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利用Hantzsch反应合成了13个N-芳基-4-(吡啶-2-基)-5-(1H-1,2,4-三唑-1-基)噻唑-2-胺衍生物,所有化合物的结构均经1H NMR,MS及元素分析确证.研究发现,溶剂对不同取代基的目标化合物的合成影响很大.生物活性测试结果表明,化合物均具有一定的杀菌活性.其中,化合物6c对番茄早疫和苹果轮纹、化合物6g对番茄早疫、化合物6h对黄瓜黑腥及化合物6i对苹果轮纹均显示80%以上的杀菌活性. 相似文献
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以2-氨基-5-取代-1,3,4-噻二唑为起始原料,设计合成16个含1,3,4-噻二唑取代基的中间体4a~4p,进而使其在POCl3及DMF作用下反应得到16个3-取代-1-(5-芳基-1,3,4-噻二唑-2-基)-1H-吡唑-4-甲醛化合物5a~5p,所合成的32个化合物均为新化合物。 采用溶液结晶法获得化合物5a晶体,通过X射线单晶衍射测得该晶体属于三斜晶系,P-1空间群。 借助 IR、1H NMR、元素分析等技术手段对合成的所有化合物结构进行了表征。 利用微量稀释法测试了化合物5a~5p的抑菌活性,结果表明,部分化合物对金黄色葡萄球菌具有抑制作用,在相同条件下化合物5h的抑菌活性最好,抑菌率达到65.30%。 相似文献
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报道了4-异丁氧基-10-羟基-1,7-二氮杂菲-2,8-二羧酸甲酯(1)的选择性合成.化合物1是以间苯二胺(3)为起始原料,经三步反应合成得来.间苯二胺和1,4-二羧酸二甲酯丁炔(4)反应生成了1,3-二-(1,2-二甲氧羰基-乙烯氨基)苯(5),随后化合物5在二苯醚中加热回流,生成4,10-二羟基-1,7-邻二氮杂菲-2,8-二羧酸甲酯(6)和4,5-二羟基-1,8-二氮杂蒽-2,7-二羧酸甲酯(7).从核磁共振氢谱中可以估算出,化合物6的产率是化合物7的7~9倍.化合物6和7的混合物通过Mitsunobu反应生成了化合物1和4,5-二异丁氧基-1,8-二氮杂蒽-2,7-二羧酸甲酯(2),其中化合物1的产率是化合物2的5~7倍.晶体结构清楚地表明化合物1中10位上的羟基与1位上的氮原子之间形成了六元环分子内氢键,而在化合物2中却没有发现分子内氢键,此现象很好的说明了氢键的形成与选择性合成之间存在着重要的联系. 相似文献
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由 2 -( 1H -1 ,2 ,4 -三唑-1 -基 ) -4 ,4 -二甲基-1 -戊烯 -3 -酮和 (硫代 )磷 (膦 )酰肼的亲核加成反应合成了六个未见文献报道的目标化合物 ,其化学结构经IR、1HNMR、MS和元素分析确证。目标化合物的生物活性数据表明 ,该类化合物对小麦锈病有较好的防治效果。 相似文献
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1,2,3-三唑化合物具有广泛的生物活性,为了发现具有杀菌活性的新型化合物分子结构,以芳醛、硝基甲烷及叠氮化钠为起始原料,合成了11个2-取代-4-芳基-2H-1,2,3-三唑类系列化合物,目标物的收率为51%~91%。核磁共振谱、质谱和元素分析等技术手段对目标化合物的结构经进行了表征。结果表明,在25 mg/L的测试质量浓度下,大部分化合物对小麦赤霉病菌及辣椒疫霉病菌显示出初步的抑菌活性,其中,化合物3a对小麦赤霉病菌的抑制率为80. 4%,化合物3b对黄瓜灰霉病菌为78. 2%,化合物3b及3h对油菜菌核病菌的抑制率分别70. 3%和75. 9%。 相似文献
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2-甲基-1-(4-芳基噻唑-2-基)-苯并咪唑-6-甲酸乙酯的合成、表征及生物活性 总被引:2,自引:0,他引:2
以4-乙酰氨基苯甲酸乙酯为原料设计合成了14 种2-甲基-1-(4-芳基噻唑-2-基)-苯并咪唑-6-甲酸乙酯新化合物. 化合物结构经质谱、1H NMR、红外光谱和元素分析等确证, 并用单晶X射线衍射仪测定了化合物5a的晶体结构. 生物活性实验结果表明, 化合物5c(500 mg/L)对小麦白粉病菌抑制率达到95%; 化合物5e对辣椒疫霉病菌(25 mg/L)的抑制率为61.9%, 对油菜菌核病菌(500 mg/L) 抑制率高达97.2%; 化合物5k(25 mg/L) 对小麦赤霉病菌抑制率为55.1%. 相似文献
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设计合成了具有降血糖活性的3-甲基-1-苯基-4-[4-[[5-甲基-2-(4-取代芳基)-噁唑-4-基]甲氧基]-芳亚甲(苄)基]}-2-吡唑啉-5-酮类化合物.用丁二酮单肟和(取代的)苯甲醛环合、氯化得到氯甲基噁唑衍生物,与对羟基苯甲醛或香兰醛缩合,再与3-甲基-1-苯基-2-吡唑啉-5-酮进行Knoevenagel反应及催化氢化得到目标化合物(Ⅰ和Ⅱ),共合成了16个未见文献报道的新化合物,并利用元素分析、IR、MS和1HNMR确证了化合物的结构.初步药理试验结果表明,所合成的化合物有抑制血糖升高的倾向以及能明显加强和延长外源性胰岛素的降血糖作用,其中化合物Ⅰb,Ⅰd和Ⅰf尤为突出,说明这类化合物可能有增强胰岛素敏感性的作用. 相似文献
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对烘烤前后南瓜籽中的化学成分进行分析并对比。采用同时蒸馏萃取装置萃取南瓜籽中的挥发性成分,采取超临界CO2萃取技术萃取南瓜籽油脂,并将其分为酸、碱、中性三个部分,用气相色谱-质谱联用方法分析其中化学成分并进行对比。结果表明,南瓜籽挥发性成分中含有多种醛类和酯类化合物,烘烤后产生了大量的烷基吡嗪,其在碱性部分中的相对含量比烘烤前提高14倍多,不饱和醛类化合物含量也有明显提高。南瓜籽油脂中的主要化学成分是油酸、亚油酸及其酯类。还含有生物活性功能成分如植物甾醇、角鲨烯和维生素E等。烘烤后除角鲨烯含量有所降低,维生素E、植物甾醇、亚麻酸等均有提高。 相似文献
