共查询到20条相似文献,搜索用时 31 毫秒
1.
The aim of this study is to prepare radiolabeled guanine with 99mTc(CO)3+ core. For this purpose, guanine has been radiolabeled with 99mTc(CO)3+ core. Quality control study of radiolabeled guanine molecule with 99mTc(CO)3+ core was performed by thin layer radio chromatography (TLRC) and high performance liquid radio chromatography (HPLRC). The
results showed that the radiolabeling yield was quite high (94 ± 3%). Beside that 99mTc(CO)3–Gua complex has showed good in vitro stability during the 24 h period. Radiopharmaceutical potential of this complex was
evaluated in Wistar Albino Rats. It was concluded that 99mTc(CO)3–Gua could be used as a nucleotide radiopharmaceutical for in vivo applications. 相似文献
2.
Ai-Yih Wang Jiunn-Liang Lin Wen-Chieh Lin 《Journal of Radioanalytical and Nuclear Chemistry》2010,284(1):21-28
The aim of this research is to use acetylacetonate as a 99mTc chelating agent label with porphyrin and evaluate its radiochemical and biological characteristics. Stannous chloride was
used as a reductant to determine the chemical and biological characterization of 99mTc-complexes from labeling porphine{4′,4′′,4′′′-(2lH,23H-Porphine-5,10,15,20-terayl)tetrakis-(benzoic acid), TPPB} with 99mTc–pertechnetate. Instant thin layer chromatography (ITLC), size exclusion chromatography (SEC), paper electrophoresis, and
UV/Vis spectrophotometry were used to evaluate chemical characterization. Finally, biodistribution and liver function tests
were applied to evaluate biological characteristics. The results of this study show that the labeling efficiency of 99mTc(acac)–TPPB was nearly 100% when using acetylacetone (acac) as a conjugator. Three major 99mTc(acac)–TPPB complexes were separated by SEC, and all of them were hydrophilic. The UV-Vis spectra of 99mTc(acac)–TPPB complexes closely resembled those of the TPPB, but the wave lengths of their peaks changed 430, 521, 556, 591
and 647 nm after complexation. The biodistribution study selected the liver as the target organ. The 99mTc(acac)–TPPB complex may cause short-term liver injury. However, this injury can be repaired, and the reagent is quickly
metabolized. Hence, the toxicity of the 99mTc(acac)–TPPB complex is within an acceptable range, and making it a promising liver imaging agent. 相似文献
3.
Syed Qaiser Shah Aakif Ullah Khan Muhammad Rafiullah Khan 《Journal of Radioanalytical and Nuclear Chemistry》2011,288(1):207-213
The labeling of garenoxacin (GXN) with technetium-99m (99mTc) using different concentrations of GXN, sodium pertechnetate (Na99mTcO4), stannous chloride dihydrate (SnCl2·2H2O) at different pH was investigated and evaluated in terms of in-vitro stability in saline, serum, binding with multi-resistant
Staphylococcus aureus (MDRSA) and penicillin-resistant Streptococci (PRSC) and its biodistribution in artificially MDRSA and PRSC infected rats. 99mTc–GXN complex with 97.45 ± 0.18% radiochemical stability was prepared by mixing 3 mg of GXN with 3 mCi of Na99mTcO4 in the presence of 150 μL of SnCl2·2H2O (1 μg/μL in 0.01 N HCl) at a pH 5.6. The radiochemical stability of the complex was evaluated in normal saline up to 240 min
of reconstitution. It was observed that the complex showed maximum RCP values after 30 min of the reconstitution and remained
more than 90% up to 240 min. The complex showed radiochemical stability in normal saline at 37 °C up to 16 h with a 17.80%
de-tagging. The complex showed saturated in-vitro binding with living MDRSA and PRSC as compared to the insignificant binding
with heat killed MDRSA and PRSC. Biodistribution behavior of the complex was assessed in artificially infected with living
and heat killed MDRSA and PRSC rats. It was observed that the accumulation of the complex in the infected (live MDRSA and
PRSC) tissue of the rats was almost five fold than in the inflamed and normal tissue. The high radiochemical stability in
normal saline at room temperature, promising in-vitro stability in serum at 37 °C, saturated in-vitro binding with living
MDRSA and PRSC, specific biodistribution behavior and high infected (target) to normal (non-target) tissue and low inflamed
(non-target) to normal (non-target) tissue ratios we recommend 99mTc–GXN complex for in-vivo localization of infection caused by MDRSA and PRSC effective stains. 相似文献
4.
