桥链七甲川菁的合成及光性能

菁是一种具有多功能用途的染料,除用作卤化银感光材料及有机光导材料的光谱增感剂、光记录材料中记录介质外,还可作为染料激光器中用的激光染料.我们曾合成了四甲川苯乙烯菁、五甲川(艹粦)及五甲川吡喃鎓等红外染料作为激光染料,测定了它们的光性能.本文合成了具有桥链的七甲川菁,研究了这些桥链七甲川菁的吸收光谱及荧光光谱,并以YAG激光倍频(532nm)作泵浦源,测定了它们的激光调谐范围、中心波长及激光转换效率.     

一种选择性检测肼的近红外荧光增强型探针的合成与表征

本文以2,3,3-三甲基-3H-吲哚与正丙基溴为原料合成季铵盐2;2与2-氯-3-羟次甲基环己烯醛缩合生成吲哚七甲川菁染料3;3与4-乙基间苯二酚在三乙胺催化下反应生成半花菁染料4;4与乙酰氯经成酯反应生成半菁类探针5。目标物5的结构经¹H NMR、 ¹³C NMR和HR-MS(ESI)表征。该探针作为荧光增强型近红外探针,可以定量检测肼,并且对肼具有良好的选择性。      

含吡喃鎓端基的苯乙烯染料合成及电子吸收光谱

多甲川染料已广泛用于银盐感光材料、电子照相、染料激光器、光记录介质及太阳能转换体系等方面。其中苯乙烯多甲川染料具有宽的吸收光谱,引起人们的重视。我们曾合成了含吡喃鎓多甲川染料,它们与含氮杂环的多甲川染料相比,吸收波长红移,并具有极好的光化学稳定性。本文合成了含吡喃鎓端基的二甲川及四甲川苯乙烯染料,测定了电子吸收光谱。     

吲哚七甲川类荧光探针在生物体应用的研究现状

菁染料是一种商品化的近红外荧光染料, 其光谱范围位于近红外区域, 此光谱区域内生物基体光吸收或荧光强度较小, 因此利用菁染料对生物体进行成像, 可以降低背景干扰. 吲哚七甲川菁染料是一类具有代表性的菁染料, 其由吲哚杂环、七甲川链和N-取代基侧链组成, 由于具有溶解性好, 最大吸收波长可调, 摩尔消光系数大等优良的光学性质, 被广泛用于肿瘤靶向治疗、蛋白标记、痕量金属离子检测等生物方面. 以吲哚七甲川为母体, 通过向母体中引入活性基团或改变它们的结构, 使探针具有不同的功能, 这已成为生物领域荧光成像的研究热点. 分别从检测金属阳离子、pH变化、小分子和靶向标记肿瘤细胞、蛋白质等方面综述了近年来用于生物体荧光成像的吲哚七甲川类荧光探针的研究进展, 其中也对荧光探针在生物体内(模型)分布、光学成像及代谢方面进行了介绍, 最后讨论了这类荧光探针存在的问题及发展趋势.     

甲川链修饰菁染料的合成研究进展

在小分子荧光探针中,菁染料由于其良好的光学特性,在成像及生物传感等领域具有广泛应用.甲川链的功能化可以显著提高染料的稳定性并改变其光物理性能和生物选择性,已成为近年来菁染料结构修饰的热点.总结了甲川链修饰菁染料的合成方法,根据甲川链取代基的不同来源,按照甲川链不同长度对甲川链修饰菁染料的研究进展分别进行综述.     

半花菁染料用于分子影像的研究进展

分子影像广泛用于基本的生物学过程研究,众多疾病诊断、治疗策略设计以及疗效评估.半花菁染料具有良好的光物理性质、生物相容性和对生物系统的低毒性,是一种比较理想的生物成像试剂.近年来,出现了大量基于半花菁染料的探针用于分子成像的研究工作.该文系统地介绍了基于半花菁染料的探针用于荧光和多模态成像的研究进展,详细地介绍了这些可...     

水溶性七甲川吲哚菁染料的合成及其在含CTAB溶液中的光谱研究

本文合成并表征了一种水溶性七甲川吲哚菁染料,测试了染料在不同溶剂和不同浓度的表面活性剂十六烷基三甲基溴化铵(CTAB)中的吸收和荧光光谱性质.结果表明:染料的最大吸收和荧光发射光谱值(乙醇中)分别是796nm和813nm.随着溶剂的黏度增大,染料的荧光强度逐渐减弱.CTAB形成胶束前,随着CTAB浓度的增大,染料的吸收...     

