Synthesis,Characterization and Properties of Bis{oxo—bis[heteroaromatic carboxylatodibenzyltin（Ⅳ）]}and Crystal Structure of Bis{oxo—bis[2—furylcarboxylatodibenzyltin（Ⅳ）]}

IntroductionThe organotin( ) derivatives of carboxylicacids have been extensively studied due to their bio-logical activities[1— 4] . In recent years more andmore reports on the synthesis,antitumour activi-ties,biocidal activities,antibiotic activities andstructural elucidation of various organotin ( )derivatives of carboxylic acids have appeared[5— 10 ] .In particular,the diorganotin ( ) complexes ofcarboxylic acids have aroused a considerable inter-est of some scientists in the structur…     

Synthesis and Crystal Structure of Di-n-butyltin（Ⅳ） Complex with 2-Oxo-propionic Acid （4-Pyridinecarbonyl） Hydrazone

The novel complex di‐n‐butyltin(IV) 2‐oxo‐propionic acid (4‐pyridinecarbonyl) hydrazone, (n‐C₄H₉)₂Sn‐[O₂CC(CH₃)=N‐N=C(‐O)C₅N‐4] (H₂O) has been synthesized and its structure has been determined by X‐ray diffraction analysis. The complex crystallizes in orthorhombic system with space group Pca2₁. Crystal data: a=2.7540(9) nm, b=0.9676(3) nm, c= 1.5750(5) nm, V=4.197(2) nm³, D_c= 1.444 g/cm³, Z=8. μ= 1.241 mm^?1. F(000)= 1856, R₁=0.0462 and wR₂=0.1001. In the crystals of the title complex, the tin atom is in six‐coordination with a distorted octahedral geometry, three oxygen atoms [O(1), O(3) and O(4)] and one nitrogen atom N(1) forming the equatorial plane and C(10)‐Sn(1)‐C(14) being the axis. Two molecules form a dimer with weak interactions of Sn‐O bonding and hydrogen bonds.     

Crystal Structure and Spectroscopic and Coordination Properties of Bis（4-fluorobenzohydroxamato）dimethyltin（Ⅳ）

An organotin（Ⅳ） complex [（CH3）2Sn（4-FC6H4CONHO）2] has been synthesized and characterized by elemental analysis, IR, ^1H NMR and X-ray single-crystal diffraction techni- ques. The crystal belongs to the orthorhombic system, space group Pbca with a = 9.7565（13）, b = 17.664（2）, c = 20.784（3）A, Z = 8, V = 3581.9（8）A^3 Dc = 1.695 g/cm^3,μ（MoKa） = 1.469 mm^-1, F（000） = 1808, R = 0.0321 and wR = 0.0838. In the molecular structure of the title complex, the tin atoms are five-coordinated in a trigonal bipyramidal geometry, and the special coordination properties of dimethyltin（Ⅳ） with hydroxamate-type ligands are also discussed.     

Synthesis and Crystal Structure of a Novel Layered Lead（Ⅱ） Carboxylate-sulfonate Compound Templated by 4,4＇-Bipyridine

A new lead(Ⅱ) carboxylate-sulfonate has been hydrothermally synthesized and characterized by X-ray single-crystal and elemental analyses. It crystallizes in triclinic, space group P, with a = 8.1573(6), b = 9.4663(7), c = 12.7488(9) , α = 89.2320(10), β = 80.7380(10), γ = 77.9760(10)°, Z = 2, V = 950.10(12) 3, Mr = 599.57, Dc = 2.096 g/cm3, μ = 9.032 mm-1, F(000) = 572, the final R = 0.0412 and wR = 0.1035. It has a 1D chain structure, and the Pb(Ⅱ) is six-coordinated. Two PbO6 polyhedra are interconnected via edge-sharing into a two-core unit. Such units are further interconnected by 3-sulfonato-benzoic acids into 1D chains which are linked by hydrogen bonds into a layer structure. The 4,4'-bipyridines are located at the interlayer space and link the layers into a supramolecular structure by π-π stacking interactions.     

