Two New Eremophilane Sesquiterpenes from Cacalia ainsliaeflora

The root of C. ainsliaeflora has been used for curing pellagra, rheumatismal edema and insecticide1. In this paper, we report the structure elucidation of two new eremophilane sesquiterpenes (1, 2) from the roots of C. ainsliaeflora. Compound 1, colorless gum, [(]: -50 (c 0.50, CHCl3). HRESI-MS showed [M+H]+ at m/z 377.19528 (calcd for C21H29O6 377.19587), corresponding to a molecular formula C21H28O6. Its IR bands (1655, 1717, 1750cm-1) and UV absorptions (221 nm) displayed the typi…     

Two New Bisabolane Sesquiterpenes from Leontopodium longifolium

Leontopodium longifolium (Compositae) have long been used as folk medicine in China for releasing a cough, expectorant and treatment of bronchitis1,2. The chemical constituents of the Leontopodium longifolium were not reported so far. Here we report the s…     

Two New Sesquiterpenes from Ligularia macrophylla

Two new eremophilane sesquiterpenes, 15β-formic ether-6-oxo-furanoeremophilane （1） and 6α, 15β-epoxy eremophila-7（11）-en-8α, 12-olide （2） were isolation from the roots of Ligularia macrophylla. Their structures were deduced from spectroscopic methods and 2D NMR experiments.     

Two New Sesquiterpenes from Inula salsoloides and Their Inhibitory Activities against NO Production

Two new sesquiterpenes, inulasalene ( 1 ) and inulasalsolide B ( 2 ), as well as 22 known compounds were isolated from the aerial parts of Inula salsoloides. The structures of the new sesquiterpenes were determined on the basis of their spectroscopic data and chemical properties. Compounds 1 – 4 exhibited potent inhibitory activities against NO production with IC₅₀ values range of 0.010–1.290 μg/ml in lipopolysaccharide (LPS)‐stimulated RAW264.7 cells.     

Two New Sesquiterpenes from Euonymus nanoides

Two new dihydroagarofuran sesquiterpenes with a novel substitution pattern:1α-(α-methyl)-butanoyl-2α,15-diacetoxy-4β-hydroxy-9β-(β-)furancarboxy-β-dihydroagarofuran (1) and 1α,2α-di-(α-methyl)-butanoyl-4β-hydroxy-9β-(β-)furancarboxy-15-acetoxy-β-dihydro-agaro-furan (2) were isolated from Euonymus nanoides. Their structures were elucidated by means of ^1H and ^13C NMR spectroscopic studies, including 2D NMR technique.     

Two New Sesquiterpenes from Ligularia veitchiana

A new furanoeremophilane and a new eudesmane were isolated from the roots of Ligularia veitchiana .Their structures were elucidated as 1 β,10β-epoxy-6β-isobutyryloxy-9-oxo-furanoeremophilane and 8α-hydroxy-4(15),11-eudesmadiene by spectroscopic methods.     

Two New Sesquiterpenes from Eupatorium lindleyanum

Various germacrane sesquiterpenes have been isolated from many species of the Eupatorium.In recent years these compounds have been increasing interest due to their insecticidal,cytotoxic,antitumor-promoting and insect-antifeedant activities1.In our present study,we have investigated the chemical constituents of Eupatorium lindleyanum DC.,which is a geo-authentic medicine of Jiangsu province.It is used as a antipyretic drug.Two novel germacrane sesquiterpenes(Figure1)were found by us from th…     

Two New Eremophilenolides from Cacalia ainsliaeflora

Two new eremophilenolides(3β-angeloyloxy-8β,10β-dihydroxy-6β-ethoxyeremophile-nolide(1)and 3β,6β-diangeloyloxy-8α-methoxy-10α-hydroxyeremophilenolide(2)were isolated from the roots of Cacalia ainsliaeflora.Their structures were elucidated by spectroscopic methods.     

Two Novel Epimeric Eremophilane Sesquiterpenes from the Flower of Cacalia tangutica

Two novel epimeric eremophilane sesquiterpenes, 7β-H-3α-angeloyl-9(10)-ene-11,12-epoxy-8-oxoeremophilane (1) and 7β-H-3α-angeloyl-9(10)-ene-11, 12-epoxy-8-oxoeremophilane (2) were isolated from the methanol extract of the flower of Cacalia tangutica (Franch.) Hand-Mazz. Their structures were characterized by 1D-, 2D-NMR (^1H-^1H COSY, HMQC, HMBC, ^1H-^1H NOESY) and HRESI-MS techniques.     

Two New Eremophilenolides from Ligularia sagitta

Chemical investigation of L.sagitta afforded two new eremophilenolides, which were identified as 6β-angeloyloxy-10β-hydroxy-8 β-methoxy-eremophil-7(11)-en-12, 8α-olide (1) and 6β, 8β-dimethoxy-10β-hydroxy-eremophil-7(11)-en-12, 8α-olide (2). Their structures were estab- lished by spectroscopic methods including 2D NMR experiments.     

大叶橐吾中三个新的艾里莫芬型倍半萜

从大叶橐吾的根部分离得到三个新的艾里莫芬型倍半萜(1, 2和3), 经多种波谱方法和单晶X射线衍射确定它们的结构分别为: 6α,15β-环氧-8β-羟基-艾里莫芬-7(11)-烯-8α,12-内酯(1), 7-乙酰基-13β-羧酸-6(7)-烯-降-艾里莫芬烷(2), 艾里莫芬-7(11)-烯-6α,15β-内酯(3). 此外, 对化合物1进行了抗菌和抗癌活性测试.     

