Synthesis of coumarans from alkenylphenols

A number of substituted coumarans, the structures of which were confirmed by UV and PMR spectroscopy, were synthesized by the reaction of phenols with 4-vinyl-1-cyclohexene in the presence of KU-2 cation-exchange resin.     

Synthesis of Difluoromethylthioesters from Aldehydes

Difluoromethylthioester compounds are yet another important kind of organofluorine compound and are reported here for the first time. They can be efficiently synthesized from various aldehydes. The synthetic method features mild reaction conditions, good tolerance of functional groups, broad substrate scope, and importantly, no metal is involved in the reaction. The approach has the potential to become an important tool for the late‐stage functionalization of advanced synthetic intermediates, and should have many applications in medicinal chemistry.     

Synthesis of ynamides from formamides

N-Formyl-tosylamides can be efficiently converted to N-ethynyl-tosylamides in two steps via the corresponding dichlorovinylamides.     

由香茅醛合成薄荷呋喃反应研究——南开大学本科生创新科研“百项工程”的实践

南开大学为了提高本科生培养质量,促进理论教学与科研实践相结合,在全校范围内开展了本科生创新科研“百项工程”项目。化学学院结合本学科自身特点,引导学生积极参加科研创新实践教学环节,取得了良好的教学效果。介绍了在本科生创新科研“百项工程”项目中以香茅醛为原料合成薄荷呋喃的新方法和“百项工程”的具体实施过程。     

Synthesis of rosefuran from citral

Conclusions The action of pyridinesulfotrioxide causes the conversion of the morpholine derivative of citral to rosefuran.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 11, pp. 2614–2615, November, 1982.     

由羰基糖合成氮杂糖

在甲醇中,二羰基糖和胺形成烯胺,通过氰化硼氢化钠双还原,以较高的收率合成了具有糖苷酶抑制活性的多羟基哌啶.通过加氢钯碳还原脱烷得到了氮杂吡喃型糖苷酶抑制剂1-脱氧野尻毒素(DNJ),其立体结构通过X-单晶衍射得以确定.采用涂钼热解石墨管,硝酸锂为基体改进剂,由石墨炉原子吸收法测定了在所合成的1-脱氧野尻毒素中的钯催化剂残留量.     

新洋茉莉醛的合成

新洋茉莉醛[Helional,2-methyl-3-(1,3-benzedioxol-5-yl)propanal]是一种名贵的单体香料,具有臭氧头香的鲜花香韵和新刈草香气。其合成是用黄樟油制得的胡椒烯丙醛经Raney Ni催化加氢得到新洋茉莉醛粗品,再经硼酸酯、减压分镏得新洋茉莉醛,产率为51％。因为Raney Ni催化选择性较低,     

Synthesis of dihydromorphinones from dihydrocodeinones

Conclusions A preparative method was proposed for obtaining dihydromorphinones based on the O-demethylation of dihydrocodeinones using the AlCl₃·Me₂S complex in CH₂Cl₂.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 2, pp. 488–489, February, 1988.     

Synthesis of thiols from isobornylphenols

4-(3-Sulfanylpropyl)-2-isobornyl-6-methylphenol and 4-(sulfanylmethyl)-2,6-diisobornylphenol were synthesized from the corresponding 4-(bromoalkyl)phenols according to known procedures. Isobornylphenol with a trimethylene linker was converted into thiol by alkaline hydrolysis of thiouronium salt. The methylene-bridged analog was obtained by reduction of S-benzyl thioacetate with LiAlH₄.     

Synthesis of ertugliflozin from d-glucose

A new synthesis of ertugliflozin from d-glucose in 7% overall yield is reported. The reaction sequence involves conversion of d-glucose to a fully protected open chain d-glucose aldehyde in 4 steps, further installation of the aglycon group by a Grignard reaction, introduction of the hydroxymethyl group by a sequential oxidation/aldol reaction/Canizzarro reduction, and finally benzylic oxidation and global deprotection.     

从邻苯二酚合成3,4-亚甲二氧基苯甲醇

胡椒醇;从邻苯二酚合成3;4-亚甲二氧基苯甲醇     

从月桂烯出发合成新铃兰醛

综述了从月桂烯出发合成新铃兰醛的不同合成方法。     

Synthesis of hypoxanthin from xanthin

Conclusions We have described a preparative method for producing hypoxanthin by heating xanthin with a mixture of formamide and benzylamine.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 12, pp. 2821–2822, December, 1969.In conclusion, we wish to express our gratitude to T. N. Sedletskaya for making the spectral studies.     

由α—羧基—硫代半缩醛合成含氮杂环化合物

利用由α-羧基－硫代半缩醛和含氨基的化合物反应,合成了六员含氮杂环化合物,其结构构通过红外,核磁、质谱和元素分析得到了证实。