Cleavage of Nucleotides by Lanthanide Metal Complexes

ＩｎｔｒｏｄｕｃｔｉｏｎＳｙｎｔｈｅｔｉｃｎｕｃｌｅａｓｅｓｗｈｉｃｈｅｆｉｃｉｅｎｔｌｙａｎｄｓｅｌｅｃｔｉｖｅｌｙｍａｋｅｎｕｃｌｅｉｃａｃｉｄｓｃｌｅａｖｅｄｕｎｄｅｒｍｉｌｄｃｏｎｄｉｔｉｏｎｓｈａｖｅｍａｎｙｉｍｐｏｒｔａｎｔｐｏｔｅｎｔｉ...     

Correlation between structure and stability of nitronic acids and nitronic esters

Ｎｉｔｒｏｎｉｃａｃｉｄｓａｎｄｎｉｔｒｏｎｉｃｅｓｔｅｒｓａｒｅｓｐｅｃｉａｌｓｐｅｃｉｅｓｏｆｏｒｇａｎｉｃｃｏｍｐｏｕｎｄｓ,ｗｈｏｓｅｓｔｒｉｋｉｎｇｐｒｏｐｅｒｔｙｉｓｉｎｓｔａｂｉｌｉｔｙ[1—3].Ｄｕｅｔｏｔｈｉｓｒｅａｓｏｎ,ｓｔｕｄｉｅｓｒｅｌａｔｅｄｔｏｔｈｅｓｅｓｐｅｃｉｅｓｈａｖｅｐｒｏｇｒｅｓｓｅｄｖｅｒｙｓｌｏｗｌｙ.Ｒｅｃｅｎｔｌｙ,ｗｅｒｅｐｏｒｔｅｄｔｈｅｓｙｎｔｈｅｓｉｓｏｆｓｔａｂｌｅｎｉｔｒｏｎｉｃａｃｉｄＩａｎｄｎｉｔｒｏｎｉｃｅｓｔｅｒＩＩ[4—6](ｆｉｇ.1),ａ…     

Sulfonation of Poly(phthalazinone ether sulfone ketone) and Its Application to Isobutene Oligomerization

Ｃｏｎｃｅｎｔｒａｔｅｄｈｏｍｏｇｅｎｅｏｕｓｍｉｎｅｒａｌａｃｉｄｓｈａｖｅｂｅｅｎｗｉｄｅｌｙｕｓｅｄａｓｃａｔａｌｙｓｔｓｉｎｉｎｄｕｓｔｒｉａｌｐｒｏｃｅｓｓｅｓｆｏｒｓｅｖｅｒａｌｄｅｃａｄｅｓ.Ｔｈｅｓｅｃａｔａｌｙｓｔｓａｒｅｃｏｒｒｏｓｉｖｅｔｏｔｈｅａｐｐａｒａｔｕｓ,ａｎｄｔｈｅｒｅａｒｅｌａｒｇｅｖｏｌｕｍｅｓｏｆｃｈｅｍｉ ｃａｌｌｙｒｅａｃｔｉｖｅｗａｓｔｅｓｔｒｅａｍｔｈａｔａｒｅｄｉｆｆｉｃｕｌｔｔｏｄｅａｌｗｉｔｈ[1 ] .Ｉｎｏｒｄｅｒｔｏｓｏｌｖｅｔｈｅｓｅｐｒｏｂ…     

Synthesis of Aminophosphine Ligands with Binaphthyl Backbones for Silver(I)-catalyzed Enantioselective Allylation of Benzaldehyde

Ｉｎｔｒｏｄｕｃｔｉｏｎ　　Ｅｎａｎｔｉｏｓｅｌｅｃｔｉｖｅａｌｌｙｌａｔｉｏｎｏｆｃａｒｂｏｎｙｌｃｏｍｐｏｕｎｄｓｉｓｏｎｅｏｆｔｈｅｕｓｅｆｕｌａｎｄｃｏｎｖｅｎｉｅｎｔｍｅｔｈｏｄｆｏｒｔｈｅｐｒｅｐａｒａ ｔｉｏｎｏｆｏｐｔｉｃａｌｌｙａｃｔｉｖｅｓｅｃｏｎｄａｒｙｈｏｍｏａｌｌｙｌｉｃａｌｃｏｈｏｌｓ .1Ａｌｔｈｏｕｇｈｎｕｍｅｒｏｕｓｗｏｒｋｏｎｔｈｅｒｅａｃｔｉｏｎｕｓｉｎｇａｓｔｏｉｃｈｉｏ ｍｅｔｒｉｃａｍｏｕｎｔｏｆｃｈｉｒａｌＬｅｗｉｓａｃｉｄｓｈａｓｂｅｅｎｒｅｐｏｒｔｅ…     

