研究型实验室信息管理系统

介绍研究型实验室信息管理系统的设计思想、工作流程、管理功能和实用价值。     

实验室信息管理系统研究与开发

给出了实验室信息管理系统的研究思路和开发方法,介绍了此系统的主要模块的功能和特点。     

实验室信息管理系统中仪器设备管理模块的设计与实现

根据资质认定、实验室认可要求,从仪器设备管理的要求和仪器设备管理工作实际出发,归纳了实验室仪器设备管理、计量溯源方面的要求以及管理环节中容易出现的问题,采用用户界面(user interface,UI)插件技术和Gojs技术开发了信息管理系统仪器设备管理模块,降低了系统维护的难度,满足了系统使用的个性化需求,实现了仪器...     

化学实验室的由来

本文论述了早期的化学研究室是如何经过了一个漫长的发展过程诞生了供少数学生使用的教学用化学实验室和供大量学生使用的学生用化学实验室。了解这一切对化学实验教学来说有着十分重要的意义。     

计算机在化学实验室自动化管理方面的应用

介绍了计算机技术在化学实验室自动化管理方面的应用动态,包括国内外在实验室信息自动化管理系统（LIMS）、实验室化学药品与材料管理系统（MIS）和实验室设备维护与校正管理系统（IMCS）的最新进展,以及上述计算机系统在实验室自动化管理方面的特点和作用。     

化学专业研究生职业伦理教育与化学实验室的管理

结合具体实例,分析了当前化学专业研究生进行职业伦理教育的必要性,探讨了研究生职业伦理教育对化学实验室管理的积极作用,阐述了化学实验室管理促进研究生职业伦理教育的主要途径,为化学专业的研究生教育和化学实验室的管理提供了有益参考。     

化学实验室安全建设与管理的分析

高校实验室的安全管理是教学和科研活动的重要保障,关系到学生和老师的切身利益。本文从化学实验室安全建设和管理方面阐述了当前实验室在安全方面的建设和管理过程中存在的问题,就在实验室安全建设的硬件、软件和制度建设与管理等多个角度进行了探讨,总结了一些相关经验。     

基础化学实验室中小型仪器设备的三种管理模式

针对基础化学实验室中小型仪器设备种类多、数量多、品牌复杂、管理难度大的特点,提出了三种管理模式,即全程化管理、分类管理和互联网+辅助管理。近年的实验室管理实践表明,这三种管理模式的有机结合和融合应用,使中小型仪器设备的管理趋于科学、规范、高效,显著提高了仪器设备的使用率和完好率,从而保障了基础化学实验教学的顺利运行和教学质量的提高。     

高等院校化学实验室废弃物问题的思考

介绍了国内化学废弃物处置方面的相关法规和管理办法,并以美国休斯顿大学为例,介绍了美国高校实验室废弃物处置机制,包括法规、机构、管理办法、责任等。以2010至2011年间美国化学会Journal of Chemical Education期刊中涉及废弃物处置的四个教学实验,阐述了"3R"(循环、减量、再利用)绿色化学原则。最后以北京大学为例,介绍我国高校化学实验室对废弃物处理的做法。     

ISO compliant laboratory quality systems and incident monitoring improve the implementation of laboratory information systems

Quality systems can provide a means of measuring the rate of occurrence of defined incidents and non-conformities. We have studied the application of laboratory quality systems to monitoring the implementation of laboratory information systems (LIS) in two similar size tertiary hospital pathology laboratories in Australia. At one site, one department implemented a quality system accredited to ISO 9001–1987 and ISO 9001–1994 while the rest of the organisation did not have a formal quality system; this site implemented the Cerner PathNet LIS. At the other site, the organisation was in the process of implementing ISO/IEC Guide 25–1990 and ISO/IEC 17025–1999; this site implemented the PJACC AUSLAB LIS. The rate of quality system incidents and non-conformities was used to track the progress of implementation of the LIS. We found that different quality systems appeared equally useful in monitoring the rate of occurrence of incidents. However, the presence of a formal quality system greatly improved the proportion of incidents that could be investigated and resolved at root cause level. Incident monitoring, as part of a formal quality system, proved to be a useful tool in monitoring and managing the implementation of these LIS. Received: 4 August 2001 Accepted: 21 March 2002     

Getting the most from your laboratory information system in the hematology laboratory

As laboratories continue to downsize, commercialize and become more businesslike in today’s managed care environment, their present and future success will greatly depend on the efficiency and flexibility of their laboratory information system (LIS). Today, LIS is a primary tool for managing business and communication. Laboratories that hope to remain competitive in today’s dynamic health care must continue to implement new and innovative approaches with their LISs. Received: 26 July 2002 Accepted: 6 August 2002 Presented at the European Conference on Quality in the Spotlight in Medical Laboratories, 7–9 October 2001, Antwerp, Belgium     

Integrating accreditation, good laboratory practice and good manufacturing practice in an industrial analytical laboratory

