共查询到20条相似文献,搜索用时 15 毫秒
1.
Julien Rouleau Alexandre Korovitch Claude Lion Miryana Hémadi Nguyêt-Thanh Ha-Duong Jean-Michel El Hage Chahine Thierry Le Gall 《Tetrahedron》2013
Potential metal chelators containing one or several acyltetronic acid moieties were prepared from cyclic or acyclic amines and polyamines, and from bis(phenols) by reaction with 1–4 equiv of 3-bromoacetyltetronic acid in the presence of potassium carbonate. The affinity constants of the chelating agents for toxic metallic cations Cd2+, Cs+, and Pb2+ and for dimethylarsinic acid were measured, at pH 7.5 and 9.3. Compound 4, an acyclic triamine containing four acyltetronic moieties, was found to complex efficiently all the tested species. 相似文献
2.
Syntheses and properties of the iron bisphosphinoethane complexes FeH2(PP)2 and FeHCl(PP)2[PP?R2PCH2CH2CH2PR2, where R?Me (PP?DMPE), Et(PP?DEPE), and n-Pr (PP?DprPE)] are reported. The complexes can be formed by reduction of the corresponding dichlorides FeCl2(PP)2 with lithium aluminium hydride in THF solution provided that ethanol or more acidic reagents are not employed during the reaction work-up. The dihydrides are notably basic compounds and can be protonated reversibly by alcohols. The dihydrides exist as equilibrating mixtures of cis and trans isomers in solution. The cis isomers of each of the dihydrides are fluxional on the NMR timescale and NMR studies indicate that the interconversion of cis isomers does not necessarily proceed via the trans isomer. 相似文献
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Mitsunori Oda Kazutaka Ogura Sayaka Kishi Kunihide Fujimori Noritaka Abe 《Tetrahedron letters》2007,48(26):4471-4475
The title azaazulene 3 was synthesized either by reaction of tropone with N-{(2-pyridyl)acetyl}pyridinium iodide in the presence of ammonium acetate or by palladium-catalyzed cross-coupling between 2-halo-1-azaazulene and 2-substituted pyridine. The compound shows relatively stronger basicity compared with 2,2′-bipyridyl. While 3 showed no emission from the S1 state but from the S2 state like azulene does, the protonated species of 3 exhibited emission from the S1 state. Cationic metal-dependent absorption and emission relating to complexation were also studied. 相似文献
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Pier Luigi Ferrarini Claudio Mori Giuliana Biagi Oreste Livi Imperio Tonetti 《Journal of heterocyclic chemistry》1984,21(2):417-419
Some 1,8-naphthyridine nitrogen mustards have been synthesized for studies of their antitumor potentialities. All the tested intermediate and target compounds are devoid of antitumor properties. 相似文献
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Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents
Ying Meng Guan Wang Yue Li Kuan Hou Yue Yuan Li-Juan Zhang Hong-Rui Song Wei Shi 《中国化学快报》2013,24(7):619-621
A series of pyrrolo[1,2-a]pyrazinone compounds(5a-9f) were synthesized,and their cytotoxic activity against SKOV-3,A549.HeLa cells in vitro were evaluated by the MTT method.Some of the compounds showed potential antitumor activity against three tumor cell lines.Among them,compounds 9c and 9d showed the most potent cytotoxic activity.The preliminary mechanism of action was discussed. 相似文献
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A novel ligand: 4,4′-bis(8-hydroxyquinoline-5-propenyl)-biphenyl (B8QPB) (1), has been synthesized by Witting-Horner reaction, and the corresponding two polymeric metal complexes were also prepared by polynuclear of the ligand with aluminium (III) (2) and zinc (II) (3) halides, respectively. The structure of the ligand was characterized by 1H NMR, FT-IR and elemental analysis techniques; polymeric metal complexes were characterized by FT-IR, UV-vis, elemental analysis techniques, conductivity measurements and gel permeation chromatography (GPC). The results indicate that the stoichiometry of polymeric metal complexes is [(C34H24O2N2)11Al12Cl28] and [(C34H24O2N2)32(ZnCl2)33]. B8QPB coordinated with metal ions to form polymers. The luminescence properties of the complexes 1-3 were investigated by UV-vis and fluorescence spectra at room temperature. The experimental results show that polymeric metal complexes 2 and 3 emit blue/green luminescence at 514 and 504 nm in the solid state and at 470 and 507 nm in DMSO solution. Thermal properties measurement and analysis show that they have good thermal stabilities. 相似文献
7.
