共查询到20条相似文献,搜索用时 375 毫秒
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Yasser M. Loksha Erik B. Pedersen Paolo La Colla Roberta Loddo 《Journal of heterocyclic chemistry》2007,44(6):1351-1356
Different analogues of TMC120 derived from pyridazin‐3(2H)‐one rings were synthesized by coupling of 3,6‐dichloropyridazine with arylacetonitriles, phenols and/or aniline derivative followed by hydrolysis and alkylation with different benzyl bromide derivatives. 相似文献
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Wafaa S. Hamama Mohamed A. Ismail Saad Shaaban Hanafi H. Zoorob 《Journal of heterocyclic chemistry》2008,45(4):939-956
This review article includes a recent development in the chemistry of 4‐thiazolidinones. Structure, basicity, synthetic aspects, reactions, and applications were also reported. 相似文献
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Said A. S. Ghozlan Ismail A. Abdelhamid Hamdi M. Hassaneen Mohamed H. Elnagdi 《Journal of heterocyclic chemistry》2007,44(1):105-108
1‐Arylhydrazonopyruvaldehydes 1 react with α,β‐unsaturated nitriles 2 to yield 6‐amino‐1,4‐dihydropyridazines 4 that are converted into pyridazinones 5 via refluxing in an acetic acid/hydrochloric acid mixture and into the ethylidenemalononitrile derivatives 6 on reflux with malononitrile in ethanolic/piperidine solution. 相似文献
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Mingliang Ma Chengwei Li Xiaoyan Li Ke Wen Yahu A. Liu 《Journal of heterocyclic chemistry》2008,45(6):1847-1849
A regioselective Suzuki coupling of 2,6‐dichloronicotinic acid with aryl boronic acids to synthesize 6‐aryl‐2‐chloronicotinic acids is described. Regioselectivity was achieved in aqueous dioxane using the routinely used catalyst Pd(PPh3)4. 相似文献
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Clare E. Gutteridge Marshall M. Hoffman Apurba K. Bhattacharjee Lucia Gerena 《Journal of heterocyclic chemistry》2007,44(3):633-637
Computer modelling suggests that 7‐benzylamino‐1‐isoquinolinamines should mediate antimalarial effects by a mechanism distinct from that employed by existing antimalarial drugs. A series of these compounds was prepared in seven synthetic steps, via reductive amination of 1,7‐isoquinolinediamine. In vitro efficacy testing of the novel compounds against Plasmodium falciparum revealed them to be potent antimalarial agents. 相似文献
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Juan C. Rodríguez‐Domínguez Alexander Balbuzano‐Deus Miguel A. López‐López Juan C. Rodríguez‐Domínguez Gilbert Kirsch 《Journal of heterocyclic chemistry》2007,44(1):273-275
An efficient two steps procedure for the synthesis of 1‐acetyl‐1H‐indol‐3‐yl acetates, starting from 2‐chlorobenzoic acids, was developed and in general, moderate to good yields were obtained 相似文献