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1.
A new bicyclo[3.2.1]octanoid neolignan rel-(7S,8R,1′S,2′R,3′S)-Δ8′-2′-hydroxy-5,1′,3′-trimethoxy-3,4methylenedioxy-7,3′,8,1′-neolignan (1) was isolated from ethanol extract from the fruit of Ocotea heterochroma Mez & Sodiro ex Mez as well as the known compounds β-friedelanol (2), meso-dehydroguaiaretic acid (3), and yangambin (4), whose structures were elucidated on the basis of their comprehensive spectroscopic analysis including 2D NMR data. Lethality
bioassay using brine shrimp (Artemia salina Leach) was evaluated with the ethanol extract from the Ocotea heterochroma’s fruit. The toxicity of this extract was greater than the toxicity of those fractions obtained in a first solvent partition
(benzene, ethyl acetate, and butanol subfractions) and that of a mixture of acetylated 2′-epimers from the new neolignan 1.
Published in Khimiya Prirodnykh Soedinenii, No. 2, pp. 158–160, March–April, 2009. 相似文献
2.
I. M. Chung H. Y. Park S. C. Chun J. J. Kim A. Ahmad 《Chemistry of Natural Compounds》2007,43(4):417-421
Three new compounds, 4-hydroxymethylene-7-(9,9,13-trimethylcyclohexyl)-heptanyl-3′,7′,7′-trimethylcyclohexa-2′,4′-dien-1′-oate
(1), 1-(n-hexadec-7-enoxy)-6-(n-octadecanoxy)-β-D-glucopyranoside (2), and (Z)-12-hydroxy-9-octadecenoic acid-12-β-D-glucopyranoside (3), along with the known compound hexacosanoic acid (4), were isolated and identified from the rice hulls of Oryza sativa. Their structures were elucidated by 1D and 2D NMR spectroscopic techniques (1H-1H COSY, 1H-13C HETCOR, DEPT) aided by EIMS, FABMS, HRFABMS, and IR spectra.
Published in Khimiya Prirodnykh Soedinenii, No. 4, pp. 344–347, July–August, 2007. 相似文献
3.
Ge Zhang Mei-Li Guo Run-Ping Li Ying Li Han-Ming Zhang Zhong-Wu Su 《Chemistry of Natural Compounds》2009,45(3):398-401
A novel compound, 4-{1′-hydroxy-1′-mercapto-1′-[1′′-2′′(N→O)-isoquinolyl]}yl-1-benzoic acid (1), together with six known compounds, 6-hydroxykaempferol-3-O-β-D-glucopyranoside (2), rutin (3), quercetin-3-O-β-D-glucopyranoside (4), kaempferol-3-O-β-D-glucopyranoside (5), cartormin (6), hydroxysafflor yellow A (7), were isolated by chromatography from the n-BuOH fraction of 50% ethanol extraction of Flos carthami. Their structures were
elucidated on the basis of spectral analysis and comparison with published data. Among them, compound 1 was shown to possess a weak protective effect against cerebral ischemic damage in rats.
Published in Khimiya Prirodnykh Soedinenii, No. 3, pp. 339–341, May–June, 2009. 相似文献
4.
D. N. Pelageev M. N. Panchenko N. D. Pokhilo V. A. Denisenko V. F. Anufriev 《Chemistry of Natural Compounds》2008,44(6):719-723
5,8-Dihydroxy-2,3,6-trimethoxy-7-ethyl-1,4-naphthoquinone (1) was used to synthesize in high yield 5,8-dihydroxy-7(1′-hydroxyethyl)-2,3,6-trimethoxy-1,4-naphthoquinone (lomazarin, 3), a pigment from Lomandra hastilis. Alkaline hydrolysis of lomazarin produced mainly 5,6,8-trihydroxy-2,3-dimethoxy-1,4-naphthoquinone (9) through a retro-aldol decomposition of the 6-keto-form of 5,6,8-trihydroxy-7(1′-hydroxyethyl)-2,3-dimethoxy-1,4-naphthoquinone
(13b) formed during the reaction. 2,5,8-Trihydroxy-7(1′-hydroxyethyl)-3,6-dimethoxy-1,4-naphthoquinone (norlomazarin, 4a), a pigment of L. hastilis, and its 3,5,8-trihydroxy-7(1′-hydroxyethyl)-2,6-dimethoxy isomer 4b were formed as a difficultly separable mixture in addition to quinone 9.
Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 581–584, November–December, 2008. 相似文献
5.
The extract of Casimiroa edulis was investigated for antihypertensive activity. The ethanol and total alkaloids (in chloroform) extracts were found to have
antihypertensive properties at doses of 500 and 200 mg/kg, respectively. Four quinolinone alkaloids were isolated and identified
as: 2-(2′-hydroxy-4′-methoxyphenyl)-5,8-dimethoxy-3-propyl-1H-quinolin-4-one (1), 5,8-dimethoxy-2-(3′-methoxyphenyl)-3-propyl-1H-quinolin-4-one (2), 5,8-dimethoxy-2-(3′,4′-dimethoxyphenyl)-3-propyl-1H-quinolin-4-one (3), and 5,6-dimethoxy-2-(2′,5′,6′-trimethoxyphenyl)-1H-quinolin-4-one (4). Interestingly, compounds 1, 2, and 3 were found to be new alkaloids. The four isolated alkaloids showed antihypertensive activity at doses of 50, 100, 200, and
300 mg/kg, respectively.
Published in Khimiya Prirodnykh Soedinenii, No. 5, pp. 473–476, September–October, 2007. 相似文献
6.
Jian-Rong Luo Hong-En Jiang You-Xing Zhao Jun Zhou Jin-Fu Qian 《Chemistry of Natural Compounds》2008,44(1):6-9
To probe the organic constituents of over 2000-year-preserved Populus euphratica found in an ancient tomb, a chemical investigation was undertaken, which led to the isolation of a new compound, 2-(4′-hydroxy-3′-methoxyphenyl)-2-oxoacetamide
(1), together with 12 known compounds (2–13) by column chromatography. Their structures were elucidated on the basis of spectroscopic evidence. It is the first time
that compounds 2–13 were isolated from this plant.
Published in Khimiya Prirodnykh Soedinenii, No. 1, pp. 7–9, January–February, 2008. 相似文献
7.
Li-Min Dai Jian Tang Hui-Liang Li Yun-Heng Shen Cai-Yun Peng Wei-Dong Zhang 《Chemistry of Natural Compounds》2009,45(3):325-329
A new stilbene glycoside, 5-methylresveratrol-3,4′-O-β-D-diglucopyranoside (1), was isolated from the n-butanol fraction of the rhizomes of Veratrum dahuricum, together with five known stilbenoids: resveratrol-3-O-β-D-glycoside (2), 4′-methylresveratrol-3-O-β-D-glycoside (3), oxyresveratrol-4′-O-β-D-glycoside (4), oxyresveratrol-3-O-β-D-glycoside (5), and oxyresveratrol-3,4′-O-β-D-diglycoside (6), and found for the first time in the investigated plant. The structures of six isolates were identified on the basis of
1D and 2D NMR data. Compounds 1–6 showed platelet aggregation inhibition, and compound 1 had an IC50 value of 383.6 μM against platelet aggregation induced by AA.
Published in Khimiya Prirodnykh Soedinenii, No. 3, pp. 279–282, May–June, 2009. 相似文献
8.
Ellagic acid derivatives from the stem bark of <Emphasis Type="Italic">Dipentodon sinicus</Emphasis>
Ellagic acid derivatives were isolated from Dipentodon sinicus and their structures were identified as 3,3′,4′-tri-O-methylellagic acid (1), 3,3′-di-O-methylellagic acid (2), 4,4′-di-O-methylellagic acid (3), 3,3′-di-O-methylellagic acid-4′-O-α-L-rhamnopyranoside (4), 3,3′,4′-tri-O-methylellagic acid-4′-O-β-D-glucopyranoside (5), 3,3′-di-O-methylellagic acid-4′-O-β-D-glucopyranoside (6), and ellagic acid (7). All the compounds were isolated for the first time from the title plant.