A series of Andro derivatives were described and evaluated for their anti-HIV activity in vitro.Compound 10 and 16b,of which TI were>10,had some anti-HTV-l activity in vitro.Therein,compound 10 which was the best potent compound,could serve as a new lead for further development of anti-AIDS agents. 相似文献
8.
Masatoshi Oue Akira Ishigaki Keiichi Kimura Yousuke Matsui Toshiyuki Shono 《Journal of polymer science. Part A, Polymer chemistry》1985,23(7):2033-2042
Poly- and bis(thiacrown ether) derivatives in which some oxygen atoms of benzocrown ether moiety are replaced by sulfur atoms have been synthesized. Their cation-binding abilities were investigated by using the solvent extraction method. The poly- and bis(benzothiacrown ether)s showed great affinity for silver ion, being more excellent in the affinity than the corresponding monocyclic analogs. They, however, possess very poor cation-binding ability for alkali and alkaline-earth metal ions. The poly- and bis(thiacrown ether)s also bind mercuric ions effectively, whereas the corresponding monomeric analogs do not at all. 相似文献
9.
S.K. Vasisht Tripat P. Kaur Jyotsna Kaushal Seema Dixit 《Journal of organometallic chemistry》1997,540(1-2):51-54
Sodium bis(trimethylstannyl)amide NaN(SnMe3)2, isolated by the reaction of trimethylstannyldiethylamine with sodium amide, reacts with tris(trimethylsilyl)hydrazino—dichloro-phosphine to form bis(trimethylsilyl)bis(trimethylstannyl)-2-phospha-2-tetrazene, (Me3Si)2N-N=P-N(SnMe3)2. Both the molecules have been isolated and characterized. 相似文献
10.
Chen Li 《European Polymer Journal》2003,39(6):1091-1097
Two series of new high fluorescent polymeric materials based on copoly(styrene-maleic anhydride) (SMA) were prepared by the condensation of SMA with fluorescent groups. One series consists of 1,8-naphthalimides derivatives that are linked with SMA. The other series were prepared by the condensation of SMA with 3,4,9,10-perylene tetracarboxylic mono-anhydride mono-imide. These simple routes to copolymer of styrene and maleic anhydride containing pendent luminescent moiety are promising in increasing fluorescent quantum yield in solid state and processing, in which styrene is employed as “diluents”. The luminescent and the preliminary photovoltaic properties of these copolymers have been investigated. 相似文献
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Synthesis and preliminary cytotoxic evaluation of substituted indoles as potential anticancer agents
Chang Qing Shi Zhang Qin Liu Wen Qing Lin Yuan Wei Chen 《中国化学快报》2007,18(8):899-901
A variety of indole derivatives were designed,synthesized and preliminarily evaluated for their in vitro cytotoxic activity in the A431 and H460 cell lines.All the compounds examined conferred unusual potency in a tumor cell cytotoxicity assay.The findings showed the indole derivatives would be a promising candidate for the development of new anticancer agents. 相似文献
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《Journal of Coordination Chemistry》2012,65(24):3922-3933
Complexes of Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) with diacetyl benzaldehyde oxalic acid dihydrazone (dbodh), CH3COC(CH3)=NNHCOCONHN=CHC6H5 and diacetyl benzaldehyde malonic acid dihydrazone (dbmdh), CH3COC(CH3)=NNHCOCH2CONHN=CHC6H5 of general composition [M(dbodh)Cl]Cl and [M(dbmdh)Cl]Cl were synthesized and characterized by microanalyses, molar conductance, magnetic susceptibility, UV–Vis, ESR and IR spectra and X-ray diffraction studies. The complexes are 1 : 1 electrolytes in DMF and are insoluble in water and common organic solvents. The dbodh and dbmdh are neutral tridentate ligands in most complexes and coordinate via one >C=O and two >C=N–groups. In Cu(II) complexes the ligands are pentadentate coordinating through three >C=O and two >C=N–groups. The magnetic moment values and UV–Vis spectra suggest square-planar geometry for Co(II) and Ni(II) complexes and distorted octahedron for both Cu(II) complexes. The ESR spectra of Cu(II) complexes show well-defined copper hyperfine lines in DMSO solution at 120 K and exhibit d x 2 ?y 2 as the ground state. The X-ray diffraction parameters for [Ni(dbodh)Cl]Cl and [Co(dbmdh)Cl]Cl correspond to a tetragonal crystal lattice. The complexes show significant antifungal activity against Alternaria sp., Curvularia sp. and Colletotrichum sp. and fair antibacterial activity against Bacillus subtilis and Pseudomonas fluorescence. 相似文献
16.
