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1.
E. V. Rudyakova V. A. Savosik L. K. Papernaya A. I. Albanov I. T. Evstaf’eva G. G. Levkovskaya 《Russian Journal of Organic Chemistry》2009,45(7):1040-1044
1-, 3-, and 5-Alkylpyrazoles, as well as linearly bridged bis-pyrazoles, were converted into the corresponding 4-formyl derivatives by Vilsmeier-Haak reaction both under standard conditions and under microwave activation in DMF over a period of 10 min. 1,1′-(Hexane-1,6-diyl)bis(3,5-dimethyl-1H-pyrazole) and 1,1′-(benzene-1,4-diyldimethylene)bis(3,5-dimethyl-1H-pyrazole) gave rise to 4-formyl derivatives at both pyrazole rings. 5-Chloro-1,3-dialkyl-1H-pyrazoles failed to undergo formylation according to Vilsmeier-Haak or under microwave activation. 1,1′-Bridged bis-3,5-dimethyl-1H-pyrazoles reacted with 2-sulfanylethanol on heating in the presence of chloro(trimethyl)silane to give the corresponding bridged bis-4-(1,4,6-oxadithiocan-5-yl)-1H-pyrazoles. 相似文献
2.
A. N. Mirskova G. G. Levkovskaya O. P. Kolesnikova O. M. Perminova E. V. Rudyakova S. N. Adamovich 《Russian Chemical Bulletin》2010,59(12):2236-2246
A general method for the synthesis of 1-alkyl(allyl)(benzyl)-substituted (indol-3-yl)-sulfanylalkanecarboxylic acids and hexane-1,6-diyl(1,4-phenylenemethylene)bisindol-3-ylsulfanylalkanecarboxylic
acids from the corresponding N-substituted indoles and bisindoles, thiourea, iodine, and halogencarboxylic acids was developed.
The oxidation of substituted (indol-3-yl)sulfanylalkanecarboxylic acids for the first time afforded their analogs containing
the sulfonyl group. New (2-hydroxyethyl)ammonium salts of 1-R-indol-3-ylsulfanyl(sulfonyl)-alkanecarboxylic acids, which are
structural analogs of highly active immunomodulators of indacetamin and VILIM, were synthesized. Among the studied (2-hydroxyethyl)ammonium
salts of 1-R-indol-3-ylsulfanylacetic and -sulfonylalkanecarboxylic acids, the compounds exhibiting high dose-dependent antiproliferative
activity by the ability to affect the spontaneous and mitogen-stimulated splenocyte proliferation of mice in vitro were found. 相似文献
3.
V. L. Gein N. N. Kasimova Z. G. Aliev M. I. Vakhrin 《Russian Journal of Organic Chemistry》2010,46(6):875-883
The reactions of methyl 2,4-dioxo-4-phenylbutanoate and methyl 2,4-dioxopentanoate with a mixture of an aromatic aldehyde
and propane-1,2-diamine, depending on the initial reactant ratio, gave 4-acyl-1-(2-aminopropyl)-5-aryl-3-hydroxy-2,5-dihydro-1H-pyrrol-2-ones and 1,1′-(propane-1,2-diyl)bis(4-acetyl-3-hydroxy-5-phenyl-2,5-dihydro-1H-pyrrol-2-one). Reactions of substituted 1-(2-aminopropyl)-2,5-dihydro-1H-pyrrol-2-ones with aromatic amines and hydrazines were studied, and the structure of one of the products, 5-(2-aminopropyl)-3,4-diphenylpyrrolo[3,4-c]pyrazol-6-one, was proved by X-ray analysis. 相似文献
4.
