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A More Efficient Synthetic Route to Perylene-porphyrin Arrays 总被引:3,自引:0,他引:3
XinGuoYANG JingZhiSUN MangWANG HongZhengCHEN 《中国化学快报》2003,14(11):1105-1108
We present an efficient synthetic route towards two kinds of perylene-porphyrin arrays. Starting from 5, 10, 15, 20-meso-tetraphenylporphyrin, two novel 9a and 9b were designed and synthesized with 40.3% and 35.1% yield, respectively. 相似文献
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A revised synthetic route to Emivirine (MKC‐442) via properly substituted β‐keto ester converted from Meldrum's Acid was developed. This method could be applied to the synthesis of a variety of MKC‐442 analogues and open the way for their systematic biological evaluation. 相似文献
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Matthias Schulze 《合成通讯》2013,43(22):3415-3422
Racemic fluoxetine was synthesized from 3-benzoylpropionic acid in five steps in 54% overall yield. 相似文献
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Istvn Moldvai Eszter Temesvri‐Major Mria Incze Gbor Drnyei va Szentirmay Csaba Szntay 《Helvetica chimica acta》2005,88(6):1344-1356
Rye is sometimes infected by a fungus called Claviceps purpurea. The term ergot designates the dark, brown, tuberous bodies which can be collected before or during harvesting and represent one of the most remarkable drugs of our therapeutic arsenal. Actually, the most significant alkaloids are metabolic products of these fungi. We elaborated three alternative total synthetic pathways to construct the ergoline skeleton, one of which – suitable for scaling up – finally resulted in (+)‐lysergic acid ( 32a ) and α‐ergocryptine ( 1 ) (Schemes 5 and 6). 相似文献
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Xue Song XU Han Bing TENG Guo Fu QIU Shu Cai LIANG Xian Ming HU 《中国化学快报》2006,17(2):177-179
Phosphinothricin, the active ingredient of the well known broad-spectrum herbicideglufosinate-ammonium, is a naturally occurring amino acid possessing the uniquemethylphosphinate moiety, and its strong herbicidal activity has been attributed to anability to inhibit glutamine synthetase in plants and bacteria1. Further research showedthat L-enantiomer of phosphinothricin was the carrier of the activity, whereas the D formonly had a small action2, therefore the stereoselective synthesis of L-pho… 相似文献
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Three naturally occurring furan–lignans and two analogs have been synthesized by a short and efficient route starting from the corresponding aryl acid. The selective reductive removal of allylic hydroxy by palladium oxide in a mixed solvent of THF–CHCl3 was employed as the key step. 相似文献
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Hydrosilation of methylenecyclohexane and hex-1-ene by octa(hydridosilsesquioxane) catalysed by hexachloroplatinic acid is a new route to polyhedral organylsilsesquioxanes. Quantitative yield of octa(cyclohexylmethylsilsesquioxane) is reached. This reaction opens a vast field of yet unknown polyhedral silsesquioxanes. 相似文献
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Pummerer's ketone 1 is obtained with an overall yield of 55 % by the following sequence: Claisen rearrangement of an arylcyclohexylether 3; allylic oxidation of the methylcycloalkylphenolic derivative 4b, then spontaneous cyclisation during demethylation to give 2. 1 is obtained by dehydrogenation of 2. NMR data agree with a cis stereochemistry at C4a and C 9b. 相似文献
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《Journal of heterocyclic chemistry》2017,54(1):206-214
The synthesis of some new thiophenyl‐derivatized and furanyl‐derivatized phenothiazine and phenoxazine dyestuffs is described. This was achieved by two methods after the synthesis of 6‐chloro‐5H‐benzo[a]phenothiazin‐5‐one, 6‐chloro‐5H‐benzo[a]phenoxazin‐5‐one, and 6‐chloro‐5H‐naphtho[2,1‐b]pyrido[2,3‐e][1,4]oxazin‐5‐one intermediates via anhydrous base condensation reaction of 2,3‐dichloro‐1,4‐naphthoquinone with 2‐aminothiophenol, 2‐aminophenol, and 2‐aminopyridinol, respectively. The first method involved treatment of tributyl(thien‐2‐yl) or tributyl(furan‐2‐yl) stannane with chlorophenothiazine/chlorophenoxazine under mild basic chemical formula (CsF) and 1,4‐dioxane or toluene solvent at 80°C to supply dazzling yellow solid in high yields. In the second method, the catalytic system was pre‐activated in acetonitrile, followed by addition of coupling partners and K3PO4 to obtain high melting and variety of highly colored products in moderate to high yields. The reaction conditions were compatible with unprotected N–H and carbonyl functional groups. The intense colors of these dyes and their ease of re‐oxidation of Na2S2O4‐reduced derivatives make them suitable as vat dyes. Also, they were found to be good colorants for textiles, papers, paint, ink, soap, polish, candle, and plastic materials. 相似文献
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Jiancheng Li Peng Wu Wenjun Jiang Bin Li Binju Wang Hongping Zhu Herbert W. Roesky 《Angewandte Chemie (International ed. in English)》2020,59(25):10027-10031
Reaction of the aluminum dialkynyl LAl(CCR)2 (L=N,N‐chelate ligand and R=organic group) with B(C6F5)3 proceeds through an intermediate with Al???η2‐C≡C side‐on coordination to form the alumoles ( 2 , 4 , 6 ). A distinctive reaction pattern indicates a new facile synthetic route to aluminum‐containing heterocycles. The synthetic process is described, and the characterization of compounds and computational calculations were carried out. Furthermore, alumoles 2 and 4 exhibit an aggregation‐induced emission (AIE) of the bright yellow fluorescence. 相似文献
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Ian R. Baird Kirsten A. Skov Brian R.James Steven J. Rettig Cameron J. Koch 《合成通讯》2013,43(19):3701-3709
EF5 (a 2-nitroimidazole containing an N-(pentafluoropropyl) acetamide substituent) is a very sensitive probe for quantifying the amount of hypoxia within cells; a much improved, short step, synthetic procedure is described for EF5, whose X-ray structure is also presented. 相似文献
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5-Isoxaz0lamineshavebeenusedasintermediatesforthesynthesis0fderivatives0fantihistaminic,analgetic,antibacterial,insecticidal,herbicidalandfungicidalactivity'.Usuallytheyaresynthesizedbytheintramolecularcondensation0fhydr0xylamineand0-nitrilegr0up'.Otherapproaches,suchasreductivecyclizati0nofZ-a-cyano-6-nitroethylenesandIithiumaIuminumhydridereduction0f3-cyanooxazoleshaveals0beenrepoFted'-'.HerewerepoFtanewsyntheticrouteofthesecompounds.Ohn0andNaruse7havereportedthatthereactionof2-chlorocycl… 相似文献
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