共查询到20条相似文献,搜索用时 31 毫秒
1.
A method for the synthesis of β-nitramino derivatives ofgem-dinitroalkanes by nitration of the products of condensation of sulfamic acid derivatives with the correspondinggem-dinitroalkanes was proposed. 相似文献
2.
Ghahremanzadeh R Azimi SC Gholami N Bazgir A 《Chemical & pharmaceutical bulletin》2008,56(11):1617-1620
A simple, clean and efficient method for the synthesis of spiro[pyrimido[4,5-b]quinoline-5,5'-pyrrolo[2,3-d]pyrimidine]-pentaone derivatives by condensation reaction of 6-amino-uracils and isatins in aqueous media is reported. These products were evaluated in vitro for their antibacterial activities. 相似文献
3.
Spectroscopic and computational studies reveal that a dimer of two units of l-tyrosine derivatives, joined by intermolecular hydrogen bonds, acts as a template in the synthesis of azacyclophanes from l-tyrosine derivatives and formaldehyde via double Mannich type reaction. When the reaction is performed with l-tyrosine, the absence of this template leads to linear products. A new azacyclophane (benzoxazinephane) was synthesized by condensation of l-tyrosine isopropyl ester and formaldehyde. 相似文献
4.
Dai LuSpyros P. Nikas Xiu-Wen HanDamon A. Parrish Alexandros Makriyannis 《Tetrahedron letters》2012,53(35):4636-4638
Resorcinol derivatives are important building blocks in the synthesis of natural products and pharmaceutical compounds including cannabinoids. Here we describe the synthesis and the structural characterization of a key resorcinol which carries a fully restricted bridged bicyclic group. We also report a potential mechanism for the acid catalyzed condensation of (+)- or (−)-3-pinanol with 2,6-dimethoxyphenol. The synthesized resorcinol facilitates the development of novel conformationally restricted cannabinoid analogs. 相似文献
5.
The synthesis of 1,2,3,4-tetrahydro-(9H)-pyrido[3,4-b]indole derivatives was carried out in one pot, by condensation of tryptamin with cycloalkanones in the presence of a polyphosphate ester as the catalyst in moderate to low yields, the aldol condensation being the main products. Reaction of tryptamine and cyclic ketones was also carried out in two stage through the imine intermediate with protic catalysis giving the tetrahydro-β-carbolines 8–14 , in good yields. 2-Methyl derivatives 15–21 , of the tetrahydro-β-carbolines, were obtained in good yields, using methyl iodide in dimethyl sulphoxide-potassium carbonate. 相似文献
6.
Weiwei Liu Chuanzhou Tao Lijuan Tang Jie Li Yan Jin Yueqiang Zhao Hongwen Hu 《Journal of heterocyclic chemistry》2011,48(2):361-364
The synthesis of hydrazone derivatives containing thiazole unit was achieved with condensation of thiosemicarbazones and ω‐bromoacetophenone at room temperature. This mild, convenient, and efficient method affords the desired products with good to excellent yields. Their structures have been determined by X‐ray diffractional analysis, 1H‐NMR, MS, elemental analysis, and IR. Thiosemicarbazones were prepared by the condensation of thiosemicarbazide with aldehydes or ketones. J. Heterocyclic Chem., (2011). 相似文献
7.
M. M. Iskakova I. M. Biktagirov L. Kh. Faizullina Sh. M. Salikhov M. G. Safarov F. A. Valeev 《Russian Journal of Organic Chemistry》2014,50(1):105-109
The Dieckmann condensation of 3,4-bis(methoxycarbonylmethyl) levoglucosenone derivative afforded two regioisomeric 9,11-dioxatricyclo[6.2.1.02,6]undecane derivatives at a ratio of 5: 3. The products can be used in the synthesis of iridoids. 相似文献
8.
Peter Wipf Stefan Werner Grace H.C. Woo Corey R.J. Stephenson Maciej A.A. Walczak Claire M. Coleman Leslie A. Twining 《Tetrahedron》2005,61(48):11488-11500
The multi-component condensation of organozirconocene, aldimine and zinc carbenoid was applied to the stereoselective synthesis of cyclopropane amino acid derivatives. These compounds served as scaffolds for the preparation of a 46-member library. The C- and N-termini of the cyclopropane amino acid derivatives were diversified by condensations with ten amines and ten acylating agents, respectively. To improve yields and accelerate library synthesis, most products were prepared under microwave irradiation and purified by polymer-bound scavengers and SPE methodology. All compounds were analyzed by LC-MS and a representative selection was fully characterized. 相似文献
9.
Arun Dhurey Dr. Subhro Mandal Prof. Dr. Animesh Pramanik 《European journal of organic chemistry》2023,26(40):e202300770
A one-pot, three-component, and atom economic synthesis of biologically and pharmaceutically important fully substituted and functionalized pyrazole derivatives has been accomplished under metal-catalyst-free benign conditions. The strategy involves early condensation of readily available cyclic β-diketones (dimidone, 4-hydroxycoumarin and 2-hydroxy-1,4-naphthoquinone) and arylglyoxals to generate a chalcone type intermediate which upon acid catalyzed condensation with ambident nucleophile arylhydrazones produces various aryl and cyclic β-diketone substituted pyrazole derivatives. The synthesis embraces high functional group tolerance, broad substrate scope, excellent yield of the products, short reaction time and operationally simple and mild reaction conditions. The synthesis provides an easy opportunity of incorporating biologically important N-diarylsulfide/selenide functionality, various enolisable cyclic β-diketones and other bioactive heterocycles concurrently to pyrazole, which may help in designing and development of pyrazole derivatives of pharmacological significance. 相似文献
10.