Synthesis and Characterization of Diorganotin Compounds {[R2Sn（ON =CHC6H5）]2O}2 and Crystal Structure of {[（C6H5CH2）2Sn（ON=CHC6H5）]2O}2

Introduction Dimeric tetraorganodistannoxanes are a kind of in-teresting organotin oxo clusters and have attracted con-siderable attention during the last several decades, in view of their unique structural features1-5 as well as their applications as biocides6,7 and in homogenous cataly-sis.8,9 In the solid state, they contain characteristic Sn4O2X2Y2 structural motifts with staircase or ladder arrangements, a planar four-membered Sn2O2 ring and, generally, penta-coordination around the tin…     

Synthesis and Crystal Structure of the Ladder-like Organotin Complex：μ-pentaoxygen bridged penta（bis-benzyltin） bis-salicylate

1 INTRODUCTION zing different structural ligands[10~12]. Recently we have used bis-benzyltin oxide to react with salicylic Organotin compounds have captured the interests acid at the molar ratio 1:1, out of our expectation, of chemists for many years due to their wide pra- the product is not our expected complex but the title ctices uses, biological activities, diverse reaction ac- compound with a novel structure. Herein we report tivities and structural characters[1~5]. It’s universally…     

Synthesis and Crystal Structure of 5-N-i-Propyl-2- （ 2＇ -nitrobenzenesulfonyl） -glutamine

The title compound, 5-N-i-propyl-2-(2′-nitrobenzenesulfonyl)-glutamine, was synthesized and its structure was confirmed by IR, MS, ¹H NMR, and elemental analysis. The single crystal structure of the title compound was determined by X-ray diffraction. The crystal belongs to Monoclinic, space group P2 (1), with a = 0.69281(11) nm, b = 0.76508(12), c = 1.5843(3) nm, = 90°, β = 90.941(3)°, γ = 90°, V = 0.8397(2) nm³, Z = 2, D_c = 1.477 g/cm³, μ = 0.236 mm^-1, F(000) = 392, R = 0.0297, and wR = 0.0664.     

Chiral and Achiral Bis（2-oxazolinylphenolato）nickel（Ⅱ） Complexes-Synthesis, Crystal Structure, and Catalytic Properties

Introduction Oxidation was a very important reaction both in synthetic pathways and in industrial processes. Metal-catalyzed oxidation provided excellent alternatives in synthetic processes. However, molecular oxygen has been applied only in a limited number of metal-catalyzed oxidations, because it was very difficult to activate molecular oxygen and most of transition metal complexes were sensitive to oxygen. It was noted that metal-catalyzed Baeyer-Villiger oxidation was a convenient method…     

Synthesis and Crystal Structure of 3-（Trichloroacetyl） Indole

1 INTRODUCTION Indole and its derivatives have attracted much at-tention due to their chemical properties as well asbiological activities[1, . They have been widely used 2]as the materials for producing pigment, perfume,plant growth regulators, etc. Recently, it has alsobeen found that some indole derivatives present anti-tumor and antiviral activities[3～5]. During our sear-ches for bioactive compounds, a series of indole deri-vatives were synthesized, among …     

二{氧合—二[2—呋喃甲酸二苄基锡（IV）]}的合成、性质及晶体结构

以二苄基氧化锡和2-呋喃基羧酸反应，合成了新的化合物二[氧合-二[2—呋喃甲酸二苄基锡(IV)]}．生物活性测试结果表明，该配合物具有较强的体外抗癌活性．X射线单晶衍射测定表明，配合物是以Sn2O2四元环为中心的、中心对称的二聚体结构，内环锡为六配位的畸变八面体结构，外环锡为五配位的加帽畸变三角双锥结构．     