The thermally unstable compounds Hg(CN)P(CF(3))(2) and Hg[P(CF(3))(2)](2) were obtained by reactions of mercury cyanide and bis(trifluoromethyl)phosphane in solution and characterized by multinuclear NMR spectroscopy. An increase in thermal stability is observed when the products form 18 valence electron complexes. The compounds [Hg(P(CF(3))(2))(2)(dppe)] (dppe = 1,2-bis(diphenylphosphanyl)ethane) and [Hg(P(CF(3))(2))(2)(Me(3)P)(2)] have been isolated in almost quantitative yield by reacting [Hg(CN)(2)(dppe)] or [Hg(CN)(2)(Me(3)P)(2)] with HP(CF(3))(2). [Hg(P(CF(3))(2))(2)(dppe)] crystallizes in the triclinic space group P1. The mercury atom is coordinated in a distorted tetrahedral fashion. The Hg-P(CF(3))(2) bonds, ca. 250 pm, are significantly longer than those of the mercury bis(phosphanides) Hg(PR(2))(2) with R = t-Bu, 245 pm, or SiMe(3), 241 pm. These easily accessible compounds [Hg(P(CF(3))(2))(2)(dppe)] and [Hg(P(CF(3))(2))(2)(Me(3)P)(2)] act as nucleophilic bis(trifluoromethyl)phosphane group transfer reagents. 相似文献
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Erfang Huang Lan Zhang Chuying Xiao Guangpeng Meng Bingqi Zhang Jianshu Hu David Chi-Cheong Wan Qingguo Meng Zhe Jin Chun Hu 《中国化学快报》1990,30(12):2157-2159
A novel series of indole-3-carboxamide derivatives (6a-6l) have been designed, synthesized and evaluated for their antioxidant activity against human neuroblastoma SH-SY5Y cell line using H2O2 radical scavenging assay. Biological activity evaluation showed that compounds 6a, 6f and 6i exhibited significant in vitro activities, which could have the potential to be developed for novel antioxidants. 相似文献
19.
Ya. N. Kreitsberga R. S. Medne A. S. édzhinya M. V. Petrova O. Ya. Neiland 《Chemistry of Heterocyclic Compounds》1986,22(11):1186-1189
A method was developed for the preparation of bis(vinylenedithio)- and bis(dimethylvinylenedithio)tetrathiafulvalenes from 1,3-dithiole-2-thione-4,5-dithiolate.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1470–1473, November, 1986. 相似文献
20.
Giovanni B. Giovenzana Claudia Guanci Silvia Demattio Luciano Lattuada Veronica Vincenzi 《Tetrahedron》2014
Bifunctional chelating agents (BFCAs) are small molecules containing a chelating unit, able to strongly coordinate a metal ion, and a reactive functional group, devised to form a stable covalent bond with another molecule. BFCAs are widely employed since their conjugation to a suitable biomolecule (e.g., a peptide or an antibody) allows the synthesis of diagnostic or therapeutic agents that specifically target diseased tissue with metals or radiometals. For this reason, BFCAs find application in diagnostic imaging, molecular imaging, and radiotherapy of cancer. The synthesis of new BFCAs based on a diethylenetriaminepentaacetic acid (DTPA) structure in which one or two carboxylic groups are replaced with phosphonic units is described. The phosphonic group, aside from being a classical isostere of the carboxylic acid in coordination chemistry, allows to modulate the physico-chemical properties of the ligands and of the corresponding complexes. 相似文献