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1.
Protolytic equilibria taking place in aqueous solutions of sodium deoxycholate (DCNa) have been studied at 25°C using 0.5M NaCl as ionic medium. Electromotive force measurements of a galvanic cell were carried out by means of a glass electrode.The reagent necessary to change the acidity of the solutions was produced in situ by supplying a constant small current.Solubility and acid constant of deoxycholic acid (HDC) have been determined for the chosen experimental conditions. Experimental data obtained in less acid solutions have been explained by assuming the presence of the species H(DC)2. The relative stability constant has been determined. At higher deoxycholate concentration the presence of a polymeric micellar species has been assumed.
Symbols H analytical excess of hydrogenions, if negative it corresponds to OH–; - h free concentration of hydrogen ions; - A total concentration of deoxycholate; - a free concentration of deoxycholate; - K a acid constant of deoxycholic acid (HDC) defined as follows: [HDC]K a =ha; - q,p stability constant of a speciesH p (DC) q defined as follows: [H p (DC) q ]= q,p h p a q ; - C 0 solubility of HDC; - formation function representing the average number of H+ bonded to deoxycholate. 相似文献
Protolytische Gleichgewichte in wäßrigen Natriumdesoxycholat-Lösungen
Zusammenfassung Die Protonierung von Natrium-Desoxycholat (DCNa) in wäßrigen Lösungen mit 0.5M NaCl wurde bei 25°C mit Hilfe von E.M.K. Messungen mit einer Glaselektrode untersucht.Das notwendige Reagens für die Umwandlung der Säure in den untersuchten Lösungen wurde in situ durch einen konstanten schwachen Strom erzeugt.Löslichkeit und Dissoziationkonstante von Desoxycholsäure (HDC) wurden unter den gewählten experimentellen Bedingungen bestimmt. Die experimentellen Daten in schwach sauren Lösungen konnten mit der Annahme der Existenz von H(DC)2 erklärt werden. Die entsprechende Konstante wurde bestimmt. Zur Erklärung der Daten in stärker konzentrierten Lösungen von Desoxycholat ist die Annahme einer polynuklearen Spezies nötig.
Symbols H analytical excess of hydrogenions, if negative it corresponds to OH–; - h free concentration of hydrogen ions; - A total concentration of deoxycholate; - a free concentration of deoxycholate; - K a acid constant of deoxycholic acid (HDC) defined as follows: [HDC]K a =ha; - q,p stability constant of a speciesH p (DC) q defined as follows: [H p (DC) q ]= q,p h p a q ; - C 0 solubility of HDC; - formation function representing the average number of H+ bonded to deoxycholate. 相似文献
2.
D. V. Mil'chenko G. V. Kudryavtsev G. V. Lisichkin 《Theoretical and Experimental Chemistry》1986,22(2):227-230
Potentiometric titration has been used to study the protolytic equilibria on the surface of carboxyl-containing silica (CS) prepared by the reaction of silica (Silokhrom S-80, Ssp = 80 m2/g) with Cl3SiCH2CH2COOCH3, followed by hydrolysis with 30% sulfuric acid. The titration curve of the vacuum-dried sample is irreversible. The titration curve of its Na+ form with hydrochloric acid proceeds lower than the titration curve of its H+ form and coincides with the titration curve of the air-dried sample (the last curve is reversible). The titration curve of CS coincides with the titration curve of butyric acid at pH < 6. At pH > 6 the titration curve of CS passes below the titration curve of butyric acid; this is due to the participation of silanol groups on the silica surface in the protolytic equilibria. The pKa of the grafted CS groups is equal to 4.80 which is close to the pKa value of butyric acid (4.78). A method has been proposed for the determination of the amount of weak acid groups grafted to the silica. It has been shown that in the titration of CS the equilibrium is established much faster than in the case of the unmodified silica.Translated from Teoreticheskaya i Éksperimental'naya Khimiya, Vol. 22, No. 2, pp. 243–247, March–April, 1986. 相似文献
3.
N. O. Mchedlov-Petrosyan V. I. Kukhtik S. I. Egorova 《Russian Journal of General Chemistry》2006,76(10):1607-1617
The dissociation constants of fluorescein halo derivatives containing substituents in the xanthene ring and/or in the phthalic acid moiety were determined in 91.4 wt % aqueous ethanol. The tautomerism of the dyes was inferred from the electronic absorption spectra of ions and molecules in this solvent and of the dichloromethane and chloroform extracts of associates of the anions with tetra-n-butylammonium cations. The equilibria in two-phase systems were considered. 相似文献
4.