梯形结构有机锡化合物二{氧合-二[2-吡啶甲酸二丁基锡(IV)]}的合成、性质和晶体结构

用二丁基氧化锡与 2 吡啶甲酸反应 ,合成了二 {氧合 -二 [2 吡啶甲酸二丁基锡 (IV) ] },并进行了元素分析、红外光谱、核磁共振锡谱表征 .X射线单晶衍射分析表明 ,化合物是以Sn2 O2 四面体为中心的 ,中心对称的二聚体结构 ,内环锡为五配位的畸变三角双锥构型 ,外环锡为六配位的畸变八面体结构 .生物活性测试结果表明 ,该配合物具有较强的体外抗癌活性 .     

两个有机锡呋喃-2-甲酸酯化合物的合成、结构及量子化学研究

氧化双[三(2-甲基-2-苯基)丙基锡]、三苄基氯化锡分别与呋喃-2-甲酸反应,合成了配位聚合物{[(C4H3O)CO2]Sn(CH2CPhMe2)3}n(1)和{[(C4H3O)CO2]Sn(CH2Ph)3}n(2)。经IR、1H NMR、元素分析和X射线衍射表征结构。1和2均属单斜晶系,配合物1空间群P21/n,晶体学参数:a=1.122 06(7)nm,b=1.747 60(11)nm,c=1.632 62(10)nm,β=91.503(3)°,Z=4,V=3.200 3(3)nm3,Dc=1.306 g.cm-3,μ(Mo Kα)=0.829 mm-1,F(000)=1 304,R1=0.023 9,wR2=0.059 4。配合物2空间群C2/c,晶体学参数:a=2.939 49(13)nm,b=1.035 36(4)nm,c=1.976 64(9)nm,β=129.582(2)°,Z=8,V=4.636 4(3)nm3,Dc=1.442 g.cm-3,μ(Mo Kα)=1.125 mm-1,F(000)=2 032,R1=0.024 2,wR2=0.060 6。配合物1和2的中心锡原子分别为四面体和三角双锥构型。通过分子间氢键作用,1和2分别形成三维结构。对配合物进行了量子化学从头计算,探讨了配合物的稳定性、分子轨道能量及一些前沿分子轨道的组成特征。     

Synthesis and Crystal Structure of Bis[（2,6—pyridinedicar—boxylato）（methanol）dibenzyltion（Ⅳ）]

A novel seven‐coordinate dimer bis[(2,6‐pyridinedicarboxylato)(methanol)dibenzyltin(IV)] was synthesized by the reaction of (PhCH₂)₃SnCl with 2,6‐pyridine dicarboxylic acid in 1:1 molar ratio in methanol solution. The structure was characterized by elemental analysis, IR and ¹H NMR spectra, and the crystal structure was determined by X‐ray single crystal diffraction analysis. The crystal belongs to monoclinic space group P2₁/n, a =0.96250(19) nm, b = 1.0947(2) nm, c = 1.9965(4) nm, β = 92.31(3)°, Z = 2, V = 2.1019(7) nm³, D_c = 1.574 g/cm³, μ = 1.248 mm^?1, F(000)=1000, R₁ = 0.0675, wR₂ = 0.0836. In the crystals of the complex, each tin atom is seven‐coordinated in a distorted bipyramidal structure.     

氮芥苯甲酸氧化二丁基锡复合物的合成、晶体结构及其体外抗癌活性研究

Di-n-butyltin oxide reacted with p-[N,N-bis（2-chloroethyl）amino]benzoic acid to yield the compounds {{4-[（ClCH2CH2）2N]C6H4COOSnBu2}2O}2 （1） and {4-[（ClCH2CH2）2N]C6H4COO}2SnBu2 （2）, which have been characterized by IR and ^1H NMR spectra. The X-ray diffractional studies of 1 reveal the structure of the molecule to be a dimer, in which the two Bu2Sn groups were linked via two bridging oxygen atoms to form a central Bu4Sn2O2 unit. And the tin atom adopts two carbons from two n-butyl groups and three oxygen atoms from the acid and the bridging oxygen. In vitro test showed compound 1 to exhibit high cytotoxicity against P388 and HL-60 cell lines.     

