Triterpenoids fromAbies species

Four new compounds were identified in a mixture of tetracyclic methyl ketones obtained by alkaline cleavage of acids of Siberian fir needles. Two of them correspond to natural acids of the 17,13-fridolanostane series of yet unknown structure.For Part 19, see Ref. 1.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2997–2999, December, 1996.     

Triterpenoids fromAbies sp.

The structure of the molecule of a new trinorlanostane hydroxyketone obtained by alkali treatment of total triterpenoid acids from the ether extract of Siberian fir needles was established using NMR spectra and X-ray analysis.For Part 15 see Ref. 1.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 748–751. March, 1996.     

Triterpenoids fromAbies species

Norrish (type II) photochemical fragmentation of 25,26,27-trinor-17,14-frido-9β-lanostane 23-ketone was performed to give the 17α-vinyl derivative, a promising intermediate for the synthesis of 4,4-dimethyl-9β-steroid derivatives. For Part 23, see Ref. 1. Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1401–1402.     

Triterpenoids fromAbies species 18. NMR spectra of abieslactone and its dehydro derivative

The contradictions in the interpretations of the¹³C NMR spectrum of a natural lanostanoid, abieslactone, and of the 1H NMR spectrum a its 9,11-dehydro derivative reported in the literature were resolved by two-dimensional¹H-¹H and¹³C-¹H (COSY) NMR spectroscopy.Translated fromIzvestiya Akademi Nauk. Seriya Khimicheskaya, No. 11, pp.2780–2784, November,1996     

Triterpenoids fromAbies species 19. (22Z)-3α-Hydroxy-17,14-fridolanosta-7,14,22,24-tetraen-26,23-olide,a new lactone from the needles of the Siberian fir

A new triterpenoid lactone with a reported rearranged lanostane skeleton was isolated from the neutral fraction of the extract from the needles of Siberian fir. Its structure was established on the basis of chemical transformations and NMR spectra using two-dimensional (COSY, COLOC) NMR spectroscopy.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp.2792–2794, November,1996For Part 18 see Ref. 1.     

Triterpenoids fromAbies species

The structure and the absolute configuration of 25,26,27-trinor-17,13-frido-9β-lanostane hydroxyketonep-bromobenzoate were established by X-ray structural analysis. This compound readily forms a 1∶1 crystal solvate withn-pentane.     

Triterpenoids fromAbies species

A new component, namely, the cyclic tautomer of previously unknown (24Z)-3, 23-dioxolanosta-8,24-dien-26-oic acid, was isolated from the acidic fraction of the extract from Siberian fir needle. The structure of the title compound was established based on the¹H NMR and circular dichroism spectra.     

Nordammarane Triterpenoids from Sanguisorba officinalis

Three new nordammarane triterpenoids, 12β‐O‐acetyl‐3β,22‐dihydroxy‐23,24,25,26,27‐pentanordammarane ( 1 ), 12β,22‐dihydroxy‐3‐oxo‐23,24,25,26,27‐pentanordammarane ( 2 ), and 3β,12β‐dihydroxy‐23,24,25,26,27‐pentanordammarane‐22‐carbaldehyde ( 3 ), were isolated from the EtOH extract of the roots of Sanguisorba officinalis. Structural elucidation of these new triterpenoids on the basis of spectroscopic analyses, including including 1D‐ and 2D‐NMR, and HR‐ESI‐MS, is reported     

大戟属三萜类结构及生物活性*

大戟属植物在全世界分布有2000多种,对于本属植物二萜类成分及生物活性的综述报道较多,但是还未见关于三萜类化学成分及生物活性的综述报道。本文综述了该属植物各种类型三萜化合物（羊毛脂烷型、环阿尔廷烷型、大戟烷型、甘遂烷型、齐敦果烷型、乌苏烷型及羽扇豆烷型等）的化学性能以及抗肿瘤、抗炎抗菌、抗病毒等主要生物活性的研究。     

Triterpenoids from the Leaves of Ilex hainanensis

Phytochemical investigation on the leaves of Ilex hainanensis Merr . led to the isolation of four new ursane‐ and oleanane‐based triterpenoids, ilexhainanins A–D ( 1 – 4 ), as well as two known compounds, 2α,3β,19α‐trihydroxyurs‐12‐ene‐23,28‐dioic acid and 2α,3β,19α‐trihydroxyolean‐12‐ene‐23,28‐dioic acid. Their structures were elucidated on the basis of chemical and spectroscopic evidence, and by comparison with literature data.     

Four New Lanostane Triterpenoids from Euphorbia humifusa

Four new lanostane triterpenoids, namely (3β)‐3‐hydroxy‐24‐methylenelanost‐8‐ene‐7,11‐dione ( 1 ), (3β)‐3‐hydroxylanosta‐8,24‐diene‐7,11‐dione ( 2 ), (3β,7α)‐3,7‐dihydroxylanosta‐8,24‐dien‐11‐one ( 3 ), and (3β,11β)‐3,11‐dihydroxylanosta‐8,24‐dien‐7‐one ( 4 ) were isolated from Euphorbia humifusa, together with 2 known compounds. The structures of these new compounds were elucidated on the basis of extensive spectroscopic analysis and comparison with the related known compounds.     

