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1.
The synthesis of substituted quinolines can be easily and greenly accomplished by the direct reaction between the corresponding aminoalcohol and ketone using PEG‐400 as reaction medium in the presence of a base, without any transition‐metal catalyst. 相似文献
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《应用有机金属化学》2017,31(2)
A magnetic nanocatalyst of Fe3O4@SiO2/ZnCl2 was prepared by supporting ZnCl2 on silica‐coated magnetic nanoparticles of Fe3O4. This recoverable catalyst was used for the synthesis of quinolines via Friedländer synthesis from 2‐aminoaryl ketones and α‐methylene ketones under solvent‐free condition. The prepared catalyst was characterized by FT‐IR, TEM, SEM, XRD, EDX, ICP‐OES, VSM and BET. It was found that Fe3O4@SiO2/ZnCl2 showed higher catalytic activity than homogenous ZnCl2, and could be reused several times without significant loss of activity. 相似文献
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A mild and efficient route for the synthesis of quinolines and polycyclic quinolines utilizing Gadolinium triflate (Gd(OTf)3) as a novel catalyst via Friedländer annulation in ionic liquid 1‐n‐butyl‐3‐methyl‐imidazolium hexafluorophosphate [Bmim][PF6] under mild conditions was described. 相似文献
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A mild, efficient, and solvent‐free version of Friedländer annulation of 2‐amino ketones and α‐methylene carbonyl compounds for the synthesis of polysubstituted quinolines using a catalytic amount of commercially available iron(III) chloride at room temperature in excellent yields is described. 相似文献
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Fe3O4@SiO2‐imid‐PMAn Magnetic Porous Nanosphere as Reusable Catalyst for Synthesis of Polysubstituted Quinolines under Solvent‐free Conditions 下载免费PDF全文
In this research, a facile one‐pot synthesis of poly‐substituted quinoline derivatives has been demonstrated by using 2‐aminobenzophenones and ethylacetoacetate or ketones in the presence of Fe3O4@SiO2‐imid‐PMAn and Fe3O4@SiO2‐imid‐PMAb nanoparticles as green and reusable catalysts under solvent‐free conditions. The reaction proceeds efficiently in excellent yields and in a state of excellent purity. The nanocatalysts can be recycled and reused for at least four times without noticeably decreasing in catalytic activity. 相似文献
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A mild, efficient, and high-yielding method for the synthesis of 2-aryl-2,3-dihydroquinolin-4(1H)-ones from their corresponding 2-amino chalcones using silica chloride (SiO2Cl) under solvent-free conditions is described. A series of 2-aryl-2,3-dihydroquinolin-4(1H)-ones containing both electron-donating and electron-withdrawing substituents were synthesized. 相似文献
7.
Structurally diverse aldehydes are successfully converted into 1,1‐diacetates with acetic anhydride using cyanuric chloride as a mild, convenient and inexpensive catalyst under solvent‐free conditions. The noteworthy features of the present system are shorter reaction times, and mild and solvent‐free conditions. Furthermore, it offers chemoselective protection of aldehydes. 相似文献
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The Friedländer synthesis offers efficient access to substituted quinolines from 2-aminobenzaldehydes and activated ketones in the presence of a base. The disadvantage of this procedure lies in the fact that relatively few 2-aminobenzaldehyde derivatives are readily available. To overcome this problem, we report a modification of this process involving the in situ reduction of 2-nitrobenzaldehydes with Fe/AcOH in the presence of active methylene compounds (AMCs) to produce substituted quinolines in high yields. The conditions are mild enough to tolerate a wide range of functionality in both reacting partners and promote reactions not only with phenyl and benzyl ketones, but also with β-keto-esters, β-keto-nitriles, β-keto-sulfones and β-diketones. The reaction of 2-nitroaromatic ketones with unsymmetrical AMCs is less reliable, giving a competitive formation of substituted quinolin-2(1H)-ones from the cyclization of the Z Knoevenagel intermediate which appears to be favored when certain large groups are adjacent to the AMC ketone carbonyl. 相似文献
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活性炭固载氯化铁催化合成柠檬酸三丁酯 总被引:13,自引:1,他引:12
研究了以活性炭固载氯化铁为催化剂 ,柠檬酸和正丁醇为原料合成柠檬酸三丁酯 ,通过正交试验和单因素检验确定了最佳合成条件 ,结果表明 :当柠檬酸用量为 0 .1mol时 ,正丁醇用量为 0 .5mol,催化剂用量为 4g ,在回流温度控制反应时间为 2h ,其酯化率可达 95 .7% 相似文献
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A potent ACAT (acyl-CoA: cholesterol acyltransferase) inhibitor SMP-797 was effectively synthesized by the urea formation of 3-amino-4-aryl-1,8-naphthyridin-2(1H)-one and 4-amino-2,6-diisopropylamine. The synthesis of the former compound involved the Suzuki coupling reaction as a key step, and the latter was prepared by the 4-selective nitration of 2,6-diisopropylaniline using 2,3,5,6-tetrabromo-4-methyl-4-nitro-2,5-cyclohexadienone. 相似文献
15.
