共查询到20条相似文献,搜索用时 0 毫秒
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N. V. Kovganko Zh. N. Kashkan Yu. G. Chernov S. K. Ananich S. N. Sokolov V. L. Survilo 《Chemistry of Natural Compounds》2003,39(5):411-437
Literature data published in 1998-2002 on the chemical synthesis of ecdysteroids and their structural analogs were reviewed. 相似文献
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Three related compounds of aripiprazole were identified during the synthesis. These related compounds were synthesized and characterized by their respective spectral data. 相似文献
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Andrej opusiski Bruno Bernet Anthony Linden Andrea Vasella 《Helvetica chimica acta》1993,76(1):94-112
The benzyl-protected glycosyl acetates 1 , 6 , 11 , and 15 react with MeOPPh2 under catalysis by TMSOTf to yield diastereoselectively the glycosylphosphine oxides 2 , 3 , 8 , 12 , 13 , and 16 , with a strong preference for the 1,2-cis-configurated anomers. Hydrogenolysis of the major products gave the crystalline, unprotected phosphine oxides 4 , 9 , 14 , and 17 , of which 4 was transformed in to the acetate 5 , and 9 into the benzoate 10 . The benzylated phosphine oxides 4 , 8 , 12 , and 16 were reduced with Cl3SiH in the presence of a tertiary amine to form the phosphines 18 , 21 , 24 , and 26 , which were transformed into the phosphine sulfides 19 , 22 , 25 , and 27 . Moreover, 18 and 21 , were characterized as the borane adducts 20 , and 23 . The structure of the (arabinofuranosyl)phosphine oxide 12 , the corresponding sulfide 25 , and of the borane complex 20 were established by X-ray analysis. According to NMR spectroscopy, the equatorial pyranosylphosphine oxide 8 , the sulfide 22 , and the borane complex 23 adopt a 4C1 conformation. The axial phosphine oxide 2 is a flattened 4C1, the sulfide 19 exists as a B2,5, and the borane complex 20 is a flattened 4C1 in the solid sate and a B2,5 in solution. Thus, the conformational behavior of these α-D -glucopyranose derivatives reflects the steric requirement of the P-substituents. 相似文献
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类胡萝卜素是一类奇特的色素,由高等植物和微生物光化学合成,作为防止单线氧通过光敏反应产生危害的必要基团,类胡萝卜素最近受到了关注。类胡萝卜素联于富勒烯上,既可大大增加在可见光区域光诱导电子转移的有效吸收断面,又可抑制富勒烯敏化单线氧的危害能力。合成了类胡萝卜素的相关化合物,报道的某些反应条件先进且简洁。 相似文献
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Yanling Wang Huan Ge Disha Wang Huan He Lu Li Yanyan Diao Zihao Shen Lili Zhu Shiliang Li Zhenjiang Zhao Honglin Li 《中国化学》2019,37(12):1259-1263
Macrocycle has attracted the attention of many researchers in the field of medicinal chemistry due to its unique advantages and good prospects, but the difficulties in drug design and synthesis of macrocycle limit its applications. In this study, a series of macrocyclic derivatives designed from anaplastic lymphoma kinase (ALK) inhibitor lorlatinib were synthesized as Janus kinase 2 (JAK2) selective inhibitors. Among them, 17f had the best inhibitory activity (IC50 = 0.177 μmol·L–1) and selectivity for JAK2 over JAK1 and JAK3, which indicated that design of the macrocyclic derivatives might be a feasible strategy for the discovery of novel selective JAK2 inhibitors. 相似文献
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Anton Budeev Grigory Kantin Dmitry Darin Mikhail Krasavin 《Molecules (Basel, Switzerland)》2021,26(9)
Diazocarbonyl compounds have found numerous applications in many areas of chemistry. Among the most developed fields of diazo chemistry is the preparation of azoles from diazo compounds. This approach represents a useful alternative to more conventional methods of the synthesis of azoles. A comprehensive review on the preparation of various azoles (oxazoles, thiazoles, imidazoles, pyrazoles, triazoles, and tetrazoles) from diazocarbonyl and related compounds is presented for the first time along with discussion of advantages and disadvantages of «diazo» approaches to azoles. 相似文献
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采用高温水解法合成了具有超顺磁性且表面修饰的Fe3O4纳米粒子,将该Fe3O4纳米粒子作为种子,采用"非经典控核生长"方法在其表面生长SiO2棒状结构,获得了非对称Fe3O4-SiO2介孔纳米粒子,通过调节硅源加入量调控非对称粒子棒状部分的长度.由于一次生长出的结构尺寸有限,使用"二次生长法"进一步增加纳米棒部分的长度,最后对该非对称粒子进行了药物的装载与释放实验,表明其对阿霉素具有缓释作用. 相似文献
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Dr. Riccardo Salvio Simone Placidi Prof. Dr. Marco Bella 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(45):10157-10174
Benzazetidines are a class of N-heterocycles potentially very interesting for a variety of purposes, including biological applications and drug design. In the past, their high ring strain has hampered the development of trustable, general, and efficient synthetic methodologies for their preparation. In this review article, the aim is to disclose all the literature contributions about the synthesis of these compounds and the study of their reactivity, from the early examples to the most recent synthetic approaches. Recently, there has been a growth of interest for this heterocycle, driven by the publication of novel synthetic methodologies based on palladium-catalyzed intramolecular C−H amination and organocatalyzed ring-closure of 2-(N-Boc-anilino)-α-ketoesters/amides. 相似文献
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通过回流对应的二茂铁苯胺和芳香醛的混合物的同样路径合成了一系列新颖的二茂铁苯基亚胺化合物(5~12)。当暴露于空气时化合物5~12稳定,不发生任何分解。所有化合物均用1H、13C NMR,MS,IR,UV-Vis和元素分析表征。还报导了化合物N-(3-bromo-2-hydroxylbenzylidene)-4-ferrocenylimine(10)的单晶结构,其结晶属单斜晶系P21/c空间群。 相似文献
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通过回流对应的二茂铁苯胺和芳香醛的混合物的同样路径合成了一系列新颖的二茂铁苯基亚胺化合物(5~12)。当暴露于空气时化合物5~12稳定,不发生任何分解。所有化合物均用1H、13C NMR,MS,IR,UV-Vis和元素分析表征。还报导了化合物N-(3-bromo-2-hydroxylbenzylidene)-4-ferrocenylimine(10)的单晶结构,其结晶属单斜晶系P21/c空间群。 相似文献
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二氯马来酰亚胺有机锡化合物的合成和结构表征 总被引:2,自引:2,他引:2
合成了14个1-三羟锡基-3,4-二氯马来酰亚胺有机锡化合物,研究了它们的核磁共振谱(^1H,^13C,^119Sn),外光谱质谱,并且得出,锡原子上的烃基对化合物的生物活性有很大的影响。 相似文献
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The covalently linked porphyrin-fullerene dyads were synthesized. The ligand 5-[4′-(4″-Phenoxybutoxy)phenyl]-N-(2-methyl)fulleropyrrolidine-10,15,20-tri-(p-methoxyphenyl)porphyrin (H2P-C60) was synthesized by 1,3 dipolar cycloaddition reaction with C60, sarcosine and H2P-CHO. The zinc porphyrin-fullerene was prepared by metalation of H2P-C60 and zinc acetate. The compounds were characterized by meams of IR, UV-Vis, ESI-MS, elemental analysis, and 1H NMR. 相似文献
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