共查询到20条相似文献,搜索用时 31 毫秒
1.
Abolghasem Davoodnia Rahele Zhiani Niloofar Tavakoli-Hoseini 《Monatshefte für Chemie / Chemical Monthly》2008,139(11):1405-1407
Starting from 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones, a synthesis pathway to the tricyclic pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidines is described. Reaction of 1,5-dihydro-4H-pyrazolo[3,4-d] pyrimidin-4-ones with phosphoryl chloride afforded the corresponding 4-chloro-1H-pyrazolo[3,4-d]pyrimidines. Treatment of these compounds with hydrazine hydrate at reflux temperature gave the hydrazino derivatives, which
were subsequently cyclized to the titled compounds on heating with orthoesters in ethanol.
Correspondence: Abolghasem Davoodnia, Department of Chemistry, School of Sciences, Islamic Azad University, Mashhad Branch,
Mashhad 91735-413, Iran. 相似文献
2.
Abdel-Rahman Farghaly Hussein El-Kashef 《Monatshefte für Chemie / Chemical Monthly》2005,292(1):217-227
The synthesis of the title compounds was achieved using 1-phenyl-5-(pyrrol-1-yl)-1H-pyrazole-3-carboxylic acid azide as starting material. The latter compound was allowed to react with alcohols and amines to afford the corresponding carbamates and urea derivatives. Alkaline hydrolysis of the carbamates gave the corresponding amine, which was acylated and/or aroylated to give amide derivatives. These and the urea derivatives were subjected to cyclodehydration to give the title compounds. Antibacterial and antifungal activities were observed for several derivatives. 相似文献
3.
Eberhard Reimann Rainer Hertel Jürgen Krauss 《Monatshefte für Chemie / Chemical Monthly》2008,139(6):673-684
Alkylation of Reissert compounds derived from 3-methylisoquinolines with several 2-cyanobenzylbromides followed by hydrolytic cleavage provided the corresponding 1-benzyl-3-methylisoquinolines. Treatment of the latter with methylmagnesiumiodide caused cyclization to the title compounds rather than formation of 2-acetylbenzylisoquinolines. 相似文献
4.
N. I. Omelichkin L. G. Minyaeva V. V. Mezheritskii 《Russian Journal of Organic Chemistry》2017,53(2):258-262
Alkylation of 3-methyl-1Н-acenaphtho[5,6]pyridazine with methyl and propyl iodides as well as with benzyl chloride in alkaline medium leads to the formation of the corresponding both N- and С-substituted pyridazine derivatives and also to the dimerization product of the initial compound. The ratio of obtained compounds depends on the used hydride, reaction temperature, and solvent. 相似文献
5.
Summary. Ethyl [4-oxo-3-(2-oxo-2-arylethyl)thiazolidin-2-ylidene]acetates and [4-oxo-3-(2-oxo-2-arylethyl)thiazolidin-2-ylidene]acetonitriles
were shown to react with substituted benzaldehydes at the endocyclic methylene group leading to the corresponding 5-arylmethylidene
derivatives. Their treatment with DMF · POCl3 complex yielded 3-oxo-5-aroyl-2-arylmethylidene-2,3-dihydropyrrolo[2,1-b]thiazole-7-carboxylic acids ethyl esters and -7-carbonitriles. The structures of the pyrrolothiazoles were confirmed by an
X-ray crystallographic study, which indicated the (Z)-configuration at the arylmethylidene moiety. 相似文献
6.
I. G. Davydenko Yu. L. Slominskii O. I. Kalchenko A. V. Gutov A. N. Chernega A. I. Tolmachev 《Russian Chemical Bulletin》2008,57(1):159-164
A procedure was developed for the synthesis of derivatives of the new heterocyclic system, benzo[cd]furo[2,3-f]indole, based on the cyclodehydration of 6-acylmethyloxy-1-alkyl-benzo[cd]indol-2(1H)-ones. Either 7- or 8-aryl derivatives of benzo[cd]furo[2,3-f]indol-4(5H)-ones can be prepared depending on the reaction conditions. The molecular and crystal structures of 7- and 8-phenylbenzo[cd]furo[2,3-f]indol-4(5H)-ones were established by X-ray diffraction. 相似文献
7.
