Dynamical behavior of a delay virus dynamics model with CTL immune response

In this paper, the dynamical behavior of a virus dynamics model with CTL immune response and time delay is studied. Time delay is used to describe the time between the infected cell and the emission of viral particles on a cellular level. The effect of time delay on stability of the equilibria of the CTL immune response model has been studied and sufficient criteria for local asymptotic stability of the disease-free equilibrium, immune-free equilibrium and endemic equilibrium and global asymptotic stability of the disease-free equilibrium are given. Some conditions for Hopf bifurcation around immune-free equilibrium and endemic equilibrium to occur are also obtained by using the time delay as a bifurcation parameter. Numerical simulation with some hypothetical sets of data has been done to support the analytical findings.     

Hopf bifurcation analysis of a density predator-prey model with crowley-martin functional response and two time delays

In this paper, a delayed density dependent predator-prey model with Crowley-Martin functional response and two time delays for the predator is considered. By analyzing the corresponding characteristic equations, the local stability of each of the feasible equilibria of the system is addressed and the existence of Hopf bifurcation at the coexistence equilibrium is established. With the help of normal form method and center manifold theorem, some explicit formulas determining the direction of Hopf bifurcation and the stability of bifurcating period solutions are derived. Finally, numerical simulations are given to illustrate the theoretical results.     

Stability and Hopf bifurcation in a delayed predator–prey system with stage structure for prey

We consider a predator–prey system of Lotka–Volterra type with time delays and stage structure for prey. By analyzing the corresponding characteristic equations, the local stability of the equilibria is investigated and Hopf bifurcations occurring at the positive equilibrium under some conditions are demonstrated. The mathematical tools which enable us to obtain the sufficient conditions, guaranteeing the global asymptotical stability of the equilibria, are the well-known Kamke comparison theorem and an iteration technique. Numerical simulations are carried out to illustrate our theoretical results.     

Stability and Hopf bifurcation of a delayed viral infection model with logistic growth and saturated immune impairment

In this paper, the stability and Hopf bifurcation of a delayed viral infection model with logistic growth and saturated immune impairment is studied. It is shown that there exist 3 equilibria. The sufficient conditions for local asymptotic stability of the infection‐free equilibrium and no‐immune equilibrium are given. We also discussed the local stability of positive equilibrium and the existence of Hopf bifurcation. Moreover, the direction and stability of Hopf bifurcation is obtained by using standard form theory and the center manifold theorem. Finally, numerical simulations are performed to verify the theoretical conclusions.     

具有多时滞的食物链系统的Hopf分支

讨论了具有时滞的食物链模型,首先我们得到了系统永久持续生存的条件,然后讨论系统在正平衡点附近发生Hopf分支的存在性;最后利用数值模拟证明所得结论.     

Global stability and periodic oscillations for an SIV infection model with immune response and intracellular delays

In this paper, we consider the combined effects of cytotoxic T lymphocyte (CTL) responses on the competition dynamics of two Simian immunodeficiency virus (SIV) strains model. One of strains concerns a relatively slowly replicating and mildly cytopathic virus in the early infection (SIVMneCL8), the other is faster replicating and more cytopathic virus at later stages of the infection (SIVMne170). It is shown that the global dynamics of the ordinary differential equations can be determined by several threshold parameters, and we prove the global stability of the equilibria by rigorous mathematical analysis. To account for a series of infection mechanism leading to viral production, we incorporate time delays in the infection term. Using the methods of constructing suitable Lyapunov functionals and LaSalle’s invariance principle, we obtain the sufficient conditions for the global attractiveness of infection-free equilibrium with both virus strains going extinct, single-infection equilibrium with one of two virus strains out-competing the other one and the two strains coexisting infection equilibrium. We establish that the intracellular delays can destabilize the single-infection equilibrium leading to Hopf bifurcation and periodic oscillations. We show that introduction of immune responses is responsible for the coexistence of two virus strains and the intracellular delays may alter the two-strain competition results. Numerical simulations are presented to illustrate the theoretical conclusions.     

