共查询到15条相似文献,搜索用时 15 毫秒
1.
1,10-Phenanthrolinium N-ylides,can react with malonitrile and aromatic aldehydes via a domino-Knoevenagel cyclization to afford a new class of trihydropyrrolo[1,2-a][l,10]phenanthroline derivatives as stable helical compounds in a simple,mild,and efficient protocol in excellent yields. 相似文献
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Jiang Ke QIN Xian Zhang BU Yu Fang WANG Zhi Yun DU Xing Yuan WANG Zhi Shu HUANG Lin MA Lin Kun AN Lian Quan GU School of Pharmaceutical Sciences Sun Yat-sen University Guangzhou School of Chemistry Chemical Engineering Sun Yat-sen University Guangzhou 《中国化学快报》2005,16(11)
Tanshinones are a series of quinone diterpenes which are isolated from Salvia miltiorrhiza Bunge known as “Danshen” in Chinese traditional medicine. They have broad pharmacological activities, such as antibacterial, anti-tumor and anti-platelet aggregation1. Tanshinones’ derivatives have been used to treat the coronary disease, cerebrovascular diseases as well as neurasthenic insomnia in clinic2. Tanshinone IIA is one of the main components of tanshinones and characterized by the presenc… 相似文献
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3-O-Decladinose-6-methyl-10,11-dehydrate-erythromycin-3-one-2'-acetate (5) is an important intermediate for the synthesis of ketolides antibiotics.[1] In the improved synthetic method of compound 5, the more common reagent PCC[2]was used instead of the expensive reagent EDC and methanesulfonic anhydride.[3~4] In this way, compound 5 was obtained efficiently and economically in five steps from clathromycin 1 without being further purfied by column chromatography. 相似文献
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Jiang Ke QIN Xian Zhang BU Yu Fang WANG Zhi Yun DU Xing Yuan WANG Zhi Shu HUANG Lin MA Lin Kun AN Lian Quan GU 《中国化学快报》2005,16(11):1451-1454
The reactions of tanshinone IIA with aromatic aldehydes have been investigated and several 2, T-(substituted arylmethylene) bis (1,6,6-trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]- furan- 10, 11-dione) derivatives were obtained, 相似文献
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自从1968年Jager合成第一个四氮[14]大环席夫碱配合物以来[1],四氮大环席夫碱配合物的研究受到人们很大的关注.这类配体与天然卟啉环非常相似,对小分子如O2、CO、CO2等均有较强的键联能力,对于研究生物体内的金属蛋白质及酶有着重要的意义[2,3].].另外,这类配合物具有作为催化剂、萃取剂、导体等潜在的应用价值. 相似文献
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Miron Teodor Căproiu Florea Dumitrascu Sergiu Shova Ileana Cornelia Chirită Alexandru Vasile Missir Dana-Mihaela Cioroianu 《Tetrahedron letters》2014
New S-thiocarbamates possessing a 10,11-dihydro-5H-dibenzo[a,d]cycloheptene moiety were obtained unexpectedly in the process of preparing new O-thiocarbamates starting from 5-dibenzosuberol (10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ol) and aroyl-isothiocyanates. These compounds were obtained via a benzylic Newman–Kwart rearrangement mechanism. The structures of the new thiocarbamates were confirmed by elemental analysis, IR, and NMR spectroscopy and by X-ray crystallography. 相似文献
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H10TTPR was prepared starting from terephthalaldehyde and characterized. Crystal structure of H10TTPR and an intermediate compound 11 were determined by X-ray diffraction analysis. A quasi-reversible redox wave at 1.15 V (vs.SCE) was observed for H10TTPR, indicating that it is a weak electron donor. 相似文献
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Xue Qiang YIN Guang Zhong YANG Yuan Chao LI* Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 《中国化学快报》2001,(7)
The diterpenoid triexpoxides lactone triptolide is a potent antileukemic, antiflammatory, immunosuppressive and antifertile principle of Tripterygium wilfordii Hook f.1,2. Many methods of synthesis of this compound have been reported in which trans-3,3b,4,9b,10, 11-hexahydro-6-methoxy-9b-methyl-7- (1-methylethyl) phenanthro {1,2-c [furan-1,5- dione]} 4 was an important intermediate. In one reported synthesis, compound 4 was obtained by CrO3/AcOH oxidation of triptophenolide methyl ether 1, b… 相似文献
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The title compound(C26H18N4O4) has been synthesized via a three-component reaction and it was characterized by means of IR and 1H NMR.Its crystal and molecular structures were determined by X-ray diffractometry.It belongs to the triclinic system,space group P1 with a = 7.7288(15),b = 11.168(2),c = 12.645(3) ,α = 107.02(3),β = 90.85(3),γ = 101.93(3)°,V = 1017.9(3) 3,Mr = 450.44,Z = 2,Dc = 1.470 g/cm3,λ = 1.54178 ,μ = 0.836 mm-1,F(000) = 468,the final R = 0.0488 and wR = 0.1180.A total of 11903 reflections were collected,of which 3642 were independent(Rint = 0.0377) and 3025 were observed with I > 2σ(I). 相似文献
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Simone Lucarini Francesca Antonietti Andrea TontiniPaola Mestichelli Mauro MagnaniAndrea Duranti 《Tetrahedron letters》2011,52(22):2812-2814
A new synthetic method to obtain the potential anticancer agent 5,6,11,12,17,18,23,24-octahydrocyclododeca[1,2-b:4,5-b′:7,8-b′′:10,11-b′′′]tetraindole (CTet), starting from 1H-indole-3-carboxaldehyde and sulfamide, is described. Although a mixture of CTet and cyclic indole trimer (CTr) is formed, higher CTet/CTr ratio (4:6) and CTet yield (15%) make our protocol more favorable than those reported in the literature. A discussion on the possible reaction mechanism is reported. 相似文献
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Hu Liu Leon M. Smith II Yunyu Mao Weitao Pan Yong‐Jiang Xu Sabina Burdzovic‐Wizeman 《合成通讯》2013,43(3):347-354
An improved route for the preparation of highly functionalized 5,6‐dihydro‐pyrimido[4,5‐b][1,4]oxazepine 1a in multigram quantities was developed. This new methodology was highlighted by the proper methoxy disposition via a regioselective methylation of 2,4,5‐trihydroxy‐benzaldehyde followed by a magnesium sulfate–promoted cyclization. 相似文献