《European Polymer Journal》2006,42(8):1786-1797
New aliphatic–aromatic α,ω-diols containing sulfur in aliphatic chain: 4,4′-(ethane-1,2-diyl)bis(benzenethioethanol) [EBTE], 4,4′-(ethane-1,2-diyl)bis(benzenethiopropanol) [EBTP], 4,4′-(ethane-1,2-diyl)bis(benzenethiohexanol) [EBTH], 4,4′-(ethane-1,2-diyl)bis(benzenethiodecanol) [EBTD], and 4,4′-(ethane-1,2-diyl)bis(benzenethioundecanol) [EBTU] were prepared by the condensation reaction of 4,4′-(ethane-1,2-diyl)bis(benzenethiol) with suitable halogen alcohols in aqueous sodium hydroxide solution. Thermoplastic nonsegmented polyurethanes containing sulfide linkages were synthesized from these diols, and hexane-1,6-diyl diisocyanate (HDI) or 4,4′-methylenediphenyl diisocyanate (MDI) by solution and melt polymerization. The reaction was carried out at 1:1 or 1.05:1 molar ratios of isocyanate and hydroxy groups in the presence of dibutyltin dilaurate as a catalyst.The structures of the diols were determined by using elemental analysis, FTIR and 1H NMR spectroscopy, and X-ray diffraction analysis. Thermal characteristics of the diols were determined by using differential scanning calorimetry (DSC). The polymers were studied to describe their structures and physicochemical, thermal (by DSC and thermogravimetric analysis) and tensile properties as well as Shore A/D hardness.All the polyurethanes possessed partially crystalline structures. Their melting temperatures were in the range of 94–179 °C (HDI) and 105–207 °C (MDI). The MDI-based polyurethanes showed higher tensile strengths, up to ∼50 MPa. 相似文献
5.
Pramod B. Pansuriya Hitesh M. Parekh Holger B. Friedrich Glenn E. M. Maguire 《Journal of Thermal Analysis and Calorimetry》2013,111(1):597-603
Bisthiourea derivatives 1,1′-(ethane-1,2-diyl)bis(3-phenylthiourea), 1,1′-(propane-1,3-diyl)bis(3-phenylthiourea), and 1,1′-(butane-1,4-diyl)bis(3-phenylthiourea) have been synthesized and characterized by IR, 1H NMR, and 13C NMR. Suitable crystals of 1,1′-(propane-1,3-diyl)bis(3-phenylthiourea) were grown for single-crystal X-ray analysis and from the data it was observed that they organize into the P-1 space group. The thermal decomposition of these compounds has been studied by TG–DSC. 相似文献
6.
F. Hamoud S. M. Ramsh V. S. Fundamenskii V. V. Gurzhii M. A. Brusina N. G. Arkhipova P. A. Sedunova N. L. Medvedskii E. S. Khrabrova 《Russian Journal of Organic Chemistry》2016,52(1):121-126
N,N′-Bis(hydroxymethyl)thiourea reacted with propane-1,3-diamine at a molar ratio of 2 : 1 to give 5,5′-propane-1,3-diylbis(1,3,5-triazinane-2-thione), whereas 1,3,5,7,11,13,15,17-octaazatricyclo[15.3.1.17,11]-docosane-4,14-dithione was obtained in the reaction with equimolar amounts of the reactants. Tricyclic product was also formed in the three-component condensation of thiourea with formaldehyde and propane-1,3-diamine at a ratio of 1 : 3 : 1. The reactions of N,N′-bis(hydroxymethyl)thiourea with ethane-1,2-diamine (2 : 1) and of thiourea with formaldehyde and butane-1,4-diamine (1 : 2 : 1) afforded 5,5′-(ethane-1,2-diyl)bis(1,3,5-triazinane-2-thione) and 5,5′-(butane-1,4-diyl)bis(1,3,5-triazinane-2-thione), respectively. 相似文献
7.
Nagavelli Vasudeva Reddy Sirassu Narsimha Lavudya Sudhakar Kumara Swamy Battula S K Althaf Hussain 《Phosphorus, sulfur, and silicon and the related elements》2016,191(8):1118-1122
Thirteen novel bis-1,2,3-triazole derivatives were synthesized under copper (I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition of N,N′-(hexane-1,6-diyl)bis(4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide) with different aryl azides and evaluated their biological activity. All the newly synthesized compounds were confirmed by 1H-NMR, infrared, and elemental analysis and mass spectral studies. The synthesized bis-1,2,3-triazoles were evaluated for their antioxidant activity, and some of them were found to exhibit good to excellent antioxidant activity (IC50: 11.13 ± 1.5 to 98.98 ± 1.7 μM) in comparison with standard references, Trolox (11.73 ± 1.5 μM) and ascorbic acid (3.34 ± 1.8 μM). The bistriazoles also exhibited excellent-to-moderate anti-bacterial activity (MIC: 2.253 to 75 µg mL?1 against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa when compared with streptomycin. N,N′-(hexane-1,6-diyl)bis(N-((1-(3,5-dimethylphenyl)-1H-1,2,3-triazol-4-yl)methyl)-4-methyl benzenesulfonamide) has completely cleaved the DNA at a concentration of 100 mg mL?1, and the remaining compounds have partially cleaved the DNA. 相似文献
8.
