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1.
蜜蜂外激素9—ODA和9—HDA的合成   总被引:2,自引:0,他引:2  
陈子康  冯静 《合成化学》1996,4(2):131-136
6-溴-2-己酮在Li2CuCl4催化下与γ-溴代巴豆酸甲酯进行格氏偶联,合成王物质9-羰基-(E)-2癸烯酸(9-ODA),将其还原得到了另一蜂王物质9-羟基-(E)-2-癸烯酸(9-HDA)。该法是合成9-ODA和9-HDA的新路线。  相似文献   

2.
6-溴-2-己酮在Li2cuCl4催化下与γ-溴代巴豆酸甲酯进行格氏偶联,合成了蜂王物质9-羰基-(E)-2-癸烯酸(9-ODA),将其还原得到另一蜂王物质9-羟基-(E)-2-癸烯酸(9-HDA)。该法是合成9-ODA和9-HDA的新路线。  相似文献   

3.
本文报道了稀土与丙氨酸-N-荒酸镍[H2NiL2]多核配合物的合成和表征。通过元素分析确定配合物的组成为RE2(NiL2)3·xH2O(RE=La、Nd、Sm-Er、Yb;x=1、4、8),并研究了配合物的摩尔电导、红外光谱和核磁共振氢谱。配合物体外抗癌活性及抑菌活性的测定结果表明,丙氨酸-N-荒酸镍及其稀土多核配合物均具一定的抗癌、抑菌活性。  相似文献   

4.
蜂王信息素的改进合成   总被引:6,自引:0,他引:6  
早在50年代,Butler等[1]发现蜂王的上颚腺能分泌一种影响工蜂活动的物质,并提出了蜂群是靠蜂王分泌的该种化学物质传递各种个体间的信息的论断,Barbier等[2]测定其结构为9-氧代-2E-癸烯酸1(蜂王物质),并首次进行了人工合成.  相似文献   

5.
三取代钨硅杂多配合物的导电性和磁性   总被引:5,自引:0,他引:5  
合成了α-NamHn[SiW9M3(H2O)3O37]·16H2O(M=Co(Ⅱ),Ni(Ⅱ),V(Ⅴ)杂多配合物),通过ICP,IR,UV,TG-DTA,XPS,EPR,极谱等手段进行了表征.配合物在室温下的电导率σ值达1×10-3S·cm-1,343K时可达1×10-2S·cm-1,是有实用化前景的新型固体电解质.变温磁化率结果表明α-Na10[SiW9Co3(H2O)3O37]·16H2O和α-Na10[SiW9Ni3(H2O)3O37]·16H2O具有反铁磁性.  相似文献   

6.
Sinulariol,Sinularial—A和Sinularic Acid—A前体化合物?…   总被引:1,自引:0,他引:1  
报道了以香叶醇为起始原料经9步反应合成Sinulariol-D,Sinularia-A和SinularicAcid-A的前体化合物(E,E,E)-2,6,10,14-四甲基-2,3-环氧-16-苯硫醚基十六碳-6,10,14-三烯-1-醇(15)的实验结果。  相似文献   

7.
杨频  李青山 《结构化学》1996,15(2):163-169
合成了9个R2SnL2型(R=乙基,正丁基和苯基;HL=苯甲酰异羟肟酸,对羟基苯甲酰异羟肟酸和水杨酰异羟肟酸)和6个(R2SnL)2O型(R=乙基,正丁基,HL同上)二烃基锡新配合物,测定了它们的分子量,红外光谱和核磁共振谱,着重研究了这些配合物的体外抗癌活性,结果表明,这二类配合物对人白血病HL-60,艾氏腹水和S-180癌细胞具有很好的抑制能力,初步探讨了结构-抗癌活性间的关系。  相似文献   

8.
3-甲基-2-丁烯酸乙酯4经SeO2反式氧化,还原,溴化得到关键中间体4-溴-3-甲基-(2E)-丁烯酸乙酯7.7与三苯基胂反应生成季Seng盐8。二氢香茅醛与8在K2CO3-乙醇-微量水的存在下反应,得到(2E,4E)-3,7,11-三甲基-2,4-十二碳二烯酸乙酯1a及其(2Z,4E)-异构体1b,产率74%,该反应具有(4E)-立体选择性,同时C-2双键发生部分构型转化。  相似文献   

9.
合成了9个R_2SnL_2型(R=乙基、正丁基和苯基;HL=苯甲酰异羟肟酸,对羟基苯甲酰异羟肟酸和水杨酰异羟肟酸)和6个[R_2SnL]_2O型(R=乙基、正丁基;HL同上)二烃基锡新配合物。测定了它们的分子量、红外光谱和核磁共振谱,着重研究了这些配合物的体外抗癌活性。结果表明,这二类配合物对人白血病HL-60,艾氏腹水和S-180癌细胞有很好的抑制能力。初步探讨了结构-抗癌活性间的关系。  相似文献   

10.
ANOVELSYNTHETICMETHODFORTHECLUSTERSFeCo_2(CO)_9-(RCCR)(R=MeO_2C,EtO_2C).X-RAYCRYSTAL STRUCTURE ANALYSES OF THE CLUSTERS FeCo_2(?..  相似文献   

