Substituted pyridines

New 4-n-alkyl-1,2,5-trimethylpiperid-4-ols with pentyl, hexyl, heptyl, nonyl, and decyl radicals in the γ-position of the piperidine ring have been obtained. Similarly-substituted piperidines have been synthesized from them.     

Substituted pyridines

2, 5-Dimethylpiperidol-4, 1, 2, 5-trimethylpiperidol-4, and the gamma isomer of 1, 2, 5-trimethyl-4-phenylpiperidol-4 are dehydrated by various methods. The secondary piperidols mentioned are used to synthesize 5-methyl-2-formylpyridine and 5-methyl-4-phenyl-2-formylpyridine.     

Substituted pyridines

2-Benzyl-3,6-dimethyl-4-phenylpyridine has been obtained from 2,5-dimethyl-4-phenyl-pyridine by the Ladenburg—Chichibabin reaction. The compounds formed in its oxidation have been studied.Translated from Khimiya Geterotsiklicheskikh Soedinii, Vol. 6, No. 6, pp. 779–781, June, 1970.     

Substituted pyridines

5-Methyl-4-phenyl-2-bromomethylpyridine, obtained from 2,5-dimethyl-4-phenylpyridine via the Wohl-Ziegler reaction, was used in the syntheses of substituted 2-aminomethyl-, 2-ethoxymethyl-, and 2-phenoxymethylpyridines.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1211–1212, September, 1971.     

Substituted pyridines

New 4-n-alkyl-1,2,5-trimethylpiperid-4-ols with pentyl, hexyl, heptyl, nonyl, and decyl radicals in the -position of the piperidine ring have been obtained. Similarly-substituted piperidines have been synthesized from them.     

Substituted pyridines

A number of amides and hydrazides of 4-phenyl-2,5-pyridine dicarboxylic acids are synthesized.     

Substituted pyridines

1,2,5-Trimethyl-4-triphenylsilyl-4-piperidol was obtained and converted to 2,5-dimethyl-4-triphenylsilylpyridine. Several transformations of the isomeric piperidols isolated and of the substituted pyridines were examined.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1637–1641, December, 1970.     

Substituted pyridines 5-methyl-4-benzyl-2-styryl(phenylethynyl)pyridines

5-Methyl-4-benzyl-2-styrylpyridine (II), its p-dimethylaminostyryl analog IV, and 5-methyl-4-benzyl-2-(1,3-dioxo-2-hydrindenyl)pyridine (V) have been prepared. II has been converted into 5-methyl-4-benzyl-2-phenylethynylpyridine (VII), 5-methyl-4-benzylpyridine-2-carboxylic acid (VIII), and 3-styryl-6, 7-benzoisoquinoline (X).Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1228–1231, September, 1970.     

Substituted pyridines. preparation of substituted stilbazoles and their reactions

5-Phenyl-9-bromotetrazolo[1, 5c]quinazoline (I) was synthesized. It was shown that I is covalently hydrated at the N₍₆₎=C₍₅₎ bond. The structure of the covalent hydrate (V) was confirmed by cleavage to 5-(2-amino-5-bromophenyl) tetrazole. The probable mechanisms of the covalent hydration and cleavage are examined. V was converted to the 5-methyl derivative (VII).For part X, see [1].     

Substituted pyridines. 2, 5-Dimethyl-4-p-nitrobenzylpyridine and its reactions

2, 5-Dimethyl-4-p-nitrobenzylpyridine has been prepared. Its nitro group has been reduced and its methylene group oxidized.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp 1225–1227, September, 1970.     

Substituted pyridines. 2, 5-dimethyl-4-styryl- and -4-phenylethy-nylpyridines

2, 5-Dimethyl-4-styrylpyridine and 2,5-dimethyl-4-phenylethynylpyridine are prepared from 2, 5-dimethyl-4-β-phenylethylpyridine. Hydration of the second of these compounds gives gw-(2,5-dimethylpyridyl-4)acetophenone.     

Synthesis and Fungicidal Activity of Substituted 3-(1,2-Oxazolidin-3-yl)pyridines

Substituted 3-(1,2-oxazolidin-3-yl)pyridines were synthesized by 1,3-dipolar cycloaddition of ethyl acrylate, styrene, and their derivatives to N-(pyridin-3-ylmethylidene)-N-phenylaminoxide. The obtained compounds exhibit a fungicidal activity.     

Substituted pyridines. 2, 5-diaroyl-4-phenylpyridines and 2, 5-diamino-4-phenylpyridines

2, 5-Dibenzoyl(di-p-toluoyl, di-p-anisoyl)-4-phenylpyridines, 2, 5-dimethyl-4-acetyl(propionyl)phenylpyridine N-oxides, and 2, 5-diamino-4-phenylpyridine have been obtained.     

微波辐射促进的3-烷基取代咪唑并[1,5-a]吡啶合成

分别在常规加热和微波辐射条件下, 由双(2-吡啶甲酰)、二(2-吡啶)甲酮与脂肪醛及醋酸铵在醋酸溶剂中反应成功地制备了3-烷基取代的咪唑并[1,5-a]吡啶. 实验结果表明: 微波法比传统的合成方法产率高、反应时间短. 产物的结构经过¹H NMR, MS和元素分析表征.     

Convenient Routes to Substituted Benzimidazoles and Imidazolo[4,5-b]pyridines Using Nitrobenzene as Oxidant

Various substituted benzimidazoles and imidazolo[4,5-b] pyridines 5a-c have been prepared by condensation of appropriate diamines and aldehydes in nitrobenzene. This method has been utilized to synthesize compounds 5f-h, which are analogues of the DNA binding fluorochrome Hoechst 33258.     

Substituted pyridines. Syntheses based on 2, 5-dimethyl-4-phenyl (β-phenylethyl)pyridine

Condensation of the methyl groups of 2, 5-dimethyl-4-phenylpyridine and 2, 5-dimethyl-4--phenylethylpyridine with some aromatic aldehydes is investigated. The cyclization of 2, 5-dimethyl-4-phenylpyridine to 3-methyl-2-azafluorene and some derivatives of the latter is effected.     

Synthesis of Substituted Imidazo[4,5-b]pyridines as Analogues of the DNA Binding Fluorochrome Hoechst 33258

Various substituted imidazo[4,5-b]pyridine analogues of Hoechst 33258 have been synthesized to explore the potential of selective helicase blockade and anticancer activity. The target compounds II a, b & d were obtained by condensation of the appropriate functionalized diamine and substituted benzimidazole aldehydes in nitrobenzene.