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1.
Condensation of 2-chlorobenzaldehyde with cyanothioacetamide and ethyl butyroylacetate results in 4-(2-chlorophenyl)-3-cyano-5-ethoxycarbonyl-6-propyl-3,4-dihydropyridine-2(1H)-thione, whose further transformation affords the corresponding substituted 2-methylthio-1,4-dihydropyridine.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 173–175, January, 2000. 相似文献
2.
Condensation of isovaleraldehyde with cyanothioacetamide and ethyl acetoacetate (or its enamine) gives 3-cyano-5-ethoxycarbonyl-4-isobutyl-6-methyl-3,4-dihydropyridine-2(1H)-thione. This compound was used in the synthesis of substituted 1,4-dihydropyridin-2-yl sulfides.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 166–168, January, 1999. 相似文献
3.
S. G. Krivokolysko V. D. Dyachenko A. N. Chernega V. P. Litvinov 《Chemistry of Heterocyclic Compounds》2001,37(10):1208-1215
The condensation of 2-chlorobenzaldehyde with cyanothioacetamide and 2-thenoyltrifluoroacetone in the presence of N-methylmorpholine takes place stereoselectively and leads to the formation of N-methylmorpholinium 4,5-trans-4-(2-chlorophenyl)-3-cyano-6-hydroxy-5-(2-thenoyl)-6-trifluoromethyl-1,4,5,6-tetrahydropyridine-2-thiolate. The latter was used to synthesize the corresponding 2-alkylthiotetrahydropyridines. The structure of 4,5-trans-4-(2-chlorophenyl)-3-cyano-6-hydroxy-2-methallylthio-5-(2-thenoyl)-6-trifluoromethyl-1,4,5,6-tetrahydropyridine was determined by X-ray crystallographic analysis. 相似文献
4.
S. G. Krivokolysko V. D. Dyachenko E. B. Rusanov V. P. Litvinov 《Chemistry of Heterocyclic Compounds》2001,37(8):987-992
4-(2-Chlorophenyl)-3-cyano-6-hydroxy-5-(2-thienoyl)-6-trifluoromethylpiperidin-2-thione, which was used for the synthesis of 2-allylthio-4-(2-chlorophenyl)-3-cyano-6-hydroxy-5-(2-thienoyl)-6-trifluoromethyl-1,4,5,6-tetrahydropyridine, was obtained by the reaction of 2-thienoyltrifluoroacetone with 2-chlorophenylphenylmethylenecyanothioacetamide or with a mixture of 2-chlorobenzaldehyde and cyanothioacetamide in the presence of N-methylmorpholine. The molecular and crystal structure of the piperidinthione have been established by X-ray crystallography. 相似文献
5.
S. G. Krivokolysko V. D. Dyachenko A. N. Chernega V. P. Litvinov 《Russian Chemical Bulletin》2000,49(4):736-739
Condensation of 4-chlorobenzaldehyde with cyanothioacetamide and dimedone in the presence of piperidine afforded piperidinium
3-(4-chlorophenyl)-2-cyano-3-(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-enyl)thiopropionimidate. This salt was studied by X-ray
diffraction analysis and used in the synthesis of the previously unknown partially hydrogenated 2-alkylthioquinolin-2-ones.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 733–737, April, 2000. 相似文献
6.
A. A. Krauze É. É. Liepin'sh Yu. É. Pelcher Z. A. Kalme I. V. Dipan G. Ya. Dubur 《Chemistry of Heterocyclic Compounds》1985,21(1):77-83
The condensation of ethyl arylidenacetoacetate with cyanothioacetamide and of arylidenecyanothioacetamides with ethyl acetoacetate or of arylidenecyanothioacetamides with ethyl -aminocrotonate gave 3-cyano-4-aryl-5-ethoxycarbonyl-6-methyl-3,4-dihydropyridine-2-thiones. PMR spectroscopy showed that the 3-cyano-4-aryl-3,4-dihydropyridine-2-thiones are formed as a mixture of cis and trans isomers.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 95–102, January, 1985. 相似文献
7.
Ethyl ethoxymethylenemalonate reacts with cyanothioacetamide andN-methylmorpholine to giveN-methylmorpholinium 3-cyano-5-ethoxycarbonyl-6-oxopyridine-2-thiolate. Alkylation of the latter yieldsS-alkyl derivatives.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 196–197, January, 1999. 相似文献
8.
S. G. Krivokolysko V. D. Dyachenko V. P. Litvinov 《Chemistry of Heterocyclic Compounds》1999,35(4):455-458
Condensation of isovaleric aldehyde with cyanothioacetamide and acetylacetone or its enamine produces 5-acetyl-3-cyano-4-isobutyl-6-methyl-3,4-dihydropyridine-2(1H)-thione,
from which 5-acetyl-3-cyano-4-isobutyl-6-methylpyridine-2(1H)-thione and the corresponding substituted 2-alkylthio-1,4-dihydropyridines
are prepared.
