Synthesis, Crystal Structure and Biological Activities of N′-(4-Methoxybenzylidene)-2-(1H-1,2,4-triazol-1-yl)acetohydrazide

The title compound, N′-(4-methoxybenzylidene)-2-(1 H -1,2,4-triazol-1-yl)acetohydrazide, was synthesized and its structure was confirmed by means of IR, MS, 1H NMR and elemental analysis. The single crystal structure of the title compound was determined by X-ray diffraction. The preliminary biological test shows that the synthesized compound has a low antifungal activity.     

Synthesis and Crystal Structure of N′-(4-fluorobenzylidene)-2-(1H-1,2,4-triazole-1-yl)acetohydrazide

IntroductionBoth triazole derivatives and Schiff base have beenreported to possess significant antifungal[1—3]and plantgrowth regulatory activities[4—6].Triazole drugs are alsovery common in the medical field,which has given animmense impetus to the res…     

Synthesis, Crystal Structure and Biological Activities of N＇ - （ 4-Methoxybenzylidene ） -2- （ 1H-1, 2,4- triazol-1-yl） acetohydrazide

The title compound, N‘-( 4-methoxybenzylidene ) -2-( IH-1, 2,4-triazol-1-yl ) acetohydrazide, was synthesized and its structure was confirmed by means of IR, MS,^1H NMR and elemental analysis. The single crystal structure of the title compound was determined by X-ray diffraction. The preliminary biological test shows that the synthesized compound has a low antifungal activity.     

Synthesis and Biological Activities of ω-Heterocyclyl-ω-(1H-1,2,4-triazol-1-yl) Acetophenones

Inrecentyears,agreatvarietyofheterocycliccompoundsbearing1H-l,2,4-triazoleringhavebeensynthesizedduetotheirbroadspectrumbiologicalactivitiesincludingantiinflammatory.insecticidal,antiviralandantiturnoractivities'-',someofwhichhavebeendevelopedintocommerciallyantifungalagentssuchastriadimefon.triadimenolanddiniconazele.Wepreviouslysynthesizedmanykindsofheterocycliccompoundssuchasl,3,4-oxadiazole,l,2,4-triazole,l,3.4-thiadiazoleandl,2.3-triazolederivativeswhichexhibitedantibacterial,antitubercul…     

Synthesis,Structure and Biological Activities of 2-(1H- 1,2,3-Benzotriazol-1-yl)-1-(4-methylphenyl)-2- (1H-1,2,4-triazol-1-yl)-1-ethanone

IntroductionTriazole derivatives have become the most rapidlyexpanding group of antifungal compounds with advanta-ges of lowtoxicity, high oral bioavailability and broad-spectrum antifungal activity, which can be used againstfungi including most yeasts an…     

Synthesis, Crystal Structure, and Biological Activities of 2-Oxo-2-aryl-1 - （ 1,2,4-triazol-1 -yl ） ethyl phenylcarbamodithioate

IntroductionAs an important type of fungicide, compoundscontaining 1,2,4-triazole groups have attracted muchattention because they exhibit a certain fungicidal acti-vity againstPuccinia reconditeand also play a role inroot-growth regulation[1—3]. However…     

Synthesis, Crystal Structure and Biological Activities of 2- （4-Fluorophenyl） -2-oxo-1-（1H-1,2,4-triazol-1-yl） ethyl morpholine-4-carbodithioate

The title compound, 2-（ 4-fluorophenyl ） -2-oxo-1-（ 1H-1, 2,4-triazol-1-yl ） ethyl morpholine-4-carbodithioate, was synthesized and its structure was confirmed by means of IR, MS, 1 H NMR and elemental analysis. The single crystal structure of the title compound was determined by X-ray diffraction. The preliminary biological test showed that the synthesized compound possesses some biological activities.     

Synthesis, Structure and Biological Activities of 2- （4-Met hoxybenzoyl ）-N-phenyl- 2- （ 1,2,4-triazol- 1-yl ） thioacetamide

The title compound, 2-(methoxybenzoyl)-N-phenyl-2-(1,2,4-triazol-l-yl) thioacetamide was synthesized by several reactions from 4-methoxyacetophenone, triazole and phenyl isothiocyanate. The structure was identified by elemental analysis, ^1H NMR, MS and IR. The single crystal structure of 2-(methoxybenzoyl)-N-phenyl-2-(1,2,4-triazol-l-yl)thioacetamide was determined withX-ray diffraction. The preliminary bioassays show that the title compound exhibits weak antifungal activities and plant-growth regulatory activity.     