Published in Khimiya Prirodnykh Soedinenii, No. 2, pp. 106–107, March–April, 2007. 相似文献
9.
New substituted anilides of the heterocyclic series 2, 4, 5, 6, 7 together with the earlier described compounds 1 and 3 (Jarak I et al. (2005) J Med Chem 48:2346), were synthesized from the corresponding heterocyclic carbonyl chlorides, methoxycarbonyl-
and cyano-substituted anilines. Compounds 2 and 7 were prepared by methylation with methyl-iodide on the amide and the pyridine nitrogen. The Pinner reaction was used in the
preparations of amidino-substituted compounds. It seems that all the prepared compounds could be biologically interesting,
especially amidino-substituted anilides prepared in the form of water-soluble hydrochlorides or hydroiodides.
Molecular and crystal structures of the three compounds, namely, 4′-methoxycarbonyl-N-phenyl-3-chlorobenzo[b]thiophene-2-carboxamide (1), N-(4′-amidinophenyl)-3-chlorobenzo[b]thiophene-2-carboxamide hydrochloride monohydrate (4) and 1-methyl-N-(4-amidinophenyl)-3-pyridine carboxamide iodide hydroiodide (7) have been determined by X-ray single-crystal diffractometry in the solid state. Compounds 1, 4 and 7 are not planar and the amide group (C=O in relation to NH group) is in trans position in all three compounds. The 3-chlorobenzo[b]thiophene moiety in 1 and 4 is oriented with the chloro substituent in cis position in relation to amide NH group. The conformational characteristics of the compounds result from the introduction
of different substituents or solvent molecules (water molecule in 4), which leads to various intermolecular hydrogen bonds formation (N–H⋯O, N–H⋯Cl, O–H⋯Cl−, N–H⋯I−) in 1, 4 and 7. Hydrogen bond formation could be responsible for the potential biological activity of the compounds. 相似文献
10.
The ortho-metalated complex [Pd(x){κ
2
(C,N)-[C6H4CH2NRR′ (Y)}] (2a–4a and 2b–3b) was prepared by refluxing in benzene equimolecular amounts of Pd(OAc)2 and secondary benzylamine [a, EtNHCH2Ph; b, t-BuNHCH2Ph followed by addition of excess NaCl. The reaction of the complexes [Pd(x){κ
2
(C,N)-[C6H4CH2NRR′ (Y)}] (2a–4a and 2b–3b) with a stoichiometric amount of Ph3P=C(H)COC6H4-4-Z (Z = Br, Ph) (ZBPPY) (1:1 molar ratio), in THF at low temperature, gives the cationic derivatives [Pd(OC(Z-4-C6H4C=CHPPh3){κ
2
(C,N)-[C6H4CH2NRR′(Y)}] (5a–9a, 4b–6b, and 4b′–6b′), in which the ylide ligand is O-coordinated to the Pd(II) center and trans to the ortho-metalated C(6)H(4) group, in an “end-on
carbonyl”. Ortho-metallation, ylide O-coordination, and C-coordination in complexes (5a–9a, 4b–6b, and 4b′–6b′) were characterized by elemental analysis as well as various spectroscopic techniques. 相似文献
11.
The Becke3LYP functional of DFT theory was used to investigate molecular structure and sodium affinity of the systems CH3CO2Na (1), CH3–O–SO3Na (2), CH3–NH–SO3Na (3), saccharide_1Na2 (4), saccharide_2Na (5), saccharide_3Na3 (6), saccharide_4Na2 (7), and saccharide_5Na2 (8), respectively, which are models of N- and O-sulfate glycosaminoglycans. Interaction enthalpies, entropies and Gibbs energies of the sodium-coordinated systems in the
gas phase were determined with the B3LYP/6-311+G(d,p) and B3LYP/6-31+G(d) methods. The computed Gibbs energies, ΔG
o
, of model systems 1–3 are negative and span a rather broad energy interval (from −500 to −1,500 kJ mol−1). Gibbs interaction energies for sodium acetate, sodium sulfate and sodium sulfamate functions of the five saccharides, systems
4–8 are always lower than those values found for the model compounds 1–3. The ionization of sodium salts of saccharides studied in gas phase is in most cases connected with considerable conformational
rearrangement of the ionic species. This rearrangement causes an additional energetic stabilization of anionic species and
is connected with the substantial release of entropy. 相似文献
12.
