具有种群Logistic增长及饱和传染率的SIS模型的稳定性和Hopf分支

该文研究一类具有种群Logistic增长及饱和传染率的SIS传染病模型,讨论了平衡点的存在性及全局渐近稳定性,得到疾病消除的阈值就是基本再生数$R_{0}=1$. 证明了,当$R_{0}<1$ 时,无病平衡点全局渐近稳定;当$R_{0}>1$ 且$\alpha K\leq 1$ 时,正平衡点全局渐近稳定;当$R_{0}>1$ 且$\Delta ={0}$ 时,系统在正平衡点附近发生Hopf分支;当$R_{0}>1$ 且$\Delta <{0}$ 时,系统在正平衡点外围附近存在唯一稳定的极限环.     

一类具有垂直传染的传染病模型的稳定性

基于动力系统的理论,讨论了一类具有垂直传染的传染病模型的稳定性.采用下一代矩阵法获得了基本再生数R₀.当R₀<1时,由Routh-Hurwitz判别法,得到了无病平衡点的局部渐近稳定性.通过构造Lyapunov函数,证明了系统在无病平衡点全局渐近稳定.当R₀> 1时,地方病平衡点存在且唯一,借助Routh判据,得出了系统在地方病平衡点局部渐近稳定的条件,并通过构造Lyapunov函数,证明了系统在地方病平衡点全局渐近稳定.最后,用数值模拟验证了结论的合理性.     

垂直传染与环境因素对野牛布鲁氏菌传播的影响研究

研究了布鲁氏菌通过水平和垂直传染在野牛种群中传播的非线性动态模型.在SIR模型中引入了环境中的布鲁氏菌对野牛的影响,并提出了一种SIRB模型.分别算出了该模型的无病平衡点P_0和地方病平衡点P*,利用再生矩阵得到模型的阈值R_0,证明了模型平衡点的稳定性由阈值的大小所决定,即R_0 1时,通过构造合适的Lyapunov函数,证得无病平衡点全局渐近稳定.当R_0 1时,利用几何方法,证得地方病平衡点全局渐近稳定.     

一类潜伏期和染病期均具有传染性的手足口病模型

根据手足口病的病理特性及传播特点,建立一类描述其传播的数学模型并对模型的动力学性态进行分析.首先利用再生矩阵的方法定义了模型的基本再生数R_0,同时通过构造Lyapunov函数和Routh-Hurwitz判据证明了当R_0≤1时无病平衡点E_0的金局渐近稳定性,R_0>1时地方病平衡点E_*的局部渐近稳定性,并进一步证明了在一定条件下地方病平衡点的全局渐近稳定性.     

一类具有离散时滞的多菌株媒介传染病模型的竞争排斥北大核心CSCD

本文建立和研究了一类具有离散时滞的多菌株媒介传染病模型.证明了当基本再生数R_0<1时,无病平衡点是全局渐近稳定的.证明了与具有最大基本再生数对应的菌株占优平衡点是局部渐近稳定的.在一定条件下,证明了菌株i占优平衡点的全局稳定性的,此时竞争排斥原理成立.     

具有空间效应及一般感染率的时滞病毒模型分析

考虑到时滞效应及空间扩散的影响,建立了一个具有一般传染率的病毒感染仓室模型,分析了模型的动力学性态.定义了模型的基本再生数R₀,讨论了平衡点的存在性,并通过构造Lyapunov函数分析了平衡点的稳定性.结果表明,当R₀<1时,无病平衡点全局渐近稳定;当R₀> 1时,无病平衡点不稳定且地方病平衡点在一定条件下全局渐近稳定.同时,以Beddington-DeAngelis感染率为例的数值模拟进一步验证和扩展了理论结果.     

