The synthesis of 1,3-diamidophospholipids

A straightforward synthesis of a small library of 1,3-diamidophospholipids is presented using readily available, cheap reagents and introducing a simple phosphoramidate protecting group strategy.     

A convenient one-pot Negishi coupling of amino-heteroaryl chlorides and alkyl bromides

A simple Ni-catalysed cross-coupling protocol for amino-heteroaryl chlorides with alkylzinc reagents has been developed. The alkylzinc reagents can be commercially available dialkylzincs or alkylzinc halides, or can be conveniently generated in situ from diethylzinc and primary alkyl bromides in the presence of the same inexpensive Ni catalyst used to effect the subsequent coupling reaction.     

Colorimetric detection of Cu2+ using of a mixture of ponceau 6R and a cationic polyelectrolyte in aqueous solution

Journal of Inclusion Phenomena and Macrocyclic Chemistry - A colorimetric chemosensor is reported for Cu2+ by a simple mixture of two commercially available reagents, ponceau 6R (P6R) and...     

Rhodium nanoparticles entrapped in boehmite nanofibers: recyclable catalyst for arene hydrogenation under mild conditions

A new recyclable rhodium catalyst was synthesized by a simple procedure from readily available reagents, which showed high activities in the hydrogenation of various arenes under 1 atm H2 at room temperature.     

A simple fluorescence assay for the detection of fluoride in water at neutral pH

A simple assay for the detection of fluoride in water by fluorescence spectroscopy was developed. The assay is based on commercially available reagents and allows sensing of fluoride in the low millimolar concentration range with high selectivity over other anions.     

A facile synthesis of 1,4-benzodiazepine derivatives via Ugi four-component condensation

A simple two-step route to 4,5-dihydro-3H-benzo[1,4]diazepin-5-ones is described. This synthesis, based on the isocyanide chemistry, allows a wide variety of substitution patterns starting from commercially available or easily obtainable reagents.     

Cobalt bis(2‐ethylhexanoate) and terpyridine derivatives as catalysts for the hydrosilylation of olefins

A simple method for the hydrosilylation of olefins by using air‐stable cobalt catalysts is developed. The catalyst system is composed of simple, cheap, and readily available cobalt(II) salts and well‐defined terpyridine derivatives as cocatalysts or ligands, and the hydrosilylation processes can be processed smoothly under mild conditions without either Grignard reagents or NaHBEt₃ as activator.     

Cu-catalyzed asymmetric conjugate additions of dialkyl- and diarylzinc reagents to acyclic beta-silyl-alpha,beta-unsaturated ketones. Synthesis of allylsilanes in high diastereo- and enantiomeric purity

A readily available and simple (MW = 444.5 g/mol) valine-based chiral phosphine is used to promote highly efficient catalytic asymmetric conjugate additions of dialkyl- and diarylzinc reagents to acyclic beta-silyl-alpha,beta-unsaturated ketones. The catalytic asymmetric protocol allows access to versatile allylsilanes that bear a trisubstituted olefin in high diastereo- and enantiomeric purity.     

Ni(0)-CMC-Na - nickel colloids in sodium carboxymethyl-cellulose: catalytic evaluation in hydrogenation reactions

A recyclable catalyst, Ni(0)-CMC-Na, composed of nickel colloids dispersed in a water soluble bioorganic polymer, sodium carboxymethylcellulose (CMC-Na), was synthesized by a simple procedure from readily available reagents. The catalyst thus obtained is stable and highly active in alkene hydrogenations.     

Recyclable gold nanoparticle catalyst for the aerobic alcohol oxidation and C-C bond forming reaction between primary alcohols and ketones under ambient conditions

A recyclable gold catalyst is synthesized from readily available reagents by immobilizing gold nanoparticles in aluminum oxyhydroxide support through a simple sol-gel method. The catalyst showed the high activity even at room temperature in the aerobic oxidation of various alcohols and in the coupling reaction between primary alcohols and ketones.     

Synthesis of 3,4-bis-Acetoxymethyl-Furan

There are available in the literature^1–3 a very limited number of useful routes for the preparation of 3,4-bis-acetoxymethyl-furan in general purpose manufacturing plant because they are either too long and/or they use specialized reagents or techniques. Our attempts to provide a solution to this problem have provided a simple short practical route to the title compound which may have more general application in the synthesis of furans. Additionally both starting materials and reagents are cheap and readily available.     