5.
《Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy》1989,45(8):803-807
The present study comprises an investigation of the optical absorption and fluorescence spectra of the title compound (HT) in homogeneous solutions of ethanol, cyclohexane, and sulphuric acid, and in aqueous micellar systems of anionic (NaLS), cationic (CTABr) and non-ionic (Triton X-100) surfactants.This compound behaves as monoprotic acid in buffer solutions of pH = 1–13 containing 3% v/v ethanol. It has pK = 8.2, but in the first excited singlet state the pK* drops to 3.9. However, another protolytic equilibrium is established with pK2 = 0.45 and pK*2 = 2.15 in concentrated H2SO4 solutions.Contrary to all other media studied, the dissociated form of HT was observed in CTABr micellar solution with an apparent red shift indicating that the HT molecules are incorporated into the detergent layer of the micelles and at the interface of the aggregates.The influence of micellar solutions on the acid—base equilibrium of HT reveals that the effect of the charge distribution of the counter ions in the double layer is much larger than the effective dielectric constant at the site of solubilization. 相似文献
6.
D. O. Ruzanov D. V. Samoilov K. V. Gensh Yu. E. Zevatskii N. P. Novoselov 《Russian Journal of General Chemistry》2011,81(6):1153-1158
A new differentiating medium for the study of prototropic equilibria is proposed: acetonitrile with a small addition of DMSO.
From the dependence of the picric acid pK
a on the content of DMSO in this medium the optimum composition of the mixture was found ensuring the stability of the pK
a values with minimal addition of DSMO: 4 wt %. It was experimentally confirmed that the addition of water in an amount up
to 0.1 wt % has virtually no effect on the measured pK
a value in a mixture with the optimum composition. 相似文献
7.
《Polyhedron》1987,6(7):1619-1620
Protonolysis of ortho-palladated asymmetric metallacycles (3: ZA = NMe2, ZB = PPh2; 4: ZA = NMe2, ZB = AsPh2; 5: ZA = AsPh2, ZB = PPh2) by acetic acid leads to the departure of PhCH2NMe2 (in the case of 3 and 4) and PhCH2AsPh2 (for 5) and formation of corresponding dimeric acetato bridged complexes 6 and 7, respectively. The relative stability of the palladocycles is determined by the nature of the donor atom and decreases in the order: P > As > N. 相似文献
8.
Jnos Zsak Maria Tomoaia-Coti
el Aurora Mocanu Emil Chifu 《Journal of colloid and interface science》1986,110(2)
A general thermodynamic treatment is given for the protolytic equilibria in an insoluble monolayer, containing surfactant molecules with n ionizable protons and able to accept m more protons, and being spread at the liquid/gas interface. The correlation between the pH of the subphase liquid and the collapse pressure of the monolayer is discussed. By using the approximation of perfect solutions and of binary surface systems (protonated and deprotonated molecular species of the surfactant) several methods are proposed for deriving apparent surface acidity constants from experimental collapse pressure vs pH curves, in the case of both miscible in monolayer miscible in collapsed bulk phase and miscible in monolayer immiscible in collapsed bulk phase, type systems. Some of these methods are based on a complete perfect solution approximation (CA) taking into account the molar fraction of the subphase liquid in the monolayer and the others use “surfactant” approximation (SA), neglecting this molar fraction. The methods proposed are tested on monolayers of carotenoid pigments spread at aqueous solution/air interfaces. Results obtained by the different methods are rather close to each other, but the approximation CA is better than SA. The apparent surface acidity constants of different carotenoids are compared with each other and discussed in terms of molecular structure and electronic effects. 相似文献
9.
10.
V. N. Britsun V. A. Doroshchuk V. S. Starova A. B. Ryabitskii M. O. Lozinskii 《Russian Journal of General Chemistry》2012,82(10):1700-1704
Concentration acidity of 2-acylthioacetamides dissolved in DMSO-H2O was measured by the method of pH-metric titration. The data obtained were extrapolated for the determination of pK a values of 2-acylthioacetamides in water and DMSO. We found that in aqueous solutions the acidity of thioacetarylamide (pK a = 5.75?C6.01) was almost independent of the nature of substituents in their N-phenyl rings, whereas in DMSO solution the nature of substituents significantly affects their ionization constants (pK a = 7.88?C11.70). The graphs were displayed and the acidity of N-aryl-3-oxobutanethioamides dependence on the Hammett constants of meta- and para-substituents in the phenyl rings derived. Water is shown to be a leveling, and DMSO a differentiating solvent for 2-acylthioacetamides. 相似文献
11.
