InCl_3·4H_2O Promoted Green Preparation of Xanthenedione Derivatives in Ionic Liquids

Xanthenediones derivatives have attracted considerable interests in recent times because they constitute a structural unit in a number of natural products1 and have been used as versatile synthons due to the inherent reactivity of the inbuilt pyran ring2. The conventional syntheses of xanthenediones were acid or base catalyzed condensation of appropriate active methylene carbonyl compounds with aldehydes3. However, many of these procedures involved longer reaction times, low yields and side re…     

An Efficient and Green Synthesis of 5-Oxo-5, 6, 7, 8-tetrahydro- 4H-benzo-[b]-pyran Derivatives Promoted by InCl_3·4H_2O Under Microwave Irradiation

Construction of tetrahydropyran rings has attracted a great deal of interests in organic synthesis in recent years1, since tetrahydropyran moiety constitutes a structural unit in a number of natural products2. In addition, tetrahydropyran derivatives possess wide range of biological activities and pharmacological properties, such as anticancer activity3 and antihypersensitivity4. Many methods for the preparation of such compounds have already been developed5. Among them, condensation of α, β…     

Multicomponent Reaction in Ionic Liquid： A Novel and Green Synthesis of 1, 4-Dihydropyridine Derivatives

1, 4-Dihydropyridine (DHP) heterocyclic ring is a common feature of various bioactivecompounds such as vasodilator, bronchodilator and antiatherosclerotic, antitumor, andantidiabetic agents1. Due to their important pharmacological activities, many methods…     

Reductive Cyclodimerization of Arylidenecyanoacetates Promoted by Sm/InCl_3·4H_2O System in Aqueous Media

Metal-mediated reactions in aqueous media have received considerable attention in the last decade1. Such aqueous reactions offer a number of advantages over conventional organometallic reactions in organic solvent in that they are practically convenient, environmentally benign and do not require strict anhydrous conditions2. In recent years, besides zinc and tin, indium has been found to be the metal of choice for promoting organic reactions in aqueous media3. Indium is considered to be mor…     

A Mild and Efficient Deprotection of Geminal Diacetates Catalyzed by FeCl3 ·6H2O in Ionic Liquid

The selective deprotection of geminal diacetates promoted by FeCl3·6H2O in the ionic liquid [bmim] [BF4] canbe efficiently achieved in good yields. The ionic liquid and the catalyst can be recycled easily and the process is car ried out under mild conditions.     

Synthesis of Tetrahydrofuran and Tetrahydropyran Derivatives Catalyzed by Tungstophosphoric Acid in Ionic Liquid

Synthesis of tetrahydrofuran and tetrahydropyran derivatives catalyzed by tungstophosphoric acid （H3PW12040） were conveniently performed with high yield from the corresponding unsaturated alcohols in ionic liquid. Sufuric acid （H2SO4）, trifluoromathanesulfonic acid （TfOH） and p-toluenesulfonic acid （TsOH） were also explored for preparing these products in ionic liquid. The catalysts and ionic liquid can be easily recovered and reused.     

Synthesis of 9-Arylpolyhydroacridine Promoted by Ionic Liquid Under Solvent-free Condition

3, 3, 6, 6-Tetramethyl-1, 8-dioxo-9-aryl-1, 2, 3, 4, 5, 6, 7, 8, 9, 10-decahydroacridines and their derivatives are polyfunctionalized 1, 4-dihydropyridine derivatives. In recent years, much attention has been focused directly on the synthesis of 1, 4-dih…     

A Novel Green Preparation of a, a''''-Bis (substituted benzylidene)-cycloalkanones Promoted by FeCl_3 6H-2O in Ionic Liquid

a, a'-Bis(substituted benzylidene)cycloalkanones were efficiently prepared from cycloalkanones and benzaldehydes in [bmim][BF4] by using iron(III) chloride hexahydrate as a catalyst. It is shown that [bmim][BF4] and iron(III) chloride hexahydrate can be quantitatively recovered and be reused effectively for many times. Compared with the known methods, this novel process has the advantage of being an envkonmentally benign process together with good yields and mild reaction conditions.     

Synthesis of the Cyclopentenylamine Derivatives Promoted by SmI2

The intermolecular reductive coupling of 1,1-diary1-2,2-drcyanoethylenes with cinnamic esters promoted by samarium( Ⅱ）iodide was studied.Functionalized cyclopentenylamine derivatives were prepared in good yields under neutral and mild conditions.     

BF_3·OEt_2 Promoted Solvent-free Synthesis of Benzimidazole Derivatives

Differently substituted benzimidazoles have been synthesized in very good yields in solvent-free conditions from o-phenylenediamine and aldehydes in the presence of BF3·OEt2 as a catalyst. The method is applicable to aromatic, unsaturated and aliphatic aldehydes and to substituted o-phenylenediamines without significant differences.     