Synthesis and Crystal Structure of Bis[(2,6-pyridinedicarboxylato)(methanol)dibenzyltin(IV)]

ＩｎｔｒｏｄｕｃｔｉｏｎＤｉｏｒｇａｎｏｔｉｎｄｅｒｉｖａｔｉｖｅｓｏｆ 2 ,6 ｐｙｒｉｄｉｎｅｄｉｃａｒｂｏｘｙｌｉｃａｃｉｄｅｘｈｉｂｉｔｈｉｇｈｉｎｖｉｔｒｏａｎｔｉｔｕｍｏｕｒａｃｔｉｖｉｔｉｅｓ .1 5Ｔｈｅｓｅｃｏｍｐｏｕｎｄｓｈａｖｅｂｅｅｎｓｙｎｔｈｅｓｉｚｅｄｂｙｔｈｅｒｅａｃｔｉｏｎｏｆｄｉｏｒｇａｎｏｔｉｎｄｉｃｈｌｏｒｉｄｅｓｏｒｄｉｏｒｇａｎｏｔｉｎｏｘｉｄｅｓｗｉｔｈ 2 ,6 ｐｙｒｉｄｉｎｅｄｉｃａｒｂｏｘｙｌｉｃａｃｉｄ ,ｂｕｔｔｈｅｒｅａｃｔｉｏｎｂｅｔｗｅｅｎｔｒｉ …     

Comparative molecular field analysis (CoMFA) of new herbicidal sulfonylurea compounds

Ｓｕｌｆｏｎｙｌｕｒｅａｈｅｒｂｉｃｉｄｅｓｈａｖｅｂｅｅｎｕｓｅｄｆｏｒｓｅｖｅｒａｌｄｅｃａｄｅｓ,ｗｈｉｃｈｐｏｓｓｅｓｓｕｌｔｒａｌｏｗｄｏｓａｇｅ,ｌｏｗｍａｍｍａｌｉａｎｔｏｘｉｃｉｔｙａｎｄｄｅｓｉｒａｂｌｅｅｎｖｉｒｏｎｍｅｎｔａｌｐｒｏｐｅｒｔｉｅｓ.ＴｈｅｙｋｉｌｌｗｅｅｄｓｂｙｉｎｈｉｂｉｔｉｎｇｔｈｅａｃｔｉｖｉｔｙｏｆＡＬＳｅｎｚｙｍｅｏｆｔｈｅｗｅｅｄｓａｎｄｄｅｓｔｒｏｙｉｎｇｔｈｅｓｙｎｔｈｅｓｉｓｏｆｂｒａｎｃｈｃｈａｉｎａｍｉｎｏａｃｉｄ.Ｓｉｎｃｅｔｈｅｅｓｔａ…     

Non－isothermalKineticsofThermalDecompositionReactionsofSchiffBaseComplexesofAminoAcidswithTranistionMetals（I）

Ｎｏｎ－ｉｓｏｔｈｅｒｍａｌＫｉｎｅｔｉｃｓｏｆＴｈｅｒｍａｌＤｅｃｏｍｐｏｓｉｔｉｏｎＲｅａｃｔｉｏｎｓｏｆＳｃｈｉｆｆＢａｓｅＣｏｍｐｌｅｘｅｓｏｆＡｍｉｎｏＡｃｉｄｓｗｉｔｈＴｒａｎｉｓｔｉｏｎＭｅｔａｌｓ（Ｉ）ＬＩＳｈｕ－ｌａｎ,ＬＩＵＤｅ－...     

Molecular and Crystal Structure of 7—Hydroxy—6,8—dimethoxyl—coumarin

1　ＩＮＴＲＯＤＵＣＴＩＯＮＣｏｕｍａｒｉｎｉｓｏｎｅｋｉｎｄｏｆｔｈｅｌａｃｔｏｎｅｏｆｏｒｔｈｏ ｈｙｄｒｏｘｙｌｃａｓｓｉａａｃｉｄ .Ｉｔｃｏｍｐｏｓｅｓａｌａｒｇｅｎｕｍｂｅｒｏｆｃｏｕｍａｒｉｃｄｅｒｉｖａｔｅｓｅｒｉｅｓｂｅｃａｕｓｅｏｆｔｈｅｄｉｆｆｅｒｅｎｔｐｏｓｉｔｉｏｎｓ,ｋｉｎｄｓａｎｄｎｕｍｂｅｒｓｏｆｔｈｅｓｕｂｓｔｉｔｕｅｎｔｇｒｏｕｐｓｗｈｉｃｈｌｉｎｋｕｐｗｉｔｈｔｈｅａｒｏｍａｔｉｃａｎｄｌａｃｔｏｎｅｒｉｎｇｓ[1 ,2 ,3] .Ｔｈｉｓｋｉｎｄｏｆｃｏｍｐｏｕｎｄｓｅｘ…     