Mohammad Hossein Mosslemin Mohammad Reza Nateghi Razieh Mohebat 《Monatshefte für Chemie / Chemical Monthly》2008,139(10):1247-1250
A clean, simple, one-pot, and efficient synthesis of 1,2-dihydro-1-aryl[1,3]oxazino[5,6-f]quinolin-3-one and 1,2-dihydro-1-arylnaphtho[1,2-e]-[1,3]oxazine-3-one derivatives was accomplished in good yields via reaction between 6-quinolinol or 2-naphthol, aromatic aldehydes, and methyl carbamate in aqueous medium catalyzed by TEBA (triethylbenzylammonium chloride).
Correspondence: Mohammad Hossein Mosslemin, Department of Chemistry, Islamic Azad University, Yazd 8916871967, Iran. 相似文献
8.
B. T. Bagmanov 《Russian Journal of Organic Chemistry》2007,43(11):1635-1641
Stereochemistry of the oxidation of N-arylbicyclo[2.2.1]hept-5-ene-endo-and-exo-2,3-dicarboximides at the double bond with peroxyacetic acid generated in situ in the presence of sulfuric acid and with an anhydrous dioxane solution of peroxyacetic acid was studied. In both cases, the reaction was stereospecific, regardless of the substituent in the N-aryl group and configuration of the imide ring, but the reaction direction depended on the presence of water in the system. In the first case, the corresponding trans-5,6-dihydroxy derivatives were formed, while in the second, exo-5,6-epoxy derivatives. The oxidation of N-arylbicyclo[2.2.1]-hept-5-ene-endo-and-exo-2,3-dicarboximides with a solution of potassium permanganate in aqueous acetone gave the corresponding N-aryl-cis-5,6-dihydroxybicyclo[2.2.1]heptane-endo-and-exo-2,3-dicarboximides. The exo,cis,exo and exo,cis,endo configurations of the synthesized compounds were determined by 1H NMR spectroscopy. 相似文献
9.
Two diastereomers of the previously unknown diketopiperazines tert-butyl 1-(5,8-dioxohexahydro-[1,3]thiazolo[3,4-a]pyrazin-3-yl)ethylcarbamate were synthesized and separated by column chro-matography on silica gel. During the cultivation of the crystal of one of compounds, the product was oxidized to corresponding tert-butyl 1-(5,8-dioxo-5,6,7,8-tetrahydro[1,3]thiazolo[3,4-a]pyrazin-3-yl)-ethylcarbamate. The X-ray crystal structure of the latter was established. 相似文献
10.
Farag A. El-Essawy Ahmed F. Khattab Adel A.-H. Abdel-Rahman 《Monatshefte für Chemie / Chemical Monthly》2007,138(8):777-785
Summary. 1-Carbethoxymethyl-4,6-dimethyl-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5,7(4H,6H)-dione was synthesized and treated with hydrazine hydrate to give the corresponding hydrazide. The latter hydrazide was treated
either with phenylisothiocyanate or with carbon disulfide/alc. KOH to afford the corresponding thiosemicarbazide and oxadiazole
derivatives. Alkylation of 2-mercapto-1,3,4-oxadiazole with dimethyl sulfate or ethyl chloroacetate gave the corresponding
2-methylthio-, and 2-ethylthioglycolate derivatives. Formation of 1,3,4-thiadiazole, 5-mercapto-1,2,4-triazole, and 1,3,4-oxadiazole
were carried out by treating of the latter thiosemicarbazide with conc. H2SO4, NaOH/HCl, and HgO. Treating of 5-mercapto-1,2,4-triazole with ethyl chloroacetate afforded the thioglycolate ester. Hydrolysis
of the latter with hydrazine hydrate afforded the hydrazide derivatives. Condensation of these hydrazides with monosaccharide
aldoses gave the corresponding sugar hydrazones. The novel compounds were tested for antiviral activity against hepatitis
B virus and showed moderate activities. 相似文献
11.
