共查询到20条相似文献,搜索用时 15 毫秒
1.
2.
A mild and efficient procedure for the synthesis of 3,4‐dihydropyrimidin‐2(1H)‐(thio)ones in phosphinite ionic liquid is described. This ionic liquid plays a dual role as both the reaction media and also a catalyst, which can be easily recovered and reused in several runs. © 2009 Wiley Periodicals, Inc. Heteroatom Chem 20:284–288, 2009; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20549 相似文献
3.
A covalently cross‐linked graphene oxide (GO) as a catalyst was prepared by a cross‐linking process using the nucleophilic reaction of zirconium (IV)‐coordinated 5,10,15,20‐tetrakis (aminophenyl)porphyrin (ZrPPh) with carboxyl groups of the edges of GO (GO‐ZrPPh). The chemical structure of catalyst was characterized by different analyses such as FT‐IR, SEM, TEM, EDS, ICP, TGA and UV. All analyses confirm the occurrence of successfully covalent immobilization of ZrPPh on the GO. Also, TEM and SEM images show that ZrPPh has been immobilized in the both of the edges and the basal plane of GO. The activity of the catalyst was studied for the synthesis of 3,4‐dihydropyrimidin‐2(1H)‐ones via Biginelli reaction. The cross‐linked catalyst is able to catalyze the reaction in short reaction times and good to excellent yields. 相似文献
4.
D. Shobha M. Adharvana Chari P. Sadanandam K. Mukkanti 《Journal of heterocyclic chemistry》2008,45(4):1225-1227
5.
2‐Chloro‐5‐(chloromethyl)‐pyridine reacted with 3,4‐dihydropyrimidin‐2(1H)‐ones 1 to afford 1‐[6‐aryl‐1‐(6‐chloropyridin‐3‐yl‐methyl)‐2‐(6‐chloropyridin‐3‐yl‐methylthio)‐4‐methyl‐1,6‐dihydropyrimidin‐5‐yl] carboxylates or ethanones 2 in good yields. The structure of the target compounds 2 was confirmed by IR, 1H NMR, EI‐MS, and elemental analyses, and compound 2a was further characterized by single crystal X‐ray diffraction. The preliminary bioassay indicated that some of the title compounds possess moderate insecticidal and fungicidal activities. J. Heterocyclic Chem., (2011). 相似文献
6.
A general and convenient route for the synthesis of dihydropyrimidines bearing the phosphoryl moiety by a one‐pot cyclocondensation involving aldehydes, urea, and O,O‐dialkyl‐2‐oxo‐propanephosphonates, using ytterbium triflate as catalyst, is reported. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:13–17, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10058 相似文献
7.
A series of novel 4‐(2‐(4‐bromophenyl)‐1,2,3‐triazol‐4‐yl)‐3,4‐dihydropyrimidin‐2(1H)‐ones/thiones were prepared by condensing 2‐(4‐bromophenyl)‐4‐formyl‐1,2,3‐triazole with 1,3‐dicarbonyl compound and urea or thiourea using Mg(NO3)2 as an efficient and cheap catalyst. The satisfactory results were obtained with excellent yields and short reaction time. J. Heterocyclic Chem., (2010). 相似文献
8.
E. Rajanarendar P. Ramesh G. Mohan E. Kalyan Rao 《Journal of heterocyclic chemistry》2007,44(2):483-486
9.
10.
Mykhaylo V. Vovk Volodymyr A. Sukach Alexander N. Chernega Volodymyr V. Pyrozhenko Andriy V. Bol'but Alexander M. Pinchuk 《Heteroatom Chemistry》2005,16(5):426-436
Functionalized 2,3‐dihydro‐1,3‐thiazin‐4(1H)‐one derivatives have been synthesized by cyclocondensation of 3‐alkyl(aryl)amino‐2‐cyano‐3‐mercaptoacrylamides with aldehydes and ketones under acidic catalysis. 6‐Alkyl(aryl)amino‐5‐cyano‐2,3‐dihy‐ dro‐1,3‐thiazin‐4(1H)‐ones, when treated with a dilute solution of potassium hydroxide, are converted into the potassium salts of isomeric compounds, 1‐alkyl‐ (aryl)‐5‐cyano‐6‐mercapto‐2,3‐dihydropyrimidin‐ 4(1H)‐ones. Alkylation of the latter with dimethyl sulfate in situ furnishes 1‐alkyl(aryl)‐6‐alkylthio‐5‐ cyano‐2,3‐dihydropyrimidin‐4(1H)‐ones, whereas boiling them in ethanol with an excess of hydrochloric acid leads to starting 2,3‐dihydro‐1,3‐thiazin‐4(1H)‐ones. © 2005 Wiley Periodicals, Inc. Heteroatom Chem 16:426–436, 2005; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20129 相似文献
11.
