翼梗五味子的研究 V: 五脂素A1, A2, 表五脂A1和epischisandrone的结构

从四川宜宾产翼梗五味子的果实中分得七个四氢萘木脂素, 其中三个鉴定为: 恩施辛enshicine, 表恩施辛epienshicine和schisandrone, 其余四个均属新化合物, 命名为五脂素wnlignan A1, 五脂素A2, 表五脂素epiwnlignan A1和epischisandrone. 它们的结构(包括绝对构型)由光谱分析和化学转化为(+)-dimethylguaiacine和(-)-dimethylisoguaiacine而阐明. 四个新化合物皆有不同程度的体外抗癌活性.     

A new flavellagic acid derivative and phloroglucinol from Rhodomyrtus tomentosa

A new flavellagic acid derivative, 3,3',4,4'-tetra-O-methylflavellagic acid and six known compounds were isolated from the stems of Rhodomyrtus tomentosa while a new phloroglucinol, named rhodomyrtosone I, and six known compounds were isolated from the fruit. Their structures were elucidated by spectroscopic analyses as well as by comparisons with related compounds.     

Phlomisflavosides A and B, new flavonol bisglycosides from Phlomis spinidens

From the aerial parts of Phlomis spinidens, two new flavonol bisglycosides, phlomisflavosides A (1) and B (2), were isolated together with the known compounds, astragalin, isoquercitrin, lamiridoside, phlomoside A, shanzhiside methyl ester, 8-O-acetylshanzhiside methyl ester, phlorigidoside C, rodioloside (=salidroside), forsythoside B, citroside A and lariciresinol-4'-O-beta-D-glucoside. The structures of the new compounds were elucidated based on spectral and chemical evidence.     

Constituents of Zingiber aromaticum and their CYP3A4 and CYP2D6 inhibitory activity

A new sesquiterpene 2,9-humuladien-6-ol-8-one (1) was isolated from methanol extract of Zingiber aromaticum, along with 15 known compounds. The structures of the isolated compounds were elucidated on the basis of spectroscopic analyses. The isolated compounds were tested for their inhibitory activity on the metabolism mediated by cytochrome P450 3A4 (CYP3A4) and CYP2D6.     

A convenient one-step preparation of diaminonitrile compounds

A new method for preparation of diaminonitrile compounds is reported.In this method primary aliphatic diamine compounds were condensed with two equivalents of benzaldehyde and sodium cyanide in presence of an aqueous solution of sodium hydrogensulfite under mild conditions.This method provides an efficient,convenient and practical method for the syntheses of diaminonitrile compounds and the products are easily isolated.The prepared new compounds were characterized by elemental analysis,IR,NMR spectroscop...     

Two new meroterpenoids, penisimplicin A and B, isolated from Penicillium simplicissimum

In the course of our research for new antifungal agents, two new meroterpenoids, penisimplicin A (1) and B (2), were isolated from Penicillium simplicissimum. The absolute structures of 1 and 2 were established by spectroscopic and chemical investigation. Penisimplicin A (1) and B (2) are rare examples of D-ring seco-meroterpenoids. Since compounds 1 and 2 showed no antifungal activities, the isolation of the compounds with antifungal activity will be attempted.     

A New Alkyl Polyglycoside from Ardisia crispa

Chemistry of Natural Compounds - A new alkyl polyglycoside, together with two known compounds (2 and 3), was isolated from the roots of Ardisia crispa (Thunb.) A. DC. Structures of these compounds...     

A new triterpenoid saponin and a diterpene glucoside from the seeds of Orychophragmus violaceus

One new triterpenoid saponin orychoside A (1) and one new diterpene glucoside orychoside B (12), together with eleven known compounds, were isolated from the seeds of Orychophragmus violaceus. The structures of the new compounds were elucidated on the basis of spectroscopic analysis. The known compounds were identified by comparison with data reported in the literature. All compounds were tested for their cytotoxic activities against the HepG2 and A549 cell lines in vitro. The new compound 1 exhibited potent cytotoxicity against the two cell lines with IC₅₀ values of 7.13 and 8.77 μM, respectively. Compounds 2, 5, 8 and 9 were found to possess obvious cytotoxicity.     

