A methodological and metabolite identification study of the metabolism of S-carboxymethyl-L-cysteine in man

Summary The analysis of 08:00–16:00 (0–8) hour urine collections following oral S-carboxymethyl-L-cysteine administration of 750 mg to 30 individuals identified S-carboxymethyl-L-cysteine, S-carboxymethyl-L-cysteine S-oxide, S-methyl-L-cysteine and S-methyl-L-cysteine S-oxide as the major urinary drug related compounds. No S-(carboxymethylthio)-L-cysteine mixed disulphide metabolite was found in the 08:00–16:00 hour urine collection but the metabolite was detected in the 16:00–00:00 (8–16) hour urune collection by paper chromatography, TLC and HPLC. The production of the S-oxide metabolites 08:00–16:00 hour urine collection) and the mixed disulphide metabolite (16:00–00:00 hour urine collection) were both shown to be biomodally distributed. A significant linear correlation of the S-oxides recovered following 08:00–16:00 hour urine collection as analysed by paper chromatography, TLC and HPLC is reported.     

Anti-inflammatory drugs. X.

In the solid-state structure of the title compound, C₄H₁₀N⁺·C₁₄H₁₀Cl₂NO₂⁻·H₂O, the asymmetric unit contains one cation, one anion and a water mol­ecule. There is a network of hydrogen bonds which is similar to that found in the hydrated diethyl­ammonium diclofenac salt. A comparison is made of the molecular conformation of the anions in the two related structures.     

Studies on Carbohydrates X. A New Method for the Preparation of Isopropylidene Saccharides

Cabohydrates reacting with acetone in the presence of molecular sieve and p—toluene sulfonic acid provided a simple, convenient, high yield and good selective process for preparation of isopropylidene carbohydrates.     

豆荚软珊瑚Lobophytum sp. 的次生代谢产物研究

从海南岛三亚海域采集的软珊瑚Labophytumsp.中分离得五个甾醇苷(1)～(5)。通过波谱分析，确定它们的化学结构依次为3'-O-乙酰基-4-O-[β-D-吡喃木糖苷]-孕甾-20-烯-3β,4α-二醇(1)，4-O-[β-D-吡喃木糖苷]-孕甾-20-烯-3β,4α-二醇(2),4'-O-乙酰基-4-O-[β-D-吡喃木糖苷]-孕甾-20-烯-3β,4α-二醇(3),4'-O-乙酰基-4-O-[β-D-吡喃阿拉伯糖苷]-孕甾-20-烯-3β,4α-二醇(4)和4-O-[β-D-吡喃阿拉伯糖苷]-孕甾-20-烯-3β,4α-二醇(5),其中1为新化合物。体外细胞毒性实验表明：化合物(1),(2)和(5)对SKMG-4,Hep-G2和CNE2三种人体癌细胞具有抑制作用。