Two new 24-hydroxylated asterosaponins from Culcita novaeguineae

Two new 24-hydroxylated asterosaponins,sodium(20R,24S)-6α-O-(4-O-sodiumsulfato-β-D-quinovopyranosyl)-5α-cholest-9(11)-en-3β,24-diol 3-sulfate(1) and sodium(20R,24S)-6α-O-[3-O-methyl-β-D-quinovopyranosyl-(1→2)-β-D-xylopyranosyl-(1→3)-β-D-glucopyranosyl]-5α-cholest-9(11)-en-3β,24-diol 3-sulfate(2),were isolated from the starfish Culcita novaeguineae.Their structures were elucidated by extensive spectral analysis and chemical evidences.     

Two New Steroidal Glycosides from Caryopteris terniflora

Two new steroidal glycosides were isolated from the Chinese medicinal plant Caryopteris terniflora. The spectroscopic and chemical evidences revealed that their structures tobe 6-(β-sitosteroyl-3-O-β-glucopyranosidyl) hexacosanate 1 and 6‘-(stigmasteroyl-3-O-β-glucopy-ranosidyl) linolenate 2, respectively.     

Isolation and structure of a galactocerebroside molecular species from the starfish Culcita novaeguineae

A galactocerebroside molecular species, CNC-2, has been isolated from the less polar lipid fraction of a chloroform/methanol extract of the starfish Culcita novaeguineae. The structure of this galactocerebroside molecular species was determined on the basis of chemical and spectroscopic evidence. CNC-2 is a phytosphingosine-type galactocerebroside molecular species with nonhydroxylated and hydroxylated fatty acyl moieties. The isolation of a galactocerebroside from echinoderms is rare.     

A new polyhydroxysteroidal glycoside from the starfish Anthenea chinensis

A new polyhydroxysteroidal glycoside,(20R,24R)-16-O-(4-O-methyl-2-acetamido-2-deoxy-β-D-galactopyranosyl)-24-ethyl- 5α-cholest-8(14)-en-3β,6β,7β,16α-tetrol(anthenoside A,1),was isolated from the starfish Anthenea chinensis.Its structure was elucidated by extensive spectral analysis and chemical evidences.1 exhibited significant cytotoxicity against human tumor K-562, BEL-7402 and U87MG cells.     

A New Phenylpropanoid Glycoside: Serratumoside A from Clerodendrum serratum

In the previous papers"', we have reported some chemical constituents fromClerodendrum serratum var. amplerghlium Moldenke. A continuation of our studies onthe same plant led to the isolation of a new phenylpropanoid, serratumoside A (l), whichis reported in this paper.Serratumoside A (l) with three known phenylpropanoid glycosides identified asacteoside', mwtinoside' and myricoside', respectively, were isolated from the Cserratum. Compound I was isolated as a brown amorphous powder, laly …     

New stigmastane type of steroidal glycosides from the roots of Vernonia cumingiana

Two new stigmastane type of steroidal glycosides, vernoniacums A and B (1 and 2), with a △7,9(11) steroidal core were isolated from the roots of Vernonia cumingiana. Their structures were elucidated based on various spectroscopic techniques, including IR, HR-FAB-MS, and 1D and 2D NMR. Both compounds were evaluated for their cytotoxicity against HeLa and HCT-8 cells, and compound 1 showed mild activity against the tested cell lines with IC50 values of 15.8 and 35.7 pounds were evaluated for their cytotoxicity against HeLa and HCT-8 cells, and compound 1 showed mild activity against the tested cell lines with IC₅₀ values of 15.8 and 35.7 μM, respectively.     

