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1.
V. A. Glushkov G. F. Krainova O. A. Maiorova V. I. Karmanov A. A. Gorbunov P. A. Slepukhin 《Russian Journal of Organic Chemistry》2012,48(4):575-581
Addition of 1,3,3-trimethyl-3,4-dihydroisoquinolines to N-benzylideneanilines gives substituted N-[2-(3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)-1-phenylethyl]anilines, whereas 2′,5′,5′-trimethyl-4′,5′-dihydro-4H-spiro[naphthalene-1,3′-pyrrol]-4-one reacts with N-benzylideneanilines along two pathways involving cyclization to substituted 2,3,3a,4,10,11-hexahydrobenzo[f]pyrrolo[2,3-d]quinolin-5(1H)-ones or elimination of the aniline residue with formation of substituted 5′,5′-trimethyl-2-styryl-4′,5′-dihydro-4H-spiro[naphthalene-1,3′-pyrrol]-4-ones. 相似文献
2.
1-α-Cyanoalkyl(aralkyl)-2-pyrazolines were obtained by the reaction of 1-alkylidene(arylidene)-2-pyrazolinium tetrafluoroborates
with metal cyanides. Reduction of the products led to substituted β-aminoalkyl-2-pyrazolines. Hydrolysis of the nitrile groups
gave the corresponding substituted acetamides.
__________
Translated from Khimiya Geterotsiklicheskikh Soedinenii, 10, 1558–1565, October 2005. 相似文献
3.
Livio Racanè Vesna Trali?-Kulenovi? Richard P. Kitson Grace Karminski-Zamola 《Monatshefte für Chemie / Chemical Monthly》2006,18(1):1571-1577
Series of cyano, dicyano, amidino, and diamidino substituted 2-phenylbenzothiazoles were prepared. Mono- and dicyano substituted
benzothiazoles were obtained by condensation of appropriate substituted benzaldehydes with 2-aminothiophenol or 4-amino-3-mercaptobenzonitrile.
The appropriate amidines or diamidines were prepared by Pinner reaction. The compounds were tested against breast, prostate, and lung cancer cell lines in a 72 h cytotoxicity assay. Many
of the compounds had at 10 μM activity equivalent to 2-(4-aminophenyl)benzothiazole, while four compounds had significantly better activity, particularly
in the breast cancer model. 相似文献
4.
Livio Racanè Vesna Tralić-Kulenović Richard P. Kitson Grace Karminski-Zamola 《Monatshefte für Chemie / Chemical Monthly》2006,137(12):1571-1577
Summary. Series of cyano, dicyano, amidino, and diamidino substituted 2-phenylbenzothiazoles were prepared. Mono- and dicyano substituted
benzothiazoles were obtained by condensation of appropriate substituted benzaldehydes with 2-aminothiophenol or 4-amino-3-mercaptobenzonitrile.
The appropriate amidines or diamidines were prepared by Pinner reaction. The compounds were tested against breast, prostate, and lung cancer cell lines in a 72 h cytotoxicity assay. Many
of the compounds had at 10 μM activity equivalent to 2-(4-aminophenyl)benzothiazole, while four compounds had significantly better activity, particularly
in the breast cancer model. 相似文献
5.
Jacek G. So?nicki 《Monatshefte für Chemie / Chemical Monthly》2000,141(8):475-486
1-Acylmethylene-3,3-dimethyl-1,3-dihydroisobenzofurans were found to be useful precursors for pyrazole synthesis. In the reaction with hydrazine monohydrate they yielded 3-(2-(α-hydroxyisopropyl)-phenyl) substituted NH-pyrazoles, whereas using alkyl- or arylhydrazine gave access to 5-(2-(α-hydroxyisopropyl)-phenyl) substituted NR-pyrazoles with good regioselectivity. Treatment with orthophosphoric acid led to C,N-fused and C,C-fused pyrazoles, respectively. 相似文献
6.