Two New Metabolites,Epoxydine A and B,from Phoma sp.

The new compounds, epoxydines A and B ( 1 and 2 , resp.), along with the known and related metabolites, 3 – 6 , were isolated from the fungal endophyte Phoma sp. The structures of the new compounds were elucidated by detailed spectroscopic analysis, and the relative configuration of 1 was confirmed by ROESY experiments. Preliminary studies indicated that compounds 2 – 5 possess good antibacterial, antifungal, and algicidal properties. Similarly, compound 1 showed antifungal and algicidal, and compound 6 antibacterial and algicidal properties.     

A Mild and Efficient Oxidation of Alcohols in Water

A mild and efficient oxidation of alcohols to the corresponding carbonyl compounds using the PhI(OAc)2 (1.1 eq.) with n-Bu4NBr (8 mol %) in water at room temperature is described.This new procedure is very simple and affords the desired carbonyl compounds in high yields.     

A benzofuran glycoside and an acetylenic acid from the fungus Laetiporus sulphureus var. miniatus

A new benzofuran glycoside, masutakeside I (1) and a new C10 acetylenic acid, masutakic acid A (2) were isolated from the fruiting bodies of the fungus Laetiporus sulphureus var. miniatus. Their structures were established by spectroscopic and chemical methods. The known compounds 3-6 were also obtained and identified as egonol, demethoxyegonol, egonol glucoside and egonol gentiobioside. Some of these compounds exhibited cytotoxicity against Kato III cells.     

Kitungolides A, B, and C, new diterpenes from a soft coral of a new genus

Three novel compounds, designated kitungolides A (1), B (2), and C (3), were isolated from a soft coral of a new genus collected at Kitungamwe, Kenya. The three new compounds are of a unique heterotricyclic skeleton. The structures and relative stereochemistry of the compounds were elucidated by interpretation of MS, COSY, HMQC, HMBC, and NOESY experiments. [structure: see text]     

A new isorhamnetin glycoside and other phenolic compounds from Callianthemum taipaicum

A new flavonol glycoside together with five known phenolic compounds were isolated from the whole herb of Callianthemum taipaicum. The compounds were identified as isorhamnetin-3-O-α-L-arabinoside-7-O-β-D-glucoside (1), isorhamnetin-3-O-β-D-glucoside (2), dibutyl phthalate (3), (+)-1-hydroxylpinoresinol-4'-β-D-glucoside (4), pinoresinol-4'-O-β-D-glucoside (5) and 2-phenylethyl-β-primeveroside (6). Compound 1 was identified as a new flavonol glycoside. The compound 6 was isolated for the first time as natural product. All compounds were isolated for the first time from the Callianthemum genus. Furthermore, the 2D-NMR data of the four known compounds 2-5 are given for the first time in this paper. All the structures were identified on the basis of detailed spectral analysis. The compounds 1 and 4 exhibited certain antifungal activity.     

A New Cell for Single Sided Headspace Sampling and Evaluation of Barrier Function in Laminated Paperboard

A new cell for single sided headspace sampling has been developed for the analysis of volatile organic compounds from food packaging paperboard and laminated paperboard. The cell, which samples the volatile organic compounds over a selected surface, is useful for determining the barrier function of laminated paperboards with respect to volatile compounds. The analysis of volatile organic compounds is carried out by purge and trap capillary gas chromatography in combination with mass spectrometric detection and compound identification. The new sampling cell was constructed to facilitate specific analysis of organic compounds from only one side of a laminated paperboard. The construction and the operating principles of the new sampling device are described. The repeatability of the single sided headspace procedure was found to be quite good. Relative standard deviations of about 5–7% were obtained for the major compounds quantified in replicate headspace analyses of a laminated paperboard. The volatile compounds released from the inner side of a food packaging paperboard sample with different surface composition on the two sides were determined. The barrier function against volatile organic compounds of some laminated paperboards was investigated employing the new headspace cell.     

