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1.
《Mendeleev Communications》2022,32(4):454-456
Novel 4-oxo-4H-furo[3,2-c]pyran-3-carboxylates and 4-oxo- 4H-furo[3,2-c]chromene-3-carboxylates were prepared from available alkyl 3-bromo-3-nitroacrylates and 4-hydroxy-6- methyl-2H-pyran-2-one or 4-hydroxycoumarin, respectively. Their structures were confirmed by NMR and X-ray data. 相似文献
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研究了3-(2'-苯基-1', 2', 3'-连三唑-4'-基)-4-氨基-5-巯基-1, 2, 4-三唑(1)与取代苯甲酸和脂肪酸(2a-r)在POCl3催化下的反应, 共合成得到18个新的3-(2'-苯基-1', 2', 3'-连三唑-4'-基)-6-烷基/芳基-均三唑并[3, 4-b]-1, 3, 4-噻二唑(3a-r), 经元素分析,IR, 1H NMR和MS进行了结构确证。 相似文献
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Ş. Hakan Üngören Mustafa Saçmacı Cengiz Arıcı Ertan Şahin Taner Arslan Fatma Kandemirli 《Phosphorus, sulfur, and silicon and the related elements》2013,188(11):2877-2890
Novel alkyl substituted 3-(4-benzoyl-1,5-diphenyl-2,3-dihydro-1H-pyrazol-3-yl)-3-oxo-2-(triphenylphosphoranylidene) propanoates (3) were synthesized from 4-benzoyl-1,5-diphenyl-1H-pyrazole-3-carbonylchloride (1) and alkyl (triphenylphosphoranylidene) acetates (2a–b). The synthesized compounds were characterized by elemental analysis, spectroscopic studies (3a–b), and single crystal X-ray diffraction (3a). The mechanism of the reaction between (1) and (2a) was studied by AM1, and the geometrical parameters of the studied molecules were also carried out in B3LYP methods with the standard 6–31G (d,p) basis set. NBO analysis were studied for 1 and 2a B3LYP methods with the standard 6–31G (d,p) basis set. 相似文献
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Yoshio Ueno 《Journal of heterocyclic chemistry》1982,19(6):1579-1580
2-Alkyl-, 4-alkyl-, and 2,4-dialkyl-3H-phenoxazin-3-ones were prepared by reacting 3H-phenoxazin-3-one with alkyl radicals in aqueous acetonitrile at 70–75°. The alkyl radicals were generated from the silver catalysed oxidative decarboxylation of acids with peroxydisulphate. 相似文献
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3-Chloropropylalkyldiethoxysilanes (alkyl: butyl, hexyl and benzyl) were synthesized by the Grignard reaction of 3-chloropropyltriethoxysilane; The amination of the formed 3-chloropropylalkyldiethoxysilanes with ethylenediamine produce 3-(2-amino-ethyl)aminopropylalkyldiethoxysilanes (alkyl: butyl, hexyl). 相似文献
8.
Allen Ko Aaron Lam Jeffrey Li Edyta M. Greer David J. Szalda Sasan Karimi Gopal Subramaniam Keith Ramig 《Tetrahedron letters》2014
2,4-Diphenyl-3H-1-benzazepine is deprotonated with either LDA or KHMDS. The resulting anion is alkylated with alkyl halides or MeOTs, giving either products of alkylation at C3, or at N, or a mixture of both. The regioselectivity depends on the base, presence of the complexing agent HMPA, and the leaving group of the alkylating agent. Using MeI as alkylating agent gives exclusively the C3-methylated product, while using MeOTs gives exclusively the N-methylated product. The N-alkylated products show evidence of stereodynamic behavior in their NMR spectra. 相似文献
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Molero D Coro J Pérez R Suárez M Martínez-Alvarez R Herrera A Martín N 《Magnetic resonance in chemistry : MRC》2007,45(1):93-98
The 1H and 13C NMR spectroscopic data for alkyl and polyamine-linked bis(2-thioxo-[1,3,5]thiadiazinan-3-yl) carboxylic acids, prepared from alkyl diamines and N4-(benzyl) spermidine have been fully assigned by combination of one- and two-dimensional experiments (DEPT, HMBC, HMQC, COSY). 相似文献
10.
The cationic polymerizations of 1, 3-pentadiene were initiated by AlCl_3 in n-hexaneat 30℃ in the presence of alkyl halides, i.e., tert-butyl chloride, tert-butyl bromide andisobutyl chloride. The effects of these halides on the polymer yield, molecular weight,crosslinking reaction, cyclization and polymer microstructure, have been investigated. Twomain side reactions, crosslinking and cyclization, were suppressed and reduced by theaddition of the halides. The proportion of 1, 4 units of polymer chains was increasedby the presence of the halides, which reduced the polymer yield and the molecular weightof polymers. 相似文献
11.
