三核铜(Ⅰ/Ⅱ)配合物[Cu(en)_2]·[Cu(pht)_2]_2的合成、晶体结构及与DNA相互作用的研究

报道了多核铜配合物[Cu(en)_2]·[Cu(pht)_2]_2(Hpht:苯妥英,即5,5-二苯基-2,2-咪唑烷酮;en:乙二胺)的溶剂热合成、晶体结构及其与DNA的相互作用.该晶体属三斜晶系,P_1~-空间群,晶胞参数:a=0.8453(2)nm,b=1.1878(3)nm,c=1.5674(4)nm,a=101.197(3)°,β=97.690(3)°,γ=103.283(3)°,V=1.476(6)nm~3,D_c=1.480 g/cm~3,Z=1,F(000)=679,μ=1.139nm~(-1),R_1=0.0402,wR_2=0.0962[I>2σ(Ⅰ)],GOF=1.035.XPS和X射线单晶衍射数据显示该配合物分子由混价铜组成,包括两个一价铜和一个二价铜,其中每个Cu(Ⅰ)分别与两个苯妥英配体提供的氮原子配位,N-Cu(Ⅰ)-N的夹角为177°,一个Cu(Ⅱ)与六个配位原子配位(CuN_4O_2),形成一个稍变形八面体结构.配合物与DNA相互作用研究表明,该配合物主要是以插入方式与小牛胸腺DNA结合.     

混价四核铜(I/II)配合物[Cu_2L_2][Cu(pht)_2]_2的合成、晶体结构及性质研究

报道四核铜配合物[Cu2L2][Cu(pht)2]2[Hpht:苯妥英,即5,5-二苯基-2,2咪唑烷酮;L:N-(3-氨基丙基)二乙醇胺]的溶剂热合成、晶体结构及其性质研究.该晶体属单斜晶系,P21/n空间群,晶胞参数:a=0.9240(1)nm,b=2.4559(2)nm,c=1.5572(2)nm,β=97.489(2)o,V=3.5035(7)nm3,Dc=1.499Mg/m3(g/cm3),Z=2,F(000)=1636,μ=1.270mm-1,R1=0.0503,wR2=0.1135[I2σ(I)],GOF=1.014.XPS结合X射线单晶结构分析,表明该配合物分子有混价铜组成,包括两个Cu(I)和两个Cu(II),其中每个Cu(I)分别与两个苯妥英配体提供的氮原子配位,N—Cu(I)—N的夹角为177.1°,每个Cu(II)与L配体的五个配位原子配位(N2O3),形成一个稍变形四方锥结构,两个Cu(II)通过N-(3-氨基丙基)二乙醇胺中的一个羟基氧桥连接形成双核阳离子,琼脂扩散法测试结果表明配合物、配体和铜盐对3种受试细菌均有一定的活性.配合物与DNA的相互作用测定研究表明,该配合物是以插入方式与小牛胸腺DNA结合.     

微量热法研究 [Cu(phen)2]2+、[Cu(bpy)2]2+与DNA的作用

用微量热法对菲咯啉合铜([Cu(phen)     

混价四核铜(Ⅰ/Ⅱ)配合物[Cu_2L_2][Cu(pht)_2]_2的合成、晶体结构及性质研究

报道四核铜配合物[Cu_2L_2][Cu(pht) _2] _2 [Hpht:苯妥英,即5,5-二苯基-2,2咪唑烷酮;L:N-(3-氨基丙基)二乙醇胺]的溶剂热合成、晶体结构及其性质研究,该晶体属单斜晶系,P2_1/n空间群,晶胞参数:a=0.9240(1) nm,b=2.4559(2) nm,c=1.5572(2) nm,β=97.489(2)°, V=3.5035(7) nm~3,Dc= 1.499 Mg/m~3 (g/cm~3),2-2,F(000)=1636,μ=1.270 mm~(-1),R_1=0.0503,Wr_2=0.1135[I>2σ(1)],GOF=1.014. XPS结合X射线单晶结构分析,表明该配合物分子有混价铜组成,包括两个Cu(Ⅰ)和两个Cu(Ⅱ),其中每个Cu(Ⅰ)分别与两个苯妥英配体提供的氮原子配位,N-Cu(Ⅰ)-N的夹角为177.1°,每个Cu(Ⅱ)与L配体的五个配位原子配位(N_2O_3),形成一个稍变形四方锥结构,两个Cu(Ⅱ)通过N-(3-氨基丙基)二乙醇胺中的一个羟基氧桥连接形成双核阳离子,琼脂扩散法测试结果表明配合物、配体和铜盐对3种受试细菌均有一定的活性.配合物与DNA的相互作用测定研究表明,该配合物是以插入方式与小牛胸腺DNA结合.     