有机锡2-(3-吡啶甲基硫代)苯甲酸酯与2-吡啶硫代乙酸酯的合成、结构与抗真菌活性

通过二乙基氧化锡、二丁基氧化锡以及三苯基氧化锡与2-(3-吡啶甲基硫代)苯甲酸和2-吡啶硫代乙酸的反应,3个四核有机锡羧酸酯以及2个单核三苯基锡羧酸酯被合成。它们的结构通过X-射线单晶衍射结构分析得到确证。生物活性测试表明,四核二丁基锡2-吡啶硫代乙酸酯以及单核三苯基锡2-(3-吡啶甲基硫代)苯甲酸酯对西瓜炭疽病菌、花生褐斑以及苹果轮纹菌等具有高的抑制活性。     

Synthesis and Properties of Triphenylgermanium Heteroaromatic Carboxylates and Crystal Structure of Triphenylgermanium 2‐Furoate

Ten triphenylgermanium heteroaromatic carboxylates Ph₃GeO₂CR (where R=2‐furanyl, 2‐furanvinyl, 2‐(5‐tertbutyl) furanyl, 2‐thiophenyl, 2‐pyridinyl, 3‐pyridinyl, 4‐pyridinyl, 3‐indolyl, 3‐indolylmethyl, 3‐indolylpropyl) were synthesized by the reaction of sodium heteroaromatic carboxylates with the triphenylgermanium chloride. All compounds were characterized by elemental analysis, ¹H NMR and MS spectra. The compounds were tested against two human tumour cell lines: MCF‐7 and WiDr. The results showed that they had high activities. The crystal structure of triphenylgermanium 2‐furoate was determined by X‐ray single crystal diffraction. The crystal belongs to monoclinic with space group P2₁/c, a = 1.1545(4), b=0.9934(3), c = 1.6284(5) nm, β= 91.59(5), Z = 4. In this crystal, the structure consists of discrete molecule containing four‐coordinate germanium atom in a distored tetrahedron.     

二苄基锡双(吗啉荒酸酯)的合成、表征及晶体结构

Dibenzyltin bis(dithiomorpholinocarbamate) was synthesized by the reaction of dibenzyltin dichloride with dithiomorpholinocarbamate. The compound was characterized by elemental analysis, IR, ¹H NMR and MS. and the crystal structure was determined by X-ray single crystal diffraction. The crystal belongs to orthorhombic with space group Pca2₁, a=1.8327(3)nm, b= 0.65678(12)nm, c=2.2583(4)nm, Z=4, V=2.718 (9)nm³, D_x=1.528g·cm^-3,μ=1.271mm^-1, F(000)=1272, R₁=0.0434, wR₂=0.1152. In the crystals, the structures consist of discrete molecules containing six-coordinate tin atoms in a distorted octahedron configuration.     

二苄基锡双(四氢吡咯荒酸酯)的合成、表征和晶体结构

Dibenzyltin bis(dithiotetrahydropyrrolocarbamate) was synthesized by the reaction of dibenzyltin dichloride with dithiotetrahydropyrrolocarbamate. The compound was characterized by elemental analysis, IR, ¹H NMR and MS. and the crystal structure was determined by X-ray single crystal diffraction. The crystal belongs to or-thorhombic with space group Pccn, a=2.1665(6)nm, b=0.9932(3)nm, c=1.1979(3)nm,α=90°,β=90°,γ=90°,Z=2,V=2.5777(12)nm³,D_c=1.529g·cm^-3,μ(MoKα)=1.330mm^-1,F(000)=1208,R₁=0.0341, wR₂=0.0627. In the crystals, the structures consist of discrete molecules in which the tin atom is six-coordinate in a distorted octahedron configuration. CCDC: 179919.