V. M. Berestovitskaya N. A. Anisimova O. N. Kataeva N. G. Makarova G. A. Berkova 《Russian Journal of General Chemistry》2007,77(9):1567-1575
1,3-Dipolar cycloaddition of alkyl 3-nitro-and 3-bromo-3-nitroacrylates to phenyl azide gives regioisomeric alkyl 5(4)-nitro-1-phenyl-4,5-dihydro-1H-1,2,3-triazole-4(5)-carboxylates, the corresponding triazoles both with and without nitro group, and alkyl 3-nitro-1-phenylaziridine-2-carboxylates. Nitrotriazolecarboxylates were found to lose the ester moiety during chromatographic separation of the products on aluminum oxide. The structure of the products was determined on the basis of IR, 1H NMR, and X-ray diffraction data. 相似文献
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James J. Kaminski S. D. Worley Nicholas Bodor 《Journal of mass spectrometry : JMS》1977,12(3):145-149
The mass spectra of a series of 3-chloro and 3-bromo alkyl substituted 2-oxazolidinones have been investigated and compared with the mass spectra of the corresponding alkyl substituted-2-oxazolidinones. Fragmentation of the 2-oxazolidinone ring system has been found to be significantly influenced by: (1) the presence of an alkyl substituent, (2) the position, number and size of the alkyl substitutents, and (3)replacement of the N? H bond by N? CI and N? Br. 相似文献
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A short synthesis of alkyl 2-(bromomethyl)aziridine-2-carboxylates and alkyl 3-bromoazetidine-3-carboxylates was developed involving amination, bromination, and base-induced cyclization of alkyl 2-(bromomethyl)acrylates. These new small ring azaheterocyclic α- and β-amino acid derivatives are promising synthons as demonstrated by their transformation to 2-(aminomethyl)aziridine-2-carboxylates and 3-aminoazetidine-3-carboxylates. 相似文献
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An improved synthesis of 3-(substituted)pyrimido[4,5-c]pyridazine-5,7(1H,6H)-diones, a known subclass of 4-deazatoxoflavins, is reported. The approach involves treatment of 3-methyl-6-(1-methylhydrazinyl)uracil with representative phenyl and alkyl glyoxal monohydrates, which in turn are obtained by selenium dioxide oxidation of the corresponding phenyl and alkyl methyl ketones. The first entry into 4-monosubstituted isomers is also reported. 相似文献
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3‐Alkyl/aryl‐3‐ureido‐1H,3H‐quinoline‐2,4‐diones ( 2 ) and 3a‐alkyl/aryl‐9b‐hydroxy‐3,3a,5,9b‐tetrahydro‐1H‐imidazo[4,5‐c]quinoline‐2,4‐diones ( 3 ) react in boiling concentrated HCl to give 5‐alkyl/aryl‐4‐(2‐aminophenyl)‐1,3‐dihydro‐2H‐imidazol‐2‐ones ( 6 ). The same compounds were prepared by the same procedure from 2‐alkyl/aryl‐3‐ureido‐1H‐indoles ( 4 ), which were obtained from the reaction of 3‐alkyl/aryl‐3‐aminoquinoline‐2,4(1H,3H)‐diones ( 1 ) with 1,3‐diphenylurea or by the transformation of 3a‐alkyl/aryl‐9b‐hydroxy‐3,3a,5,9b‐tetrahydro‐1H‐imidazo[4,5‐c]quinoline‐2,4‐diones ( 3 ) and 5‐alkyl/aryl‐4‐(2‐aminophenyl)‐1,3‐dihydro‐2H‐imidazol‐2‐ones ( 6 ) in boiling AcOH. The latter were converted into 1,3‐bis[2‐(2‐oxo‐2,3‐dihydro‐1H‐imidazol‐4‐yl)phenyl]ureas ( 5 ) by treatment with triphosgene. All compounds were characterized by 1H‐ and 13C‐NMR and IR spectroscopy, as well as atmospheric pressure chemical‐ionisation mass spectra. 相似文献
18.
Catalytic Asymmetric Intramolecular Homologation of Ketones with α‐Diazoesters: Synthesis of Cyclic α‐Aryl/Alkyl β‐Ketoesters 下载免费PDF全文
Dr. Wei Li Fei Tan Xiaoyu Hao Gang Wang Yu Tang Prof. Dr. Xiaohua Liu Dr. Lili Lin Prof. Dr. Xiaoming Feng 《Angewandte Chemie (International ed. in English)》2015,54(5):1608-1611
A catalytic asymmetric intramolecular homologation of simple ketones with α‐diazoesters was firstly accomplished with a chiral N,N′‐dioxide–Sc(OTf)3 complex. This method provides an efficient access to chiral cyclic α‐aryl/alkyl β‐ketoesters containing an all‐carbon quaternary stereocenter. Under mild conditions, a variety of aryl‐ and alkyl‐substituted ketone groups reacted with α‐diazoester groups smoothly through an intramolecular addition/rearrangement process, producing the β‐ketoesters in high yield and enantiomeric excess. 相似文献
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V. N. Britsun A. N. Borisevich A. N. Esipenko M. O. Lozinskii 《Chemistry of Heterocyclic Compounds》2006,42(4):546-550
The products of cyclocondensation of 3-oxo-3-R1-N-R2-propanethioamides with 3-aryl-2-propenoyl chlorides in acetone in the presence of potassium carbonate are 5-acyl-1-aryl(alkyl)-4-aryl-6-thioxopiperidin-2-ones,
5-acyl-2-aryl-6-aryl(alkyl)amino-2,3-dihydro-4H-thiopyran-4-ones, and 2-acetonylidene-3,6-diaryl-5,6-dihydro-4H-1,3-thiazin-4-ones,
the structure of which is proven by both spectral methods and chemical conversions.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 623–628, April, 2006 相似文献
20.
以3-(对甲基)苯胺甲烯基-6-甲基-5,6-二氢-二氢吡喃-2,4'-二酮为例,用半经验量子化学方法和UHF/6-311G水平上的从头算研究了3-芳胺甲烯基-6-烷基-5,6-二氢-二氢吡喃-2,4'-二酮类农药化合物催化氢化的反应机理.通过对反应物、中间物和产物的生成热、净电荷、键序以及前线轨道能量的计算和分析认为标题化合物的催化氢化反应不仅发生了碳碳双键的加成反应,还同时发生了碳氮键的催化氢解反应. 相似文献