Ulrich Englich Ingo Prass Karin Ruhlandt-Senge Thorsten Schollmeier Frank Uhlig 《Monatshefte für Chemie / Chemical Monthly》2002,133(7):931-943
Summary. Hydrido substituted stannasilanes of the type or (Z = H, Me, Ph; R, R′ = alkyl, Ph) are accessible by reaction of either alkali metal stannides (MSn(Z)R
2; M = Li, Na) with halogen substituted silanes (; X = F, Cl) or chlorostannanes (R
2SnCl2, Ph3SnCl) and fluorosilanes in the presence of magnesium. Stannasilanes with halogen substituents at the silicon as well as the tin atom are formed by
treatment of the hydrido substituted stannasilanes with CHCl3 or CCl4. The hydrido substituted stannasilanes decompose in contact with air to distannanes and siloxanes or to the linear (
t
Bu2Sn(–O–
t
Bu2Si–OH)2) and cyclic ((–
t
Bu2Sn–O–
i
Pr2Si–O–)2) stannasiloxanes.
Received November 29, 2001. Accepted (revised) January 16, 2002 相似文献
7.
Jacek G. Sośnicki 《Monatshefte für Chemie / Chemical Monthly》2000,131(5):475-486
Summary. 1-Acylmethylene-3,3-dimethyl-1,3-dihydroisobenzofurans were found to be useful precursors for pyrazole synthesis. In the
reaction with hydrazine monohydrate they yielded 3-(2-(α-hydroxyisopropyl)-phenyl) substituted NH-pyrazoles, whereas using
alkyl- or arylhydrazine gave access to 5-(2-(α-hydroxyisopropyl)-phenyl) substituted NR-pyrazoles with good regioselectivity. Treatment with orthophosphoric acid led to C,N-fused and C,C-fused pyrazoles, respectively.
Received November 4, 1999. Accepted (revised) December 3, 1999 相似文献
8.
Q. Zhong L. He T. E. Beesley W. S. Trahanovsky P. Sun C. Wang D. W. Armstrong 《Chromatographia》2006,64(3-4):147-155
The comparisons of five different chiral stationary phases (CSPs) based on 2,6-dinitro-4-trifluoromethylphenyl (DNP-TFM) ether substituted β-cyclodextrin are presented. The five CSPs differ from each other in the linkage/spacer chemistry, or on the position of the substituents on β-cyclodextrin, or in the sequence of the synthetic procedure. The results show that there are two optimum combinations: (1) DNP-TFM randomly substituted on the β-cyclodextrin as the chiral selector along with a carbamate linkage chain bonding it to the silica support; and (2) β-cyclodextrin derivatized by DNP-TFM substituents only on the C-2 and C-3 positions of the cyclodextrin with an ether linkage chain anchoring it to the silica gel. These two combinations show complementary separations for some enantiomers. The spacer chain effect is much more pronounced for the CSP based on the β-cyclodextrin derivatives with DNP-TFM substituents only on C-2 and C-3 positions than its randomly substituted counterpart. The sequence of derivatizing the cyclodextrin and attaching it to silica gel also affects its selectivity and efficiency. The β-cyclodextrin should be derivatized before it is linked to the silica gel. 相似文献
9.
According to the chemical design, electrorheological properties of supramolecular complex from β-cyclodextrin polymer (β -CDP)
were discussed. Six supramolecular complexes of β-cyclodextrin polymer with substituted salicylic acid and 3-hydroxy-2-naphthoic
acid were synthesized by the solid-phase self-assembly method, and their component and structure were characterized by NMR,
FT-IR, UV-vis and the fluorescence analysis. Then the electrorheological properties of their suspensions in silicone oil were
investigated under DC electric fields. It was found that the yield stresses of these supramolecular complex ER fluids were
7.3–9.8 kPa at 4 kV/mm in DC electric field, which were enhanced by 34%–72% compared with that of pure β-CDP. Among them,
that of β-CDP/3-hydroxy-2-naphthoic acid ER fluid was the highest. It was also found that the ER effect of supramolecular
complexes can be controlled by changing different guests. When the substituted group is at phenyl ring, ER behavior can be
slightly adjusted by the different substituted groups, their number as well as their position at phenyl ring. This can be
proved by the measurement of dielectric properties. 相似文献
10.