T. G. Shevchenko Lugansk State Pedagogical Institute, Lugansk 348011, Ukraine; e-mail: kgb@lgpi.lugansk.ua; N. D. Zelinskii
Institute of Organic Chemistry of the Russian Academy of Sciences, Moscow 117913, Russia;
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 516–519, April, 1999. 相似文献
9.
Three-component condensation of benzooxazol-2-yl-, benzothiazol-2-yl-, and 5-ethoxycarbonyl-4-methyl-1,3-thiazol-2-ylguanidines
with orthoesters and aroylacetonitriles afforded 4-aryl-5-cyano-2-hetarylaminopyrimidines.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 6, pp. 1049–1050, June, 2006. 相似文献
10.
11.
Morpholinium 5-arylcarbamoyl-3-cyano-6-methyl-4-(5-methyl-2-furyl)-1,4-dihydropyridine-2-thiolates have been obtained by the
interaction of enamines of acetoacetanilides with 5-methyl-2-furfurylidenecyanothioacetamide. Alkylation of the salts gives
thioethers and oxidation gives the corresponding substituted pyridine-2(1H)-thiones. The structure of 2-allylthio-3-cyano-5-(2-methoxyphenylcarbamoyl)-6-methyl-4-(5-methyl-2-furyl)-1,4-dihydropyridine
was studied by X-ray crystallographic analysis.
__________
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 51–58, January, 2006. 相似文献
12.
S. G. Krivokolysko V. D. Dyachenko V. P. Litvinov 《Chemistry of Heterocyclic Compounds》1999,35(12):1441-1442
The condensation of acetaldehyde with cyanothioacetamide and ethyl benzoylacetate in the presence of N-methylmorpholine leads to the formation of 3-cyano-5-ethoxycarbonyl-4-methyl-6-phenylpyridine-2(1H)-thione. Alkylation of the last afforded the corresponding substituted 2-alkythiopyridines.T. G. Shevchenko Lugansk State Pedagogical Institute, Lugansk 348011, Ukraine. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences (RAN),Moscow 117913, Russia.Translated from Khimiya Geterotsklicheskh Soedinenii, No. 12, pp. 1645–1646, December, 1999. 相似文献
13.
The reactions of 3- or 4-hydroxybenzaldehydes with cyanothioacetamide and Meldrum's acid in the presence ofN-methylmorpholine affordedN-methylmorpholinium 5-cyano-4-(3-or 4-hydroxyphenyl)-2-oxo-1,2,3,4-tetrahydropyridine-6-thiolates, respectively. The resulting
compounds were used in the synthesis of substituted 6-alkylthio-1,2,3,4-tetrahydropyridin-2-ones.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2333–2336. December, 1999. 相似文献
14.
15.
A. S. Alimbayeva O. A. Nurkenov A. Kh. Zhakina I. V. Kulakov D. M. Turdybekov K. M. Turdybekov 《Russian Journal of General Chemistry》2009,79(7):1532-1536
By reaction of 2-vinyloxyethyl isothiocyanate with salicylic acid hydrazide a synthesis of the corresponding thiosemicarbazide
was performed. Alkaline hydrolysis of the latter led to an intramolecular heterocyclization into 1,2,4-triazole derivative.
When cyclization was carried out in the water-alkali medium, 2-vinyloxyethyl fragment was shown to be hydrolyzed to form 4-(2-hydroxyethyl)-5-(2-hydroxyphenyl)-2H-1,2,4-triazolo-3(4H)-thione, whose spatial structure was established by XRD analysis. 相似文献
16.
N-Methylmorpholinium 4-aryl-5-cyano-2-oxo-2-oxo-1,2,3,4-tetrahydropyridine-6-thiolates were obtained by the condensation of
aromatic aldehydes, cyanothioacetamide, and Meldrum's acid in the presence ofN-methylmorpholine. They were then used in the syntheses of substituted 6-alkylthio-3,4-dihydropyridin-2(1H)-ones and 4,5-dihydrothieno[2,3-b]pyridin-6(7H)-ones.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 1852–1856, October, 1997. 相似文献
17.
18.
5-Amino-4-cyano-8-isobutyl-7-isopropyl-6-thiocarbamoyl-2-azabicyclo[2.2.2]oct-5-en-3-thione was synthesized by the condensation of isovaleryl aldehyde with cyanothioacetamide. The structure of the product was established by X-ray crystallography. 相似文献
19.
A solid phase synthesis of substituted quinolin-2(1H)-one-3-carboxylic acids is described. The products are formed in a two-step synthesis in which ortho-aminophenones are first coupled to malonic acid bound to the Wang Resin followed by ring closure via an intramolecular Knoevenagel condensation. 相似文献
20.
LI Qian-rong XUE Song YIN Hao 《高等学校化学研究》2006,22(1):40-44
IntroductionIn1893,Pietro Biginelli reported the first synthe-sis(termed the Biginelli reaction)of3,4-dihydropyrim-idinone(denoted as“oxo-orO-Biginelli compound”in-cluding its derivatives,type A in Scheme1).In thelast decade,interest in these compounds … 相似文献