双炔酸多层LB膜的光敏聚合研究

选用(口恶)花菁染料为光敏剂,将其镶嵌到双炔酸LB膜中,利用Ar~+离子激光514.5 nm照射LB膜,观察到双炔酸LB膜的光敏聚合及(口恶)花菁染料荧光的猝灭,对其光敏聚合机理进行了讨论。     

新型中位取代七甲川菁染料的合成及光稳定性研究

本文合成了两种新型中位取代近红外七甲川菁染料,采用核磁1 HN-MR和HRMS质谱对其结构进行了表征.并测试了染料在不同溶剂中的吸收光谱和荧光发射光谱性质.染料3b、3c在甲醇中的最大吸收波长和最大荧光发射波长分别为677/790nm和647/786nm,斯托克斯位移分别为113 nm、139nm.经过光降解实验测试得到3种染料3a—3c在乙醇中的光降解速率常数分别为1.21×10-3 mol/min、1.81×10-3 mol/min和2.14×10-3 mol/min.循环伏安法测得染料3a—3c的氧化电位分别在0.729V、0.624V和0.598V.光降解实验表明:七甲川菁染料中位亚甲基链上吸电基取代增强染料光稳定性,供电基取代减弱染料的光稳定性;供-吸电子能力强弱决定了染料的光稳定性强弱;同时中位氯原子取代与共轭链上的氢键作用有利于染料的稳定性增强,中位氮原子取代无法形成很好的氢键作用,不利于染料稳定性的提高.     

γ-谷氨酰转移酶近红外比率型荧光探针的设计与成像

γ-谷氨酰转肽酶(GGT)在诸多肿瘤组织中高表达,是一种重要的肿瘤标志物,对其活性的准确检测有助于相关疾病的早期诊断与治疗.本文将谷胱甘肽(GSH)共价修饰于七甲川花菁染料上作为GGT的酶切位点,研制了一例可用于GGT活性检测的近红外比率型荧光探针(Cy-GGT).该探针具有良好的水溶性,向其溶液中加入GGT,荧光发射波长由808 nm蓝移至616 nm (蓝移192 nm).较大的发射位移可避免两个信号之间的串扰,提高检测的准确性.实验表明,探针Cy-GGT可特异性检测GGT活性,检测限为0.02 mU/mL,并可用于活细胞和动物体中GGT的活性检测和荧光成像,能够区分肿瘤细胞与正常细胞,有望在相关疾病的早期诊断与治疗中发挥积极作用.     

蓝光有机存储染料研究进展

近年来,蓝光有机存储染料作为超高密度存储技术的核心已经日益受到人们的广泛关注,出现了与之相关的大量专利文献报道.本文介绍了卟啉染料、偶氮染料、菁染料、芪类染料和香豆素衍生物染料等蓝光染料的合成及应用,并对蓝光有机存储染料的发展趋势作了展望.     

Synthesis and Application of 2-Arylazo-3-Cyano Thieno [2,3-b]Naphthoquinones

The paper describes the synthesis of 2-amino-3-cyanothieno[2,3-b]naphthoquinone and its utilisation to prepare range of azo disperse dyes. These novel arylazo dyes were studied with respect to their color and constitution relationship. Application of these dyes on polyester fibres and their fastness properties were stated. These dyes were characterised by PMR, IR and visible absorption spectra.     

Polyurethanes as polymerizable dyes for hydrophobic polyester fabric

The present invention is to provide a novel benzothiazole-type polymerizable dye containing a urethane bond. A series of monomeric dyes have been prepared by diazotization of various 2-aminobenzothiiazole and coupled with Resorcinol. The polymeric dyes have been prepared by polycondensation of monomeric dyes with hexamethylene diisocyanate (HMDI), and they are characterized by molecular weight, non-aqueous conductometric titration, thermogravimetry analysis, IR, visible spectroscopy, and elemental analysis. The monomeric dyes have also been characterized by elemental analysis and IR spectra. The purity of all the dyes have been checked by thin layer chromatography, and their dyeing performance on nylon and polyester was assessed. The dyeing on polyester fiber had yellow, orange and pink shades with moderate to good light and wash fastness. Polymerizations of monomeric dyes with HMDI on dyed polyester have also been carried out. Color and dyeability of the polymeric dyes have been discussed by comparing them with their corresponding monomeric dyes. The percentage dye bath exhaustion and fixation on fiber have been found to be from good to very good. The dyeing of monomeric dyes showed very good color fastness properties, and their corresponding polymeric dyes showed excellent fastness to light, washing, perspiration, solvent resistance, and sublimation.     

