变厚度聚焦换能器对声焦域轴向长度影响的研究*

针对不同厚度的病变组织,改变声焦域轴向长度能提高高强度聚焦超声在临床治疗过程中的安全性和有效性。基于多频超声波叠加原理,该文提出了变厚度(多频)聚焦换能器,并设计了两种类型变厚度聚焦换能器。根据瑞利积分法推导了变厚度聚焦换能器声场,计算和分析了变厚度聚焦换能器的声焦域轴向长度,并与等厚度(单频)聚焦换能器声焦域轴向长度进行对比。结果显示,变厚度聚焦换能器中心到边缘的厚度变化趋势与声焦域轴向长度变化相关,中间薄两边厚换能器声焦域轴向长度缩短,中间厚两边薄换能器声焦域轴向长度变长,且实验验证了理论的正确性。研究结果可为变厚度聚焦换能器声场研究和高强度聚焦超声的临床治疗提供参考。     

基于任意阵的最小方差无失真响应聚焦波束形成的被动定位方法

将最小方差无失真响应(MVDR)聚焦波束形成近场被动定位方法应用到平面任意结构阵列上,可以很好地解决线列阵由于阵长较长,在实际使用中存在布放困难、部分阵元失效影响定位性能等问题。本文首先分析了平面任意结构阵列的近场接收信号模型,推导出阵列流型,然后将MVDR聚焦波束形成技术应用到该模型中,得到了基于任意阵的MVDR聚焦波束形成近场被动定位方法。仿真验证了该方法的可行性和有效性。     

时间反转方法用于高强度聚焦超声的焦点偏移补偿

传统的高强度聚焦超声(HIFU)治疗中实际焦点和预设焦点容易出现偏移,为考察时间反转方法对HIFU治疗中焦点偏移的补偿效果,采用时域有限差分方法求解Westervelt方程,建立高强度聚焦声场数值模型。数值计算得到在人体软组织中进行HIFU治疗时,采用时间反转方法后焦点偏移距离最大仅为1.6 mm。脂肪层厚度及声源强度改变对时间反转聚焦精度影响不大,F数(焦点距离同换能器孔径的比值)降低时,焦点偏移减小。研究表明在人体软组织吸收系数和非线性系数范围内,时间反转方法可有效补偿焦点偏移,达到更好的聚焦效果。      

超声平面波同相正交信号频域波束形成算法

针对频域平面波波束形成算法尚不能直接应用于采用正交解调的超声成像系统中的实际问题,提出一种平面波同相正交信号频域波束形成方法。以平面波射频信号频域波束形成算法为基础,根据射频信号与同相正交信号波数空间变量之间的关系,推导了平面波同相正交信号与对应图像的频谱映射表达式,从而实现对正交解调后信号的频域超声图像重建。采用2016年Plane Wave Imaging Challenge in Medical Ultrasound (PICMUS)发布的仿真、仿体及在体原始回波数据对这一方法进行验证,并评估图像的分辨率和对比噪声比。仿真和仿体实验结果表明,相对于射频信号的频域波束形成算法,该算法可获得与之相同的图像质量,并将成像速度提高了约4倍。在体实验数据的成像结果也验证了该算法在实际应用中的有效性。     

基于合成孔径技术的内镜超声相控阵成像算法

利用孔径大小为2.32mm的16阵元换能器,搭建了一套16通道的内镜超声相控阵成像实验系统。在此基础上提出了一种适用于内镜成像的相控阵成像算法(PAI),该算法利用延时和叠加算法(DAS)取得扫描线数据,再利用合成孔径技术中的相干样点叠加,得到高分辨率图像。该相控阵成像算法实现了发射和接收的动态聚焦。经FieldII仿真和内镜探头超声成像实验验证,与延时和叠加算法以及动态接收聚焦算法(DRF)相比,图像的理论横向分辨率分别提高了93.68%和17.5%,实验获得的实际横向分辨率分别提高了92.78%和14.69%,验证了相控阵成像算法和实验系统的可行性。     

超声虚源成像中自适应双向空间逐点聚焦方法

针对传统超声成像中图像分辨率和对比度随深度下降的问题,提出了一种基于虚源的自适应双向空间逐点聚焦超声成像方法。首先,使用超声换能器线列阵分子孔径分别定焦点发射和接收超声波,采集扫描线数据;然后将焦点视为虚拟点声源,计算虚源到空间成像点的延时,利用合成孔径原理再次进行空间逐点聚焦;在合成过程中采用相干系数进行自适应加权。采用空间脉冲响应法对不同深度的点目标和囊目标仿真成像,从而量化分辨率和对比度。在F数为1.5、焦距为10 mm时(对应子孔径阵元数为17)可以获得与64通道定焦点发射、动态聚焦接收相当的图像质量且在所有深度上保持一致。实际硬件平台的体模成像实验进一步验证了方法的有效性。该方法可在整个成像深度范围内保持和常规成像一致的分辨率和对比度,从而获得更优的整体成像效果。     