Racemic monomorine ( 12 ) is prepared in six steps in 26% overall yield from 2-butyl-1H-pyrrole and ethyl (E)-but-2-enoate by exploiting the rhodium(II)-acetate-catalyzed decomposition of (4RS)-4-(2′-butyl-1′ H-pyrrol-1′-yl)-1-diazopentan-2-one ( 7 ). 相似文献
9.
Synthesis of 3,3′-(1,6-hexanediyl)bis-pyrimidine derivatives and 3,4-dithia[6.6](1.3)pyrimidinophane
Toshio Kinoshita Shirou Odawara Keiko Fukumura Sunao Furukawa 《Journal of heterocyclic chemistry》1985,22(6):1573-1576
Several 3,3′-(1,6-hexanediyl)bis[6-methyl-2,4(1H,3H)-pyrimidinedione] derivatives ( 4a, 4b , and 4c ) were synthesized from 1,6-(hexanediyl)bis[6-methyl-2H-1,3-oxazine-2,4(3H)-dione] (3) . Compound 4c was converted to 6, which reacted with thiourea giving thiuronium salt 7 . 3,3′-(1,6-Hexanediyl)bis [1-(2-mercaptoethyl)-6-methyl-2,4(1H,3H)-pyrimidinedione] (9) was obtained by the hydrolysis of 7 , and then 9 was oxidized to 12,22-dimethyl-3,4-dithia[6.6] (1.3)-1,2,3,4-tetrahydro-2,4-dioxopyrimidinophane (10) . 相似文献
10.
Susanne Stockmann Jocelyn Bruce Jorn Miller Klaus R. Koch 《Acta Crystallographica. Section C, Structural Chemistry》2008,64(3):o166-o170
In the structures of 3,3,3′,3′‐tetraethyl‐1,1′‐(propane‐1,3‐diyldicarbonyl)bis(thiourea), C15H28N4O2S2, (I), 3,3,3′,3′‐tetraethyl‐1,1′‐(butane‐1,4‐diyldicarbonyl)bis(thiourea), C16H30N4O2S2, (II), and 3,3,3′,3′‐tetrabutyl‐1,1′‐(hexane‐1,6‐diyldicarbonyl)bis(thiourea), C26H50N4O2S2, (III), compound (I) displays resonance‐assisted hydrogen bonding, (II) exhibits an inversion centre, and both (II) and (III) are characterized by intermolecular hydrogen bonds between the carbonyl O atoms and thioamide H atoms, leading to chains of hydrogen‐bonded molecules throughout the structures. The accurate structural data for these molecules is expected to assist in molecular modelling and other studies currently in progress. 相似文献
11.
The reaction of 1H‐indol‐2,3‐diones with 1,6‐dibromohexane has resulted in the formation of new 1H‐indol‐2,3‐diones‐1,1′‐(1,6‐hexanediyl)bis in quantitative yields. These compounds have been used for the synthesis of novel [3′‐(2,3‐dimethyl‐5‐oxo‐1‐phenyl‐3‐pyrazolin‐4‐yl)spiro[3H‐indol‐3,2′‐thiazolidine]‐2,4′‐dione]‐1,1′‐(1,6‐hexanediyl)bis via bis Schiff's bases, [3‐(2,3‐dimethyl‐5‐oxo‐1‐phenyl‐3‐pyrazolin‐4‐yl) imino‐1H‐indol‐2‐one]‐1,1′‐(1,6‐hexanediyl)bis. 相似文献
12.