一类具有细胞内时滞和免疫反应的病毒动力学模型

研究一类具有细胞内时滞和免疫反应的病毒感染模型,利用Lasalle不变集原理和构造Lyapunov函数方法证明:当基本再生数R_01时,未感染平衡点E_0全局渐近稳定,也即病毒消失;给出了边界平衡点E~0,E_1,E_2局部稳定性的充分条件和τ=0时正平衡点E_3的存在和全局渐近稳定性条件;最后,通过数值模拟验证了理论结果.     

考虑治疗的离散HIV病毒模型的动力学性态（英文）

本文主要研究一类带有治疗的离散HIV模型的持续性和全局稳定性.通过定义基本再生数,我们得到当R_01时,模型的非感染平衡点是全局渐近稳定的,病毒将会消失.当R_0 1时,病毒将会持续存在.通过构造李雅普诺夫函数证明了当1 R_0N时,模型的感染平衡点是全局渐近稳定的.模型的阈值动力学性态和对应的连续模型是一致的.     

一类具有时滞的流行病模型分析

讨论了一类带有时滞的SE IS流行病模型,并讨论了阈值、平衡点和稳定性.模型是一个具有确定潜伏期的时滞微分方程模型,在这里我们得到了各类平衡点存在条件的阈值R0;当R0<1时,只有无病平衡点P0,且是全局渐近稳定的;当R0>1时,除无病平衡点外还存在唯一的地方病平衡点Pe,且该平衡点是绝对稳定的.     

具有标准发生率和因病死亡率的离散SIS传染病模型的全局稳定性分析

主要研究了具有标准发生率和因病死亡率的离散SIS传染病模型的动力学性质,利用构造Lyapunov函数,得到模型无病平衡点和地方性平衡点的全局稳定性,即无病平衡点是全局渐近稳定的当且仅当基本再生数R_0≤1,地方病平衡点是全局渐近稳定的当且仅当R_0>1.     

Stability and bifurcation analysis of a viral infection model with delayed immune response

In this paper, we study a viral infection model with an immunity time delay accounting for the time between the immune system touching antigenic stimulation and generating CTLs. By calculation, we derive two thresholds to determine the global dynamics of the model, i.e., the reproduction number for viral infection $R_{0}$ and for CTL immune response $R_{1}$. By analyzing the characteristic equation, the local stability of each feasible equilibrium is discussed. Furthermore, the existence of Hopf bifurcation at the CTL-activated infection equilibrium is also studied. By constructing suitable Lyapunov functionals, we prove that when $R_{0}\leq1$, the infection-free equilibrium is globally asymptotically stable; when $R_{0}>1$ and $R_{1}\leq1$, the CTL-inactivated infection equilibrium is globally asymptotically stable; Numerical simulation is carried out to illustrate the main results in the end.     

The dynamic behavior of deterministic and stochastic delayed SIQS model

In this paper, we present the deterministic and stochastic delayed SIQS epidemic models. For the deterministic model, the basic reproductive number $R_{0}$ is given. Moreover, when $R_{0}<1$, the disease-free equilibrium is globally asymptotical stable. When $R_{0}>1$ and additional conditions hold, the endemic equilibrium is globally asymptotical stable. For the stochastic model, a sharp threshold $\overset{\wedge }{R}_{0}$ which determines the extinction or persistence in the mean of the disease is presented. Sufficient conditions for extinction and persistence in the mean of the epidemic are established. Numerical simulations are also conducted in the analytic results.     

一类有迁移的SIS流行病模型

研究一类种群有迁移的流行病模型,得到了这类模型的基本再生数R0,证明了R0＜1无病平衡点是局部渐近稳定的,而当R0＞1时无病平衡点是不稳定的.进一步讨论了疾病持续存在与无病平衡点和地方病平衡点全局稳定的条件.     

Modelling and stability of epidemic model with free-living pathogens growing in the environment

To understand the impact of free-living pathogens (FLP) on the epidemics, an epidemic model with FLP is constructed. The global dynamics of our model are determined by the basic reproduction number $R_0$. If $R_0<1$, the disease free equilibrium is globally asymptotically stable, and if $R_0>1$, the endemic equilibrium is globally asymptotically stable. Some numerical simulations are also carried out to illustrate our analytical results.     