V. V. Bakharev A. A. Gidaspov E. V. Peresedova D. B. Krivolapov E. V. Mironova I. A. Litvinov 《Chemistry of Heterocyclic Compounds》2009,45(9):1075-1080
1,3,5-Triazinylnitrile oxides were prepared in situ from 2-R-4-R′-1,3,5-triazin-6-ylnitroformaldoximes and were treated with
substituted acetylenes to give 3,5-disubstituted isoxazoles. The X-ray data obtained for 5-hydroxymethyl-3-(4′-dimethylamino-2′-methoxy-1,3,5-triazin-6′-yl)isoxazole
is discussed. 相似文献
11.
O. V. Fedotova M. I. Skuratova P. V. Reshetov M. A. Panov 《Chemistry of Heterocyclic Compounds》2005,41(12):1480-1483
It has been shown that 2-spiro(3-R-6,6-dimethyl-4-oxo-2,3,4,5,6,7-hexahydrobenzofuran)-2′-(5′, 5′-dimethylcyclohexane-1′,3′-diones)
undergo conversions in reactions with ammonium acetate and hydrazine hydrate into substituted dihydropyridin-2-ones and tetrahydro-1,2-diazepin-7-ones
respectively as a result of ring-opening of the spirodimedonyl fragment through the corresponding amides and hydrazides of
δ-keto acids.
__________
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1800–1804. December, 2005. 相似文献
12.
P. S. Silaichev M. V. Dmitriev Z. G. Aliev A. N. Maslivets 《Russian Journal of Organic Chemistry》2010,46(8):1173-1177
Ethyl 1-alkyl-4,5-dioxo-2-phenyl-4,5-dihydro-1H-pyrrole-3-carboxylates reacted with 3-arylamino-5,5-dimethylcyclohex-2-en-1-ones as carbon-centered 1,5-binucleophiles to
give the corresponding substituted ethyl 1′-alkyl-3,3-dimethyl-1,2′-dioxo-5′-phenyl-1′,2,2′,3,4,10-hexahydro-1H-spiro[acridine-9,3′-pyrrole]-4′-carboxylates whose structure was proved by X-ray analysis. 相似文献
13.
Claudia Lar Gheorghe-Doru Roiban Romina Mariana Crăsneanu Ilişca Mihalca Elena Bogdan Anamaria Terec Ion Grosu 《Central European Journal of Chemistry》2011,9(2):218-223
The synthesis and photophysical properties of several 6,6″ symmetrically substituted 4′-aryl-2,2′:6′,2″-terpyridine derivatives
are reported herein. The UV-Vis spectra in acetonitrile as well as in dichloromethane show two intense bands in the UV areas
252–262 nm and 275–290 nm while the fluorescence emission spectra are only slightly influenced by chemical derivatization. 相似文献
14.
Reactions of aliphatic β-amino-β-(trichloromethyl)vinyl ketones with an excess of ethyl-enediamine at room temperature afford
substituted 2-acetonylideneimidazolidines. The structure of 2-pivaloylmethyleneimidazolidine was established by X-ray diffraction
analysis. 相似文献
15.
V. A. Glushkov E. V. Rotermel’ T. F. Odegova Yu. V. Shklyaev 《Russian Journal of Organic Chemistry》2011,47(9):1318-1322
Hydrolytic cleavage of 1-substituted 2-azaspiro[4.5]undeca-1,6,9-trienes in acid medium is accompanied by dienone-phenole
rearrangement with formation of substituted N-[2-(p-hydroxyphenyl)ethyl] carboxylic acid amides. 1,2-Dimethoxy-3-oxo-15-phenyl-14-azadispiro[5.1.5.2]pentadeca-1,4,14-triene
and 2′-R-7a′-methyl-3a′,4′,5′,6′,7′,7a′-hexahydrospiro[cyclohexa[2,5]diene-1,3′-indol]-4-ones undergo analogous cleavage. 相似文献
16.
Lichitsky B. V. Komogortsev A. N. Dudinov A. A. Krayushkin M. M. 《Russian Chemical Bulletin》2009,58(7):1504-1508
A new method for the synthesis of hitherto unknown substituted 1,7-dihydrospiro-[pyrazolo[3,4-b]pyridine-4,3′-indole]-2′,6(1′H,5H)-diones based on three-component condensation of 5-aminopyrazoles with Meldrum’s acid and isatins is developed. 相似文献
17.