A two-step synthesis of 1,5-disubstituted tetrazoles containing a siloxy or sulfonamide group

A simple two-step route to the synthesis of 1,5-disubstituted tetrazoles containing a β-siloxy or β-sulfonamide group is presented. The synthesis takes place via an isocyanide-based multicomponent reaction and allows incorporation of a wide variety of substitution patterns starting from commercially available reagents. This is followed by cyclization of the ketenimines with trimethylsilyl azide without using any catalyst or activation.     

Simple and efficient protocol for the synthesis of functionalized styrenes from 1,2-dibromoethane and arylboronic acids

[reaction: see text] A simple and efficient protocol for the preparation of functionalized styrenes is disclosed that employs the palladium-catalyzed cross-coupling reaction of arylboronic acids with vinyl bromide, generated in situ from 1,2-dibromoethane. The reaction is carried out under mild reaction conditions. Compared with the cross-coupling reactions usually employed to obtain vinylarenes, this protocol is very simple, overcomes the inconvenience of using of ethylene under pressure, and uses air-stable and widely available arylboronic acids instead of vinyl organometallic reagents.     

Simple Sulfinate Synthesis Enables CH Trifluoromethylcyclopropanation

A simple method to convert readily available carboxylic acids into sulfinate salts by employing an interrupted Barton decarboxylation reaction is reported. A medicinally oriented panel of ten new sulfinate reagents was created using this method, including a key trifluoromethylcyclopropanation reagent, TFCS‐Na. The reactivity of six of these salts towards C? H functionalization was field‐tested using several different classes of heterocycles.     

Simple Sulfinate Synthesis Enables C?H Trifluoromethylcyclopropanation

A simple method to convert readily available carboxylic acids into sulfinate salts by employing an interrupted Barton decarboxylation reaction is reported. A medicinally oriented panel of ten new sulfinate reagents was created using this method, including a key trifluoromethylcyclopropanation reagent, TFCS‐Na. The reactivity of six of these salts towards C H functionalization was field‐tested using several different classes of heterocycles.     

A new scalable synthesis of entecavir

A new synthesis of entecavir from d-glucose in an average total yield of 3.5% was achieved via an intramolecular nitrile oxide cycloaddition (INOC) reaction and a Peterson olefination as key-steps. The present process was designed for industrial application, using widely available raw materials, simple and cheap reagents and avoiding low reaction temperatures, which are very common in the synthetic approaches towards similarly complex structures.     

From 1,2,4-triazines towards substituted pyridines and their cyclometallated Pt complexes

A new, efficient methodology for the synthesis of substituted thienylpyridines includes the synthesis of 3-thienyl-1,2,4-triazines using simple heterocyclisation followed by easy transformation of the triazine ring to a pyridine through an aza Diels-Alder approach. A variety of substituted pyridines can be easily achieved using cheap, commercially available reagents such as bromoacetylarenes, aroyl hydrazides, norbornadiene, and enamines in various combinations. New thienylpyridines form phosphorescent cyclometallated Pt complexes.     

Recyclable graphite oxide promoted efficient synthesis of 2-phenyl quinazoline derivatives in the presence of TBHP as an oxidant

A novel and efficient protocol for the synthesis of 2-phenyl quinazoline derivatives is developed by recyclable graphite oxide as a catalyst, devoid of moisture sensitive metal catalysts and corrosive acidic reagents. This new procedure has afforded the desired products in good to excellent yields. The graphite oxide can be synthesized by a simple adoptable procedure from inexpensive and readily available graphite and is recoverable and reusable up to four cycles, without any loss of activity.     

C−N Axial Chiral Hypervalent Iodine Reagents: Catalytic Stereoselective α-Oxytosylation of Ketones

A simple synthesis of a library of novel C−N axially chiral iodoarenes is achieved in a three-step synthesis from commercially available aniline derivatives. C−N axial chiral iodine reagents are rarely investigated in the hypervalent iodine arena. The potential of the novel chiral iodoarenes as organocatalysts for stereoselective oxidative transformations is assessed using the well explored, but challenging stereoselective α-oxytosylation of ketones. All investigated reagents catalyse the stereoselective oxidation of propiophenone to the corresponding chiral α-oxytosylated products with good stereochemical control. Using the optimised reaction conditions a wide range of products was obtained in generally good to excellent yields and with good enantioselectivities.     

A simple route to chiral phosphinous acid-boranes

We report a simple one-pot synthesis of enantiomerically enriched alkyl- and arylphenylphosphinous acid-borane starting from readily available (R(P))-(-)-menthylhydrogenophenylphosphinate and organolithium reagents.