Bright,Color-Tunable Fluorescent Dyes in the Vis/NIR Region: Establishment of New “Tailor-Made” Multicolor Fluorophores Based on Borondipyrromethene

A new series of high-performance fluorophores named Keio Fluors (KFL), which are based on borondipyrromethene (BODIPY), are reported. The KFL dyes cover a wide spectral range from the yellow (547 nm) to the near-infrared (NIR, 738 nm) region, and their emission wavelength could be easily and subtly controlled based on simple molecular modifications only, without losing their optical properties. This “tailor-made” synthetic strategy for tuning the emission wavelength enabled the creation of fourteen KFL dyes with well-controlled emission colors (yellow, orange, red, far-red, and NIR). Moreover, these KFL dyes also retain their excellent optical properties, such as spectral bands sharper than quantum dots, high extinction coefficients (140 000–316 000 M ⁻¹ cm⁻¹), and high quantum yields (0.56–0.98), without any critical solvent polarity dependent decrease of their brightness. These advantageous characteristics make the KFL dyes potentially useful as new candidates of fluorescent standard dyes to substitute or to complement existing long-wavelength fluorescent dyes, such as cyanines, oxazines, rhodamines, or other BODIPY dyes.     

Bischromophoric styrylpyridinium dyes. Spectroscopic properties of 1,3-bis-[4-(p-N,N-dialkylaminostyryl)pyridinyl]propane dibromides

The photophysical properties of newly synthesized bischromophoric solvatochromic stilbazolium dyes, 1,3-bis-[4-(p-N,N-dialkylaminostyryl)pyridinyl]propane dibromides (C1-C9), were studied in a series of solvents and their spectroscopic properties were compared with structurally related, monochromophoric styrylpyridinium dyes (SP1-SP9). The position of the UV-vis absorption spectra maximum of novel dyes is only slightly solvent polarity dependent in contrast to the fluorescence spectra that show pronounced solvatochromic effect demonstrated by a large Stokes shifts. The influence of the solvent on absorption and emission spectra, and the solvatochromic properties observed for both ground and first excited states for all the dyes were used for the evaluation of their excited state dipole moments. The ground state dipole moments of both mono- and bischromophoric dyes were established by applying ab initio calculations. The calculations and measurements unexpectedly show that the bischromophoric dyes are characterized by ground state dipole moments being equal to about half of that characterizing their monomeric equivalents, while the excited state dipole moments of bischromophoric dyes are about 10-25% higher in comparison to their monomeric equivalents.     

近红外荧光探针及其在生物分析中的应用进展

本文评述了自1999年以来近红外荧光探针和标记试剂及其在生物分析中的应用进展。包括:菁染料、噻嗪和噁嗪染料、含四吡咯基团染料(酞菁和卟啉)、罗丹明类、BODIPY、稀土离子配合物和量子点等。描述了它们在荧光测定和毛细管分离荧光检测以及免疫荧光分析方面的应用。引用文献75篇。     

Synthesis of pH-activatable red fluorescent BODIPY dyes with distinct functionalities

A series of tunable pH-dependent BODIPY dyes were synthesized and further functionalized in a Knoevenagel condensation reaction with various aldehydes. In this fashion, monofunctional dyes containing an alkyne, azide, or carboxylic acid (masked as its methyl ester) as ligation sites as well as asymmetrical bifunctional dyes were obtained, without compromising their pH-dependency. In addition, fluorescence excitation and emission maxima for these dyes were shown to be significantly red-shifted in comparison to their tetramethyl precursors.     

新型水溶性荧光标示剂吲哚方酸菁染料的合成及光谱性能

用方酸与不同的N烷基取代吲哚啉季铵盐缩合制备了一系列对称的水溶性方酸菁染料. 通过核磁共振氢谱和质谱对合成的染料结构进行了表征, 研究了它们在不同溶剂中的吸收和发射光谱. 结果表明, 随着溶剂极性的增大, 染料的吸收光谱发生蓝移, 表现为负向溶剂化效应, 在极性溶剂中的荧光量子产率比在水中的大. 考察了N位取代基对染料水溶液光稳定性的影响, 结果表明在吲哚环N原子上引入较大的苄基有助于提高光稳定性, 且随着苄基上取代基吸电子能力的增强, 染料的光稳定性增强.     

Synthesis,Absorption Spectra Studies and Biological Activity of Some Novel Conjugated Dyes

Novel monomethine 2a‐f , dimethine 4a‐f and tetramethine 6a‐h cyanine dyes were prepared as conjugated dyes. Such dyes incorporating coumarin and/or quinoline derivatives 1a‐d . These dyes were synthesized to study their spectral behavior, solvatochromism and biological activity. These dyes are characterized by elemental analysis, IR, ¹H NMR and mass‐spectra.     

SYNTHESIS AND APPLICATION OF 2-(ARYLAZO)-8-NITRONAPHTHO[1,2-d] THIAZOLE DISPERSE DYES

Abstract

The paper describes the synthesis of 2-amino-8-nitronaphtho[1,2d]thiazole and its utilization to prepare a range of heterocyclic azo disperse dyes. These arylazo dyes were studied with respect to their color and constitution relationship. These dyes were applied on polyester fibre and their fastness properties were evaluated.