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本文研究了纯稀土金属中微量硅的钼蓝测定方法,在pH=1.2时,加入酒石酸破坏磷钼酸以消除磷的干扰,以抗坏血酸为还原剂,在λ=810nm处,测定吸光度,测定浓度范围为0.0005% ̄0.015%。 相似文献
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Three sensitive and accurate spectrophotometric methods have been developed for the assay of enalapril maleate and ramipril, each in its dosage forms. These methods depend on the reaction of the drugs with p-chloranilic acid, the reaction with picric acid, and the ion-pair salt formation with bromocresol green. The proposed methods have been applied to the analysis of these drugs in their commercial tablets. The results obtained were precise and accurate. 相似文献
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Eltanany B. M. El-Hadi H. R. Abd Zaazaa H. E. Eissa M. S. 《Journal of Applied Spectroscopy》2021,88(5):1081-1087
Journal of Applied Spectroscopy - Chloramphenicol (CHL), dexamethasone sodium phosphate (DSP), and tetrahydrozoline HCl (THZ) are co-formulated for conjunctivitis treatment. The ternary mixture... 相似文献
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Five simple and accurate methods are presented for the determination of terazosin (TZ) in tablets. These methods are based on: the direct measurements of the first and second derivative spectra of samples (A), the reaction of TZ with chloranil (CH) in aqueous solution of pH 9 to give an intense yellow color measured at 340 nm (B), the reaction of the drug with mercurochrome (MER) in aqueous alkaline medium to give an intense red color measured at 543 nm (C), the formation of an ion-pair salt between the drug and bromocresol purple (BCP) with subsequent absorbance measurements at 412 nm (D), and a sensitive fluorimetric method (E). The latter method was extended to determine TZ in presence of its degradation products. 相似文献
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A simple and sensitive spectrofluorimetric method was developed for the determination of ezetimibe in its pharmaceutical formulations.
The proposed method is based on investigation of the fluorescence spectral behavior of ezetimibe in sodium dodecyl sulfate
(SDS) micellar system. In aqueous solution of acetate buffer pH 5.0, the fluorescence intensity of ezetimibe was greatly enhanced,
200% enhancement, in the presence of SDS. The fluorescence intensity of ezetimibe was measured at 380 nm after excitation
at 268 nm. The fluorescence-concentration plot was rectilinear over the range of 0.03–3.0 μg/mL with lower detection limit
of 3.08 × 10−3 μg/mL. The method was successfully applied to the analysis of ezetimibe in its commercial tablets; the results were in good
agreement with those obtained with the reported method. The application of the proposed method was extended to the stability
studies of ezetimibe after exposure to different forced degradation conditions, such as acidic, alkaline, photo and oxidative
conditions, according to ICH guidelines. 相似文献
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A highly sensitive, simple and rapid spectrofluorimetric method was developed for the determination of Terbinafine HCl (TRH) and linezolid (LNZ) in their pharmaceutical formulations. The proposed method is based on measuring the native fluorescence of the studied drugs in water at 336 nm after excitation at 275 nm for TRH and 375 nm after excitation at 254 nm for LNZ. The fluorescence–concentration plots were rectilinear over the range of 0.02–0.15 μg/mL for TRH and 0.5–5.0 μg/mL for LNZ. With lower detection limits of 3.0 and 110.0 ng/mL and a lower quantification limit of 9.0 and 320.0 ng/mL for TRH and LNZ, respectively. The method was successfully applied to the analysis of TRH in its commercial tablets, cream, gel and spray formulations and the results were in good agreement with those obtained with the official method. In addition the method was also applied to the analysis of LNZ in its capsule and I.V solution and the results were in good agreement with those obtained with the comparison method. The effect of sensitizers was studied. The method was extended to the determination of the studied drugs in spiked human plasma and the results were satisfactory. 相似文献
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研究了头孢克洛与茚三酮之间的显色反应,确定了反应条件,建立了一种简便而灵敏的测定头孢克洛的分光光度法.实验表明,头孢克洛与茚三酮在pH为5.4的水溶液中,沸水浴1h可以反应完全,产物的最大吸收波长λmax=565nm,表观摩尔吸光系数为4.53×103L·mol-1·cm-1.头孢克洛质量浓度在10-90mg·L-1范围内服从比耳定律,相关系数为0.9993,测定结果的相对标准偏差为1.16%(n=6),回收率在99.0%以上.本方法用于测定制剂中头孢克洛的含量结果与药典法相符. 相似文献
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乙酰螺旋霉素的间接光度法测定 总被引:2,自引:1,他引:1
本文建立了一种乙酰螺旋霉素的新的分析方法,乙酰螺旋霉素在盐酸、磷酸混合液中显棕色,该溶液在470nm处有最大吸收,可用于乙酰螺旋霉素的间接光度法测定。其其线性范围是2.0-50.0mg/mL,相关系数是0.9995,回归方程是y=3.56×10^-3+1.025C。本法用于乙酰螺旋霉素的实际样品测定,结果令人满意。 相似文献
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用分光光度法研究缬氨酸与7,7,8,8-四氰基对苯醌二甲叉(TCNQ)的荷移反应.确定以pH=9.2的三酸缓冲溶液为介质,在50C的水浴中加热30min,形成稳定的络合物,其λmax=417nm,表观摩尔吸光系数ε=7.8×103L·mol-1·cm-1,在1-9μg/mL的范围内符合比耳定律,回收率在96.7%-102.7%,相对标准偏差小于2.9%. 相似文献
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