Jianjun Wang Jing Yang Zeyi Yan Xiaojiang Duan Cunmin Tan Yinglin Shen Wangsuo Wu 《Journal of Radioanalytical and Nuclear Chemistry》2011,287(2):465-469
This work reports the synthesis, radiolabeling and preliminary biodistribution results in tumor-bearing mice of [99mTc(CO)3(IDA–PEG3–CB)]−. The novel chlorambucil derivative was successfully synthesized by conjugation of iminodiacetic acid (IDA) to chlorambucil
via a pegylated linker. The ligand could be labeled by [99mTc(CO)3]+ core in high yield to get [99mTc(CO)3(IDA–PEG3–CB)]−, which was very hydrophilic and was stable at room temperature. Biodistribution studies in tumor-bearing mice showed that
[99mTc(CO)3(IDA–PEG3–CB)]− accumulated in the tumor with favorable uptake and retention. The good accumulation in tumor tissue with high tumor/muscle
ratios warrants further research to improve tumor targeting efficacy and pharmacokinetic profile of radiolabeled chlorambucil
derivative by structural modification. 相似文献
5.
Jianjun Wang Xiaojiang Duan Huining Mao Jing Yang Tingting Niu 《Journal of Radioanalytical and Nuclear Chemistry》2011,288(2):635-639
This work reports the synthesis, radiolabeling and preliminary biodistribution results in tumor-bearing mice of the 99mTc(CO)3–AOPA colchicine conjugate. The novel ligand was successfully synthesized by conjugation of N-(acetyloxy)-2-picolylamino (AOPA) to deacetylcolchicine via a short carbonyl-methylene linker. Radiolabeling was performed
in high yield with [99mTc(CO)3]+ core. 99mTc(CO)3–AOPA colchicine conjugate was hydrophilic and was stable at room temperature. Biodistribution studies in tumor-bearing mice
showed that 99mTc(CO)3–AOPA colchicine conjugate accumulated in the tumor with good uptake and retention. However, its clearance from normal organs
was not so fast, resulting in poor T/NT ratios. Further modification on the linker or/and 99mTc-chelate to improve the tumor targeting efficacy and in vivo kinetic profiles is currently in progress. 相似文献
6.
E. M. Bond S. Glover D. J. Vieira R. S. Rundberg G. Belier V. Meot D. Hynek Y. Jansen J. Becker R. Macri 《Journal of Radioanalytical and Nuclear Chemistry》2008,276(2):549-554
This paper describes the preparation of samples for an experiment to measure the cross-section for 235U(n,n′)235mU in a fast fission spectrum of neutrons provided by a fast pulsed reactor/critical assembly. Samples of 235mU have been prepared for the calibration of the internal conversion electron detector that is used for the 235mU measurement. Two methods are described for the preparation of 235mU. The first method used a U-Pu chemical separation based on anion-exchange chromatography and the second method used an alpha
recoil collection method. Thin, uniform samples of 235mU+235U were prepared for the experiment using electrodeposition. 相似文献
7.