超声虚源成像中自适应双向空间逐点聚焦方法

针对传统超声成像中图像分辨率和对比度随深度下降的问题,提出了一种基于虚源的自适应双向空间逐点聚焦超声成像方法。首先,使用超声换能器线列阵分子孔径分别定焦点发射和接收超声波,采集扫描线数据;然后将焦点视为虚拟点声源,计算虚源到空间成像点的延时,利用合成孔径原理再次进行空间逐点聚焦;在合成过程中采用相干系数进行自适应加权。采用空间脉冲响应法对不同深度的点目标和囊目标仿真成像,从而量化分辨率和对比度。在F数为1.5、焦距为10 mm时(对应子孔径阵元数为17)可以获得与64通道定焦点发射、动态聚焦接收相当的图像质量且在所有深度上保持一致。实际硬件平台的体模成像实验进一步验证了方法的有效性。该方法可在整个成像深度范围内保持和常规成像一致的分辨率和对比度,从而获得更优的整体成像效果。      

3D打印衍射元件的高分辨太赫兹计算机辅助层析成像研究（特邀）

提出了一种由三维打印技术制作的用于0.3 THz波束调控的二元相位型衍射透镜,可产生轴向焦深为25 mm、腰斑直径为1 mm的太赫兹聚焦波束。将该聚焦波束应用于连续太赫兹波计算机辅助层析成像,不仅将成像分辨率提高到1.5 mm,而且由于扩大了系统景深,提高了成像保真度。这类利用三维打印技术制作的二元衍射元件可有效应用于低频太赫兹波段的光束调控,为太赫兹成像系统的性能优化以及聚焦元件的设计制备提供一种有效途径。     

基于回波平移序列的快速三维磁共振温度成像方法

高强度聚焦超声（HIFU）是一种无创的热消融疗法，为保证其安全性和有效性，需要一种精度高、速度快的测温方法在其治疗过程中对温度进行监控.基于质子共振频率位移（PRFS）的磁共振温度成像（MRT）对温度具有较高的灵敏度，且与温度具有良好的线性关系，因此常被用于引导HIFU治疗.然而在实际应用中，HIFU治疗的最大隐患在于可能造成表皮灼伤，并且灼伤区域可能与焦点区域相隔较远.因此MRT的监控范围十分重要.本文基于三维回波平移成像序列，结合可控混叠的空间并行成像技术，实现了时间分辨率为3 s的快速三维温度成像.为了验证该方法的精度，本文首先设计了仿体降温实验，利用光纤温度计验证回波平移序列测温的准确度和精确度.然后在室温条件下扫描离体猪肉组织，对比加速前后的MRT的测温精确度.在HIFU加热条件下扫描离体猪肉组织，对比加速前后的MRT的测温准确度.结果显示，本文提出的方法可以在3 s内完成三维温度精准测量，对于HIFU治疗的安全监控具有重要意义.     

双层塑料靶丸的X射线相衬成像

 为对微聚焦X射线相衬成像技术应用于双层以及多层塑料靶丸成像和特征分析进行可行性研究,基于类同轴X射线成像技术,综合考虑成像放大倍数、分辨率和衬度等因素,选择合适的实验参数,成功获得了较为清晰的双层塑料靶丸X射线相衬成像照片;采用数字图像处理技术的图像分割手段,如拉普拉斯高斯边缘检测法等对所成像中靶丸边界特征进行分析处理,获得了双层靶丸内层厚度为（10.5±0.6） μm,外层厚度为（9.2±0.7） μm,靶丸外径为（273.3±1.0） μm等参数。     

Guided-Wave Two-Dimensional Acousto-Optic Scanner Using Proton-Exchanged Lithium Niobate Waveguide

Two-dimensional scanning of a 0.6328 mum guided-light beam has been realized using noncolinear acousto-optic (AO) coplanar Bragg diffraction together with colinear AO guided-mode to substrate radiation-mode conversion in a Z-cut Xpropagation LiNbO3 proton-exchanged (PE) waveguide. The two surface acoustic (SAW) waves utilized are at the center frequencies of 500 and 200 MHz, propagating in the Y and X axes, respectively. Two-dimensional scanning of approximately 720 resolvable light beam spots, namely, 18 40 (horizontal vertical) scanning, has been demonstrated using a light beam of 1.0 mm aperture. The total number of resolvable beam spots can be greatly increased from 720 by simply utilizing SAW transducers of larger bandwidth and a light beam of greater aperture. It should also be possible to significantly increase the diffraction efficiency from 3 % by optimizing the parameters of the PE waveguide and the SAWs.     

Effect ofγ-radiation on the spectral luminescence characteristics of impure cadmium tungstate crystals

Results of a study of the effect of γ-radiation on the spectral luminescence properties of cadmium tungstate crystals doped with silver, bismuth, and molybdenum cations are presented. Spectral characteristics of the nondnnnoped crystals are briefly described. Absorption and photo and X-ray luminescence spectra of the crystals taken before and after exposure to γ-radiation (5.5·10⁴ Gy) are compared. It is found that the spectral characteristics of the crystals doped with silver, bismuth, and molybdenum cations do not change markedly after the exposure. The relation between the type of impurity-induced defects, individual characteristics of the impurity cations, and the character of the effect of γ-radiation on the spectral luminescence properties of impure crystals is analyzed (preliminarily). Translated from Zhurnal Prikladnoi Spektroskopii, Vol. 64, No. 1, pp. 55–60, January–February, 1997.     