A series of trifluoromethyl-substituted arenes were studied in their reactions with Br?nsted superacids. The products from these reactions suggest the formation of reactive electrophiles, such as carbocations, acylium cations or equivalent electrophilic species. As such, Friedel-Crafts-type reactions occur between these species and arene nucleophiles. NMR studies were done, and the results suggest the formation of an acyl group from the trifluoromethyl groups in the superacid. 相似文献
12.
Properties of responsible for biological activity tetrazoles are considered. Examples are given of active pharmaceutical ingredients of modern drugs containing the tetrazole ring in the molecular structure. New publications on the synthesis and investigations of biological activity of promising tetrazole-containing compounds are cited. 相似文献
13.
Cob(I) alamin ( 1(I) )-catalyzed reduction of the aldehyde 2 led to the two crystalline cyclopropanols 3 and 4 (see Scheme 2). The protolytic ring-opening starting from 3 produced the saturated aldehydes 6 and 7;8 was formed in traces only (see Scheme 3). The protolysis starting from 3 led, therefore, mainly to retention of configuration at the spiro C-atom ( 7 ); ring-opening with inversion was observed in traces only ( 8 ). Starting from 4 , the protolysis produced 9 and 7 ; the absence of 8 showed this protolysis to proceed 9 and 7 ; the absence of 8 showed this protolysis to proceed exclusively with inversion of configuration at the spiro center. Of the p-bromobenzoate 5 (cf. Scheme 2) the structure has been determined by X-ray analysis. 相似文献
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16.
A. P. Volovodenko R. E. Trifonov P. V. Plekhanov G. L. Rusinov D. G. Bresnev V. A. Ostrovskii 《Chemistry of Heterocyclic Compounds》2000,36(6):714-721
The first and second protonations of annelated azoloazines have been investigated quantitatively in aqueous solution. Compounds investigated were pyrazolo[1,5-a]pyrimidine (pKBH
– 0.03±0.02, pKBH
2+ –7.87±0.30), 1,2,4-triazolo[4,3-b]-1,2,4-triazine (pKBH
+ –0.04±0.02, pKBH
2+ –8.00±0.10), 1,2,4-triazolo[1,5-a]pyrimidine (pKBH
+ 0.21±0.03, pKBH
2+ –9.00±0.09) and its 6R derivatives (R=NO2, Br, Cl). The annelated azoloazines studied are weaker bases than their unannelated analogs. According to quantum chemical calculations (AM1), protonation of these heterocycles may occur both at the azole and the azine fragments of the molecule.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 816–824, June, 2000. 相似文献
17.
G. I. Koldobskii 《Russian Journal of Organic Chemistry》2006,42(4):469-486
The review summarizes the methods of functionalization of tetrazoles, which were reported from 2001 to mid 2005, and analyzes main strategies in the development of this field of tetrazole chemistry. 相似文献
18.
A. V. Fokin Yu. N. Studnev V. P. Stolyarov A. A. Mel'nikov 《Russian Chemical Bulletin》2000,49(5):949-951
(Difluoroamino)tetrazoles were obtained by direct fluorination of 5-aminotetrazoles with gaseous fluorine. Reactions of 2-(oxoalkyl)-
and 2-(hydroxyalkyl)tetrazoles with difluoroamine yielded [(difluoroamino)alkyl]tetrazoles.
Deceased
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 950–952, May, 2000. 相似文献
19.
20.
Mchedlov-Petrosyan N. O. Vodolazkaya N. A. Martynova V. P. Samoilov D. V. El'tsov A. V. 《Russian Journal of General Chemistry》2002,72(5):785-792
Ionization constants of thiofluorescein, 4-nitro-, 4,5-dinitro-, 2,4,5,7-tetrabromo-, and 2,4,5,7-tetraiodothiofluoresceins, and also of 4,5-dibromofluorescein and N-ethyl-4,5-dinitroazafluorescein in 50 wt % aqueous ethanol have been determined. The electronic absorption spectra of their ionic and molecular forms have been recorded and analyzed. The behavior of these dyes can be described in terms of the scheme of prototropic equilibria proposed previously for fluorescein and its halo derivatives. 相似文献