Syed Qaiser Shah Aakif Ullah Khan Muhammad Rafiullah Khan 《Journal of Radioanalytical and Nuclear Chemistry》2011,288(1):131-136
Garenoxacin (GXN) was modified to its dithiocarbamate followed by radiolabeling with technetium-99m (99mTc) through [99mTc-N]2+ core. The suitability of the 99mTcN–Garenoxacin dithiocarbamate (GXND) complex as a potential multiresistant Staphylococcus aureus (MDRSA) and penicillin-resistant Streptococci (PRSC) infection radiotracer was assessed in artificially infected rats (AFRT). The radiolabeled complex was investigated
for its radiochemical purity (RCP), permanence in serum using HPLC and TLC methods. In vitro binding with MDRSA and PRSC was
performed at 37 °C. The 99mTcN–GXND showed maximum RCP of 98.00 ± 0.22% and remained more than 90% stable up to 4 h. The 99mTcN–GXND showed saturated in vitro binding with living MDRSA and PRSC, respectively. The complex showed normal biodistribution
in healthy rats (HRT), however in AFRT, seven fold uptakes was observed in infected muscle as compared to inflamed and normal
muscles. Based on the high RCP, stability in serum, better in vitro binding with bacteria, biodistribution behavior and the
target to non-target (infected to inflamed muscle) ratio, we recommend the 99mTcN–GXND complex for in vivo investigation of MDRSA and PRSC infection in human. 相似文献
8.
N. V. Aksenov H. Bruchertseifer G. Ya. Starodub G. K. Vostokin E. E. Tereshatov G. A. Bozhikov S. V. Shishkin S. N. Dmitriev 《Journal of Radioanalytical and Nuclear Chemistry》2009,279(1):341-343
A rapid method for the preparation of 87Y/87mSr radionuclide generator from a rubidium chloride target irradiated with 35 MeV α-particles is described. A simple two-step
procedure is used to obtain a carrier-free 87mSr isotope with a high enough radiochemical yield and high purity in the final aqueous fraction. 相似文献
9.
T. Takeda M. Fujiwara M. Kurosawa N. Takahashi M. Tamura T. Kawabata Y. Fujikawa K. N. Suzuki N. Abe T. Kubota T. Takahashi 《Journal of Radioanalytical and Nuclear Chemistry》2018,317(2):811-824
In this paper, cheap liquorice residue was used to prepare activated carbon (AC), thioacetamide (TAA) was used to modify the AC, and the adsorption experiments were conducted in the simulated acid radioactive wastewater with low uranium concentration to study the adsorption behavior and mechanism for uranium by TAA modified AC (TAA–AC). The removal efficiency by TAA–AC was 92.1–98.2% from the 1 mg L?1 uranium solution at pH 2–6. The adsorption equilibrium data were well fitted by Dubinin–Radushkevich model, and the maximum adsorption capacity was estimated to be 340 mg g?1. TAA–AC showed an enhanced selectivity for uranium in the presence of competitive ions. Furthermore, the adsorption experiments were conducted in the actual acid radioactive wastewater with low uranium concentration from an in situ leach uranium mine. The high adsorption rate (98.3%) and selectivity (Kd?=?3.78×104 mL g?1) for uranium were observed in the actual acid radioactive wastewater, and the adsorption rate was found to maintain 96.2% over six cycles of adsorption–desorption. 相似文献
10.
I. P. Pozdnyakov E. M. Glebov S. G. Matveeva V. F. Plyusnin A. A. Mel´nikov S. V. Chekalin 《Russian Chemical Bulletin》2015,64(8):1784-1795
Primary photophysical and photochemical processes were studied for PtIVBr6 2– and PtIVCl6 2– complexes in water and methanol by ultrafast kinetic spectroscopy upon excitation in the band region of charge transfer from the ligand-centered group π-orbitals to the eg*-orbital of PtIV complex anion (LMCT bands). The data obtained earlier upon excitation in the region of d—d bands were compared. Irrespective of the excitation wavelength, the photochemical properties of complexes are caused by the reactions of intermediates proceeding in the picosecond time range. These intermediates were identified as PtIVBr5 – upon photolysis of PtIVBr6 2– and, presumably, the Adamson radical pair [PtIIICl5 2–(C 4v )...Cl?] upon photolysis of PtIVCl6 2–. The difference in the exciting light wavelengths has an impact only on the first step of these processes, i.e., transition from the Franck—Condon excited state to intermediates. 相似文献
11.