Femtosecond Transform-Limited Pulse Generation by Compensating for the Linear Chirp of SPM Spectra in Dispersion Shifted Fibers

A simple technique of pulse compression, based on the linear chirp compensation of self-phase modulation (SPM) spectra in dispersion shifted fibers, is demonstrated. The optimization procedure is carried out, for a short span of a single-mode fiber, using a parabolic law, which describes the behavior of the squared output pulse width versus the pump peak power in the case of Gaussian pulses. The experimental results give a minimum pulse duration of 233 fs, which is in good agreement with the model. Shorter and coherent pulses, down to 90 fs, have been obtained by inserting an interference filter at the optical output.     

Sorting of bending magnets for the SSRF booster

The Shanghai Synchrotron Radiation Facility(SSRF)booster ring,a full energy injector for the storage ring,is deigned to accelerate the electron beam energy from 150MeV to 3.5GeV that demands high extraction efficiency at the extraction energy with low beam loss rate when electrons are ramping.Closed orbit distortion(COD)caused by bending magnet field uniformity errors which affects the machine performance harmfully could be effectively reduced by bending magnet location sorting.Considering the affections of random errors in measurement,both ideal sorting and realistic sorting are studied based on measured bending magnet field uniformity errors and one reasonable combination of bending magnets which can reduce the horizontal COD by a factor of 5is given as the final installation sequence of the booster bending magnets in this paper.     

Measurement of nonlinear coefficient of optical fiber based on small chirped soliton transmission

We measure the waveform and phase curves of short optical pulses before and after transmission over different lengths of fibers by use of the pulse analyzer with the frequency-resolved optical gating (FROG),and numerically simulate pulse evolution under the experimental conditions.The nonlinear coefficient of the fiber is given by comparing the experimental results with the numerical ones.Difference between the experiment and numerical simulation is analyzed.     

Resonance scattering of canonical elastic shells in absorbing fluid medium

Resonance scattering of elastic spherical shell and cylindrical shell while the surrounding fluid medium has absorption is studied. The normal mode solution derived using exact elastic theory and the separation of variables is still applicable. However, the scattering form function has to be modified for the absorbing medium, otherwise the unreasonable result would be obtained. The backscattering form function in the absorbing medium is redefined, and the form function of elastic spherical and cylindrical shell with vacuum or solid matter filled is calculated in various absorption conditions. The results show that the absorption of surrounding fluid leads to notable attenuation of the coincidence resonances in the mid-frequency, but it has a little influence on the low-frequency resonance scattering induced by the filler inside the shell.     

Single-beam self-referenced phase-sensitive surface plasmon resonance sensor with high detection resolution

A versatile and low-cost single-beam self-referenced phase-sensitive surface plasmon resonance(SPR)sensing system with ultra-high resolution performance is presented.The system exhibits a root-mean-square phase fluctuation of ±0.0028.over a period of 45 min.i.e.a resolution of±5.2×10-9 refractive index units.The enhanced performance has been achieved through the incorporation of three design elements:a true single-beam configuration enabling complete self-referencing so that only the phase change associated with SPR gets detected,a differential measurement scheme to eliminate spurious signals not related to the sensor response,and the elimination of retardation drifts by incorporating temperature stabilization in the liquid crystal phase modulato .Our design should bring the detection sensitivity of non-labeling SPR biosensing closer to that achievable by conventional fluorescence-based techniques.     

Influences of SiO2 protective layers and annealing on the laser-induced damage threshold of Ta2O5 films

Ta2O5 films are prepared on BK7 substrates with conventional electron beam evaporation deposition.The effects of SiO2 protective layers and annealing on the laser-induced damage threshold (LIDT) of the films are investigated.The results show that SiO2 protective layers exert little influence on the electric field intensity(EFI)distribution,microstructure and microdefect density but increase the absorption slightly.Annealing iS effective on decreasing the microdefect density and the absorption of the films.Both SiO2 protective layers and annealing are beneficial to the damage resistance of the films and the latter is more effective to improve the LIDT.Moreover,the maximal LIDT of Ta2O5 films is achieved by the combination of SiO2 protective layers and annealing.     

A stereo matching algorithm using multi-peak candidate matches and geometric constraints

Gray cross correlation matching technique is adopted to extract candidate matches with gray cross correla- tion coefficients less than some certain range of maximal correlation coefficient called multi-peak candidate matches. Multi-peak candidates are extracted corresponding to three closest feature points at first. The corresponding multi-peak candidate matches are used to construct the model polygon. Correspondence is determined based on the local geometric relations between the three feature points and the multi-peak candidates. The disparity test and the global consistency checkout are applied to eliminate the remaining ambiguous matches that are not removed by the local geometric relational test. Experimental results show that the proposed algorithm is feasible and accurate.