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Tetraacetal tetraoxa-cage compounds 3a, 3b, 4a, 4b, 7, 13,14 , and 15 were synthesized by a short sequence. They were obtained from ozonolysis of endo adducts la, lb, 2a, 2b , and 6 in dichloromethane at ?78 °C followed by reduction with dimethyl sulfide. Ozonolysis of 7-anti-trimethylsilyl-5,6-bis-endo-diacetylnorbornene 8 under the same reaction conditions did not give the tetraoxa-cage 9 . The methylsulfinyl oxa-cage 13 derived from l-methylthio-5,6-bis-endo-diacetylnorbornene 11 was converted to compounds 14 and 15. 相似文献
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The reactions of dilactones based on bicycl[2.2.1] heptane and [2.2.2]octane systems with Grignard reagents and LiA1H4 furnished polyfunctional cyclopentanes and oxa-cage compounds resulting from extensive transannular interactions. 相似文献
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Novel benzocyclobutene derivatives, 3-mercaptobicyclo[4.2.0]octa-1,3,5-triene (2), and 3-chlorosulfonylbicyclo[4.2.0]octa-1,3,5-triene (3), have been synthesized in good yields from easily accessible bromobenzocyclobutene 5. 相似文献
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H. S. Abd-Elghaffar M. A. El-Hashash S. F. Mohamed A. A. Ibrahim A. E. Amr M. A. Al-Omar E. S. Nossier 《Russian Journal of General Chemistry》2020,90(4):686-696
A new series of fused 1,3-indandione derivatives has been synthesized and evaluated for anti-proliferative activity. 2-Alkene-1,3-indandione derivatives have been used as the precursors of a number of tricyclic compounds. The latter have been tested for anti-proliferative activity. 相似文献
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Naki Çolak Yılmaz Yıldırır Mustafa Kavutcu Nilhan Nurlu 《Monatshefte für Chemie / Chemical Monthly》2007,138(12):1283-1287
Summary. Methotrexate (MTX) is a folate antagonist used in treatment of several chronic inflammatory and neoplastic conditions. In this study, new MTX-like compounds that may-be potential anticancer agents were synthesized and their structures were determined by IR, UV, GC-MS,
1H NMR, and 13C NMR spectra. Also, in this study, a series structurally related to MTX or folate analogous compounds were evaluated whether they have inhibitory properties on the dihydrofolate reductase activity
(DHFR). 相似文献
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YongCHU MingXiaXU DingLU 《中国化学快报》2004,15(9):1011-1014
Based on our previous studies of 3D-QSAR, 38 novel objective compounds belonging to 4 series were designed and successfully synthesized directed by the idea of reconstructing the structure of non-pharmacophores while reserving essential ones in triazoles. In vitro pilot studies on their antifungal activities showed that most compounds have inhibitory effects on C.albicans and some inhibit S.cerevisiae also. The effects on C.albicans of 5 compounds are more potent than or equal to that of fluconazole or itraconazole. 相似文献
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以二芳基乙酮(4a~4f)和取代丙酮(5a~5c)为原料,KHCO3为碱,100 ℃空气条件下,在DMSO中经二芳基乙酮氧化、羟醛缩合一锅法合成了12个羟基环戊烯酮化合物(6a~6l),其中6d, 6h和6i为新化合物,其结构经1H NMR, 13C NMR和HR-MS(ESI)表征。 相似文献
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Cemil İbis Sibel Sahinler Ayla Neslihan Beyazit Hakan Bahar 《Phosphorus, sulfur, and silicon and the related elements》2013,188(11):1643-1651
Abstract Thiosubstituted butadiene and butenyne compounds were synthesized from the reactions of 1,1,3,3,4,4-hexachloro-1-butene or 1,1,2,4,4-pentachlorobuta-1,3-diene with different thiols in EtOH/H2O solution of NaOH. Tris(thio)substituted butadiene compound was treated with potassium tert-butoxide to obtain tris(thio)substituted butatrienyl halide compound. The novel sulfoxide compounds were synthesized from the reactions of polyhalobutadiene compounds with aliphatic thiols in CHCl3 with m-CPBA at 0°C. The structures of the novel compounds were characterized by micro analysis, FT-IR, 1H-NMR, 13C-NMR, and MS. 相似文献
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新型吡唑并嘧啶并吡唑三元稠合化合物的合成 总被引:1,自引:0,他引:1
Novel fused heterotricyclic compounds 3—6 containing two different dipyrazolopyrimidine framework were prepared from 1a—1d. The reaction of 1 with K2CO3 in DMSO or NaH in DMF led to the formation of 2 or 3, respectively, which reacted further to afford 6 or 5, respectively. 相似文献
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1,3,3-三甲基-2-亚甲基吲哚啉合成新工艺研究 总被引:2,自引:0,他引:2
1,3,3┐三甲基┐2┐亚甲基吲哚啉合成新工艺研究马新起李明静乔聪震(河南大学化学化工学院开封475001)侯希峰(开封化学试剂总厂475001)马新起男,33岁,讲师,从事化学工程教学精细化学品的开发与研究。河南省教委资助研究项目1997-06-3... 相似文献
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