Synthesis,Crystal Structure and Biological Activities of O-[（Z）-2-Methylbenzyl] 1-Phenyl-2-（1H-1,2,4-triazol-1-yl）ethanone Oxime

The crystal structure of the title compound （C18H18N4O, Mr = 306.36） has been determined by single-crystal X-ray diffraction. The crystal is of triclinic, space group P1 with α = 4.783（0）, b = 13.577（1）, c = 13.830（1） A, α = 63.581（2）, β = 88.326（2）, γ = 86.161（2）°, V= 802.5（1） A3, Z= 2, Dc = 1.268 g/cm^3, F（000） = 324, μ（MoKa） = 0.082 mm^-1, the final R = 0.0497 and wR = 0.1199 for 3094 observed reflections （I 〉 2σ（I））. The dihedral angles between the phenyl （C（1）-C（4）-（6）） and triazole, the phenyl （C（13）-C（15）-C（18）） and triazole, and the two phenyl rings are 7.9（1）, 69.9（1） and 67.8（1）°, respectively. Strong C-H…π interaction joins molecules into a chain along the c axis and contributes to the stability of the structure. Preliminary bioassay results show that the title compound possesses excellent and selective fungicidal activity against Colletotrichum gossypii but displays moderate to weak insecticidal activity against aphides.     

Synthesis of N,N′-bis[4-(1H-1,2,3-triazol-1-yl)furazan-3-yl]-methylenediamine derivatives

[3+2] Cycloaddition of azide groups of N,N′-bis(4-azidofurazan-3-yl)methylenediamine to 1,3-dicarbonyl compounds and malonodinitrile was shown to proceed regioselectively with the formation of the corresponding N,N′-bis[4-(1H-1,2,3-triazol-1-yl)furazan-3-yl]methylenediamine derivatives. The reactions of N,N′-bis(4-azidofurazan-3-yl)methylenediamine with cyanoacetic acid ethyl ester and amide led to the formation of the product of transformation of the azide group in the starting compound to the amino groups.     

Synthesis,Structure and Biological Activities of S-[α-(4-Methoxyphenylcarbonyl)-2-(1,2,4-triazole-1-yl)] ethyl-N,N-dime-thyldithiocarbamate

IntroductionAsanimportanttypeoffungicides ,triazolecom poundsarehighlyefficient,lowpoisonousandinwardab sorbent.1 3Atpresent,thestudiesontriazolederivativesaremainlyconcentratedoncompoundswithtriazoleastheonlyactivegroup .Therearefewreportsoftriazolecom poundsthatcontainbothtriazolegroupandotheractivegroupinasinglemolecule .Dialkyl substituteddithiocar bamatesaltshavealsoshowninterestingbiologicalef fects .4 N ,N Dialkyldithiocarbamatehasbeenknownasbroad rangefungicidesandhavingdifferentfung…     

Synthesis, Crystal Structure and Antitumor Activity of 4-tert-Butyl-N-（2-fluorophenyl）-5- （1H-1,2,4-triazol-1-yl）-thiazol-2-amine

The title compound has been synthesized by the reaction of 1-bromo-3,3-dime- thyl-1- (1H-1,2,4-triazol-1-yl)butan-2-one with 1-(2-fluorophenyl)thiourea, and its crystal structure was determined by single-crystal X-ray diffraction. The crystal belongs to the orthorhombic system, space group Pbca with a=15.2568(6), b=12.1533(5), c=16.7307(7) , Z=8, V=3102.2(2)3, Mr=317.39, Dc=1.359 g/cm3, S=1.05, μ=0.223 mm-1, F(000)=1328, the final R=0.034 and wR=0.097 for 2590 observed reflections (I>2σ(I)). X-ray crystal structure presents the intramolecular N-H…N hydrogen bond, which plays an important role in stabilizing the crystal structure. In addition, the preliminary biological test on the title compound shows good antitumor activity, with IC50 of 0.122 μmol/mL against the Hela cell line.     