P. S. Silaichev Z. G. Aliev A. N. Maslivets 《Russian Journal of Organic Chemistry》2009,45(1):126-130
Isopropyl 2-(1-aryl-4,5-dioxo-2-phenyl-4,5-dihydro-1H-pyrrol-3-yl)-2-oxoacetates reacted with N-substituted 3-amino-5,5-dimethylcyclohex-2-en-1-ones to give the corresponding 1′-substituted (Z)-6′,6′-dimethyl-3-[phenyl(arylamino)methylidene]-6′,7′-dihydro-3H-spiro[furan-2,3′-indole]-2′,4,4′,5(1′H,5′H)-tetraones. The structure of 1′-benzyl-6′,6′-dimethyl-3-[(Z)-phenyl(phenylamino)methylidene]-6′,7′-dihydro-3Hspiro[furan-2,3′-indole]-2′,4,4′,5(1′H,5′H)-tetraone was proved by X-ray analysis. 相似文献
13.
I. B. Rozentsveig B. A. Shainyan E. V. Kondrashov E. V. Rudyakova G. N. Rozentsveig K. A. Chernyshev G. G. Levkovskaya 《Russian Journal of Organic Chemistry》2008,44(9):1332-1337
N-(2,2,2-Trichloroethylidene)arenesulfonamides react with 1H-pyrrole and 1-methyl-1H-pyrrole to give the corresponding N-[2,2,2-trichloro-1-(1H-pyrrol-2-yl)ethyl]arenesulfonamides. The reaction of N-(2,2,2-trichloroethylidene)trifluoromethanesulfonamide with pyrrole leads to a mixture of 2-mono-and 2,5-disubstituted pyrroles, whereas in the reaction with 1-methyl-1H-pyrrole only the 2-substituted compound is formed. N-(2,2-Dichloro-2-phenylethylidene)-4-methylbenzenesulfonamide reacts with 1H-pyrrole to form N-[2,2-dichloro-2-phenyl-1-(1H-pyrrol-2-yl)ethyl]-4-methylbenzenesulfonamide, and its reaction with 1-methyl-1H-pyrrole gives a mixture of 2-and 3-monosubstituted derivatives. The results of quantum-chemical calculations of the initial reactants and products indicate that the process is orbital-controlled. A good agreement is observed between the experimental data and theoretical conclusions concerning the dependence of the reaction regioselectivity on the nature of substituents in the electrophile molecule. 相似文献
14.
Alexander V. Stepakov Anna G. LarinaVitaly M. Boitsov Alexander P. MolchanovVladislav V. Gurzhiy Galina L. Starova 《Tetrahedron letters》2012,53(27):3411-3415
The reactions of unactivated bis(methylene)cyclopropanes with nitrones and nitrile oxides have been investigated. The 1,1-diaryl-2-isopropylidene-3-methylenecyclopropanes react with the C,N-diarylnitrones to give a mixture of 2,2-dimethyl-1,6-diaryl-3-(diarylmethylene)piperidin-4-ones and 5-methyl-1-aryl-1-(arylamino)-4-(diarylmethylene)hex-5-en-3-ones. 2,3-Dihydro-3-methylenepyridin-4(1H)-ones are obtained by reaction of 1,1-diaryl-2-isopropylidene-3-methylenecyclopropanes with nitrile oxides. 相似文献
15.
In this work, 3,3′-(((1E,1′E)-(H,12H-5,11-methanodibenzo[b,f][1,5]diazocine-2,8-diyl)bis(ethene-2,1-diyl))bis(1,1-dimethyl-1H-benzo[e]indole-3-ium-2,3-diyl))bis(propane-1-sulfonate) (1), 3,3’-(((1E,1′E)-(6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine-2,8-diyl)bis(ethene-2,1-diyl))bis(3,3-dimethyl-3H-indole-1-ium-2,1-diyl))bis(propane-1-sulfonate) (2), 2,2’-((1E,1′E)-(6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine-2,8-diyl)bis(ethene-2,1-diyl))bis(1,3,3-trimethyl-3H-indol-1-ium) iodide (3) and 2,2’-((1E,1′E)-(6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine-2,8-diyl)bis(ethene-2,1-diyl))bis(1,1,3-trimethyl-1H-benzo[e]indol-3-ium) iodide (4) were designed and synthesized by ethylene bridging of the N-substituted indolium salts and the Tröger’s Base (TB) framework. The probes exhibited a longer absorption and emission wavelength and the emission wavelength of them in dichloromethane (DCM) was more than 600 nm, performed a red fluorescence. All of the probes could work on the extreme acidic and the extreme alkaline environments and showed a good liner response in the working pH range. Especially, 2 and 4 were soluble in water and manifested a good pH sensing in a water system. Also, 1H NMR analysis illustrated how these dyes worked as the pH-sensitive fluorescence probes. In addition, they performed excellent reversibility, high selectivity and good photostability. 相似文献
16.