A Steroidal Glycoside from Cynanchum versicolor Bunge

Cynanchum versicolor Bunge, one species of the well known Chinese herbal medicine “paiwei”, has been used as an antifebrile and diuretic agent for a long time in China1. Previous phytochemical studies in this species have reported the occurrence of some…     

Chlorophytoside A, a New Labdane Diterpene Glycoside from Chlorophytum laxum

A new labdane-type diterpene glycoside 1 , chlorophytoside A, had been isolated from Chlorophytum laxum R.Br. The structure had been elucidated as (10S)-6α-hydroxylabda-8,13-dien-15,16-olide 3R-O-β-D-glucopyranoside on the basis of chemical and spectroscopic data.     

A New Enolate Furostanoside from Asparagus Filicinus

The roots of Asparagus filicinus Buch.-Ham are used to treat lung diseases such asbronchitis, pneumonities and cough in folk medicinel. Some steroidal glycosides havebeen isolated and characterized from the roots of this plant by several research groups'-'.In this paper, we report the isolation of a new unusual furostanol glycoside possessing anenolate moiety, whose strUcture was determined by I D and ZD NMR methods, FABMS,and hydrolysis. Bioassay results showed that the compound exhibit…     

Two New Steroidal Saponins from Tacca plantaginea

Two new C27 steroidal glycosides, named taccaoside A(1) and B(2), were isolated from the traditional Chinese herb Tacca plantaginea. The spectroscopic and chemical evidences revealed their structures to be 26-O-β-D-glucopyranosyl-(25R)-3β,26-dihydroxy furost-5,20-diene-3-O-[α-L-rhamnopyranosyl(1→2)]-[α-L-rhamnopyranosyl(1→3)]-β-D-glucopyranoside(1) and 26-O-β-D-glucopyranosyl-(25R)-3β,26-dihydroxy furost-5,20-diene-3-O-[α-L-rhamnopyranosyl-(1→2)]-[β-D-glucopyranosyl(1→3)-α-L-rhamnopyranosyl(1→3)]-β-D-glucopyranoside(2),respectively.     

Two New Steroidal Glycosides from Liriope muscari

Liriope muscari (Decn.) Bailey (Liliaceae) is a folk medicinal plant used as a substitute of Ophiopogon japonicus (Thunb.) Ker-Gawl., mainly distributing in Quanzhou, Fujian Province, China1. Previously, we reported the isolation and identification of two…     

A New Dihydroflavone Glycoside from Glycyrrhiza uralensis

A new dihydroflavone glycoside was isolated from the underground parts of Glycyrrhiza uralensis. Its structure was elucidated as 7-hydroxyl-4′-O-]3-D-(6″-O-α-hydroxylpropionyl) glucopyranosyl dihydroflavone by spectral methods.     

Asterosaponin P2 from the Far-Eastern starfishpatiria (asterina) pectinifera

A new polyhydroxylated steroidal glycoside, asterosaponin P₂, was isolated from the Far-Eastern starfishPatiria (Asterina) pectinifera. The glycoside was identified as the 24R)-29-O-[2-O-sulfo-α-L-arabinofuranosyl]-24-ethyl-5α-cholestane-3β, 6α,8β,15α,16β,29-hexol Na salt. Published inIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 1818–1820, October. 2000     

Two New Cardenolide Glycosides from Biondia hemsleyana

Two new cardenolide glycosides, biondianosides A and B, were isolated from the roots of endemic plant of Biondia hemsleyana (Warb.) Tsiang. Their structures were elucidated as periplogenin-3-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl(1→4)-β-D-cymaropyranoside (1) and 17βH-periplogenin-3-O-β-D-cymaropyranoside (2) by the spectroscopic and chemical methods.     