Transport property of polyaniline and its molecular weight dependence

Ｔｈｅｅｌｅｃｔｒｉｃａｌｃｏｎｄｕｃｔｉｖｉｔｙ(σ)ｏｆｐｏｌｙａｎｉｌｉｎｅ(ＰＡｎ)ｄｏｐｅｄｗｉｔｈｉｎｏｒｇａｎｉｃｐｒｏｔｏｎｉｃａｃｉｄｓｉｓａｂｏｕｔ10Ｓ/ｃｍａｎｄσ(Ｔ)∝ｅｘｐ[-(Ｔ0/Ｔ)1/2].Ｉｔｍｅａｎｓｔｈａｔσｉｎｃｒｅａｓｅｓｗｉｔｈｉｎｃｒｅａｓｉｎｇｔｅｍｐｅｒａｔｕｒｅａｎｄｔｈｅｔｒａｎｓｐｏｒｔｐｒｏｐｅｒｔｙｉｓｉｎａｃｃｏｒｄａｎｃｅｗｉｔｈｔｈｅｖａｒｉａｂｌｅｒａｎｇｅｈｏｐｐｉｎｇ(ＶＲＨ)ｍｏｄｅｌ[1].Ａｆｔｅｒｓｔｒｅｔｃｈｉｎｇ,ｔｈｅＨＣｌｄｏｐ…     

NMR Studies of a New Binding Mode of the Amino Acid Esters by Porphyrinatozinc(Ⅱ)

ＩｎｔｒｏｄｕｃｔｉｏｎＡｍｏｎｇｔｈｅｉｎｔｅｒａｃｔｉｏｎｓｂｅｔｗｅｅｎｐｏｒｐｈｙｒｉｎｓａｎｄｆｕｎｃｔｉｏｎａｌｍｏｌｅｃｕｌｅｓｓｕｃｈａｓａｍｉｎｏａｃｉｄｓ ,ｕｂｉｑｕｉｎｏｎｅｐｌａｙｓｉｍｐｏｒｔａｎｔｂｉｏｌｏｇｉｃａｌｆｕｎｃｔｉｏｎｓ .Ｔｈｅｍｏｌｅｃｕｌａｒｒｅｃｏｇｎｉｔｉｏｎｏｆａｍｉｎｏａｃｉｄｓａｎｄｔｈｅｉｒｄｅｒｉｖａｔｉｖｅｓｉｓａｎｉｍｐｏｒｔａｎｔｔｏｐｉｃｆｏｒｂｏｔｈｕｎｄｅｒｓｔａｎｄｉｎｇｔｈｅｍｅｃｈａｎｉｓｍｏｆａｍｉｎｏａｃｙｌ ｔｒ…     

5-雄烯-3β, 7α, 17β-三醇和5-雄烯-3β, 7β, 17β-三醇的合成

以5-雄烯二醇为原料,用微生物转化的方法合成了两个重要的神经甾体5-雄烯-3β, 7α, 17β-三醇和5-雄烯-3β, 7β, 17β-三醇。所用菌种总枝毛霉为我们自己筛选,并首次应用于5-雄烯-3β, 7α, 17β-三醇和5-雄烯-3β, 7β, 17β-三醇的合成中。     

胆甾-4α-甲基-8-烯-3β，7α-二醇二乙酸酯的结构与性质研究

Lophenol, cholest-4α-methyl-7-en-3β-ol (1), obtained from Dracaena cochinchinensis (Lour.) S. C. Chen, was structurally modified. It was acetylated to protect 3β-hydroxyl group, and then oxidised by selenium dioxide in acetic acid to give cholest-4a-methyl-8-en-3β, Ta-diol diacetate (3). This compound 3 is unstable in chloroform solution or when heated and easily converted to a diene compound, cholest-4a-methyl-7,14-dien-3β-ol acetate (4). The structures of 3 and 4 were elucidated by means of IR, ^1H NMR, ^13C NMR and MS, and the absolute configuration of 3 was established by X-ray crystallography. The property of 3 was also discussed in this paper. Both 3 and 4 are new compounds and were reported for the first time.     

