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1.
Reactions of some 2-hydrazinopyrimidine hydrochlorides with potassium thiocyanate gave 1-(pyrimidin-2-yl)thiosemicarbazides
which underwent Hantzsch condensation with aryl chloromethyl ketones to produce 1-(pyrimidin-2-yl)-2-(4-aryl-1,3-thiazol-2-yl)hydrazine
hydrochlorides. The protonation was accompanied by mutually dependent tautomeric rearrangements of heterocyclic fragments. 相似文献
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Bhovi K. Venkatesh Yadav D. Bodke S. A. Biradar 《Phosphorus, sulfur, and silicon and the related elements》2013,188(9):1926-1931
A protocol for the synthesis of 3-[4-(1-benzofuran-2-yl)-1,3-thiazol-2-yl]-2-(4-aryl)-1,3-thiazolidin-4-one derivatives (5a–e) has been developed from 1-(1-benzofuran-2-yl)-2-bromoethanone (2),which served as a key intermediate for the synthesis of the title compounds. The reaction of compound 2 with thiourea furnished 4-(1-benzofuran-2-yl)-1,3-thiazol-2-amine 3, which upon further reaction with various aromatic aldehydes, gave Schiff bases 4a–e. These Schiff bases, when treated with thioacetic acid in the presence of catalytic amount of anhydrous ZnCl2, yielded thiazolidinone derivatives 5a–e. All the newly synthesized compounds have been characterized by analytical and spectral data and screened for their antimicrobial and analgesic activity. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. 相似文献
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Kumar B. Ravi Kumar A. Kishore Reddy B. Srinivas Shashikala K. Laxminarayana E. 《Russian Journal of Organic Chemistry》2022,58(4):580-583
Russian Journal of Organic Chemistry - tert-Butyl 4-[(E)-but-1-en-3-yn-1-yl]-3-{[tert-butyl(dimethyl)silyl]oxy}-1H-indole-1-carboxylate has been synthesized with a good yield and selectivity... 相似文献
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Gein V. L. Bobrovskaya O. V. Russkikh A. A. Dmitriev M. V. Yankin A. N. 《Russian Journal of Organic Chemistry》2019,55(5):602-607
Russian Journal of Organic Chemistry - The reaction of methyl aroylpyruvates with 2-(4-aminobenzenesulfonamido)thiazole (norsulfazole) in acetic acid-ethanol (1: 1) afforded methyl... 相似文献
6.
Filippova P. V. Chernov N. M. Shutov R. V. Yakovlev I. P. 《Russian Journal of General Chemistry》2019,89(12):2471-2479
Russian Journal of General Chemistry - A procedure has been developed and optimized for the synthesis of 3-{[4-methyl-3-(4-methylpiperazin-1-yl)]pent-1-en-1-yl}-4H-chromen-4-ones (as... 相似文献
7.
Masterova N. S. Ryabova S. Yu. Alekseeva L. M. Shashkov A. S. Chernyshev V. V. Granik V. G. 《Russian Chemical Bulletin》2009,58(9):1973-1980
Russian Chemical Bulletin - Reactions of 3-acetoxy-2-(2,2-dicyanovinyl)indole with hydrazine hydrate and methyl-and phenylhydrazines afforded new indolin-3-one derivatives, namely,... 相似文献
8.
(R)-2-{[4-(3-甲氧基丙氧基)-3-甲基吡啶-2-基]甲基亚硫酰基}- 1H-苯并咪唑的合成 总被引:1,自引:0,他引:1
以2,3-二甲基吡啶为起始原料, 经过11步反应, 不对称合成了质子泵抑制剂的关键中间体: (R)-2-{[4-(3-甲氧基丙氧基)-3-甲基吡啶-2-基]甲基亚硫酰基}-1H-苯并咪唑. 研究了用手性高效液相色谱拆分对映体、测定产品光学纯度的方法, 结果表明目标产品的ee值达到99%. 通过IR, UV, MS以及1H NMR分析对重要中间体和目标产品进行了结构鉴定. 相似文献
9.
Reddy S. Ramakrishna Reddy G. Ganga Reddy Ch. Venkata Ramana Laxminarayana E. 《Russian Journal of Organic Chemistry》2022,58(6):858-864
Russian Journal of Organic Chemistry - A series of new benzamidine derivatives have been synthesized in good yields by involving 1-(1H-benzimidazol-2-yl)-2-bromoethanone,... 相似文献
10.