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The adsorption of phenol and nitrophenols on hypercrosslinked polymeric adsorbent wasstudied as a function of the solution concentration and temperature. Adsorption isotherms of phenoland nitrophenols on hypercrosslinked resin were determined. These isotherms were modeledaccording to the Freundlich adsorption isotherm. The isotherms for phenol and nitrophenols onhypercrosslinked resin were assigned as L curves. Thermodynamic parameters were calculated for allphenol and nitrophenols. The kinetics experiment results showed that the adsorption rates were of thefirst-order kinetics. The rate constants at 303K were calculated. 相似文献
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Samir A. Patel Milan V. Patel Arabinda Ray Rajni M. Patel 《Journal of polymer science. Part A, Polymer chemistry》2003,41(15):2335-2344
Low molecular weight poly(ether ketone)s were synthesized from phenol, 1,4‐phenylenedioxy diacetylchloride, chloroacetylchloride, and dichloroalkanes [1,2‐dichloroethane and dichloromethane] by a Friedel–Crafts reaction with anhydrous aluminum chloride as a catalyst and carbon disulfide as a solvent. The conditions for the preparation of the poly(ether ketone)s and the chlorine contents obtained with the Carius method were examined, and a reaction scheme for each resin was established. The molecular weights and polydispersities of the resins were obtained by gel permeation chromatography. The polyketones were characterized by IR spectroscopy. The characteristic frequencies due to different functional groups were assigned. The thermal properties of the resins were studied with thermogravimetry and differential scanning calorimetry. The characteristic temperatures of thermal degradation for the poly(ether ketone)s were evaluated with thermogravimetric analysis. The kinetic parameters for the decomposition reactions of the resins were obtained with Broido and Doyle's method, and the heats of fusion were obtained from differential scanning calorimetry thermograms. The polyketones were thermally stable up to 200 °C. All the polyketones were tested for their microbial properties against bacteria, fungi, and yeast. The effect of poly(ether ketone)s on the growth of these microorganisms was investigated, and the polyketones were found to inhibit the growth of the microorganisms to a considerable extent. © 2003 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 41: 2335–2344, 2003 相似文献
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Effect of gallium, aluminium, and chromium on silica supported V-Mg-O catalysts during oxidative dehydrogenation of propane: Kinetic study