A new triterpenoid from roots of Laportea crenulata and its antifungal activity

A new triterpenoid 2alpha,3beta,21beta,23,28-penta hydroxyl 12-oleanene and two known compounds were isolated from the roots of Laportea crenulata Gaud. The structures of all compounds were elucidated on the basis of various spectroscopic data. The two known compounds beta-sitosterol and beta-sitosterol 3-beta-D-glucopyranoside are also the first report of isolation from this plant. The antifungal activity of new triterpenoid was studied against Aspergillus flavus, Aspergillus niger, Candida albicans, and Rhizopus aurizae, and compared with the activity of nystatin (30 microg disc(-1)). This compound has shown moderate activity against tested fungi.     

A novel benzofuran derivative, a new olean-type triterpene and other constituents from Ligularia odontomanes

A novel benzofuran derivative (R)-(+)-Ligulaodonin A (1) and a new olean-12-ene triterpene (5), as well as 10 known compounds were isolated from the whole plant of Ligularia odontomanes HAND.-MAZZ. The structures of the new compounds were determined by spectroscopic evidence, including IR, UV, EI-MS, positive HR-ESI-MS, 1D-NMR and 2D-NMR. The absolute configuration of 1 was elucidated on the basis of circular dichroism (CD) data.     

A new pentacyclic cucurbitane glucoside and a new triterpene from the fruits of Gymnopetalum integrifolium

A new pentacyclic cucurbitane glucoside, named aoibaclyin (1) and a new triterpene (2) have been isolated from the EtOH extract of the fruits of Gymnopetalum integrifolium Kurz (Cucurbitaceae), together with three known compounds, bryoamaride (3), 25-O-acetylbryoamaride (4) and beta-sitosterol 3-O-beta-D-glucopyranoside (5). The structures of these compounds were elucidated by spectroscopic analyses.     

First total synthesis of two new heterocyclic compounds:Bretschneiderazines A and B

Facile synthesis of the two new natural heterocyclic compounds bretschneiderazines A（2） and B（3）,isolated from an extract of the stems of Bretschneidera sinensis,is reported.We employed the cyclization reaction of benzamide by directed lithiation and sequential treatment with sulfur and phosgene as key steps.All new compounds have been fully characterized by means of IR,¹H NMR,¹³C NMR,and HRMS.     

Structure-based Design,Synthesis and Anti-influenza A Virus Activities of Substituted Phenyl-coupled Heterocyclic Ethylamide Derivatives

A series of new substituted phenyl-coupled heterocyclic ethylamide derivatives was designed and synthesized as anti-influenza agents. In vitro anti-influenza A(A/PR/8/34 H1N1 strain) activities of these compounds were investigated and compared to those of the commercial antiviral drugs(Arbidol and Ribavirin) against the influenza. Specifically, among these twelve compounds exhibiting moderate levels of antiviral activity against influenza A, compounds 30c and 30d are the most effective ones, and as efficacious as the positive control Ribavirin and much more effective than Ingavirin and Arbidol, indicating that they are prospective candidates for further exploration. These results are also consistent with the docking study results in terms of the design of compounds targeting influenza A via viral nucleoprotein.     

A new lignan and other constituents from Zanthoxylum armatum DC

A new lignan (1), named armatumin, along with 25 known compounds, was isolated from Zanthoxylum armatum. The structure of compound 1 was elucidated using spectroscopic methods. Compounds 7, 8, 11, 13, 16, 20 and 21 were first isolated from Z. armatum and compounds 14 and 19 were isolated for the first time from Rutaceae.