Synthesis and Crystal Structure of 4-Phenyl-5-(1′- t-butyl-5′-methyl-4′-pyrazolyl)-1,2,4-triazol-3-thione

The crystal structure of 4-phenyl-5-(1′-t-butyl-5′-methyl-4′-pyrazolyl)-1,2,4-triazol- 3-thione 5 (C16H19N5S, Mr = 313.42) has been determined by single-crystal X-ray diffraction analysis. The crystal belongs to monoclinic, space group P21/c with a = 6.680(2), b = 27.44(1), c = 9.388(4)(A。), β = 106.738(6)°, V = 1648(1)(A。)3, Z = 4, Dc = 1.263 g/cm3, μ= 0.200 mm-1, F(000) = 664, R = 0.0608 and wR = 0.1176. The results confirmed that 5 can be assigned to the thione tautomeric form.     

Synthesis, Dimeric Crystal Structure, and Biological Activities of N-(4-Methyl-6-oxo-1,6-dihydro-pyrimidin-2-yl)-N′-(2-trifluoromethyl-phenyl)-guanidine

IntroductionPlants have a more extensive biosynthetic capacitythan animals, which is attributed to the fact that ani-mals rely on their diet for the supply of many biochemi-cal compounds and their precursors. Owing to thisdifference, plants contain numero…     

Synthesis and study of N-(1-phenylethylidene)-N-(4H-1,2,4-triazol-4-yl)amine, N′-(4H-1,2,4-triazol-4-yl)benzamidine, and cobalt(ii), nickel(ii), and copper(ii) complexes based on these ligands

Methods were developed for the synthesis of complexes of Co^II, Ni^II, and Cu^II nitrates and chlorides with N-(1-phenylethylidene)-N-(4H-1,2,4-triazol-4-yl)amine (L¹) and N′-(4H-1,2,4-triazol-4-yl)benzamidine (L²). The Co^II and Ni^II complexes have a linear trinuclear structure. The Cu^II complexes are polynuclear. Both ligands are coordinated to the metal ions in a bidentate-bridging mode through the N(1) and N(2) atoms of the heterocycle. In all compounds, the coordination polyhedron can be described as a distorted octahedron. The molecular and crystal structure of the [Ni₃(L¹)₆(EtOH)₂(H₂O)₄](NO₃)₆·2EtOH·4H₂O complex was established.     

Structure and Biological Activities of 3-Phenyl-2-[1-benzoyl-1- （1,2,4-triazol-1-yl）] Methenyl Thiazolidine

The title compound 3-phenyl-2-[1-benzoyl-1-(1,2,4-triazol-1-yl)]methenyl thiazolidine was synthesizedfrom acetophenone, triazole, phenylthioisocyanate and 1,2-dibromo-ethane by several step reactions. Itsstructure was identified by means of ^1H NMR, MS and IR spectrometries. The single crystal structure of 3-phenyl-2-[1-benzoyl-1-(1,2,4-triazol-1-yl)]methenyl thiazolidine was determined by X-ray diffraction.The preliminary bioassays have shown that the title compound exhibits the weak activities of fungicide andplant growth regulator.     

Synthesis and Crystal Structure of1,4-Bis（1H-1,2,4-triazol-1-methyl）benzene

1 INTRODUCTION 1,2,4-Triazole derivatives are used as ingradients in several antiallergic, antivirial, antibacterial drugs, etc.[1～4]. 1,2,4-Triazole and its derivatives are also very interesting ligands because they combine the coordination geometry of…     

Structure and Biological Activities of 2-（ 1,3-Dithiolan-2-ylidene）-1-phenyl-2- （ 1,2,4-triazol-1 -yl ） ethanone

In order to find leading compounds with an excellent fungicidal activity, the title compound 2-（ 1,3-dithiolan-2- yl-idene）-1-phenyl-2-（ 1,2,4-tfiazol-1-yl） ethanone was synthesized according to the biological isosterism and its structure was confirmed by means of IR, MS, ^1 H NMR and elemental analysis. The single crystal structure of the title compound was determined by X-ray diffraction. The preliminary biological test shows that the synthesized compound exhibits some biological activities.     

Syntheses,Structure and Biological Activities of 2-(1H-Benzo [1,2,3]triazole-1-yl)-1-(3-methyl-4-bromobiphenyl)-2-(1H-1,2,4-triazole-1-yl)ethanone

Introduction1,2,4-Triazole derivatives represent an interesting class of heterocyclic compounds[1]and have become the most rapidly expanding group of antifungal compounds with the advantages of toxicity, high oral bioavailabi-lity, and broad spectrum of a…