化学学院专业介绍——化学生物学专业

南开大学是国内最早建立化学生物学学科、最早开展化学生物学本科生和研究生培养的高校之一。南开大学化学学院从2012年开始招收化学生物学专业本科生,迄今为止培养了5届共98名毕业生;经过多年教学实践,在化学生物学专业人才培养方面积累了经验,取得了一定成效。介绍了南开大学化学学院化学生物学本科专业的基本情况、课程设置、培养特色和目标、育人成效等。     

吉林大学超分子化学生物学学科的建设与发展:从超分子化学到生命机制探索及疫苗、药物研发

吉林大学是国内较早进行化学与生物学交叉研究的高校之一。为了推动吉林大学化学与生物学的深度融合,同时结合本校在超分子化学领域的积累与优势形成研究特色,本校提出了发展超分子化学生物学的构想,并建立了吉林大学超分子化学生物学研究中心。回顾了吉林大学化学与生物学交叉融合的发展历程,介绍了超分子化学生物学学科的发展现状及未来发展方向。     

化学生物学实验课程体系的建立

将化学学科教师的学术研究与本科生的化学生物学实验课程建设紧密结合,建立化学生物学创新实验课程体系。     

基于创新能力培养的化学专业本科实验教学新体系的构建与实践

课程体系是人才培养的载体。为了更好地培养拔尖创新人才,南京大学化学国家级实验教学示范中心依据化学学科的特点和发展趋势,以科学内容的内在联系和研究规律为主线构建了“化学实验基础?化学合成与表征+化学原理与测量?化学功能分子实验+化学生物学综合实验+基于项目的研究实验”实验课程新体系,按照一流课程建设要求(高阶性、创新性和挑战度)对实验教学内容进行了优化,并建立起与之相适应的实验教学平台。新课程体系综合考虑了化学一级学科的整体性和关联学科的交叉性,在南京大学化学化工学院“拔尖计划”和“强基计划”学生中实施,教学效果显著。     

化学生物学实验的教学实践及其安全管理

作为化学领域的新兴二级学科,化学生物学利用化学的原理、方法和具有生物活性的化合物来研究生命过程中的问题。本文主要介绍了清华大学为"学堂人才计划"学生培养建立的实验课程平台——"化学生物学实验"课程的教学实践、体会和安全管理。     

培养化学生物学复合型本科生的探索

1　培养化学生物学复合型人才的时代背景　　生命体系是目前化学研究最重要的对象之一。几年前 ,我国就已有学者提出 ,分子以上层次的化学是研究化学、生物学复杂系统的一部分 ,它将会在从生物医学到化学之间的辽阔领域展现出新的活力[1] ,并预测可能会产生一门被称为化学生物学的交叉学科[2 ] 。最近 ,吴厚铭先生通过对当今各国学科现状与文献的分析 ,认为化学生物学这一重要的新兴交叉学科已经形成[3 ] 。该学科适应化学与生物学和医学等学科领域相互交叉、相互渗透的趋势 ,采用生物学家不熟悉的化学手段 ,如运用小分子或人工设计合成的分…     

化学学科能力建构的基本问题探讨

探讨了化学学科能力的内涵、化学学科能力的构成要素、化学学科能力水平的发展以及化学学科能力的评价等问题。基于化学学科本质及特殊要求界定了化学学科能力内涵及其核心要素, 并以“学习进程”的相关理论为基础建立了化学学科能力发展及评价框架。     

法庭化学与化学

简单叙述了法庭化学与化学的关系，法庭化学是化学的一个特殊组成部分，化学的发展促进法庭化学的发展，法庭化学在侦破案件中起重要作用。本文还介绍了法庭化学研究的内容及与相关学科的关系。     

服务于新农科的环境岩土与生态保护课程中化学知识体系设计

新农科建设为我国高校专业与课程改革建设带来新的机遇与挑战。本文针对新农科建设中，土木工程学科农业农村基础设施相关环境岩土、生态保护等课程中化学知识严重不足的问题，对相关课程中化学基础知识授课内容、方法进行系统分析和优化设计。经多年教学检验，课程改革很好地提升了土木工程专业学生化学知识工程设计与实践能力。     

医用基础化学教材改革的几点思考

化学是医学、药学和生物学的重要基础。特别是近年来分子生物学(molecularbiology)、分子医学(molecularmedicine),遗传组学(genomics)、蛋白组学(proteomics)、代谢组学(metabonomics)等学科的相继出现,标志着生命科学的发展进入了分子水平,化学在生命科学中的重要性更加突出。如何不失时机地将化学学科作为一个基础学科整体介绍给医学、药学和生物学的学生,又在教学中将化学与医学、药学和生物学的紧密联系介绍给学生,从而构建出一套对医学、药学和生物学学生适用的生物医药类专业化学基础课体系,并在此基础上,搭建为生物医药类专业学生服…     