配合物[Cu(PTA)(phen)2]·(PTA)·(H2O)4的合成、晶体结构及电化学性质

The title complex has been synthesized by using terephthalic acid (PTA), 1,10-phenanthroline (phen) and copper monohydrate. It crystallizes in monoclinic space group C2/c with a=2.959 0(2) nm, b=1.466 4(10) nm, c=1.764 3(12) nm, β=105.593(11)°, V=7.372(9) nm³, Dc=1.489 g·cm^-3, Z=8, F(000)=3 416, R₁=0.043 6, wR₂= 0.151 9. The crystal structure shows that the copper atom is coordinated with four nitrogen atoms from two phens and one oxygen atom from one terephthalic acid, forming a distorted square-pyramid coordination geometry. The cyclic voltametric behavior of the complex is also reported. CCDC: 277047.     

微量热法研究 [Cu(phen)2]~(2 )、[Cu(bpy)_2]~(2 )与DNA的作用

用微量热法对菲咯啉合铜（ [Cu(phen)2]2＋）和联吡啶合铜（ [Cu(bpy)2]2＋）与小牛胸腺 DNA的相互作用进行了研究,依据 McGhee-Von Hippel邻近排斥方程确定了结合反应的平衡常数 K、结合位点距离 n及热力学参数Δ rHm、Δ rGm和Δ rSm。结果表明这两种铜的配合物与 DNA之间均可形成稳定的三元配合物,且反应为熵驱动过程, DNA与这些配合物的键合过程中同时存在插入和静电作用两种模式,插入作用的强弱与金属配合物中配体的平面性质有关。     

新型铜配合物[Cu(PyPt)(NO3)2]合成、结构、表征及其与DNA相互作用

本文报道了新型铜配合物[Cu(PyPt)(NO3)2](HPyPt是N-2-吡啶基-N'-苯基硫脲)的合成、结构、波谱表征及其与DNA相互作用研究.该配合物属三斜品系P1空间群,其中a=0.761 52(15)nm,b=0.80957(16)nm,c=1.311 3(3)nm,α=76.01(3)°,β=89.59(3)°,γ=68.24(3)°,V=0.7255(2)nm3,Z=2.利用荧光光谱法、紫外光谱法和粘度法初步研究了[Cu(PyPt)(NO3)2]与小牛胸腺DNA的相互作用,计算其与DNA结合常数Kb为1.63×103 L·mol-1.     

双核钒席夫碱配合物[VO(μ2-O)(o-Vanillin-en)]2的合成、结构及与DNA相互作用

在甲醇体系中乙酰丙酮氧钒与邻香草醛缩牛磺酸钾席夫碱在乙二胺存在下反应得到一个双核钒配合物。通过红外光谱和X-射线单晶衍射对其进行了表征。晶体结构表明该化合物的晶体属于三斜晶系，P1空间群，晶胞参数为a=0.898 67(19)nm，b=1.159 3(3) nm，c=1.200 0(3) nm，α=106.872(3)°，β=102.718(4)°，γ=94.905(3)°，Z=2。通过紫外吸收光谱法和循环伏安法研究了钒配合物与小牛胸腺DNA间的相互作用。紫外吸收光谱法得到配合物与DNA的结合常数为1.77×10⁴ dm³·mol^-1。     

N-邻苯二甲酰甘氨酸双核铜(Ⅱ)配合物的合成、晶体结构及与DNA的作用

合成了新的双核铜(Ⅱ)配合物:[Cu₂(DMSO)₂(ODPA)₄]·2DMSO(其中,DMSO=二甲基亚砜,ODPA=N-邻苯二甲酰甘氨酸)。通过X-射线单晶衍射测定了该配合物的结构。配合物晶体属于三斜晶系,空间群P1,晶胞参数:a=1.036 1(2) nm,b=1.127 3(2) nm,c=1.212 6(2) nm,α=84.084(2)°,β=81.765(3)°,γ=82.163(2)°晶胞体积;V=1.383 6(4) nm³,晶胞结构基元数;Z=1,D_c=1.508 g·cm^-1,最后的残差因子:R=0.075 0,wR₂=0.192 7。用紫外和荧光光谱等方法研究了配合物与DNA的相互作用。结果表明,配合物以部分插入方式与DNA作用,凝胶电泳实验结果表明,该配合物能够切割pBR322 DNA。     