Raf Bussels 《Tetrahedron》2005,61(5):1167-1174
In a novel two- or three-step synthetic route, S-(1,4-phenylenebis(propane-2,2-diyl)) bis(N-methyldithiocarbamate) is reacted at low temperature with various alkyl chloroformates to form various S-tert-alkyl-N,N-alkoxycarbonylmethyl-dithiocarbamate RAFT agents. Also an alternative and novel synthetic route towards S-(1,4-phenylenebis(propane-2,2-diyl)) bis(N-methyldithiocarbamate), is proposed. 相似文献
17.
E. G. Mesropyan G. B. Ambartsumyan A. A. Avetisyan A. S. Galstyan I. R. Arutyunova 《Russian Journal of Organic Chemistry》2005,41(1):67-69
1-Phenoxy-3-piperidinopropan-2-ol, 1-(5-methyl-1,3-benzothiazol-2-ylsulfanyl)-3-phenoxypropan-2-ol, 1-(2-hydroxy-3-phenoxypropyl)azepan-2-one, 1,1′-(6-chloro-1,3-benzothiazol-2-ylimino)bis(3-phenoxypropan-2-ol), 1-(1,3-benzothiazol-2-ylsulfanyl)-3-phenoxypropan-2-ol, 1,1′-(piperazine-1,4-diyl)bis(3-phenoxypropan-2-ol), and 1,3-bis(2-hydroxy-3-phenoxypropyl)barbituric acid were synthesized by condensation of 1,2-epoxy-3-phenoxypropane with the corresponding amines and thiols.__________Translated from Zhurnal Organicheskoi Khimii, Vol. 41, No. 1, 2005, pp. 70–72.Original Russian Text Copyright © 2005 by Mesropyan, Ambartsumyan, Avetisyan, Galstyan, Arutyunova. 相似文献
18.
19.
N. A. Ivanova Z. R. Valiullina O. V. Shitikova E. G. Galkin D. V. Lyubetskii M. S. Miftakhov 《Russian Journal of Organic Chemistry》2006,42(10):1435-1439
Treatment of 2,3,5-trichloro-5-[(E)-2,3-diiodoprop-1-en-1-yl]-4,4-dimethoxycyclopent-2-en-1-one with SmI2 in THF gives 5,5′-[(1E,5E)-2,5-diiodohexa-1,5-diene-1,6-diyl]bis(2,3-dichloro-4,4-dimethoxycyclopent-2-en-1-one) and its meso form at a ratio of 3:1. 相似文献
20.
Zhi-Fang Fan Xin Xiao Yun-Qian Zhang Sai-Feng Xue Qian-Jiang Zhu Zhu Tao Gang Wei 《Journal of inclusion phenomena and macrocyclic chemistry》2011,71(3-4):577-581
A bromide salt of 2,2??-(hexane-1,6-diyl) diisoquinolinium (K6) was designed, synthesized and introduced to construct a novel framework induced by ??···?? stacking of 2,2??-(alkylene-1,??-diyl)diisoquinolinium from Q[6]-based pseudo-rotaxanes. The crystal structure of the compound revealed that the assembled framework based on the Q[6]-2,2??-(alkylene-1,6-diyl)diisoquinolinium pseudo-rotaxanes have stoichiometries of {(K6)@(Q[6])}2+·2Br?·7(H2O). The compound 1 has a novel three-dimensional framework constructed of two different channels?Done containing stacked isoquinolyl moieties from the K6@Q[6] pseudorotaxanes and the other containing the bromide anions. 1H NMR spectra analysis was performed and confirmed the pseudorotaxane interaction model in which the 2,2??-(alkylene-1,6-diyl)diisoquinolinium guest threads into the cavity of Q[6] with the alkyl chain included inside the cavity and the two end isoquinolyl moieties protruding from the two opening portals. Absorption spectrophotometric and fluorescence spectroscopic analyses of the host?Cguest inclusion complex in aqueous solution found that the complexes were most stable at a host:guest mole ratio of 1:1. At this ratio, the complex has binding constants (K) ~106. 相似文献