11.
A new approach was proposed for the synthesis of 9-oxo-2E-decenoic acid, a multifunctional pheromone of queen honeybee (Apis mellifera L.), starting from the available telomer of butadiene and water (2E,7-octadien-1-ol) using in the key steps partial ozonolysis of the corresponding carbonyl compound, selective oxidation of the conjugated aldehyde into a carboxylic acid, and alkylation of acetoacetic ester to introduce the oxo group.  相似文献   

12.
Optically active (4R,8RS)-dimethyldecanal, an analog of the aggregation pheromone of the flour beetles Tribolium confusum and T. Castaneum, and (4R)-methylnonan-1-ol, the sex pheromone of the yellow mealworm Tenebrio molitor L., are synthesized using ozonolytic transformation of (6R,10)-dimethyl-9-undecen-2-one to (6R)-methyl-9-hydroxynonan-2-one in the key step. The starting compound is available as enantiomerically enriched (ee ~50%) (S)-(+)-3,7-dimethyl-1,6-octadiene.  相似文献   

13.
Mei-Li Xu 《合成通讯》2014,44(23):3435-3440
In the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), 9-triptycylisothiocyanate has been synthesized in 91% yield from carbon disulfide and sterically hindered 9-triptycylamine at room temperature. 9-Triptycylisothiocyanate can be further converted to 1-benzyl-3-(9-triptycyl)thiourea. (10-Amino-9-triptycyl)carboxylic acid has also been successfully synthesized via a three-step route starting from methyl 10-nitroanthracene-9-carboylate. Its amino and carboxylic groups can undergo acetylation and amidation, respectively.  相似文献   

14.
Recently,severalkindsoftotalsyntheticmethodsfornaturallyoccurringfuranoidfattyacids(F-acids)whichhavemanybiologicalactivities1havebeendeveloped2.Inthepresentpapertheauthorswishtoreportanewsimplerouteofsynthesizing9-(5-pentyl-carbomethoxyheptyl)triphenylphosphoniumbromideinthepresenceofpotassiumcarbonateandl,2-butyleneoxideinanunexpectedlylowyield(34%),mainlyduetotheextremelyunstablecharacterof2inbasicconditions,especiallyforstrongbaselikesodiummethoxidewhichgaverisetoconsiderableresinification…  相似文献   

15.
Electrocarboxylation of anthrone in the presence of CO2 to anthrance-9-carboxylic acid directly was carried out. The electroreduction behavior of anthrone was examined by cyclic voltammetry in the absence and presence of CO2. Then the influences of the supporting electrolytes, temperature, electrode material and anthrone concentration on the carboxylation yield were investigated. Under the optimized conditions, anthrancene-9-carboxylic acid was obtained in a good yield(96.1%).  相似文献   

16.
Some new mono-, bis-spiro- and dispiro-β-lactams have been synthesized from imines derived from 9H-fluoren-9-one and a ketene derived from 9H-xanthene-9-carboxylic acid or phenoxyacetic acid by a [2+2] cycloaddition reaction in good to excellent yields varying from 45 to 83%. The biological activity of these monocyclic β-lactams was successfully investigated against Plasmodium falciparum K14 resistant strain with excellent EC50 values up to 5 μM.  相似文献   

17.
Two approaches to the synthesis of 9-oxo-and 10-hydroxy-2E-decenoic acids, biologically active components of queen substance and royal jelly of honeybees, respectively, were proposed starting with allyl bromide and 1,7-octadiene and using chemo-and regioselective transformations of the common intermediate building block 7-octen-1-ylacetate. __________ Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 58–60, January–February, 2008.  相似文献   

18.
The terminal dienyne of (9Z)-9,13-tetradecadien-11-ynal, the sex pheromone of the avocado seed moth, Stenoma catenifer, was constructed by coupling a vinyl iodide precursor with commercially available 1-buten-3-yne with Pd catalysis, resulting in a short and efficient synthesis of the pheromone.  相似文献   

19.
Summary The reaction of 2-(10-diazo-10H-anthracen-9-ylidene)-malonodinitrile (1) with the cryptohydride system formic acid - triethylamine was studied. The reaction product turned out to be anthracen-9-yl-acetonitrile (2a) instead of the expected 10-dicyanomethyl-9,10-dihydro-anthracene-9-yl formate. Compounds related to1 yielded in this reaction the corresponding 10-substituted anthracen-9-yl-acetonitriles. A mechanism of this reaction is proposed. The product of the formic acid promoted decomposition of1, compound3b, as well as its tautomer4b were also obtained.
Zur Reaktion von 2-(10-Diazo-10H-anthracen-9-yliden)-malodinitril und Verwandten Verbindungen mit dem Kryptohydridsystem Ameisensäure - Triethylamin
Zusammenfassung Die Reaktion von 2-(10-Diazo-10H-anthracen-9-yliden)-malodinitril (1) mit dem Kryptohydridsystem Ameisensäure — Triethylamin wurde untersucht. Das Umsetzungsprodukt stellte sich als Anthracen-9-yl-acetonitril (2a) und nicht als erwartetes 10-Dicyanomethyl-9,10-dihydroanthracen-9-yl-format heraus. Verwandte Verbindungen reagierten in dieser Reaktion zu 10-substituierten Anthracen-9-yl-acetonitrilen. Ein Mechanismus für diese Reaktion wird vorschlagen. Das Produkt der durch Ameisensäure initiierten Zersetzung von1, Verbindung3b, wie auch sein Tautomer4b, wurden ebenfalls dargestellt.
  相似文献   

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