共查询到20条相似文献,搜索用时 0 毫秒
1.
Mohamed Salah K. Youssef Ahmed A. Omar 《Monatshefte für Chemie / Chemical Monthly》2007,138(10):989-995
Summary. 5-Amino-3-(3-methyl-5-oxo-1-phenyl-2-pyrazolin-4-yl)-7-phenyl-7H-thiazolo[3,2-a]pyrimidine-6-carbonitrile was synthesized via the reaction of 4-(2-aminothiazol-4-yl)-3-methyl-1-phenyl-2-pyrazolin-5-one with benzylidene malononitrile and was then transformed
to related fused heterocyclic systems. The antifungal and antibacterial studies revealed in some cases excellent biocidal
properties. 相似文献
2.
Mohamed Salah K. Youssef Ragaa A. Ahmed Mohamed S. Abbady Shawkat A. Abdel-Mohsen Ahmed A. Omar 《Monatshefte für Chemie / Chemical Monthly》2008,45(8):553-559
4-(2-Aminothiazol-4-yl)-3-methyl-5-oxo-1-phenyl-2-pyrazoline was synthesized via the reaction of 4-bromoacetyl-3-methyl-5-oxo-1-phenyl-2-pyrazoline with thiourea [7] and was transformed to related fused
heterocyclic systems. The antifungal and antibacterial studies revealed in some cases excellent biocidal properties. 相似文献
3.
4.
Aghekyan A. A. Mkryan G. G. Panosyan H. A. Buniatyan G. M. Muradyan R. E. 《Russian Journal of Organic Chemistry》2020,56(3):440-445
Russian Journal of Organic Chemistry - Gewald reaction of 4-oxo-1-phenylcyclohexane-1-carbonitrile with ethyl cyanoacetate and elemental sulfur in the presence of diethylamine afforded ethyl... 相似文献
5.
6.
以芳醛、丙二腈与6-甲基-4-羟基-2-吡喃酮为原料,醋酸酐为溶剂,超声辐射下一步合成了2-氨基-7-甲基-4-芳基-5-氧代-4H, 5H-吡喃并[4,3-b]吡喃-3-腈系列产物.产率达72%~83%.产物结构经红外光谱、核磁共振和元素分析测试技术表征.其中化合物4e的结构经单晶X射线衍射进一步确证,单晶体属单斜晶系,空间群C2/c,晶胞参数:A=2.14917(7)nm, b=0.82498(2)nm, c=1.79137(6)nm, α=90°, β=112.104(2)°, γ=90°, Mr=314.72, V=2.94254(16)nm3, Z=8, Dc=1.421kg/m3, F(000)=1296, R=0.0495, wR=0.0878. 相似文献
7.
8.
A multicomponent, catalyst-free reaction for the synthesis of fused 6-amino-3-methyl-4-aryl-1H-pyrazolo [3,4-b] pyridine-5-carbonitrile from 3-amino-5-methylpyrazole, malononitrile, and substituted aldehydes under ultrasound irradiation in short reaction times (8–10 min) with good yields (85–98%) is reported.
9.
Susanta Kumar Borthakur Pabitra Kumar Kalita Sukanya Borthakur 《Journal of heterocyclic chemistry》2020,57(3):1261-1265
A series of novel 3,7-diphenyl-7-amino[1,3]-thiazolo[3,2-a]pyrimidine-6-nitrile derivatives 3 were synthesized by refluxing 2-amino-4-phenyl-1,3-thiazole 1 and arylidinemalononitrile 2 in propanol using NaOH as catalyst. Various synthesized products were characterized by 1H NMR, mass spectrometry (MS), infrared (IR), and elemental analysis. Antifungal activities of the synthesized compounds were done by testing against Rhizoctonia solani and Drechslera orazae, two fungal pathogens causing diseases on rice crops. 相似文献
10.
S. A. Yamashkin G. A. Romanova I. S. Romanova M. A. Yurovskaya 《Chemistry of Heterocyclic Compounds》2003,39(9):1188-1196
The behavior of 5-amino-2-phenyl- and 5-amino-1-methyl-2-phenylindoles in reactions with acetoacetic, trifluoroacetoacetic, and ethoxymethylenemalonic esters, leading to the preparation of pyrrolo[2,3-g]- and pyrrolo[3,2-f]quinolines with functional substituents has been studied. 相似文献
11.
12.
13.
N. T. Pokhodylo R. D. Savka V. S. Matiichuk N. D. Obushak 《Russian Journal of General Chemistry》2009,79(2):309-314
By cycloaddition of arylazides to acetylacetone are obtained derivatives of 1,2,3-triazole. In the reaction of 1-[5-methyl-1-(R-phenyl)-1H-1,2,3-triazol-4-yl] ethanones (IIa–IIe) and 1-[4-(4-R-5-methyl-1H-1,2,3-triazol-1-yl)phenyl] ethanones (VIIa-VIIe) with isatin are obtained 2-[1-(R-phenyl)-5-methyl-1H-1,2,3-triazol-4-yl]-4-quinolinecarboxylic acids (IIIa–IIIe) and 2-[4-(4-R-5-methyl-1H-1,2,3-triazol-1-yl)phenyl] -4-quinolinecarboxylic acids (IXa, IXb), respectively. We found that 1-[5-methyl-1-(R-phenyl)-1H-1,2,3-triazol-4-yl] ethanones (IIa–IIe) readily transform into [5-methyl-1-(R-phenyl)-1H-1,2,3-triazol-4-yl] acetic acids (IVa–IVc) by the method of Wilgerodt-Kindler. The (5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)acetic acid reacts with 5-phenyl-4-amino-4H-1,2,4-triazol-3-thiol affording 6-[(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl) methyl]-3-phenyl[1,2,4] triazolo[3,4-b] [1,3,4] thiadiazole (VI).