Jan A. Claußen Gonzalo Ochoa Maritza Páez Juan Costamagna Miguel Gulppi Tebello Nyokong Fethi Bedioui José H. Zagal 《Journal of Solid State Electrochemistry》2008,12(5):473-481
We have investigated the electrocatalytic activity of several substituted and unsubstituted cobalt–phthalocyanines of substituted
tetraphenyl porphyrins and of vitamin B12, for the electro-oxidation of 2-mercaptoacetate, with the complexes pre-adsorbed on a pyrolytic graphite electrode. Several
N4-macrocyclic were used to have a wide variety of Co(II)/(I) formal potentials. The electrocatalytic activity, measured as
current at constant potential, increases with the Co(II)/(I) redox potential for porphyrins as Co–pentafluorotetraphenylporphyrin < Co–tetrasulfonatotetraphenylporphyrin < Co-2,2′,2″,2‴tetra-aminotetraphenylporphyrin
and decreases for cobalt phthalocyanines as Co-3,4-octaethylhexyloxyphthalocyanine > Co–octamethoxyphthalocyanine > Co–tetranitrophthalocyanine
Co–tetraaminophthalocyanine > Co–unsubstituted phthalocyanine > Co–tetrasulfonatophthalocyanine > Co–perfluorinated phthalocyanine.
Vitamin B12 exhibits the maximum activity. A correlation of log I (at constant potential) versus the Co(II)/(I) formal potential of the catalysts gives a volcano curve. This clearly shows
that the search for better catalysts for this reaction point to those N4-macrocyclic complexes with Co(II)/(I) formal potentials close to −0.84 V versus SCE, which correspond to an optimum situation
for the interaction of the thiol with the active site.
Dedicated to Prof. Dr. Teresa Iwasita on the occasion of her 65th birthday in recognition of her numerous contributions to
interfacial electrochemistry. 相似文献
18.
Treatment of substituted 2-(2,4-dihydroxyphenacyl)thiazole and 2-(2,4-dihydroxyphenacyl)benzothiazole with propionic and isobutyric
anhydrides gives the substituted 2-ethyl-and 2-isopropyl-7-acyloxychromones. The use of pivaloyl chloride gives 1-pivaloyloxy-2-hetarylstyrene
derivatives.
__________
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 835–840, June, 2008. 相似文献
19.
Bikau Shukla Akira Miyoshi Mitsuo Koshi 《Journal of the American Society for Mass Spectrometry》2010,21(4):534-544
The role of methyl radicals in the networking of sp2 carbons has been explored through kinetic analysis of mass spectra of the gas-phase products of the pyrolysis of toluene
and toluene/acetone mixtures. Pyrolytic reactions were performed in a flow tube reactor at temperatures of 1140–1320 K and
a constant total pressure of 10.38 Torr with a residence time of 0.585 s. On addition of acetone, methyl substituted products
and their derivatives were enhanced. Mass peaks were observed in several sequences at an interval of 14 mass units; these
ions correspond to methyl substituted products formed as a result of hydrogen abstraction (−H) followed by methyl radical
addition (+CH3). Each major peak was usually preceded by a peak at two mass units lower, which was likely produced through dehydrogenation/dehydrocyclization
(−H2) of methyl substituted products. Detected species include a large number of alkyl, cyclotetrafused (CT), cyclopentafused
(CP) mono-, di-, and polycyclic aromatic hydrocarbons (PAHs) along with primary PAHs. The analysis showed that MAC (methyl
addition/cyclization) has a unique capacity to induce the sequential growth of hexagonal networks of sp2 carbons from all fusing sites [1] of a PAH. Moreover, MAC was found capable of answering an important question in PAH growth,
which is expansion of the CT → CP → hexagonal network for which other reported mechanisms are inefficient. 相似文献
20.
The reactions of aliphatic β-amino-β-trifluoromethylvinyl ketones with an excess of ethylenediamine at room temperature afforded
the corresponding 2,3-dihydro-1H-1,4-diazepines or substituted 2-acetonyl-2-trifluoromethylimidazolidines (the latter were obtained when the approach to the
carbonyl group was sterically hindered).
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2305–2308, November, 1998. 相似文献