Zh. S. Nurmaganbetov E. E. Shultz S. V. Chernov A. Zh. Turmukhambetov R. B. Seydakhmetova M. M. Shakirov G. A. Tolstikov S. M. Adekenov 《Chemistry of Heterocyclic Compounds》2011,46(12):1494-1499
The reaction of harmine with phenacyl bromides or ethyl bromoacetate gives quaternized harmine derivatives. The cyclization
of the phenacylharminium salts yields the corresponding 2-aryl-11H-indolizino[8,7-b]indoles. Vilsmaier-Haack formylation of 11H-indolizino[8,7-b]indoles leads to the corresponding 3,10-bisformyl derivatives. The acylation proceeds selectively at C(3) to give 3-acetyl-2-aryl-11H-indolizino[8,7-b]indole. 相似文献
12.
Chetan B. Sangani Divyesh C. Mungra Manish P. Patel Ranjan G. Patel 《Central European Journal of Chemistry》2011,9(4):635-647
A new series of twenty four derivatives of pyrano[3,2-c]chromene IVa-x bearing 1H-pyrazole were synthesized by a one pot, base-catalyzed cyclocondensation reaction of 1H-pyrazole-4-carbaldehyde Ia-l, malononitrile II and 4-hydroxycoumarin IIIa-b. All the synthesized compounds were characterized by elemental analysis, FT-IR, 1H NMR and 13C NMR spectral data. All the synthesized compounds were screened against six bacterial pathogens, namely B. subtilis, C. tetani, S. pneumoniae, S. typhi, V. cholerae, E. coli and for antifungal activity against two fungal pathogens, A. fumigatus and C. albicans using the broth microdilution MIC method. Some of the compounds were found to be equipotent or more potent than commercial
drugs against most of employed strains, as evident from the screening data.
相似文献
13.
Mohammad Rahimizadeh Mehdi Pordel Mehdi Bakavoli Zahra Bakhtiarpoor Ala Orafaie 《Monatshefte für Chemie / Chemical Monthly》2009,140(6):633-638
Abstract New imidazo[4,5-a]acridone derivatives were synthesized from the rearrangement of 3H-imidazo[4′,5′:3,4]benzo[c]isoxazoles. New imidazo[4,5-a]acridines were obtained from the reaction of imidazo[4,5-a]acridones in boiling POCl3. All of these compounds exhibited antimicrobial activities comparable to streptomycin as reference drug.
Graphical abstract
相似文献
14.
Summary. A new synthetic route was developed for the preparation of trans-3-hydroxy-16,17-seco-pregna-5,17(20)-dien-16-al, using Grob fragmentation as the key step. This seco-steroid contains a formyl group and an unsaturated side-chain in a sterically favourable position, and is therefore a promising starting material for the synthesis of novel condensed steroid heterocycles.Received March 22, 2003; accepted April 22, 2003
Published online September 25, 2003 相似文献
15.
V. S. Matiichuk M. A. Potopnyk N. D. Obushak 《Russian Journal of Organic Chemistry》2008,44(9):1352-1361
Reactions of arenediazonium chlorides with ethyl 2-methyl-and 2-chloro-4-oxobutanoates gave, respectively, ethyl 2-(arylhydrazono)propanoates and chloro(arylhydrazono)acetates. Ethyl 2-(arylhydrazono)-propanoates reacted with the Vilsmeier-Haak reagent to give ethyl 1-aryl-4-formyl-1 H-pyrazole-3-carboxylates. Ethyl 1-aryl-4-acetyl-5-methyl-1H-pyrazole-3-carboxylates were obtained by reaction of chloro(arylhydrazono) acetates with acetylacetone. Reactions of the obtained pyrazole derivatives with hydrazine and methylhydrazine led to the formation of the corresponding 3,4-R 2 1 -6-R2-2-aryl-2,6-dihydro-7H-pyrazolo-[3,4-d]pyridazin-7-ones (R1, R2 = H, Me) which were subjected to alkylation and sulfurization. 相似文献
16.