Triterpenoids from Eugenia grandis: structure elucidation by NMR spectroscopy

A new pentacyclic triterpenoid, 2alpha,3beta-dihydroxylup-12-en-28-oic acid (1) and a rarely encountered pentacyclic triterpenoid, 3beta-hydroxylup-12-en-28-oic acid (2), together with five known compounds, friedelin (3), 3beta-friedelinol (4), betulinic acid (5), oleanolic acid (6) and beta-sitosterol (7) were isolated from the chloroform extract of stem bark of Eugenia grandis (Syn: Syzygium grande). The structure and stereochemistry of the new compound (1) and the rarely encountered compound (2) were established by 1D and 2D NMR spectroscopic techniques. All the above isolated compounds from this plant are reported for the first time.     

Triterpenoids fromAbies species. I. Abiesonic acid — A triterpenoid with a new carbon skeleton from the oleoresin ofAbies sibirica

The structure and stereochemistry of abiesonic acid — a new triterpenoid with a modified 3,4-secolanostane carbon skeleton isolated in the form of the dimethyl ester from the oleoresin of the Siberian fir — has been established with the aid of x-ray structural analysis. On irradiation with UV light, this ester is converted reversibly into its 24Z- isomer.     

Three New Serratane Triterpenoids from Phlegmariurus squarrosus

Three new serratane triterpenoids, (3α,14α,15α,21α)‐3,14,15,21,29‐pentahydroxyserratan‐24‐oic acid ( 1 ), (3α,21β)‐serrat‐14‐ene‐3,21,24,30‐tetraol ( 2 ), and (3α,21α)‐serrat‐14‐ene‐3,21,24,29‐tetraol ( 3 ), were isolated from Phlegmariurus squarrosus, together with eight known compounds. Their chemical structures were elucidated on the basis of in‐depth spectroscopic analyses.     

Triterpenoids from the Mangrove Plant Hibiscus tiliaceus

Three new triterpenoids with the rarely occurring nigrum skeleton, namely (20E)‐22‐hydroxynigrum‐20‐en‐3‐one ( 1 ), 21β‐hydroxynigrum‐22(29)‐en‐3‐one ( 2 ), and 21α‐hydroxynigrum‐22(29)‐en‐3‐one ( 3 ), were isolated from the mangrove plant Hibiscus tiliaceus. Additionally, five known triterpenoids including friedelin ( 4 ), 12‐oleanen‐3β‐ol ( 5 ), 3β‐hydroxy‐12‐oleanen‐28‐oic acid ( 6 ), 20(29)‐lupen‐3β,28‐diol ( 7 ), and cucurbita‐5,23‐dien‐3β,25‐diol ( 8 ) were also isolated and identified. The latter structures were elucidated by a detailed NMR and MS analyses, as well as by comparison with reported literature data.     

Synthesis of 30-Amino Derivatives of Lupane Triterpenoids

New derivatives of betulin and betulinic acid containing various amines on C-30 that are of interest as potentially biologically active agents were prepared. __________ Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 571–577, November–December, 2005.     

Triterpenoids and lignans from the stems of Schisandra glaucescens

Two new triterpenoids, 24(E)-3α,12α-dihydroxyl-lanost-9(11),24-dien-26-oid acid (1) and 3,4-seco-24(Z)-6α,7β-dihydroxyl-cycloart-4(28),24-dien-3,26-dioic-3-methyl ester (2), and ten known ones (3–12), together with eight lignans (13–20), were isolated from the stems of Schisandra glaucescens. Their structures were established on the basis of extensive spectroscopic analyses. Compounds 1–3, 5–7, 9, 11–13 and 15–18 were isolated from this species for the first time. 1 and 2 were evaluated for their in vitro cytotoxicities against the mouse cancer B16 cell line, human cancer HepG2 and MCF7 cell lines by MTT assay.     

Two New Cycloartane Triterpenoids from Kleinhovia hospita

Two new cycloartane triterpenoids, (23R)‐21,23:23,27‐diepoxycycloarta‐1,24‐diene‐3,27‐dione ( 1 ) and (3α)‐(α‐L ‐arabinopyranosyloxy)‐1α‐hydroxy‐23‐oxocycloartan‐28‐oic acid ( 2 ), together with six known pentacyclic triterpenoids, 3 – 8 , and five known C₂₉ steroids, 9 – 13 , were isolated from Kleinhovia hospita. The structures of these compounds were determined by analysis of their spectroscopic data. Moreover, the absolute configuration of 1 was confirmed by quantum‐chemical TDDFT calculation of its ECD spectrum. All compounds were evaluated for their cytotoxic activities against human colon carcinoma (HCT116) and gastric carcinoma (SGC7901) cell lines, and compounds 6, 7, 8, 11 , and 12 exhibited antiproliferative activities with IC₅₀ values ranging from 23.0 to 91.8 μM .     

Two New Cucurbitane Triterpenoids from Immature Fruits of Momordica charantia

Two new cucurbitane triterpenoids, kuguacin X ( 1 ) and kuguaglycoside I ( 2 ), together with three known analogs, were isolated from immature fruits of Momordica charantia. By detailed analysis of IR, NMR, and MS data, acid hydrolysis, and comparison with spectroscopic data of known compounds, the new compounds were determined to be (23E)‐5β,19‐epoxycucurbita‐6,23‐diene‐3β,22ξ,25‐triol ( 1 ) and (23E)‐5β,19‐epoxycucurbita‐6,23‐dien‐19‐on‐3β,25‐diol 3‐O‐β‐D ‐allopyranoside ( 2 ).