Two new 14, 15-secopregnane-type steroidal glycosides from the roots of Cynanchum limprichtii

Two new steroidal glycosides 1 and 2, along with three known ones (3–5), were isolated from the 95% ethanol extract of the roots of Cynanchum limprichtii Schltr. The structure of the new compounds was elucidated as 3-O-α-L-diginopyranosyl-(1→4)-β-D-digitoxopyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-thevetopyranosyl-14, 16:15, 20:18, 20-triepoxy-14, 15-secopregn-4, 6, 8 (14)-triene (1) and 3-O-α-L-cymaropyranosyl-(1→4)-β-D-digitoxopyranosyl- (1→4)-β-D-3-demethyl-2-deoxythevetopyranosyl-14, 16: 15, 20: 8, 20-triepoxy-14, 15-secopregn-5, 8 (14)-diene (2) on the basis of spectroscopic analysis together with acidic hydrolysis. All compounds showed cytotoxic activity against the human cancer cell line HL60, with IC₅₀ values of 55.36, 65.41, 17.88, 17.68 and 33.5 μM, respectively. While, only compound 3 showed cytotoxicity against the Caco-2 cell line, with an IC₅₀ value of 67.47 μM.     

Two New Xanthone Glycosides from Swertia Tetraptera

Swertia tetraptera Maxim. is a high altitude perennial plant growing on grassy and moist meadows in the Qinhai-Xizang Plateau. It is used in Tibetan folk medicine for the treatment of hepatic, choleric and inflammatory disease1. In this paper, we report the structure elucidation of two new xanthone glycosides named tetraswerosides A ( 1 ) and B ( 2 ) isolated from the whole plant of Swertia tetraptera.Figure 1 The key HMBC correlations for 1Compound 1 was obtained as yellow amorphous sol…     

Dissectol A,A Novel Monoterpene Glycoside from Incarvillea dissectifoliola

Dissectol A,a novel monoterpene glycoside was isolated from the methanol part of the 95% EtOH extract of Incarvillea dissecfoliola and its structure was determined by 1D and 2D NMR data.     

A New Bianthraqinonc Glycoside from Eremurus chinensis

Eremurus chinensis Fedtch has a wide distribution in the western part of China; it hasbeen used in Chinese folk medicine for the treatment of rheumatism and physicalweaknessl. Only few reports describe polysaccharides'-' rather than other chemicalconstituents from the genus Eremurus. We report here the isolation and structuralelucidation of a new bianthraquinone glycoside, 8-O- P -D-glucopyranosyl-2,7'-hi(l,8dihydroxy-3-methyl-9,10-anthraqu 1 from E. chinensis.The EtOAc soluble fraction ob…     

Paeonivayin, A New Monoterpene Glycoside from Paeonia delavayi

Paeoniarootbark,"Dan-Pi"inChinese,isoneofthemostimportantherbaldrugswhichhasbeenusedfortreatmentofmuscularspasm,chestpains,diarrhoea,bloodandliverdisordersaswellasageneralanalgesicintraditionalChinesemedicine.SignificantchemicalandpharmacologicalinvestigationshavebeenconductedonthedifferentspeciesofPaeonia'-',P.albifiora,P.anomala,P.lacli/loraandP.sloffflllicosa.Asoneofthemainsourcesof"Dan-Pi",theconstituentsofP.delayal'iFranch.havenotbeenstudied.Inthecourseofourstudyonpharmacologicallyac…     

Dracaenoside A and B, New C-22 Steroidal Lactone Glycosides from the Stem of Dracaena cochinchinensis

Two new C-22 steroidal lactone glycosides, named dracaenoside A and B were isolated from the methanol extract of the fresh stem of Dracaena cochinchinensis. Their structures were established as (20S)3β,14α,16β-trihydroxy pregn-5-ene-22-carboxylic acid (22,16)-lactone 3-O-α-L-rhamnopyranosyl (1→2)[ α-L-rhamnopyranosyl (l→4)]-β-D-glucopyranoside and (20S)3β, 14α,16β-trihydroxy pregn-5-ene-22-carboxylic acid (22,16)-lactone 3-O-α-L-rhamnopyranosyl (1→2)[β-D-glucopyranosyl(1→3)]-β-D-glucopyranoside by means of 2D NMR spectral and chemical methods. It is the first time that steroidal lactone glycosides were isolated from the genus Dracaena.