N-邻苯二甲酰甘氨酸双核铜(Ⅱ)配合物的合成、晶体结构及与DNA的作用

合成了新的双核铜(Ⅱ)配合物：[Cu₂(DMSO)₂(ODPA)₄]·2DMSO(其中,DMSO=二甲基亚砜,ODPA=N-邻苯二甲酰甘氨酸)。通过X-射线单晶衍射测定了该配合物的结构。配合物晶体属于三斜晶系,空间群P1,晶胞参数：a=1.036 1(2) nm,b=1.127 3(2) nm,c=1.212 6(2) nm,α=84.084(2)°,β=81.765(3)°,γ=82.163(2)°;晶胞体积V=1.383 6(4) nm³,晶胞结构基元数Z=1,D_c=1.508 g·cm^-3,最后的残差因子：R=0.075 0,wR₂=0.192 7。用紫外和荧光光谱等方法研究了配合物与DNA的相互作用。结果表明,配合物以部分插入方式与DNA作用,凝胶电泳实验结果表明,该配合物能够切割pBR322 DNA成Form Ⅱ。     

[Cu(HDPC)2]·(HOx)2·6H2O的合成及晶体结构

The new complex formulated [CU(HDPC)₂]·(HOx)₂·6H₂O(HDPC^- is pyridine-2,6-dicarb-oxylate,Hoxis 8-Hydroxyquindine) has been synthesized and the crystal structure was determined by X-ray diffraction .The crystal structure of the complex belongs to monoclinic system with space group C2/c. a=18.423(3)Å, b=10.384(2)Å,c=19.139(2)Å, α=γ=90°, β=111.050(10)°, V=3417.0(9)ų, Z=4, D_c=1.544Mg·m^-3, μ=0.722mm^-1. In the crystal Cu(Ⅱ) ion is six coordinated to form a distorted octahedron.     

氢键构筑的二维网状结构镍配合物[Ni(en)2(dpas)2]的合成、晶体结构及电化学性质

A new 2D Hydrogen-bonded network complex [Ni(en)2(dpas)2] (Nadpas=sodium diphenylamine sulphonic acid salt,en=ethanediamine) has been synthesized in aqueous solution,and characterized by elemental analysis,IR. The crystal structure was determined by single-crystal X-ray diffraction. The complex crystallizes in space group P21/c,with cell parameters a=0.605 6(5)nm,b=1.448 1(5) nm,c=1.711 9(5)nm,β=93.257(5)°,and V=1.498 9(14) nm3,Dc=1.497 g·cm-3,Z=2,F (000)=708,R=0.027 7,wR=0.072 5. The crystal structure shows that the nickel atom is coordinated with four nitrogen atoms from the two en and two oxygen atoms from two dpas to form a mononuclear complex. Furthermore,the adjacent complex units are extended into a 2D supramolecular network through hydrogen bonds.     

二维Hofmann类双金属配合物Cu(DMF)_2[Pt(CN)_4]的合成及晶体结构(英文)

A two-dimensional cyanide-bridged Cu(Ⅱ)-Pt(Ⅱ) bimetallic complex has been synthesized by solution diffusion method using [Pt (CN)4]2- and [Cu (L)]2+ (L =3,10-diethanol-1,3,5,8,10,12-hexaazacyclotetradecane) as building blocks. Unexpectedly, the obtained complex Cu(DMF)2[Pt(CN)4] (1) is an analogue of the well-known Hofmann -type clathrate without macrocyclic ligand. Single-crystal X-ray diffraction reveals that 1 crystallizes in monoclinic, space group C2/m, a=1.624 8(6) nm, b=0.739 3(3) nm, c=0.695 5(3) nm, β=108.969(4)°. The crystal structure of 1 consists of two-dimensional corrugated metal cyanide sheets without interpenetration stacking along the a axis in an ABAB packing mode.     

[COH(NH2)2]2[Cu(pic)2(ClO4)2]的合成与晶体结构

The title compound was synthesized by reaction of Cu(ClO₄)₂， picolinic acid and carbamide in C₂H₅OH/CH₃CN solution， and characterized by single-crystal X-ray diffraction. It crystallizes in the orthorhombic system， space group Pbca with a=14.0481(8)， b=9.0130(5)， c=18.626(1)?， V=2358.3(2)?³， Z=4， D_x=1.771g·cm^-3， μ=1.235mm^-1 and F(000)=1276. The final R factor is 0.0440 for 1434 observed reflections. The X-ray analysis revealed that the copper(Ⅱ) atom is coordinated by two picolinic ligands in the equatorial plane， while the two oxygen atoms of perchlorate occupy the axial positions of octahedron with lengthened Cu-O distances， resulting in a 4+2 elongated octahedral environment. In the compound， there also exist two protonated carbamide cations for charge balance. CCDC： 195354.     