Two New Eremophilenolides from Ligularia tongolensis

Chemical investigation of L. tongolensis afforded two new eremophilenolides, which were identified as 3β-（2＇-methylbutanoyloxy）-8βH-eremophil-7（11）-en-12, 8α（14, 6α）-diolide （1）and 8βH-eremophil-3, 7（11）-dien-12, 8α （14, 6α）-diolide （2）. Their structures were established by spectroscopic methods including 2D NMR experiments.     

Two New Sesquiterpenes from Eupatorium findleyanum

Two new germacrane sesquiterpenes： 3,8,14-trihydroxy- 1 （10）E,4Z, 11 （13）-germacra- trien-12, 6-olide, 8-（2-methyl-4-hydroxyl-2E-butenoyl）, 3,14-diacetoxy （eupalinolide A, 1）, and 3,8,14-trihydroxy-1（10） E, 4E, 11（13）-germacratrien-12,6-olide, 8-2-methyl-4-hydroxyl-2E- butenoyl）, 3,14-diacetoxy （eupalinolide B, 2） were isolated from Eupatorium lindleyanum. Their structures were elucidated by means of ^1H and ^13C NMR spectroscopic analysis, including 2D NMR technique.     

Two New Eudesmanoildes from Sonchus transcaspicus

Two new sesquiterpene lactone glycosides were isolated from the whole plant ofSonchus transcaspicus. Their structures were elucidated as 1β--O-β-D-glucopyranosy-5α, 6βH-eudesma-3-en-12, 6αt-olide and 1β--O-β-D-glucopyranosy-15-O-(p-hydroxylphenylacetate)-5α，6β H-eudesma-3, ll(13)-dien-12, 6α-olide by spectral methods (HRMS, 1D and 2D NMR).     

New Sesquiterpenes from Cacalia ainsliaeflora

Two new eremophilane sesquiterpenes, 3β-angeloyloxy-8-oxo-eremophil-6(7)-en-12-oic acid 1 and 3β-angeloyloxy-10β-hydroxy-8-oxo-eremophil-6(7)-en-12-oic acid 2, and a novelnor-eremophilane derivative, 3β-angeloyloxy-10β-hydroxy-8-oxo-eremophil-6(7)-en 3 were isolated from the roots of Cacalia ainsliaeflora. Their structures were elucidated by spectroscopic methods, including 2D NMR.     

两个新的海洋倍半萜

从稠密短指软珊瑚Sinularia conferta 中分离得1个新倍半萜confertol(1)。 从荑柔软珊瑚Nephthea albida分离得1个新倍半萜nephalbidol(2)和1个已知的多 羟基甾醇nephalsterol A(3)，应用波谱方法测定了的化学结构和相对构型。     

Sesquiterpenoids from the Aerial Parts of Inula japonica

Fourteen sesquiterpenoids with an eudesmane C‐atom skeleton, including four new ones, (1β,5α,7β,8β,11β)‐5‐hydroperoxy‐1‐hydroxyeudesm‐4(15)‐eno‐12,8‐lactone ( 1 ), (1β,5α,7β,8β)‐8‐(acetyloxy)‐5‐hydroperoxy‐1‐hydroxycostic acid methyl ester ( 12 ), and a mixture of (1β,3β,4β,7β,8β)‐1,3‐dihydroxyeudesma‐5,11(13)‐dieno‐12,8‐lactone ( 7 ) and (1β,3β,4β,7β,8β,11β)‐1,3‐dihydroxyeudesm‐5‐eno‐12,8‐lactone ( 8 ), were isolated from the aerial parts of Inula japonica (Asteraceae). Their structures were determined by extensive spectroscopic methods, and those of 7 and 12 confirmed by means of single‐crystal X‐ray diffraction analysis.     

Two New Eremophilane Sesquiterpene Lactones from Ligularia myriocephala Ling

Two new eremophilane sesquiterpene lactones, 1β-angeloyloxy-6β, 10β-dihydroxy-8β- methoxyeremophila-7（ll）en-8α,12-olide and 1β-angeloyloxy-6β,10α-dihydroxy-8α-methoxyeremo- phila-7（ 11）en-8β, 12-olide were isolated from the extract of the whole plant of Ligularia myriocephala Ling. Their structures and stereochemistry were elucidated by various spectroscopic methods including intensive 2D-NMR techniques （COSY, gHMQC, gHMBC and ^1H-^1H NOESY） and HR-ESIMS.     

Two New Sesquiterpenes from Euonymus nanoides

Two new sesquiterpenes,1β-(β-)furancarboxy-4α,13-diacetoxy-9β-cinna-moyloxy-β-dihydroagarofuran(1) and 1β，6α-di-(α-methyl)-butanoyl-4α-hydroxy-9β-enzoyloxy-13-acctoxy-β-dihydroagarofuran (2), were isolated from the seed oil of Euonymous nanoides,Their strucures were elucidated on the basis of spectral data.     

A New Guaianolide from Saussurea macrota

A new guaianolide was isolated from Saussurea macrota.Its structure was elucidated by NMR spectroscopic and X-ray diffraction methods.