Andrzej Danel Ewa Gondek Mateusz Kucharek Pawe Szlachcic Arkadiusz Gut 《Molecules (Basel, Switzerland)》2022,27(9)
This paper summarises a little over 100 years of research on the synthesis and the photophysical and biological properties of 1H-pyrazolo[3,4-b]quinolines that was published in the years 1911–2021. The main methods of synthesis are described, which include Friedländer condensation, synthesis from anthranilic acid derivatives, multicomponent synthesis and others. The use of this class of compounds as potential fluorescent sensors and biologically active compounds is shown. This review intends to summarize the abovementioned aspects of 1H-pyrazolo[3,4-b]quinoline chemistry. Some of the results that are presented in this publication come from the laboratories of the authors of this review. 相似文献
16.
A silica‐based chiral stationary phase (CSP) derived from L‐α‐norleucinyl‐ and pyrrolidinyl‐disubstituted cyanuric chloride was prepared for the enantioseparation of methyl esters of N‐(3,5‐dinitrobenzoyl) amino acids by high‐performance liquid chromatography. The chromatographic results show that effective enantioseparation of methyl esters of N‐(3,5‐dinitrobenzoyl)amino acids, except for proline, was achieved on this chiral stationary phase. The chromatographic resolution of racemic n‐propyl ester of N‐(3,5‐dinitrobenzoyl)valine on CSP‐B is better than that of racemic methyl ester of N‐(3,5‐dinitrobenzoyl)valine on CSP‐B or CSP‐A reported previously (J. Chromatogr. A, 676 (1994) 303). The comparison of the chromatographic results obtained in this study with those on CSP‐A reported previously reveals that steric effect, instead of hydrophobic interaction, between the n‐butyl group attached to the chiral center of the chiral selector and the alkyl group attached to the chiral center of the chiral selectand plays a significant role in chiral discrimination. The increase in the selectivity factor of methyl esters of N‐(3,5‐dinitrobenzoyl)amino acids with bulky alkyl groups was examined on CSP‐B. 相似文献
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A simple and efficient method for the convenient synthesis of 2-arylbenzimidazole has been described on reaction with o-phenylenediamine and various aromatic aldehydes using cobalt(II) chloride hexahydrate as a catalyst. The method is cost-effective, high-yielding, clean, and selective. 相似文献
19.
A new application of silica chloride as an easily available and reusable solid acid catalyst for the synthesis of benzimidazole and its derivatives through the condensation of o‐phenylenediamines and orthoesters under thermal and solvent‐free conditions is described. This novel and eco‐friendly method is very cheap and has many advantages including excellent yields, short reaction time, and simple work‐up procedure. 相似文献
20.
Mohammad Ali Zolfigol Farhad Shirini Arash Ghorbani Chogamarani 《Phosphorus, sulfur, and silicon and the related elements》2013,188(9):2019-2025
Nitrophenols can be obtained via direct nitration of phenols with silica chloride, NaNO2, and wet SiO2 at room temperature in moderate to high yields. 相似文献