共查询到20条相似文献,搜索用时 15 毫秒
1.
I. A. Strakova E. Yu. Gudrinietse Ya. Ya. Linaberg A. Ya. Strakov D. R. Kreitsberga 《Chemistry of Heterocyclic Compounds》1970,6(4):481-485
The alkylation of 4-oxo-3,6,6-trimethyl-4,5,6,7-tetrahydroindazole with alkyl halides forms mixtures of 1-alkyl and 2-alkyl derivatives which have been separated by fractional crystallization from n-hexane. The 4-oxo-1-alkyl-,-1-aryl-, and -1-acyl-4,5,6,7-tetrahydroindazoles have characteristic frequencies in their IR spectra at 1540-1530 cm–1, and the corresponding 2-substituted derivatives have frequencies at 1565-1555 cm–1. The introduction of an alkyl substituent at a nitrogen atom decreases the basicity of 4,5,6,7-tetrahydroindazole by 0.6 orders of magnitude, the 1-alkyl isomers being somewhat stronger bases than the 2-alkyl isomers. 相似文献
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2-Amino-4-[3-methyl-3-(5,6,7,8-tetrahydro-2-naphthyl)cyclobutyl]thiazole was synthesized by reaction of 1-methyl-1-(5,6,7,8-tetrahydro-2-naphthyl)-3-chloroacetylcyclobutane with thiourea in ethanol, and its subsequent transformations afforded new derivatives which were tested in vitro for antibacterial activity against some bacteria using the disk diffusion technique.__________From Zhurnal Organicheskoi Khimii, Vol. 40, No. 12, 2004, pp. 1861–1865.Original English Text Copyright © 2004 by Koparr, Cansz, Ahmedzade.The original article was submitted in English. 相似文献
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Corinne Le Goff Pascal Bouyssou Jacques Chenault 《Journal of heterocyclic chemistry》1994,31(1):153-160
A series of fused tetracyclic quinolonecarboxylic acids was prepared for biological evaluation. These compounds were synthesized by a route involving a regiospecific functionalization of 5-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline to obtain a series of new substituted 7-methyl-6,7,8,9-tetrahydro-3H-imidazo[4,5-f]quinolines and 6-methyl-5,6,7,8-tetrahydro-1H-imidazo[4,5-g]quinolines as convenient precursors of quinolones. 相似文献
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Gein V. L. Nosova N. V. Lezhnina D. D. Gein O. N. Voronina E. V. Starovoytova M. O. Dmitriev M. V. 《Russian Journal of General Chemistry》2021,91(1):57-63
Russian Journal of General Chemistry - The reaction of 2-aryl-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxamides with hydrazine hydrate in ethanol gave... 相似文献
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The reaction of 3-methyl-4-oxo-4,5,6,7-tetrahydroindazoles with benzaldehydes gave 5-benzylidene-3-methyl-4-oxo-4,5,6,7-tetrahydroindazoles. Under Mannich conditions, 3-methyl-1-phenyl-4,5,6,7-tetrahydroindazole gave 5-aminomethyl-3-methyl-4-oxo-1-phenyl-4,5,6,7-tetrahydroindazoles. 相似文献
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Yoram Houminer 《Journal of heterocyclic chemistry》1981,18(1):15-17
5,6,7,8-Tetrahydroquinoxaline derivatives containing an oxygen functionality in the 6-position were prepared by ring closure of suitable 2,3-disubstituted pyrazines such as 6 and 12 . The chemistry of these novel 5,6,7,8-tetrahydroquinoxalines is discussed. 相似文献
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By a combination of hydrolysis, decarboxylation, and methylation diethyl 1-methyl-3-hydroxy-5-phenylpyrrole-2,4-dicarboxylate was converted into 1-methyl-3-methoxy-5-phenyl-pyrrole-2,4-dicarboxylic acid (5) and into the isomeric compounds ethyl 1-methyl-2-phenyl-4-methoxypyrrole-3-carboxylate (4a) and ethyl 1-methyl-3-methoxy-5-phenylpyrrole-2-carboxylate (9a). 1-Methyl-2-phenyl-4-methoxypyrrole-3-carboxylic acid was synthesized both by the selective decarboxylation of 5 and by the hydrolysis of 4a. Hydrolysis of 9a, however, did not give the corresponding acid, but rather an oxidation product, 1-methyl-3-methoxy-5-hydroxy-5-phenyl-3-pyrrolin-2-onc (10a). Compound 10a was shown to arise from the air oxidation of the completely decarboxylated product, 1-methyl-2-phenyl-4-methoxypyrrole. Reduction of 9a with lithium aluminum hydride gave 1-methyl-3-methoxy-5-phenylpyrrole-2-methanol, which yielded 10a upon oxidation with silver oxide. 相似文献