Original Russian Text ? N.T. Pokhodylo, R.D. Savka, V.S. Matiichuk, N.D. Obushak, 2009, published in Zhurnal Obshchei Khimii,
2009, vol. 79, no. 2, pp. 320–325. 相似文献
14.
The crystal structure of the title compound ethyl 3-(4-chlorophenyl)-3,4-dihydro-6- methyl-4-oxo-2-(pyrrolidin-1-yl)furo[2,3-d]pyrimidine-5-carboxylate (C20H20ClN3O4, Mr= 401.84) has been prepared and determined by single-crystal X-ray diffraction. The crystal is of monoclinic, space group P21/n with a = 20.6215(9), b = 8.5311(4), c = 21.6886(9) A^°, β = 91.607(1)°, V = 3814.0(3)A^°^3, Z = 8, Dc = 1.400 g/cm^3, F(000) = 1680, μ = 0.233 mm^-1, R = 0.0718 and wR = 0.1545 for 6717 observed reflections with I 〉 2σ(I). X-ray diffraction analysis reveals two crystallographically independent molecules in the asymmetric unit. 相似文献
15.
MO Wen-Yan HE Hong-Wu② 《结构化学》2007,26(2):172-176
The title compound, 3-[2-(4-fluoro-phenyl)-ethyl]-5-methyl-4-hydroxyl-4-methyl- 7-methylsulfanyl-3,4-dihydro-pyrido[4,3-d]pyrimidine-8-carbonitrile, has been prepared and dete- mined by single-crystal X-ray diffraction. The crystal belongs to the triclinic system, space group P1 with a = 6.8754(8), b = 10.2617(12), c = 13.3491(16) , α = 93.163(2), β = 96.704(2), γ = 102.421(2)°, V = 910.35(19) 3, Z = 2, Mr = 370.44, Dc = 1.351 g/cm3, μ = 0.203 mm-1, F(000) = 388, the final R = 0.0573 and wR = 0.1497. X-ray analysis reveals that the pyridine and pyrimidine rings are almost coplanar. 相似文献
16.
A series of 1,5-disubstituted 3-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-2-pyrazolines were synthesized by the reaction of α,β-unsaturated ketones derived from dehydroacetic acid and
hydrazine in hot acetic acid or propionic acid. The structures of all new compounds were elucidated by microanalyses, 1H and 13C NMR, IR, and mass spectroscopic measurements. 相似文献
17.
The reaction of 2-amino-4-methyl-6-(2-pyridyl)-7,8-dihydroindazolo[4,5-d]thiazole, obtained by treating 3-methyl-4-oxo-1-(2-pyridyl)-4,5,6,7-tetrahydroindazole with pyridinium bromide perbromide and then with thiourea, and 2-amino-4-methyl-6-phenyl-7,8-dihydroindazolo[4,5-d]thiazole with 4-bromo-, 4-fluoro-, 4-dimethylamino-, 4-methoxy-, 3,4-dimethoxy-, and 3,4-methylenedioxybenzaldehydes, furfural, pyridinecarbaldehyde, and thiophenecarbaldehyde gave the corresponding Schiff bases. The products of the condensation of these aminothiazoles with cinnamaldehyde, 1-(2-pyridyl)- and 4-chloro-1-(2,4-difluorophenyl)-5-formyl-3-methyl-6,7-dihydroindazoles, 2-formyl-dimedone, and 2-formyl-1,3-indanedione were also obtained. 相似文献
18.
19.
Krishna C. Majumdar Safalla K. Ghosh Paritosh Biswas 《Monatshefte für Chemie / Chemical Monthly》2000,52(10):967-973
A simple and efficient synthesis of the hitherto unreported ring systems pyrano[3,2-f]quinolin-2(7H)-one and furo[3,2-f]quinolin-2-one was accomplished via a thermal [3,3]-sigmatropic rearrangement. 相似文献
20.
Eberhard Reimann Rainer Hertel Jürgen Krauss 《Monatshefte für Chemie / Chemical Monthly》2008,25(1):673-684
Alkylation of Reissert compounds derived from 3-methylisoquinolines with several 2-cyanobenzylbromides followed by hydrolytic cleavage provided
the corresponding 1-benzyl-3-methylisoquinolines. Treatment of the latter with methylmagnesiumiodide caused cyclization to
the title compounds rather than formation of 2-acetylbenzylisoquinolines. 相似文献