Reactions of 2-(4,5-dihydro-3-furyl)-1,3-diphenyl-1,3-diaza-2λ3-phospholidine (1) with nitrile imines are multistep processes involving cleavage of one P-N bond of the diazaphospholidine ring to form substituted
5-(2-chloroethyl)-4-(N,N′-diphenylethylenediamino)-1,4-dihydro-1,2,4λ5-diazaphosphorines 4 as final products. Analogs of phospholidine 1, namely, 4,5-dihydro-3-furylphosphonous dipiperidide and dimorpholide, react with C,N-diphenylnitrile imine with retention of both P-N bonds to give 5-(2-hydroxyethyl)-1,2,4-diazaphosphorinium chlorides.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1590–1593, July, 2005. 相似文献
13.
Five ellagic acid glycosides were isolated from Aphananthe aspera and their structures were identified as 3-O-methylellagic acid-4′-O-α-L-rhamnopyranoside (1), 3-O-methylellagic acid-4′-O-β-D-xylopyranoside (2), 3,3′-di-O-methylellagic acid-4′-O-β-D-xylopyranoside (3), 3,3′, 4-tri-O-methylellagic acid-4′-O-β-D-glucopyranoside (4), and 3,3′-di-O-methylellagic acid-4′-O-α-L-rhamnopyranoside (5) on the basis of spectroscopic analysis. Compound 1 is new, and all the compounds were isolated for the first time from the title plant.
Published in Khimiya Prirodnykh Soedinenii, No. 5, pp. 458–459, September–October, 2007. 相似文献
14.
I. F. Makarevich S. N. Kovalenko T. D. Gusarova Yu. I. Gubin 《Chemistry of Natural Compounds》2009,45(1):40-44
Twelve compounds including secologanin, loganin, the aglycon of loganin, and a new iridoid called glucologanin were isolated
from fruit of common snowberry Symphoricarpos albus (L.) Blake. The structure of glucologanin was confirmed using PMR and mass spectroscopy and chemical transformations. 2′,3′,4′,6′,7-Penta-O-acetylloganin and 2′,3′,4′,6′-tetra-O-acetylloganin were synthesized.
Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 37–40, January–February, 2009. 相似文献
15.
V. V. Dotsenko S. G. Krivokolysko V. P. Litvinov 《Chemistry of Heterocyclic Compounds》2007,43(11):1455-1459
5,11-Disubstituted derivatives of 1′-isopropyl-8-thioxospiro[3,5,7,11-tetrazatricyclo[7.3.1.02,7]tridec-2-ene-13,4′-piperidine]-1,9-dicar bonitrile was obtained by the interaction of 10-amino-9-aza-3-azonia-7,11-dicyano-3-isopropylspiro[5,5]undeca-7,10-diene-8-thiolate
with 2 equiv. of a primary amine and excess of formaldehyde. An anomalous reaction product was obtained with o-toluidine — 7,9-dicyano-1′-isopropyl-3-(2-methylphenyl)-1,2,3,4-tetrahydrospiro[pyrido[1,2-a][1,3,5]triazine-8,4′-piper idinium]-6-thiolate.
__________
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, 1709–1713, November, 2007. 相似文献
16.
Hyun-Jung Lee Oh-Kyu Lee Yeong-Han Kwon Don-Ha Choi Ha-Young Kang Hyeon-Yong Lee Ki-Hyon Paik Hak-Ju Lee 《Chemistry of Natural Compounds》2006,42(4):415-418
Four known isoflavone glucosides have been isolated from the bark of Amorpha fruticosa, which is a traditional remedy plant,
for the first time. They were elucidated as 3′-hydroxy-4′-methoxyisoflavone-7-O-β-D-glucopyranoside (1), 4′,6-dimethoxyisoflavone-7-O-β-D-glucopyranoside (2), 4′-methoxyisoflavone-7-O-β-D-glucopyranoside (3), and 3′,5-dihydroxy-4′-methoxyisoflavone-7-O-β-D-glucopyranoside (4), based on the UV, FT-IR, EIMS, FABMS, HREIMS, and NMR (1H and 13C, DEPT, COSY, NOESY, HMQC, and HMBC) data.