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A. Ya. Strakov N. N. Tonkikh M. V. Petrova I. A. Strakova 《Chemistry of Heterocyclic Compounds》1997,33(4):441-444
Reactions of 4-hydrazinobenzoic acid with 2-formyl- and 2-acetyldimedones were utilized to synthesize 6,6-dimethyl- and 3,6,6-trimethyl-1-(4-hydroxycarbonylphenyl)-4-oxo-4,5,6,7-tetrahydroindazoles
corre-spondingly, and the reaction with 2-cyano-3-ethoxy-5,5-dimethylcyclohex-2-en-1-one gave 2-(4-hydroxy-carbonylphenyl)-3-amino-4-oxo-6,6-dimethyl-4,5,6,7-tetrahydroindazole.
Riga Technical University, Riga LV-1658. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 516–519, April,
1997. 相似文献
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The action of nitrous acid on 2-amino-6-nitro-N-methylaniline affords 1-methyl-7-nitro-benzotriazole. The corresponding 7-amino-, acetylamino-, and benzoylamino-derivatives have been prepared. Thus the compounds and their derivatives previously assigned the 1-methyl-7-nitro structure are the 4-substituted compounds. 相似文献
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5-HT3 receptor antagonists, such as Ondansetron, are used for anti-emesis after chemotherapy, radiotherapy and operations. Some
Ondansetron analogs possessing piperazine ring as side chains were synthesized in our lab. Thus, one of the two carbonyl groups
of starting material 1,3-cyclohexandione (1) was condensed with phenylhydrazine hydrochloride to form monophenylhydrazone (2). 1,2,3,9-Tetrahydro-4H-carbazol-4-one (3) was prepared from 2
via cyclization and rearranged in the presence of ZnCl2. Through a methylation reaction, compound 3 was converted to 1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one (4). 3-Dimethylaminomethyl substituted compound (5) was synthesized from 4 by a Mannich reaction in glacial acetic acid. Nine novel 1,2,3,9-tetrahydro-9-methyl-3-(4-substituted-piperazin-1-ylmethyl)-4H-carbazol-4-one derivatives (6a–6i) were synthesized through nucleophilic substitution reaction of 5 with piperazines. The structures of all the target compounds were determined by elemental analysis, IR, MS, 1H NMR and 13C NMR spectra. The results of preliminary pharmacological test show that part of the novel compounds have antiemetic activity
comparable to that of the control Ondansetron.
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Translated from Chinese Journal of Organic Chemistry, 2008, 28(2) (in Chinese) 相似文献
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S. Z. Vatsadze M. L. Kostochka V. P. Lezina V. G. Vinokurov P. M. Klodt N. V. Zyk 《Russian Chemical Bulletin》2005,54(1):257-258
1,5-Dicarbonyl derivatives of piperidine and tropane were studied in the heterocyclization with hydroxylamine hydrochloride. All the 5,6,7,8-tetrahydro-1,6-naphthyridines obtained exhibit a pronounced analgesic effect.__________Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 251–253, January, 2005. 相似文献
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M. S. Khaikin 《Chemistry of Heterocyclic Compounds》1970,6(12):1489-1490
Some 4-methyl- and 4-phenyl-3-hydroxycoumarins were synthesized by the reaction of phenols with -acetoxyacetyl- or -acetoxybenzoylacetic esters.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1595–1596, December, 1970. 相似文献