Vakhid A. Mamedov Nataliya A. Zhukova Victor V. Syakaev Tat'yana N. Beschastnova Milyausha S. Kadyrova Anastasiya O. Isaeva Sevil V. Mamedova Elena L. Gavrilova Shamil K. Latypov Oleg G. Sinyashin 《Journal of heterocyclic chemistry》2019,56(8):2221-2234
Facile and efficient methods for the synthesis of 3‐benzylquinoxalin‐2(1H)‐ones and thiazolo[3,4‐a]quinoxalin‐4(5H)‐ones by the reaction of the readily available 3‐(α‐chlorobenzyl)quinoxalin‐2(1H)‐ones and thiourea have been developed, with multiple roles of the latter. Possible mechanisms are discussed. These two‐step sequences can be performed in a one‐pot manner to produce the desired products in moderate to high yields. 相似文献
12.
Shujiang Tu Fang Fang Songlei Zhu Tuanjie Li Xiaojing Zhang Qiya Zhuang 《Journal of heterocyclic chemistry》2004,41(2):253-257
Simple and improved conditions have been found to carry out the Biginelli reaction for the synthesis of 3,4‐dihydropyrimidin‐2(1H)‐one derivatives. This synthesis was performed using potassium hydrogen sulfate as the promoter in ethylene glycol solution. Compared with the classical Biginelli reaction conditions, this new method has the advantage of excellent yields (85–95%) and short reaction time (0.5–2 h). 相似文献
13.
14.
Cobalt‐based metal coordination polymers with 4,4′‐bipyridinyl groups: highly efficient catalysis for one‐pot synthesis of 3,4‐dihydropyrimidin‐2(1H)‐ones under solvent‐free conditions
下载免费PDF全文
![点击此处可从《应用有机金属化学》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Jin‐Hua Wang Gui‐Mei Tang Shi‐Chen Yan Yong‐Tao Wang Shi‐Jie Zhan E Zhang Yu Sun Yuan Jiang Yue‐Zhi Cui 《应用有机金属化学》2016,30(12):1009-1021
Three new metal coordination complexes, namely [Co(BPY)2(H2O)2](BPY)(BS)2(H2O)4 ( 1 ), [Co(BPY)2(H2O)4](ABS)2(H2O)2 ( 2 ) and [Co(BPY)(H2O)4](MBS)2 ( 3 ) (BPY = 4,4′‐bipyridine, BS = phenylsulfonic acid, ABS = p‐aminobenzenesulfonic acid, MBS = p‐methylbenzenesulfonic acid), were obtained under hydrothermal conditions. Complexes 1 , 2 , 3 were structurally characterized using single‐crystal X‐ray diffraction and infrared spectroscopy. All of them display low‐dimensional motifs: complex 1 displays a two‐dimensional structure; and complexes 2 and 3 exhibit a one‐dimensional tape structure. Through strong intermolecular hydrogen bonding interactions and weak packing interactions, all of them further stack to generate a three‐dimensional supramolecular architecture. Catalysts 1 , 2 , 3 were involved in the green synthesis of a variety of 3,4‐dihydropyrimidin‐2(1H)‐ones under solvent‐free conditions through Biginelli reactions. The corresponding catalytic product was obtained in quantitative yields (99%) under eco‐friendly synthesis conditions for the variety of reactions. Catalysts 1 , 2 , 3 exhibit excellent efficiency for the desired product, and their catalytic performance shows the following order: 2 > 1 ≈ 3 , which can be ascribed to the hydrophobic interactions of different phenylsulfonate groups. The catalytic performance for the Biginelli reaction is not only dependent on the selected solvents, but also inversely proportional to the polarities of the solvents. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
15.
Masoud Nasr‐Esfahani Bahador Karami Morteza Montazerozohori Karim Abdi 《Journal of heterocyclic chemistry》2008,45(4):1183-1185
16.
One‐pot Synthesis of 1,2,3,4‐Tetrahydropyrimidin‐2(1H)‐thione Derivatives and their Biological Activity
下载免费PDF全文
![点击此处可从《Journal of heterocyclic chemistry》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Mounir A. I. Salem Magda I. Marzouk Marwa S. Salem Ghazala A. Alshibani 《Journal of heterocyclic chemistry》2016,53(2):545-557
2‐Thioxo/oxo‐1,2,3,4‐tetrahydropyrimidine‐5‐carboxylate derivatives 2a , 2b , 2c , 2d were prepared by the reaction of ethyl acetoacetate and thiourea or urea with aldehydes using NH4Cl as a catalyst. Compounds 2a and 2c reacted with mono and bihalogenated compounds such as ethyl iodide, chloroacetonitrile, epichlorohydrin, acetyl chloride, ethyl bromoacetate, chloroacetic acid, chloroacetylchloride, and/or oxalyl chloride to afford compounds 3 , 4a , 4b , 5 , 6a , 6b , 7 , 8 , 9 and 10 , respectively. Compounds 2a , 2c , and 7 were allowed to react with p‐fluorobenzaldehyde to yield the corresponding products 11a , 11b , and 12 , respectively. Oxidation of 2a and 2c gave 2b , 13a , 13b , 14 , 15 , 16 dependent on the oxidizing agent used. Vilsmeiere‐Haack formylation of 2a and 2b with POCl3/DMF afforded 17a and 17b . Chlorination of 2b and 2d gave the chlorinated derivative 18a and 18b , which reacted with thiourea to give thioureidopyrimidine 19a and 19b . Reactions of 2a with hydrazine monohydrate, semicarbazide hydrochloride, and sodium hydroxide gave compounds 20 , 21 , 22 , respectively. The cytotoxicity and in vitro anticancer evaluation of some prepared compounds have been assessed against two different human tumor cell lines including breast adenocarcinoma MCF‐7 and human hepatocellular carcinoma HepG2. Antimicrobial and antioxidant activities of some compounds were investigated. The newly synthesized compounds were characterized by IR, 1H‐NMR, 13C‐NMR, and mass spectral data. 相似文献
17.