Published in Khimiya Prirodnykh Soedinenii, No. 4, pp. 336–338, July–August, 2006. 相似文献
17.
A new flavonoid, kaempferol-3,4′-di-O-α-L-rhamnopyranoside (1), and three known flavonoids (2–4) were isolated from the aerial parts of T. communis L. The structure of the new compound was elucidated on the basis of spectroscopic data. Compounds 1 and 2 showed significant antioxidant activity (IC50 187.151 ± 0.821 μM, and 92.079±0.513 μM, respectively), whereas compounds 3 and 4 showed moderate activity in DPPH free radical scavenging assays.
Published in Khimiya Prirodnykh Soedinenii, No. 3, pp. 295–297, May–June, 2009. 相似文献
18.
A new chromone-substituted dihydrotriflavonol, (2S,3S)[6-{(3S) 3″,5″-dihydroxy-6″-methoxydihydrochromone}5,3′,4′,5′-tetrahydroxy-7-methoxy-3-O-8-dihydroflavone]2 3-O-8[6-{(3S) 3″,5″-dihydroxy-6″methoxydihydrochromone}3,5,3′,4′,5′-pentahydroxy-7-methoxydihydroflavonol] was isolated from the leaves
of Anogeissus pendula. The structure was determined by UV, 1H NMR, 13C NMR, HMBC, and CD data. 相似文献
19.
V. Yu. Korotaev Yu. A. Skorik A. Yu. Barkov M. I. Kodess A. Ya. Zapevalov 《Russian Chemical Bulletin》2005,54(11):2545-2549
3,3,3-Trifluoro-N′-(3-trifluoromethylphenyl)-1,2-propanediamine (5) was synthesized by the reaction of 2-diazo-1,1,1-trifluoro-3-nitropropane or 3,3,3-trifluoro-1-nitropropene with 3-aminobenzotrifluoride
followed by the reduction of the nitro group. The Michael 1,4-addition of diamine 5 to acrylic acid occurs only at the N(1) atom and affords N-mono-or N,N-dicarboxyethyl derivatives 6 and 7, depending on the reactant ratio. Protolytic equilibria 5–7 in aqueous solutions were studied by pH-potentiometry and UV spectroscopy. Only the aliphatic amino group can be protonated
in an aqueous solution, while the aromatic amino group remains unprotonated even in 12 M HCl. The stability constants of transition metal (Cu2+, Ni2+, Zn2+) complexes with ligands 5–7 were determined by pH-potentiometric titration. The stability of the complexes and selectivity of the ligands toward Cu2+ ions increase with an increase in the number of N-carboxyethyl groups.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2465–2469, November, 2005. 相似文献
20.
D. L. Lipilin A. Yu. Tyurin O. Yu. Smirnov A. M. Churakov Yu. A. Strelenko V. A. Tartakovsky 《Russian Chemical Bulletin》2006,55(7):1239-1242
Treatment of 2-(tert-butyl)-1,2,3,4-benzotetrazinium tetrafluoroborates with sodium thiocyanate afforded 2-(tert-butylazo)phenyl isothiocyanates 3, which exist in equilibrium with 2-(tert-butyl)-1,2,4-benzotriazine-3(2H)-thiones 3′. The equilibrium depends on the substituents R in the benzene ring: the percentage of the open isomer 3 is about 20% for R = H or Me; for R = Cl or Br, the equilibrium is completely shifted to cyclic isomer 3′. The equilibrium is slow on the time scale of the 1H and 13C NMR experiments. For compounds 3a/3′a (R = H), the spectra at 24 °C show two sets of signals, while those at 0 °C contain only signals for isomer 3′a.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1192–1195, July, 2006. 相似文献