2-(4-Oxo-3,4-dihydro-2-quinazolinylmethyl)benzoic Acids

Condensation of 2-cyanomethylbenzoic acid with anthranilic acids gave a series of 2-(4-oxo-3,4-dihydro-2-quinazolinylmethyl)benzoic acids which are structural analogs of the alkaloid glycosminine (2-benzyl-1,2-dihydro-4-quinazolone).     

Molecular structures of methyl 4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-1-methyl-1H-pyrazol-5-carboxylate and methyl 4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-1-methyl-1H-pyrazol-3-carboxylate

The structure of methyl 4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-1-methyl-1H-pyrazol-5-carboxylate is determined by X-ray crystallography and further used to elucidate the structure of methyl 4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-1-methyl-1H-pyrazol-3-carboxylate, using the data of homo- and heteronuclear 2D NMR correlation spectroscopy.     

Synthesis of 1-[(1,2-dithiol-3-ylidene)methyl]pyrrolo[1,2-a]pyrazines and 2-[(1,2-dithiol-3-ylidene)methyl]pyridines from 1,2-dithiole-3-thiones

Benzo- and pyridoannulated 1,2-dithiole-3-thiones react with compounds containing an activated methyl group such as 1-methyl-3,4-dihydropyrrolo[1,2-a]pyrazine and 2-methylpyridines to furnish substituted 1,2-dithiol-3-ylidenes.     

Synthesis and Properties of 6,7,8-Substituted 2-(4-Oxo-3,4-dihydro-2-quinazolinyl)acetonitriles

2-(4-Oxo-3,4-dihydro-2-quinazolinyl)acetonitriles have been obtained by the interaction of -cyanoethylthioiminoacetate with substituted anthranilic acids. Prototropy became apparent in the series of synthesized compounds. Reactions of the 2-(4-oxo-3,4-dihydro-2-quinazolinyl)acetonitriles have been carried out with (hetero)aromatic aldehydes leading to the formation of 3-aryl-2-(4-oxo-3,4-dihydro-2-quinazolinyl)acrylonitriles.     

Synthesis of 2[(4,6-diphenyl-2H-pyran-2-ylidene)methyl]-4,6-diphenylpyrylium perchlorate

The title compound was prepared by the condensation of 4,6-diphenyl-2H-pyran-2-one and acetophenone in phosphorus oxychloride. The absorption spectrum of this 2,2-methine dye is compared with those of the corresponding 2,4- and 4,4-methine dyes.     

Efficient Synthesis of 2-[(Alkyltellanyl)methyl]-2,3-dihydro-1-benzofurans from Tellurium Tetrahalides and 2-Allylphenols

Russian Journal of Organic Chemistry - Efficient methods have been proposed for the synthesis of 2-[(alkyltellanyl)methyl]-2,3-dihydro-1-benzofurans in up to 90% yield through generation of...     

Electrochemical Synthesis of 2-(2-Chlorophenyl)-2-[(3,4- dihydroxyphenyl)(methyl)amino]cyclohexanone

Russian Journal of Electrochemistry - Electrochemical oxidation of catechol has been studied in the presence of ketamine as a drug in phosphate buffer solution mixed with ethanol using voltammetric...     

Studies on pyrrolidinones. Synthesis of 1-[(N-acetylarylamino)methyl]pyroglutamic acid derivatives

Pyroglutamic acid was transformed into 1-[(N-Acetylarylamino)methyl]pyroglutamic acid derivatives by using trimethylsilyl variations of the Mannich reaction.     

Synthesis of 2-diphenylphosphinoyl-3,5-(diaryl)-3,4-dihydro-2H-thiopyrans by the reaction of a bis[(diphenylphosphinoyl)methyl]sulfide with chalcones

The NaH-promoted tandem Michael addition/intramolecular Horner-Wittig reaction of bis(diphenylphosphinoylmethyl)sulfide with chalcones afforded 3,4-dihydro-2H-thiopyrans 3a-l in 78-88% yield.     

Synthesis of 2-[5-amino-2,3-dihydro-4H-imidazol-4-ylidene]malononitriles

Using the system of tetracyanoethylene, ammonium acetate and a carbonyl compound, the preparation of 2-[5-amino-2,3-dihydro-4H-imidazol-4-ylidene]malononitriles was carried out. The structures of these new dihydroimidazoles were determined by NMR experiments and by X-ray crystallography.     

2-芳基-5-[(4-芳基噻唑-2-基)甲基]-1,3,4-噁二唑的合成

以硫代酰胺和α-溴代酮为原料,经4步反应合成了N,N′-二酰基肼(6),6在POCl3作用下脱水环化,合成了7个未见文献报道的2-芳基-5-[(4-芳基噻唑-2-基)甲基]-1,3,4-噁二唑类化合物,其结构经1H NMR,IR,MS和元素分析表征。     

Synthesis, molecular, and crystal structure of 3,4-bis[(2,6-di-tert-butyl-4H-pyran-4-ylidene)methyl]cyclobut-3-ene-1,2-dione and -1,2-dithione

Two new dyes have been prepared, 3,4-bis[(2,6-di-tert-butyl-4H-pyran-4-ylidene)methyl]-cyclobut-3-ene-1,2-dione and -1,2-dithione. Their molecular and crystal structures have been studied by X-ray diffraction, and their spectral properties have been characterized. The heterocyclic fragments in the dyes molecules are in the trans-position with respect to the bonds connecting chromophore CH group with the 4-membered ring. Substitution of the carbonyl oxygen to sulfur leads to change in the crystal packing.     

Synthesis of Novel 2-(4-Oxo-3,4- Dihydroquinazolin-2-Ylsulfinylmethyl)-3H-Quinazolin-4-One

Abstract

Condensation of 2-mercapto-3H-quinazolin-4-one (1) with chloroacetic acid gave 4-oxo-3,4-dihydroquinazoline-2-yl-sulfanyl)-acetic acid (2) that with anthranilamide (3) gave 2-(4-oxo-3,4-dihydroquinazolin-2-ylsulfanylmethyl)-3H-quinazolin-4-one (4). Oxidation of 4 with sodium hypochlorite in alkaline medium gave the novel product, 2-(4-oxo-3,4- dihydroquinazolin-2-ylsulfinyl methyl)-3H -quinazolin-4-one) (5). The entire sequences of reactions in this work have been carried out using eco-friendly solvents and green conditions.

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