurjar MK 《Chemical communications (Cambridge, England)》2002,(6):614-615
Synthesis of tetrakis(cyclopropylmethyl)methane, a new symmetric product has been described using the radical mediated gem-diallylation of cyclopropylmethyl xanthate as a key step and its single crystal X-ray analysis established its C2-symmetry. 相似文献
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Gullapalli Kumaraswamy Gajula Ramakrishna Ragam Raju Mogilisetti Padmaja 《Tetrahedron》2010,66(52):9814-9818
An expedient synthesis of enantioenriched substituted (benzofuran-yl)-aryl and heteroaryl carbinols, is described. A key feature of this protocol is synthesis of functionally varied benzofuran scaffolds via a Rap-Stoermer reaction/catalytic asymmetric transfer hydrogenation (ATH) using substituted salicylaldehyde and α-haloaryl, heteroaryl ketones. 相似文献
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An efficient synthesis of 9,10-disubstituted phenanthrenes is described in this Letter. These novel useful building blocks were obtained in a one-pot reaction including Suzuki-Miyaura cross-coupling followed by a Dieckmann-Thorpe ring closure under microwave irradiation. The selection of the appropriate reagents and the optimal reaction conditions to isolate the intermediate biphenyl compound or the final substituted phenanthrenes in high yields will be discussed in this Letter. 相似文献