共查询到19条相似文献,搜索用时 125 毫秒
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发展了一条合成苯丙素苷类化合物的通用路线,并依据此路线完成了苯丙素苷毛蕊花糖苷(Acteoside)和异毛蕊花糖苷(Isoacteoside)的全合成及紫茎女贞苷J(Ligupurpuroside J)的首次全合成.其中的关键步骤是应用金(Ⅰ)催化的鼠李糖邻炔基苯甲酸酯给体与多羟基裸露的2-苯乙基葡萄糖苷进行区域选择性糖苷化反应,成功构建天然苯丙素苷中常见的α-(1→3)糖苷键.该合成路线减少了保护基的使用,简洁高效. 相似文献
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灯台生物碱具有复杂多样的结构和显著的生理活性,针对此类分子的化学合成引起了有机化学界的广泛关注。其中的代表性化合物strictamine在结构上具有笼状的methanoquinolizidine核心骨架和C7位全碳季碳手性中心,在合成上具有重要挑战。关于该化合物的全合成已有超过40年的研究历史,而直到最近两年才取得突破性的进展。本文针对2016年以来关于strictamine的三条全合成和四条形式合成路线进行简要介绍,主要剖析了各条合成路线中的关键策略和反应,并对进一步的研究进行了展望。 相似文献
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介绍和剖析了用Nicolaou法全合成紫杉醇的方法,包括合成的战略和路线,关键反应和保护基的应用等. 相似文献
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洋茉莉醛中间体3,4-亚甲二氧基苯乙醇酸的合成与表征 总被引:1,自引:0,他引:1
茉莉醛又称胡椒醛,学名3,4-亚甲二氧基苯甲醛(3,4-methylenedioxy benzaldehyde),广泛应用于合成香料、医药、食品、日化、电镀等领域.目前全球洋茉莉醛生产主要集中在我国、日本、美国和欧盟,总产能约1万吨/年.我国和日本主要采用天然黄樟油路线合成洋茉莉醛.随着全球生产量的不断增大,黄樟油资源面临枯竭,研究和开发以简单化学品为原料的全合成方法成为当务之急[1][2].在酸催化下,以乙醛酸和胡椒环为原料合成3,4-亚甲二氧基苯乙醇酸,再经氧化得到洋茉莉醛的路线,具有工艺设备简单、三废少、收率高、产品纯度高等优点,成为替代黄樟油路线法较为理想的全合成路线[3][4]. 相似文献
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以3-乙氧基-2-环己烯酮羰基邻位芳基化反应与Tsuji-Trost反应的串联反应作为关键步骤来构筑季碳中心, 完成了番杏科生物碱Mesembrine的全合成. 从商品化原料出发经6步反应以17.8%的总收率合成得到(±)-Mesembrine. 相似文献
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The formal total synthesis of racemic efaroxan, a 2-disubstituted 2,3-dihydrobenzofuran having interesting therapeutic properties, and the preparation of some 5-amino derivatives were achieved using a convergent approach. The key intermediates of both syntheses were obtained after a [3+2] cycloaddition reaction between two easily accessible partners. 相似文献
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Richard P Hsung Kevin P ColeLuke R Zehnder Jiashi WangLin-Li Wei Xiao-Fang YangHeather A Coverdale 《Tetrahedron》2003,59(3):311-324
A 20-step total synthesis of (±)-arisugacin A with an overall yield of 2.1% is described here in detail. This synthesis features a formal [3+3] cycloaddition reaction of α,β-unsaturated iminium salts with 6-aryl-4-hydroxy-2-pyrones through a highly stereoselective 6π-electron electrocyclic ring-closure of 1-oxatriene. A strategic dihydroxylation-deoxygenation protocol leading to the desired angular C12a-OH was developed to serve as a critical step in leading to the final total syntheses of arisugacin A. This synthetic endeavor also led to an interesting and unexpected retro-aldol-aldol sequence in the AB-ring. 相似文献
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This article brings together for the first time reviews of all the synthetic attempts towards the spirocyclic histrionicotoxin alkaloids published since the discovery of the group in 1971. This covers 5 total syntheses of the fully unsaturated parent alkaloid HTX-283A, 7 total syntheses of perhydrohistrionicotoxin, 15 total syntheses of other members of this alkaloid family, 25 formal syntheses, and 19 partial syntheses involving the successful formation of the core azaspirocyclic structure but lacking advancement towards the target structure. 相似文献
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Elizabeth A. Ilardi 《Tetrahedron》2009,65(16):3261-11939
Joubertinamine and mesembrine are two related alkaloids isolated from Sceletium plants. From the perspective of chemical synthesis, the major challenge posed by joubertinamine and mesembrine is undoubtedly the construction of the benzylic quaternary stereogenic center. We became intrigued by the prospect of applying successive sigmatropic rearrangements to build the key structural features of these alkaloids in enantioselective manner. In this article, we detail our results in this area, which include the enantioselective total synthesis of (−)-joubertinamine and (−)-mesembrine. 相似文献
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The total syntheses of dichroanone and dichroanal B, as well as the formal syntheses of taiwaniaquinol B and taiwaniaquinone D, are reported. 相似文献
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Cross metathesis as a general strategy for the synthesis of prostacyclin and prostaglandin analogues
[reaction: see text] A cross metathesis (CM) approach has been successfully applied to introduce fully functionalized omega-side chain appendages of various prostacyclin and prostaglandin analogues, resulting in high (E)-selectivities for the C13-C14 double bond and leading to the total syntheses of isocarbacyclin, 15R-TIC, carbacyclin, and PGF(2)(alpha) and the formal syntheses of 15-deoxy-TIC and PGJ(2). 相似文献
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Biosynthesis, total syntheses, and antitumor activity of tanshinones and their analogs as potential therapeutic agents 总被引:1,自引:0,他引:1
Tanshinones are a series of abietane diterpenes, isolated exclusively from Salvia miltiorrhiza and related species. More than 40 tanshinones and their analogs have been isolated since the 1930s. Their biosynthetic pathway correlates with the MEP/DOXP pathway, and many key enzymes, such as mCPS, are responsible for establishing their molecular scaffolds and stereospeci?city. Because of their unique structural characteristics and promising biological activities, total syntheses of various tanshinones have attracted the interest of many synthetic chemists, including R. H. Thomson, H. Kakisawa, R. L. Danheiser, Y. Inouye and J. K. Snyder. Tanshinones and their analogs exhibit interesting and broad antitumor activity in various cell and animal models. Most recently, the tanshinone analog neo-tanshinlactone has shown potent and selective activity against breast cancer. This review will discuss the biosynthesis, total syntheses, and antitumor activities of tanshinones,especially neo-tanshinlactone and its analogs. 相似文献
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青蒿素和鹰爪素A是从中药中分离的两个含过氧基团的抗疟活性组分。特别是青蒿素已成为新型的抗疟药物,因而引起合成化学家的极大兴趣。现对该两个化合物的全合成作一综述。 相似文献