An application of ultrasonic irradiation in the one‐pot synthesis of N‐acetyl‐2‐aryl‐1,2‐dihydro‐(4H)‐3,1‐benzoxazin‐4‐ones from the condensation reaction between aromatic aldehydes and anthranilic acid in the presence of excess amount of acetic anhydride has been explored. The reactions proceed smoothly under mild and solvent‐free conditions at room temperature in the absence of any catalyst to afford the products in good to excellent yields. © 2011 Wiley Periodicals, Inc. Heteroatom Chem 22:106–113, 2011; View this article online at wileyonlinelibrary.com . DOI 10.1002/hc.20663 相似文献
18.
19.
Design and Synthesis of Novel 3‐(Phenyl)‐2‐(3‐substituted propylthio) Quinazolin‐4‐(3H)‐ones as a New Class of H1‐Antihistaminic Agents
下载免费PDF全文
![点击此处可从《Journal of heterocyclic chemistry》网站下载免费的PDF全文](/ch/ext_images/free.gif)
A series of novel 3‐(phenyl)‐2‐(3‐substituted propylthio) quinazolin‐4‐(3H)‐ones were synthesized by the reaction of 2‐(3‐bromopropylthio)‐3‐(phenyl) quinazolin‐4‐(3H)‐one with various amines. The starting material, 2‐(3‐bromopropylthio)‐3‐(phenyl) quinazolin‐4‐(3H)‐one was synthesized from aniline. When tested for their in vivo H1‐antihistaminic activity on conscious guinea pigs, all the test compounds protected the animals from histamine‐induced bronchospasm significantly. Compound 2‐(3‐(4‐methylpiperazin‐1‐yl) propylthiothio)‐3‐(phenyl) quinazolin‐4(3H)‐one ( Ph5 ) emerged as the most active compound (73.23% protection) of the series when compared with the reference standard chlorpheniramine maleate (70.09% protection). Compound Ph5 shows negligible sedation (5.01 %) compared with chlorpheniramine maleate (29.58%). Therefore, compound Ph5 can serve as the leading molecule for further development into a new class of H1‐antihistaminic agents. 相似文献
20.
An Efficient and Facile Synthesis of 5‐(Thiophene‐2‐carbonyl)‐6‐(trifluoromethyl)‐tetrahydro‐pyrimidin‐2(1H)‐one and 6‐(Thiophen‐2‐yl)‐4,5‐dihydropyrimidin‐2(1H)‐one from Same Substrates Under Different Conditions
下载免费PDF全文
![点击此处可从《Journal of heterocyclic chemistry》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Rong Liang‐Ce Yunyun Zha Sheng Xia Linlin Ji Jing Zhang Peijun Cai 《Journal of heterocyclic chemistry》2016,53(1):56-63
A series of 5‐(thiophene‐2‐carbonyl)‐6‐(trifluoromethyl)‐tetrahydropyrimidin‐2(1H)‐one and 6‐(thiophen‐2‐yl)‐4,5‐dihydropyrimidin‐2(1H)‐one derivatives have been synthesized from the reactions of aromatic aldehydes, 4,4,4‐trifluoro‐1‐(thien‐2‐yl)butane‐1,3‐dione and urea under the different conditions with high yields. In this research, it was found that the p‐toluenesulfonic acid was an efficient catalyst for obtaining 5‐(thiophene‐2‐carbonyl)‐6‐(trifluoromethyl)‐tetrahydropyrimidin‐2(1H)‐one derivative. At the same time, solvent‐free and NaOH were the preferred conditions for the synthesis of 6‐(thiophen‐2‐yl)‐4,5‐dihydropyrimidin‐2(1H)‐one derivative. Moreover, because of short reaction time, excellent yields, simple setup, this research offered an efficient process for preparing these kind compounds. 相似文献