《Arabian Journal of Chemistry》2019,12(7):1168-1175
Rutile phase of TiO2 nanoparticles were readily prepared and identified as an efficient heterogeneous catalyst for the synthesis of a library of quinoxaline derivatives by condensation reaction of isatin derivatives with o-phenylenediamine under solvent-free conditions. The presented method is mild, environmentally friendly, inexpensive and highly effective to give the products in good to excellent yields. The recyclability of the catalyst is another emphasis of proposed methodology. 相似文献
11.
二氧化钛纳米粒子催化合成Hantzsch酯和多氢喹啉衍生物(英文) 总被引:2,自引:0,他引:2
Mahmood TAJBAKHSH Ehsan ALAEE Heshmatollah ALINEZHAD Mohammad KHANIAN Fatemeh JAHANI Samad KHAKSAR Parizad REZAEE Mahgol TAJBAKHSH 《催化学报》2012,(9):1517-1522
1,4-Dihydropyridine and polyhydroquinoline derivatives have been prepared efficiently in a one-pot synthesis via Hantzsch condensation using nanosized titanium dioxide as a heterogeneous catalyst.The present methodology offers several advantages such as excellent yields,short reaction times (30-120 min),environmentally benign,and mild reaction conditions.The catalyst can be readily separated from the reaction products and recovered in excellent purity for direct reuse. 相似文献
12.
A series of 3,3′‐(benzylene)bis(4‐hydroxy‐2H‐chromen‐2‐one) derivatives have been synthesized from condensation reactions of 4‐hydroxycoumarin with benzaldehydes under thermal solvent‐free conditions. This environmentally friendly synthesis is uncatalyzed and affords the desired products in excellent yields. 相似文献
13.
Akbar Mobinikhaledi Hassan Moghanian Maryam Deinavizadeh 《Comptes Rendus Chimie》2013,16(11):1035-1041
A simple and efficient procedure for the synthesis of 9H-xanthene or bisphenol derivatives has been developed by one-pot condensation of xylenols with aromatic aldehydes in the presence of p-toluenesulfonic acid (pTSA) as a catalyst under solvent-free conditions at 100 °C. It is noteworthy that the condensation reaction of 3,5-xylenol with aldehydes produces 9H-xanthene derivatives, while the reaction with other xylenols leads to the corresponding bisphenol derivatives. Different types of aromatic aldehydes are used in the reaction and in every case the products were obtained in good to excellent yields. The structures of these compounds were established on the basis of IR, 1H NMR, 13C NMR and CHN data. 相似文献
14.
A Convenient and Efficient Synthesis of 2‐Thioxoquinazolinone Derivatives via Microwave Irradiation 下载免费PDF全文
Weiwei Liu Qiang Zhang Feng Gong Zhiling Cao Yunfeng Huo 《Journal of heterocyclic chemistry》2015,52(2):317-321
The synthesis of 2‐thioxoquinazolinone derivatives was achieved by condensation of isatoic anhydride, primary amine, and carbon disulfide under microwave irradiation. This convenient and efficient method affords the desired products with good to excellent yields. Satisfactory infrared spectroscopy, 1H NMR, and high‐resolution mass spectrometry (electrospray ionization) spectra were obtained for all compounds described. 相似文献
15.
Byproducts of peptide synthesis, formed in the course of accidental attack by Pd-activated oxygen on ethanol and triethylamine in reaction media, have been identified as products of condensation between peptides and acetaldehyde, and demonstrated to represent N,N′-alkylidenepeptides, i.e. derivatives of 4-imidazolidinones. The same products are obtained by direct action of acetaldehyde on the respective peptides, and analogs resulted in some cases when acetaldehyde was replaced by formaldehyde or acetone. The condensation is reversible, imidazolidinone stability depending on structural features of both the involved peptide and carbonyl compound. There are evidently implications of these findings with respect to the chemistry and biochemistry of peptides and proteins. 相似文献
16.
V. A. Tartakovsky A. S. Ermakov N. V. Sigai D. B. Vinogradov 《Russian Chemical Bulletin》2000,49(6):1082-1085
A method for the synthesis of 5-alkyl-1,3-dinitro-1,3,5-triazacyclohexanes and linear polynitramines was proposed. It includes
the reaction of aliphatic amines with sulfamates and formaldehyde and nitration of the reaction products. The yield and composition
of nitramino derivatives depend on the conditions of the condensation and nitration.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 6, pp. 1088–1091, June, 2000. 相似文献
17.
18.
《Journal of heterocyclic chemistry》2017,54(2):1077-1083
The reaction of indoles with ninhydrin has been reported to provide only 1:1 condensation products (cf. A or 8 ) that show good antioxidant and anti‐inflammatory activity. In the present work, our synthetic challenge for the synthesis of innovative, highly substituted tetra‐indole indanes of type 1 via a 4:1 condensation reaction in acetic acid gave two unexpected new products, the diazatruxene derivatives 3 and 4 . The novel structures have been characterized by their analytical and spectral data including 1D‐ and 2D‐NMR. With 5‐chloroindole, only the known 1:1 reaction. 相似文献
19.
The pot, atom, and step-economic synthesis of Rosettacin topo-I poison and its derivatives has been achieved using a novel domino N-amidoacylation/aldol-type condensation, followed by decarboxylation of the ester function. The key domino procedure simply involves mixing HOBt ester as new reagent with lactam and NaH together in THF or THF/ DMF. The reaction seems to be general and led to suitable N-heterocyclic products in moderate to good yields. 相似文献
20.
The chemical structure of the two condensation products of dicyclohexylcarbodiimide (DCC) with the precursors of the mono-pyrrole homologues of distamycin and with the mono and tri-pyrrole homologues of congocidine were established. The two products isolated were proven to be condensation products between 4-aminopyrrole derivatives and dicyclohexylcarbodiimide (DCC). 相似文献