浅析化学生物学实验课程的有效教学方法

作为高年级化学专业本科生的综合性实验课程,化学生物学实验课为学生提供了拓宽知识体系及培养相关实验技术能力的平台。本文主要介绍了笔者在改进实验课教学过程中所做的尝试,包括设置"实验考查点"以提高实验效率,通过"翻转课堂"形式引入改进内容以及根据教材合理拓宽实验内容等。多种方式的综合应用有助于教与学的互动,更适应实验课程交叉性和不断发展的需要。     

Inferring the chemical mechanism from structures of enzymes

Chemistry has once again embraced the study of enzyme mechanism as a core discipline. Chemists are uniquely able to contribute to the analysis of enzymes through their understanding of the reactivity of atoms. In this tutorial review for the Corday-Morgan medal, I will concentrate on the work from my lab over the past six years. I discuss enzymes which transform carbohydrates and incorporate halogens. The tutorial review will emphasise the strengths and limitations of structural biology as a means to deducing the chemical mechanism.     

关于为拔尖人才培养开设的"学科前沿"类课程的探讨

With the implementation of the basic discipline of "Top Talent Training Program" (the "East Ever Project"), more and more new reforms and attempts are being made in various universities. In the process of innovation and exploration, a new curriculum is being implemented, that is, the "the frontier aspects of disciplines" course. Through investigation and research, we found that many colleges and universities in China are carrying out or trying to carry out such courses, and the students who participated have different benefits. This paper mainly discusses the current situation of the development of the frontier courses of many universities in China, and gives suggestions based on the two courses of Tang Aoqing Honors Program in Science of chemistry in Jilin University. This paper provides reference for other colleges and universities to open such courses.     

化学生物学在生物芯片技术中的角色

化学生物学是一个新兴的化学与生物学的交叉学科.它的基本任务是揭示生命运动的化学本质,发展生命调控的化学方法,提供生命研究的化学技术.本文以化学生物学在生物芯片技术发展中扮演的角色为例讨论当前化学生物学发展的特点.     

Chemical biology: the promise, and confusion, of adolescence.

It takes time for any new scientific discipline to gain momentum, and chemical biology is no exception. But with the formation of new training programs and interdisciplinary departments, the changes are coming.     

合成生物学展望

近年来,合成生物学快速发展成为一个新兴交叉学科领域,研究重点逐渐由基因线路、简单元件和模块的设计构建转向设计与构建复杂的人工生物系统.本文阐述了合成生物学与化学工程学科的内在联系,并从基因组的人工设计合成与编辑、人工细胞的设计合成、人工合成多细胞体系及其应用等方面展望了未来合成生物学的发展趋势.     

契合生物专业有机化学课堂教学改革与实践

Organic chemistry is an important basic course for biology-majored students. Starting from the perspective of stimulating students' interest in learning, breaking through the key and difficult points, and realizing the course education, this paper proposes that teachers should combine the characteristics of biology discipline, strengthen the chemical cognition of biologically functional molecules or biomass components, and promote the cultivation of students' interdisciplinary integration consciousness. At the same time, this paper explores the teaching reform of organic chemistry for biology-majored students so as to lay a foundation for cultivating interdisciplinary talents with comprehensive innovation ability.     

Imaging methods for elemental, chemical, molecular, and morphological analyses of single cells

Combining elemental, chemical, molecular, and morphological imaging information from individual cells with a lateral resolution well below 1?×?1 μm² is the current technological challenge for investigating the smallest dimensions of living systems. In the race for such analytical performance, several techniques have been successfully developed; some use probes to determine given cellular contents whereas others use possible interactions between cellular matter with light or elements for characterization of contents. Morphological techniques providing information about cell dimensions have, when combined with other techniques, also opened the way to quantitative studies. New analytical opportunities are now being considered in cell biology, combining top-performance imaging techniques, applied to the same biosystem, with microscopy (nm–μm range) techniques providing elemental (micro-X-ray fluorescence, particle-induced X-ray emission, secondary-ion mass spectrometry), chemical (Raman, coherent anti-stokes Raman, Fourier-transform infrared, and near-field), molecular (UV–visible confocal and multiphoton), and morphological (AFM, ellipsometry, X-ray phase contrast, digital holography) information. Dedicated cell-culture methods have been proposed for multimodal imaging in vitro and/or ex vivo. This review shows that in addition to UV–fluorescent techniques, the imaging modalities able to provide interesting information about a cell, with high spatial and time resolution, have grown sufficiently to envisage quantitative analysis of chemical species inside subcellular compartments.     

“学案式”基础化学实验报告探讨与实践

Lab reports are an integral part of the fundamental chemical laboratory teaching and necessary for students to master the chemical knowledge. However, there are some problems such as simple contents in current teaching and learning of fundamental chemistry laboratories in universities. In this paper, a "learning-guidance mode" lab report based on classical experiments was studied to enrich the format and contents of the lab report. Upon examination, the contents of the "learning-guidance mode" lab report throughout every aspect and whole process of laboratory teaching can help students to establish self-learning consciousness and improve self-learning ability and exploration spirit. Meanwhile, it can also train students to possess capability of scientific thinking and solving problems, thus enhancing the effect of teaching of fundamental chemistry laboratory.