Summary. 5-Methylenolether derivatives of pyrrolo[3,4-a]carbazoles were obtained from cycloadditions between 3-(1-methoxyvinyl)-1-tosylindole and N-substituted maleimides. They
were transformed into the hydroxy derivatives by treatment with H2SO4, selectively reduced to the ether by H2/Pd–C, and in the imide moiety by L-Selectride?. From the analogous BOC protected indole derivative the parent α,β-unsaturated ketones were obtained, which were transformed into hydroxyimino compounds,
and which could be deprotected by heating to the melting point. Deprotection of the tosyl derivatives was not successful.
The imide part of the molecule was hydrolyzed using methanolic NaOH. The stereochemistry of all products was elucidated mainly
by spectroscopic methods, and compared with results of calculations. 相似文献
17.
Hussein El-Kashef Pascal Rathelot Patrice Vanelle Sylvain Rault 《Monatshefte für Chemie / Chemical Monthly》2007,138(5):469-476
Summary. 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile was converted into the corresponding 2-(pyrrol-1-yl) derivative, followed by reduction of the latter
compound into the corresponding amine. This amine and its acyl, aroyl, and arylidene derivatives were used as synthons in
the synthesis of several title compounds. 相似文献
18.
S. C. Mojumdar P. Šimon A. Krutošíková 《Journal of Thermal Analysis and Calorimetry》2009,96(1):103-109
(E)-3-(1-Benzofuran-2-yl)propenoic acid (1) was prepared from 1-benzofuran-2-carbaldehyde under the Doebner’s conditions. The obtained acid was converted to the corresponding
azide 2, which was cyclized by heating in diphenyl ether to [1]benzofuro[3,2-c]pyridine-1(2H)-one (3). This compound was aromatized with phosphorus oxychloride to chloroderivative 4 which was reduced with zinc and acetic acid to the title compound 5. [1]Benzofuro[3,2-c]pyridine-2-oxide (6) was synthesized by reaction of 5 with 3-chloroperoxybenzoic acid in dichloromethane. Treatment of 6 with benzoyl chloride and potassium cyanide (Reissert-Henze reaction) was shown to produce the corresponding [1]benzofuro[3,2-c]pyridine-1-carbonitrile (7). The title compound was used for preparation of complexes Cu2(ac)4(bfp)2 (8) and CoCl2(bfp)2 (9), where ac=CH3CO2− and bfp=[1]benzofuro[3,2-c]pyridine. Both oxygen atom of carboxylate ions is used in the coordination to Cu(II). Thermal
properties of the complexes 8 and 9 have been studied by TG and DTA and both complexes exhibited high thermal stability while complex 9 are thermally more stable than complex 8. 相似文献
19.
E. V. Kondrashov E. V. Rudyakova G. N. Rozentsveig I. B. Rozentsveig K. A. Chernyshev L. B. Krivdin G. G. Levkovskaya 《Russian Journal of Organic Chemistry》2009,45(9):1365-1374
N-(Trifluoromethylsulfonyl) and N-arylsulfonyl polychloroacetaldehyde imines reacted with pyrrole, 1-alkyl-, 1-benzyl-, and 1-(4-nitrophenyl)-substituted pyrroles,
and bis-pyrroles to give the corresponding 2-[1-(sulfonylamino)polychloroethyl]-1H-pyrroles or mixtures of 2- and 3-[1-(sulfonylamino)polychloroethyl]-1H-pyrroles, depending on the nature of the Schiff base and substituent on the pyrrole nitrogen atom and reaction conditions.
The first synthesis of 2,5-disubstituted NH-pyrrole by reaction of pyrrole with Schiff bases was described. 相似文献
20.
Summary. Treatment of meso-tetra(tert-butyl)porphyrin with sulfuric acid/n-butanol affords a mixture of porphyrin and mono-tert-butylporphyrin in relatively high yield. 相似文献