配合物[Cd(NIT4Py)2][Au(CN)2]2的合成与晶体结构

A Cd(II)-nitronyl nitroxide radical complex with dicyanoaurate(I) bridges [Cd(NIT4Py)₂][Au(CN)₂]₂, was synthesized and characterized by elemental analyses, IR spectrum and X-ray diffraction single-crystal structure analysis. Crystal data for the complex: triclinic, space group P1, a=0.720 9(11) nm, b=0.960 3(15) nm, c=1.284(2) nm, α=75.38(2)°, β=85.46(2)°, γ=68.38(2)°, V=0.800(2) nm³, Z=1, and R₁ [I>2σ(I)]=0.055 8. The title complex consists of infinite one-dimensional chains of [Cd(NIT4Py)₂][Au(CN)₂]₂, in which [Cd(NIT4Py)₂] moieties are conne-cted by [Au(CN)₂]^- μ₂-bridging ligands. Each cadmium(II) ion is six-coordinated in a distorted and centrosymmetric octahedral environment. CCDC: 258357.     

(NO2Ql)2[Ni(mnt)2]的合成和晶体结构((NO2Ql)+=1-(4-nitrobenzyl)-quilorinium;mnt2-=maleonitriledithiolate)

合成了离子对配合物(NO2Q1)2[Ni(mnt)2],并用元素分析和红外光谱进行了表征.单晶结构分析结果表明三斜晶系,空间群p-1.晶胞参数a=8.2240(16)A,6=10.777(2)A,c=12.137(2)A,α=72.58(3).,β=72.82(3)°,γ=68.78(3)°,V=935.4(3)A3,Z=1.(NO2Ql)+和[Ni(mnt)2]2-分别形成了完全分立的柱状堆积结构.在阴离子堆积柱内,Ni(Ⅱ)离子形成了一维均匀链.阳离子间,比邻的芳环间存在弱的π…π作用.     

Synthesis,Crystal Structure,and DNA‐Binding Properties of a New Cd(II) Complex Involving 2‐(2‐1H‐Imidazolyl)‐1H‐Imdazolium Ligand

A new Cd(II) complex of Cd(H₃biim)₂(NCS)₂Cl₂ [H₃biim=2‐(2‐1H‐imidazolyl)‐1H‐imidazolium] was synthesized and characterized by elemental analyses, FT‐IR and X‐ray single crystal diffraction. In the X‐ray crystallography structure, the cadmium(II) ion is coordinated by two nitrogen atoms of two 2‐(2‐1H‐imidazolyl)‐ 1H‐imdazolium, two nitrogen atoms of two thiocyanate ions and two Cl^?. The interaction of the complex with calf thymus DNA was investigated through electronic absorption spectroscopy, fluorescence spectroscopy, viscosity measurement, cyclic voltammetry and gel electrophoresis. These results show that the Cd(II) complex can electrostatically bind to the phosphate group of DNA backbone. Interestingly, we found that the complex can cleave the pBR322 DNA at pH=7.2 and 37°C.     

配合物[Cu(H2biim)2]Br2的合成和晶体结构

The complex [Cu(H₂biim)₂]Br₂ (H₂biim=2,2′-biimdazole) has been synthesized and structurally charac-terized. It crystallizes in the Monoclinic system, space group C2/c with a=1.422 5(4) nm, b=0.931 2(2) nm, c=1.343 1(3) nm, β=116.227(4)°, V=1.595 9(7) nm^-3, R₁=0.060 2, wR₂=0.152 8 and Z=4. The copper ion has a sligh-tly distorted square planar coordination configuration with four nitrogen atoms from two H₂biim ligands. The complex has a one-dimensional chain structure, which is formed by hydrogen bonds and semi-coordinate bonds. CCDC: 624679.     

Crystal structure of [Cu(en)2](ReO4)2

At T = 150 K the crystal structure of [Cu(en)₂] (ReO₄)₂ (en is ethylenediamine) is studied: a = 6.6229(1) ?, b = 14.2968(3) ?, c = 7.4859(2) ?, β = 102.415(1)°, V = 692.24(3) ?,³, P2₁/c space group, Z = 2, d _x = 3.282 g/cm³. Packing of complex cations is shown to be single layered and pseudohexagonal. Perrhenate anions are located between these layers and additionally coordinate copper atoms with Cu...O distances being 2.504(3) ?.