Effects of time delays on bifurcation and chaos in a non-autonomous system with multiple time delays

Time delays are often sources of complex behavior in dynamic systems. Yet its complexity needs to be further explored, particularly when multiple time delays are present. As a purpose to gain insight into such complexity under multiple time delays, we investigate the mechanism for the action of multiple time delays on a particular non-autonomous system in this paper. The original mathematical model under consideration is a Duffing oscillator with harmonic excitation. A delayed system is obtained by adding delayed feedbacks to the original system. Two time delays are involved in such system, one of which in the displacement feedback and the other in the velocity feedback. The time delays are taken as adjustable parameters to study their effects on the dynamics of the system. Firstly, the stability of the trivial equilibrium of the linearized system is discussed and the condition under which the equilibrium loses its stability is obtained. This leads to a critical stability boundary where Hopf bifurcation or double Hopf bifurcation may occur. Then, the chaotic behavior of such system is investigated in detail. Particular emphasis is laid on the effect of delay difference between two time delays on the chaotic properties. A Melnikov’s analysis is employed to obtain the necessary condition for onset of chaos resulting from homoclinic bifurcation. And numerical analyses via the bifurcation diagram and the top Lyapunov exponent are carried out to show the actual time delay effect. Both the results obtained by the two analyses show that the delay difference between two time delays plays a very important role in inducing or suppressing chaos, so that it can be taken as a simple but efficient “switch” to control the motion of a system: either from order to chaos or from chaos to order.     

一类具有时滞的Watt型恒化器模型的稳定性分析

基于"比例依赖"理论,研究了一类具有时滞和Watt型功能反应函数的恒化器模型.详细讨论了正平衡点的局部渐近稳定性,证明了系统在特定的时滞参量值下将产生Hopf分支.利用Lyapunov-LaSalle不变性原理,得到了正平衡点全局渐近稳定的充分条件.     

Analysis of a viral infection model with delayed immune response

It is well known that the immune response plays an important role in eliminating or controlling the disease after human body is infected by virus. In this paper, we investigate the dynamical behavior of a viral infection model with retarded immune response. The effect of time delay on stability of the equilibria of the system has been studied and sufficient condition for local asymptotic stability of the infected equilibrium and global asymptotic stability of the infection-free equilibrium and the immune-exhausted equilibrium are given. By numerical simulating,we observe that the stationary solution becomes unstable at some critical immune response time, while the delay time and birth rate of susceptible host cells increase, and we also discover the occurrence of stable periodic solutions and chaotic dynamical behavior. The results can be used to explain the complexity of the immune state of patients.     

含两时滞捕食-被捕食系统的稳定性及分歧

本文研究一类含两相异时滞的捕食－被捕食系统的稳定性及分歧。首先，我们讨论两相异时滞对系统唯一正平衡点的稳定性的影响，通过对系数与时滞有关的特征方程的分析，建立了一种稳定性判别性。其次，将一个时滞看成分歧参数，而另一个看作固定参数，我们证明了该系统具有HOPF分歧特性。最后，我们讨论了分歧解的稳定性。     

Hopf bifurcation analysis in a multiple delayed innovation diffusion model with Holling II functional response

A nonlinear mathematical model with Holling II functional response describing the dynamics of nonadopter and adopters population in a stage structured innovation diffusion model, which incorporates the evaluation stage (multiple delays), is proposed. Firstly, we study the stability and the existence of periodic solutions via Hopf bifurcation with respect to both delays at the positive equilibrium by analyzing the distribution of the roots of the corresponding exponential characteristic equation obtained through the variational matrix. The direction of the Hopf bifurcation and the stability of the bifurcating periodic solutions are determined with the help of normal form theory and center manifold theorem. Meanwhile, various cases are discussed to examine the effect of different delays on the stability of delayed innovation diffusion system and are also established numerically. It is also observed that the cumulative density of external influences has a significant role in developing maturity stage (adoption stage) in the system. Finally, numerical simulations are carried out to support and supplement the analytical findings.     

A dynamic IS-LM business cycle model with two time delays in capital accumulation equation

In this paper, we analyze a augmented IS-LM business cycle model with the capital accumulation equation that two time delays are considered in investment processes according to Kalecki’s idea. Applying stability switch criteria and Hopf bifurcation theory, we prove that time delays cause the equilibrium to lose or gain stability and Hopf bifurcation occurs.     