Fragmentation Mechanism of Trans—α—Aryl—β—enamino Esters

Electron impact-induced fragmentation mechanism of Trans-α-Aryl-β-enamino esters were investigated using mass-analyzed ion kinetic energy (MIKE) spectrometry and high resolution accurate mass data It was found that the main characteristic fragmentations of compounds studied were:an odd electron ion M^ -EtOH was formed by losing a neutral molecule of ethanol;and the skeletal rearrangements took place;and the ring opening reaction happened after losing a carbon monoxide;and the typical McLafferty rearrangement underwent in ester group.The cycliztion reation caused by losing neutral molecule of TsNH2 due to the ortho-effects of substituted group of gromatic ring was also observed.     

Selective α-Bromination of β-Keto Esters in Reusable PEG-400 under Mild and Catalyst-free Conditions

An efficient bromination protocol for the synthesis of α-bromo-β-keto esters has been developed. In PEG-400 （poly（ethylene glycol-400））, a variety of β-keto esters were treated with NBS （N-bromosuccinimide） at room temperature to selectively afford the corresponding α-monobromination products in excellent yields. It is noteworthy that the reaction was conducted under mild, environmentally benign and catalyst-free conditions.     

Catalytic Hydrogenation of α,β-Epoxyketones to β-Hydroxyketones with Two Sulfinyl Analogues of Coenzyme NADH Models

An efficient method for the selective hydrogenation of a series of α,β-epoxyketones to β-hydroxyketones using catalytic amount of two sulfinyl analogues of NAD^＋ model compounds is reported. The lack of any diastereoselectivity for the formation of β-hydroxyketones with optically pure sulfinyl analogue of NAD^＋ model supports the radical mechanism proposed previously.     

SmI2－Mediated Addition Reaction of α－Halomethylsulfones to Carbonyl Compounds. A Convenient Synthesis of β－Hydroxysulfones

Due to the chemoselective dehalogenation by SmI2, the addition of a-halomethylsulfones to carbonyl compounds afforded ,β-hydroxysulfones. Those reactions with α-bromomethylsulfones gave the products in moderate to good yields. The SmI2-mediated addition of gem-dihalomethylsulfones to ketones also afforded α-halo-β-hydroxysulfones in moderate yields.     

KF-蒙脱土催化下丙二腈与α,β-不饱和酮的迈克尔加成反应

本论文研究了KF-蒙脱土催化下丙二腈与α,β-不饱和酮的迈克尔加成反应,研究发现在不同的反应温度下可以得到加成和环化两种不同的产物。该方法和现有的方法相比具有产率高、反应条件温和、操作简单、试剂易得等优点。     

Veronicafolin－β-环糊精的物化表征及Veronicafolin－羟丙基-β-环糊精包合物溶解性的增强

用氢谱、红外光谱、X-射线粉末衍射、热分析、元素分析等测试方法研究了Veronicafolin (3,5,4′-三羟基-6,7,3′-三甲氧基黄酮) 和β-环糊精 (β-CD) 的固体包合物的谱学特征。元素分析结果显示形成Veronicafolin-β-CD·20H2O包合物，其中C：39.58%, H: 5.75%，表明包合物中主客体比为1∶1。该包合类型属于A_L-型。通过紫外-可见分光光度法研究了在羟丙基-β-环糊精（HP-β-CD）的存在下Veronicafolin的相溶解度曲线，测得校正曲线为y = 24148x + 0.0075 (r=0.9999)，相溶解曲线为y=0.4738x-2.0×10^-7 (r=0.9490)，包结平衡常数Ks为4.5×10⁶mol-1。HP-β-CD提高了黄酮醇Veronicafolin的溶解度。     

Synthesis and Characterization of α-Bromo Chalcone Derivatives

α-Bromo chalcones containing 2-thiene ring were prepared in good yields by the condensation of 1-(thien-3-yl)ethanone with aromatic aldehydes, followed by bromination with bromine and selective dehydrobromination with triethyl amine at room temperature.     

过无溶剂、无催化的aza-Michael加成反应合成b氨基酸衍生物

本文报道一种安全,环境有好,经济实用的合成b氨基酸衍生物的新方法。利用α,β不饱和化合物和脂肪族胺,通过无溶剂、无催化的aza-Michael加成反应,高产率的合成b氨基酸衍生物。