 The Analytical Laboratory of BASF is a central service unit for chemical analysis which can be used by all departments within the company. It carries out routine as well as non-routine work and has a high amount of R&D orders. A quality system conforming with GMP rules was installed in the 1970s, followed by a GLP system about 6 years later. In 1995 an EN 45001 certificate was granted, which also stated the conformity with ISO 9002. A "types of test" orientated system was chosen for accreditation. This was better suited to the needs of a testing laboratory with a high amount of non-routine work than a purely test-procedure orientated accreditation. An integrated quality system has now been developed from these activities. It has partly common elements and partly differing elements taking into account specific regulations. For example, instrument calibration, staff training, validation of test procedures and the use of computerized systems are covered by uniform rules. Other elements such as handling of samples and report generation are arranged according to the individual requirements of the various standards. Rules and regulations are laid down in a system of documents which comprise the quality manual, general standard operating procedures (SOPs), laboratory-specific SOPs and test procedures. The quality system has been accepted by other accreditiation bodies on application of special accreditations (workplace safety, biodegradable polymers). But it has had no advantageous influence on getting GLP certification. An integrated system is very complex and requires appreciable resources. Management of processes and documentation can only be handled by extensive use of computers. Frequent training of staff and internal audits are necessary to keep the system at an acceptable level. In order to reduce the complexity of quality management regulations a harmonization of the different quality systems would be desirable. Received: 1 October 1998 · Accepted: 10 January 1999     

Russian-language chemical information in Chemical Abstracts Service and VINITI

The flow of Russian-language chemical information of 1997 in theChemical Abstracts (CA) database (DB) and in the corresponding parts of the multi-subject database of the Russian Institute for Scientific and Technical Information (VINITI) is analyzed. The CA coverage corresponds to not only the “Khimiya” (Chemistry) DB but also, fully or partly, to at least six other VINITI DBs. The total array of the Russian-language documents in these DBs exceeds that in the CA array almost twofold, even taking into account the possible overlap. This is due to the limited-circulation (“gray”) literature and nonspecialized journals. The distribution of Russian-language publications among the CA parts and sections is mapped. Their ranking shows that applied works are presented most fully in CA, some sections of organic and physical chemistry are presented at a level higher than the average level, and the biochemical part of the Russian-language document flow appears to be presented most poorly. Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 183–187, January, 2000.     

Russian-language chemical information in Chemical Abstracts Service and VINITI

The flow of Russian-language chemical information of 1997 in theChemical Abstracts (CA) database (DB) and in the corresponding parts of the multi-subject database of the Russian Institute for Scientific and Technical Information (VINITI) is analyzed. The CA coverage corresponds to not only the “Khimiya” (Chemistry) DB but also, fully or partly, to at least six other VINITI DBs. The total array of the Russian-language documents in these DBs exceeds that in the CA array almost twofold, even taking into account the possible overlap. This is due to the limited-circulation (“gray”) literature and nonspecialized journals. The distribution of Russian-language publications among the CA parts and sections is mapped. Their ranking shows that applied works are presented most fully in CA, some sections of organic and physical chemistry are presented at a level higher than the average level, and the biochemical part of the Russian-language document flow appears to be presented most poorly. Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 183–187, January, 2000.     

The technological and economic management of the environmental variable in the pharmaceutical–chemical industry

Industrial risks increate with technological progress. The study of potential risks is routine in the pharmaceutical–chemical industry. Here, like in other industrial activities, a risk coefficient is introduced that varies within space time limits.A control system of environmental safety and health monitoring processes should be based on the data obtained from Hazard and Operability Studies (HAZOP).The space variable influences the chemical risk coefficient that applies to the whole the production cycle (including waste recycling). For the sake of prevention, many enterprises have adopted the integrated management system, which is now moving to an additional required feature: environment and health protection and safety assurance inside and outside the industrial area (in compliance with UNI, ISO 14000 and OHSAS 18001standards).Our goal is to examine the technological–scientific–environmental changes in the pharmaceutical–chemical sector in order to asses the new extent of chemical regarding management systems.This will entail a cultural change that will call for the necessary economic strategies for industries to implement the appropriate environmental–technological programs.     

Sense and nonsense of laboratory accreditation

 An open mind is essential for the implementation and improvement of total quality management. Leadership, as such, is of no value without a vision concerning corporate culture and human resources. Therefore, constant communication between partners within a corporate body is the cornerstone for empowerment. The evaluation of ideas and complaints is considered to be essential for the identification of strengths and weaknesses of a system, whereas, competition and benchmarking may reveal surprising opportunities for improvement. We discuss the idea that customer-oriented efficiency in a hospital environment may be classified as a critical success factor.     

The impact of LIMS design and functionality on laboratory quality achievements

 A laboratory information management system (LIMS) can make a major contribution to the quality and therefore to the efficiency and competitiveness of a laboratory. Since it can impact all aspects of a laboratory's organization it must be the key if not the principal player of the laboratory's quality system. It should support the laboratory in establishing, maintaining and applying quality procedures thereby enabling the laboratory to achieve its quality goals. As a tool, LIMS permits the laboratory to input and use its own know-how and experience to optimize the total organization (internal and external) and workflow of generated information. However, perceived "quality" in the context of an LIMS, can be viewed as being made up of different facets such as the security, reliability and accessibility of information as well as its turn around time and production cost. This paper reviews the role of a LIMS in the laboratory and the contribution that both system design and functionality can have on "building quality ". Received: 5 October 1998 · Accepted: 20 October 1998     

Chemical network algorithms for the risk assessment and management of chemical threats

A network of chemical threats: Current regulatory protocols are insufficient to monitor and block many short-route syntheses of chemical weapons, including those that start from household products. Network searches combined with game-theory algorithms provide an effective means of identifying and eliminating chemical threats. (Picture: an algorithm-detected pathway that yields sarin (bright red node) in three steps from unregulated substances.).     

Plans for implementation of a quality system in the control laboratory of the Romanian National Medicines Agency

This paper describes the practical implementation of a quality system in the control laboratory of the National Medicines Agency, Romania, the main aim being the alignment of the requirements of the control of drugs in Romania with European Union standards. Activity in this field is relatively new in Romania, however, it is of great importance to Romania’s compliance with international standards. Received: 13 September 2000 Accepted: 19 February 2001