Organic Reactions in Ionic Liquids： Ionic Liquid-promoted Efficient Synthesis of Disubstituted and Trisubstituted Thioureas Derivatives

In ionic liquid [Bmim][BF4], a series of disubstituted and trisubstituted thiourea derivatives were synthesized from phenyl and butyl isothiocyanate with a variety of amine in excellent yield.     

A New and Efficient Synthesis of Wedelolactone Derivatives

A new and facile method based on an intermolecular cycloaddition was described for the synthesis of wedelolactone derivatives.     

Heck Arylation of Cyclohexene Promoted by Ultrasonic and Micro wave in Ionic Liquid： a Novel Method of the Synthesis of 3-Naphthylcyclohexene

Palladium catalyzed arylation or vinylation of olefins by aryl halides are well known as the Mizoroki-Heck reaction and have proved to be of genuine synthetic utility for C-C bond formation1. Although a lot of progress has been made in Heck coupling react…     

Synthesis and Thermodynamic Properties of MgO·B_2O_3·4H_2O

ＩｎｔｒｏｄｕｃｔｉｏｎＴｈｅｒｅａｒｅｍａｎｙｋｉｎｄｓｏｆｍａｇｎｅｓｉｕｍｂｏｒａｔｅｓ ,ｂｏｔｈｎａｔｕｒａｌａｎｄｓｙｎｔｈｅｔｉｃ .Ａｂｏｒａｔｅｄｏｕｂｌｅｓａｌｔ (2ＭｇＯ·2Ｂ2 Ｏ3 ·ＭｇＣｌ2 · 14Ｈ2 Ｏ)ｎａｍｅｄｃｈｌｏｒｏｐｉｎｎｏｉｔｅｗａｓｏｂ ｔａｉｎｅｄｆｒｏｍｔｈｅｎａｔｕｒａｌｃｏｎｃｅｎｔｒａｔｅｄｓａｌｔｌａｋｅｂｒｉｎｅ .1Ｉｎｏｒｄｅｒｔｏｆｉｎｄｔｈｅｆｏｒｍｉｎｇｒｅｌａｔｉｏｎｂｅｔｗｅｅｎｔｈｅｄｏｕｂｌｅｓａｌｔａｎｄｍａｇｎｅｓｉｕｍ ｂｏｒａ…     

Zirconyl Chloride Promoted Highly Efficient Domino Synthesis of New 1, 2, 3, 4-Tetrahydroquinoline Derivatives in Water

The tetrahydroquinoline moiety is present in various natural products, and many tetra- hydroquinoline derivatives exhibit a broad range of biological activities1. Therefore, it has attracted continuous interest to develop methods for the synthesis of tetr…     

InCl_3·4H_2O Catalyzed Aldol Condensation of Cycloalkanones with Aromatic Aldehydes

a, a-Bis (substituted) benzylidenecycloalkanones are widely used as precursors for synthesis of bioactive pyrimidine derivatives and their synthesis have attracted considerable attention1. Aldol condensation of cyclopentanone or cyclohexanone with aldehydes is employed, and the reactions were carried out in the presence of strong acids or bases2. Recently, the application of metal ions as catalyst in this type of reaction has been reported3. For example, RuCl3 has been reported to be an exc…     

Room‐Temperature Ionic Liquid–Promoted Williamson's Synthesis of Ethers: A Facile Synthesis of Diaryloxymethanes

A simple and efficient method has been developed for the synthesis of phenolic ethers using room‐temperature ionic liquid, not only as solvent but also as promoter. Ionic liquid was recycled and subsequently reused without any loss of the product.     

Facile Synthesis of Ureas in Ionic Liquid

The urea functional group is of importance in a wide range of biological compounds such as enzyme inhibitors1 and pseudopeptides2. Substituted ureas are widely applied in fine chemical industry, especially pesticides3 and pharmaceuticals4. Many investigations have been made to search for an efficient and practical method to synthesize ureas. The typical procedure for the synthesis of ureas is treating isocyanates with primary or secondary amines in organic solvents5. In the presence of trans…     

Efficient and Green Method for the Synthesis of 1,5‐Benzodiazepine and Quinoxaline Derivatives in Water

Various 1,5‐benzodiazepine and quinoxaline derivatives have been synthesized in water with excellent yields using a catalytic amount of indium chloride at room temperature. This synthetic protocol is nontoxic, safe, and environmentally benign.     

An Efficient Solid-state Synthesis of 2-Thio-4-imidazolidinone Derivatives

In recent years increasingly intense interest has been directed towards the generation of small organic molecules by solid-state reactions, which has many advantages over conventional solution phase synthesis such as high efficiency and selectivity, easy separation and purification and environmental acceptability.