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The oxidative dehydrogenation (ODH) of propane was conducted on gallium, aluminum, and chromium doped Si30VMgO catalysts. On doping, the concentrations of the phases responsible for the activity and selectivity increased in their concentrations. The reaction studies were conducted in a tubular steel reactor at temperatures of 753, 783, 813, and 843 K and atmospheric pressure. The total flow rates of the feed were chosen as 30, 40, 50, and 60 ml/min. The propane to oxygen ratios were chosen at 1 : 1, 2 : 1, and 3 : 1, respectively. The effect of various dopants on the activity and selectivity of the catalysts was studied. Deactivation studies were conducted over all the catalysts. The kinetic data were analyzed in terms of power law models and Langmuir-Hinshelwood (LH) models. The kinetic data results were analyzed by comparing the effect of dopants. Statistical model discrimination was done for the proposed models. AIC and BIC criteria were used for discrimination of the models. 相似文献
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A series of binary and ternary rare earth complexes with para-substitued benzoic acids and 1,10-phenanthroline were synthesized. The phosphorescence spectra were measured and the lowest triplet state energies of ligands were determined, the phosphorescence lifetimes were obtained and intramolecular energy transfer mechanism between ligands was studied. The luminescence properties were also measured and were in agreement with the prediction. The energy match and intramolecular energy transfer process in these binary and ternary complexes were discussed in detail. 相似文献
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简单介绍了生物柴油的生产原料,综述了用废弃油脂生产生物柴油的现状和方法。废弃油脂生产生物柴油的方法主要有物理法和化学法,物理法主要有掺和法和微乳法,化学法主要有热裂解法和酯交换法。目前生产中采用化学法的酯交换法、以酸碱两步催化法的工艺为主,而生物酶法和超临界法是研究热点。 相似文献
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致癌性多环芳烃萘、蒽、芘的分析方法比较 总被引:4,自引:1,他引:3
利用薄层色谱(TLC)、紫外光谱(UV)、反相高效液相色谱(RPHPLC)对多环芳烃(PAHs)萘、蒽、芘的分析方法进行了研究。TLC中使用环己烷:氯仿(5:4,V/V)作为展开剂时,三者的R,值分别为0.78、0.65和0.72;用UV法在溶液中测定了三者的最大吸收波长分别为303、380、338nm;当流动相为甲醇:水(9:1,V/V)时三者在RP—HPLC中的保留时间为4.179、5.190、6.178min,5次重复RSD分别为1.1%、1.8%、0.91%,并用于实际水样中萘、蒽、芘的分析。 相似文献
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JIN Xiaoyuan LI Aiming CHEN Jinlong ZHANG Quanxing State Key Laboratory of Pollution Control Resources Reuse School of the Environment Nanjing University Nanjing China 《Chinese Journal of Reactive Polymers》2002,(2)
1. INTRODUCTION Nitrophenols are versatile raw materials in chemical industry and used in a great diversity of applications such as herbicides, insecticides and bactericides. Due to their extreme toxicity and adverse effect upon human and biota at very l… 相似文献