一类具有阶段结构和时滞的捕食模型的稳定性及Hopf分支(英文)

研究一类具有阶段结构和时滞的捕食模型.通过特征方程分别分析了正平衡点和边界平衡点的局部稳定性,到了系统Hopf分支存在的充分条件.通过规范型理论和中心流型定理,给出了确定Hopf分支方向和分支周期解的稳定性的计算公式.     

Effect of herd shape in a diffusive predator-prey model with time delay

In this paper, we deal with the effect of the shape of herd behavior on the interaction between predator and prey. The model analysis was studied in three parts. The first, The analysis of the system in the absence of spatial diffusion and the time delay, where the local stability of the equilibrium states, the existence of Hopf bifurcation have been investigated. For the second part, the spatiotemporal dynamics introduce by self diffusion was determined, where the existence of Hopf bifurcation, Turing driven instability, Turing-Hopf bifurcation point have been proved. Further, the order of Hopf bifurcation points and regions of the stability of the non trivial equilibrium state was given. In the last part of the paper, we studied the delay effect on the stability of the non trivial equilibrium, where we proved that the delay can lead to the instability of interior equilibrium state, and also the existence of Hopf bifurcation. A numerical simulation was carried out to insure the theoretical results.     

时滞偏害系统的稳定性和分歧分析

本文讨论了具离散和分布时滞的偏害系统.以时滞作为分歧参数,通过分析原系统在正平衡点处线性化系统的特征方程,获得了正平衡点渐近稳定以及在它周围分歧出周期解的条件.另外,通过使用规范形和中心流形定理,我们获得了Hopf分歧的方向和分歧周期解稳定性的显式算法.最后,数值模拟支持了我们的理论分析.     

一类偏泛函微分方程的Hopf分支

讨论了一类具有限时滞含迁移的Prey-Predator系统平衡态的稳定性和Hopf分支,表明当系统的6个独立参数在一定范围内取值时,随着时滞的增加,系统平衡态的稳定性在一定范围内交替变化,而每一次平衡态稳定性的改变都相伴有Hopf分支发生.     

Linear stability and Hopf bifurcation analysis for exponential RED algorithm with heterogeneous delays

In this paper, the exponential RED algorithm with heterogeneous delays is considered. Local stability of the equilibrium solution of this algorithm is investigated based on analyzing the corresponding transcendental characteristic equation. Some general stability criteria involving the delays and the system parameters are derived by using generalized Nyquist criteria. In particular, using one of the delays as the bifurcation parameter, when the delays exceed a critical value, the exponential RED system undergoes a supercritical Hopf bifurcation. The explicit formulas determining the stability and the direction of periodic solutions bifurcating from the equilibrium are obtained by applying Hassard et al’s approaches. Finally, some numerical simulations are performed to verify the theoretical results.     

Stability and Hopf Bifurcation of a Virus Infection Model with a Delayed CTL Immune Response

In this paper, a virus infection model with standard incidence rate and delayed CTL immune response is investigated. By analyzing corresponding characteristic equations, the local stability of each of feasible equilibria and the existence of Hopf bifurcations at the CTL-activated infection equilibrium are established, respectively. By means of comparison arguments, it is verified that the infection-free equilibrium is globally asymptotically stable if the basic reproduction ratio is less than unity. By using suitable Lyapunov functional and LaSalle＇s invariance principle, it is shown that the CTL-inactivated infection equilibrium of the system is globally asymptotically stable if tile immune response reproduction ratio is less than unity and the basic reproduction ratio is greater than unity. Numerical simulations are carried out to illustrate the theoretical result.     

Dynamics of an epidemic model with relapse and delay

In this paper, we consider a new epidemiological model with delay and relapse phenomena. Firstly, a basic reproduction number $R_0$ is identified, which serves as a threshold parameter for the stability of the equilibria of the model. Then, beginning with the delay-free model, the global asymptotic stability of the equilibria is obtained through the construction of suitable Lyapunov functions. For the delay model, the stability of the positive equilibrium and the existence of the local Hopf bifurcation are discussed. Furthermore, the application of the normal form theory and center manifold theorem is used to determine the direction and stability of these Hopf bifurcations. Finally, we shed light on corresponding biological implications from a numerical perspective. It turns out that time delay affects the stability of the positive equilibrium, leading to the occurrence of periodic oscillations and disease recurrence.