Analysis of an HIV model with post-treatment control

Recent investigation indicated that latent reservoir and immune impairment are responsible for the post-treatment control of HIV infection. In this paper, we simplify the disease model with latent reservoir and immune impairment and perform a series of mathematical analysis. We obtain the basic infection reproductive number $R_{0}$ to characterize the viral dynamics. We prove that when $R_{0}<1$, the uninfected equilibrium of the proposed model is globally asymptotically stable. When $R_{0}>1$, we obtain two thresholds, the post-treatment immune control threshold and the elite control threshold. The model has bistable behaviors in the interval between the two thresholds. If the proliferation rate of CTLs is less than the post-treatment immune control threshold, the model does not have positive equilibria. In this case, the immune free equilibrium is stable and the system will have virus rebound. On the other hand, when the proliferation rate of CTLs is greater than the elite control threshold, the system has stable positive immune equilibrium and unstable immune free equilibrium. Thus, the system is under elite control.     

Global dynamical analysis of a heroin epidemic model on complex networks

In this paper, a heroin epidemic model on complex networks is proposed. By the next generation matrix, the basic reproduction number $R_0$ is obtained. If $R_0<1$, then the drug-free equilibrium is globally asymptotically stable. If $R_0>1$, there is an unique endemic equilibrium and it is also globally asymptotically stable. Our results show that if the degree of the network is large enough, the drug transmission always spreads. Sensitivity analysis of the basic reproduction number with the various parameters in the model are carried out to verify the important effects for control the drug transmission. Some simulations illustrate our theoretical results     

Birds movement impact on the transmission of West Nile virus between patches

Spatial heterogeneity plays an important role in the distribution and persistence of many infectious disease. In the paper, a multi-patch model for the spread of West Nile virus among $n$ discrete geographic regions is presented that incorporates a mobility process. In the mobility process, we assume that the birds can move among regions, but not the mosquitoes based on scale-space. We show that the movement of birds between patches is sufficient to maintain disease persistence in patches. We compute the basic reproduction number $R_{0}$. We prove that if $R_{0}<1$, then the disease-free equilibrium of the model is globally asymptotically stable. When $R_{0}>1$, we prove that there exists a unique endemic equilibrium, which is globally asymptotically stable on the biological domain. Finally, numerical simulations demonstrate that the disease becomes endemic in both patches when birds move back and forth between two regions.     

Global analysis of a multi-group animal epidemic model with indirect infection and time delay

The transmission mechanism of some animal diseases is complex because of the multiple transmission pathways and multiple-group interactions, which lead to the limited understanding of the dynamics of these diseases transmission. In this paper, a delay multi-group dynamic model is proposed in which time delay is caused by the latency of infection. Under the biologically motivated assumptions, the basic reproduction number $R_0$ is derived and then the global stability of the disease-free equilibrium and the endemic equilibrium is analyzed by Lyapunov functionals and a graph-theoretic approach as for time delay. The results show the global properties of equilibria only depend on the basic reproductive number $R_0$: the disease-free equilibrium is globally asymptotically stable if $R_0\leq 1$; if $R_0>1$, the endemic equilibrium exists and is globally asymptotically stable, which implies time delay span has no effect on the stability of equilibria. Finally, some specific examples are taken to illustrate the utilization of the results and then numerical simulations are used for further discussion. The numerical results show time delay model may experience periodic oscillation behaviors, implying that the spread of animal diseases depends largely on the prevention and control strategies of all sub-populations.     

具常数输入及饱和发生率的脉冲接种SIQRS传染病模型

研究了具有常数输入及饱和发生率的脉冲接种SIQRS传染病模型,得到了疾病消除与否的阈值R_0=1.证明了当R_01时,系统存在全局渐近稳定的无病周期解;当R_01时,系统一致持久.