F. Güntepe H. Sara?o?lu N. ?al?skan ?. Yüksektepe A. ?ukuroval? 《Journal of Structural Chemistry》2011,52(3):596-601
The title compound 2-{[3-Methyl-3-phenyl-cyclobutyl)-thiazol-2-yl]-hydrazonomethyl}-phenol (C21H21N3S1O1) crystallizes in the P-1 triclinic space group with a = 5.8880(4) ?, b = 9.5618(5) ?, c = 17.0484(10) ?, α = 80.214(5)°, β = 80.532(5)°, γ = 80.116(5)°. In addition to molecular geometry and packing from X-ray experiment, we have
also calculated the molecular geometry and vibrational frequencies of the title compound in the ground state using density
functional theory DFT (B3LYP) with the 6–31G(d,p) basis set. Apart from this, the structure of the title compound is characterized by 1H NMR, 13C NMR, IR and UV-vis. Spectra, and the experimental emission energies are compared with the HOMO-LUMO energy gaps calculated
by the DFT method. 相似文献
11.
Pujari Vijay Kumar Vinnakota Srilalitha Kakarla Ramana Kumar Maroju Sreedhar Ganesh Arram Pervaram S. 《Russian Journal of General Chemistry》2018,88(7):1502-1507
Russian Journal of General Chemistry - A novel series of (E)-1-{2/3/4-[(1-aryl-1H-1,2,3-triazol-4-yl)methoxy]phenyl}-3-(2-morpholinoquinolin-3-yl)prop-2-en-1-ones is synthesised from terminal... 相似文献
12.
Gein V. L. Varkentin L. I. Kazantseva M. I. Dmitriev M. V. Yankin A. N. 《Russian Journal of General Chemistry》2019,89(11):2196-2200
Russian Journal of General Chemistry - The reactions of tryptamine with aromatic aldehyde and methyl benzoylpyruvate at room temperature leads to the formation of... 相似文献
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Abdou O. Abdelhamid Ali A. Al-Atoom 《Phosphorus, sulfur, and silicon and the related elements》2013,188(7):1629-1646
Abstract Thiazolylacetonitrile was used in the synthesis of coumarin, pyrazolo[4,3]pyrimidines, 1,3,4-thiadiazolines, aminothiophenes, and thiazoles in a good yields. Also, pyrazolo[4,5-d]triazolino[4,5-a]pyrimidines, pyrazolo[4,5-d]thiazolino[3,2-a]pyrimidines, and pyrazolo[4,5-d]tetrazolino[1,5-a]pyrimidines were synthesized from pyrazolo[4,5-d]pyrimidine. Structures of the newly synthesized were elucidated by elemental analysis, spectral data, and alternative synthesis routes whenever possible. Some synthesized compounds were tested for their antimicrobial activity. 相似文献
15.
Fedorchenko T. G. Lipunova G. N. Shchepochkin A. V. Valova M. S. Tsmokalyuk A. N. Slepukhin P. A. Chupakhin O. N. 《Russian Journal of Organic Chemistry》2020,56(1):38-48
Russian Journal of Organic Chemistry - New 2-(5-aryl-6-R-3-phenyl-5,6-dihydro-4H-1,2,4,5-tetrazin-1-yl)-1,3-benzothiazoles were synthesized from the corresponding formazans by alkylation and... 相似文献
16.
Yu. M. Volovenko T. A. Volovnenko A. V. Tverdokhlebov I. G. Ryabokon' 《Russian Journal of Organic Chemistry》2001,37(9):1323-1329
Reactions of 2-(4-aryl-1,3-thiazol-2-yl)-3-oxo-4-chlorobutyronitriles with primary aromatic amines result in nucleophilic substitution of the chlorine atom by amino group, followed by intramolecular addition of the secondary amino group to the cyano group. The products are 5-amino-1-aryl-4-(4-aryl-1,3-thiazol-2-yl)- 2,3-dihydro-1H-pyrrol-3-ones which are structurally related to the known antiischemic drugs. 相似文献
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Ravinaik B. Rao M. V. B. Rao P. T. S. R. K. P. Ramachandran D. Reddy D. R. S. 《Russian Journal of Organic Chemistry》2021,57(4):624-630
Russian Journal of Organic Chemistry - A series of substituted N-(4-{5-[4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]-4-(2,3,4-trimethoxyphenyl)-1,3-thiazol-2-yl}phenyl)benzamides were designed... 相似文献
19.
S. A. Maklakov Yu. I. Smushkevich I. V. Magedov 《Chemistry of Heterocyclic Compounds》2002,38(8):904-907
A method was developed for the production of indole compounds containing an amino group at positions 4 and 6 of the benzene ring on the basis of the indolization of the 3-acetylaminophenylhydrazone of ethyl levulinate. A series of derivatives of 2-(4-amino-2-methyl-1H-indol-3-yl)- and 2-(6-amino-2-methyl-1H-indol-3-yl)acetic acids at the 4- and 6-amino group were synthesized. 相似文献