The radiolabeling of trovafloxacin dithiocarbamate (TVND) with technetium-99m using [99mTc-N]2+ core was investigated and biologically assessed as prospective infection imaging agent. The achievability of the 99mTcN-TVND complex as a future MRSA infection radiotracer was investigated in artificially methicillin-resistant Staphylococcus aureus (MRSA) infected male Sprague–Dawley rats (MSDR). Radiochemically the 99mTcN-TVND complex was characterized in terms of radiochemical purity (RCP) in saline, in vitro permanence in serum, in vitro
binding with MRSA and biodistribution in living and heat killed MRSA infected MSDR. Radiochemically the complex showed stability
in saline with a 97.90 ± 0.22% yield and serum at 37 °C up to 4 h. The 99mTcN-TVND complex showed saturated in vitro binding with MRSA. Normal in vivo uptake in the MRSA infected MDRS was observed
with a five fold uptake in the infected muscle as compared to inflamed and normal muscles. The high RCP values, in vitro permanence
in serum, better in vitro binding with MRSA, biodistribution behavior and the target to non-target (infected to inflamed muscle)
ratios posed the 99mTcN-TVND complex as a promising MRSA infection radiotracer. 相似文献
12.
A. N. Charkin O. V. Dudarev A. N. Salyuk N. E. Shakhova V. I. Sergienko I. P. Semiletov 《Doklady Chemistry》2017,476(1):211-214
The first results of activity measurement of short-lived radium isotopes dissolved in water in the Anadyr River–Bering Sea transit system are presented. The trends of the radionuclide behavior after passage through high-gradient river–coastal sea water mixing zone were identified and the exchange rate of the horizontal mixing was determined. The 224Ra/223Ra activity ratio was used to construct the “radium age” model, which served for estimating the residence time of brackish water in the Anadyr River estuary. The factors affecting this value were elucidated. 相似文献
13.
Boukraa Yamina 《Russian Journal of Physical Chemistry A, Focus on Chemistry》2016,90(13):2642-2645
A study on the extraction of copper(II), cobalt(II), and nickel(II) from solutions containing ions of both metals with N-salicylideneaniline(SAN) in chloroform has been realized. Distribution of the metal ions in wide range of pH has been studied. Extraction of copper(II) was always favored over that of cobalt(II). Extraction of copper(II) from binary metal solution is selective and it can be quantitatively separated from cobalt(II). The equilibrium constant of the extraction of cobalt and nickel from an aqueous solution containing both metals using SAN were evaluated. The separation factors for cobalt and nickel were expressed as a function of the distribution of nickel and cobalt. From these results, salicylideneaniline is an adequate extractant for extractive separation of such mixtures. 相似文献
14.
Abstract The title compound, labeled with 13C in the ethyl groups was synthesized from K13CN and low-molecular-weight components. The synthetic relay compound was 31(32)[13C]-xanthobilirubinic acid methyl ester in a synthetic route that leads to a label in the ethyl β-substituent of a dipyrrinone
model for bilirubin. This labeled dipyrrinone was oxidatively coupled to the dimethyl ester of mesobiliverdin-XIIIα, thereby
providing a route to a 13C-labeled mesobiliverdin and mesobilirubin, with one carbon of each ethyl being 98% 13C-enriched.
Graphical Abstract
相似文献
15.
16.
Makoto Takezaki Hiroyuki Aoki Michiko Kodama Toshihiro Tominaga 《Journal of Thermal Analysis and Calorimetry》2010,101(3):1149-1153
The solubility of hexadecyltrimethylammonium tetrachloroaurate (CTA·AuCl4) in water was measured at different temperatures of 288.2, 293.2, 298.2, 303.2, and 308.2 K. The enthalpy change associated
with the formation of the CTA·AuCl4 precipitate was estimated on the basis of the van’t Hoff equation and was found to be −42.5 ± 2.8 kJ mol−1 at 298.2 K. The calorimetric enthalpy change for the CTA·AuCl4 precipitate formation was directly determined by isothermal titration calorimetry performed at 298.2 K and was found to agree
well with that estimated from the van’t Hoff equation. 相似文献
17.
A. S. Kubasov E. Yu. Matveev E. S. Turyshev I. N. Polyakova K. Yu. Zhizhin N. T. Kuznetsov 《Doklady Chemistry》2017,477(1):257-260
The interaction of the [B10H10]2– and [B12H12]2– anions with aliphatic and aromatic nitro compounds (RNO2, where R = Et, n-Pr, i-Pr, tert-Bu, Ph) has been studied under irradiation with visible and UV light. It has been shown that, depending on the reaction conditions, both mono- and disubstituted nitro-closo-decaborates can be selectively obtained in yields up to 50%. 相似文献
18.
A. C. Yanes J. J. Velázquez J. del-Castillo J. Méndez-Ramos V. D. Rodríguez 《Journal of Sol-Gel Science and Technology》2009,51(1):4-9
Nanostructured transparent glass-ceramics with composition of 95SiO2–5LaF3 co-doped with 0.3Yb3+, 0.1Ho3+ and 0.1Tm3+ (mol%) were synthesized by thermal treatment of precursor sol–gel derived glasses. X-ray diffraction and transmission electron
microscopy analysis point out the precipitation of hexagonal LaF3 nanocrystals with diameter ranging from 11 to 20 nm in these nano-glass-ceramics. White light generation by means of efficient
blue, green and red up-conversion luminescence under infrared excitation at 980 nm was observed and involved mechanisms were
analyzed. Colour tuneability is achieved by varying the up-conversion emission ratios as a function of pump power. 相似文献
19.
O. V. Glumov V. A. Bodnar N. A. Mel’nikova V. E. Yakobson I. V. Murin 《Russian Journal of Electrochemistry》2017,53(8):846-851
KTiOPO4 crystals, both pure and doped with rubidium Rb+ and fluorine F– ions, were grown in temperature range from 1060 to 846°С from salt solvent containing potassium metaphosphate КРО3 and potassium orthophosphate К3РО4 by using a Czochralski modified method. Potassium–sodium titanyl phosphate crystals were obtained from KTiOPO4 crystals by the potassium isomorphic replacement with sodium; to this purpose, sodium chemical diffusion from NaNO3 melt was used. Their ionic conductivity was studied by the electrochemical impedance spectroscopy method. The KTiOPO4 crystal doping with rubidium and sodium ions was shown to lower the conductivity, whereas the doping with fluorine ions results in increased conductivity. 相似文献
20.
As part of a mass spectrometric investigation of the binding properties of sulfonamide anion receptors, an atmospheric pressure
chemical ionization mass spectrometric (APCI-MS) method involving direct infusion followed by thermal desorption was employed
for identification of anionic supramolecular complexes in dichloromethane (CH2Cl2). Specifically, the dansylamide derivative of tris(2-aminoethyl)amine (tren) (1), the chiral 1,3-benzenesulfonamide derivatives of (1R,2S)-(+)-cis-1-amino-2-indanol (2), and (R)-(+)-bornylamine, (3), were shown to bind halide and nitrate ions in the presence of (n−Bu)4N+X− (X− = Cl−, NO3−, Br−, I−). Solutions of receptors and anions in CH2Cl2 were combined to form the anionic supramolecular complexes, which were subsequently introduced into the mass spectrometer
via direct infusion followed by thermal desorption. The anionic supramolecular complexes [M+X]−, (M=1–3, X−=Cl−, NO3−, Br−, I−) were observed in negative mode APCI-MS along with the deprotonated receptors [M−H]−. Full ionization energy of the APCI corona pin (4.5 kV) was necessary for obtaining mass spectra with the best signal-to-noise
ratios. 相似文献