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1.
Three cholestane bisdesmosides, together with the corresponding aglycone, were isolated from the whole plant of Reineckia carnea. By detailed analysis of the 1D‐ and 2D‐NMR spectra, chemical methods, and comparison with spectral data of known compounds, the structures were determined to be (1β,3β,16β,22S)‐cholest‐5‐ene‐1,3,16,22‐tetrol ( 1 ), (1β,3β,16β,22S)‐cholest‐5‐ene‐1,3,16,22‐tetrol 1,16‐di(β‐D ‐glucopyranoside) ( 2 ), (1β,3β,16β,22S)‐cholest‐5‐ene‐1,3,16,22‐tetrol 1‐[O‐α‐L ‐rhamnopyranosyl‐(1→2)‐β‐D ‐glucopyranoside] 16‐(β‐D ‐glucopyranoside) ( 3 ), (1β,3β,16β,22S)‐cholest‐5‐ene‐1,3,16,22‐tetrol 1‐(β‐D ‐glucopyranoside) 16‐(3‐O‐acetyl‐β‐D ‐glucopyranoside) ( 4 ). Compounds 3 and 4 appeared to be new compounds, while compound 1 was isolated for the first from a natural source. Compound 2 was isolated from the genus Reineckia for the first time. 相似文献
2.
Two new isospirostanol sapogenins named(25R)-5β-spirostane-(1α,3α)-diol(1) and(25R)-5β-spirostane-(1α,2α,3α,4α)tetrol(2) were isolated from the whole herb of Reineckia camea(Andr.) Kunth.The structures of the sapogenins were elucidated bychemical and spectral methods. 相似文献
3.
A new polyhydroxylated pregnane, named lβ,2β,3β,4β,5β,6β-hexolhydroxy-pregn-16-en-20-one (1), along with nine known (2–10) steroidal saponins were isolated from the whole plant of Reineckia carnea. Structure elucidations of all compounds were established by interpretation of their NMR spectral data, HR-ESI-MS and comparing with literatures. In addition, these compounds were evaluated with anticomplement activity. The result showed that compound 1 exhibited anticomplement effects with the CH50 values of 0.043 mg/mL, but saponins (2–10) showed no inhibition. Interestingly, hydrolysis of steroidal saponins (2–10) resulted in its aglycones (2a–10a) correspondingly which showed anticomplement activity with the CH50 values of 0.049–0.156 mg/mL. 相似文献
4.
David Pertuit Tayebe Baghery Lotfabad Anne‐Claire Mitaine‐Offer Tomofumi Miyamoto Chiaki Tanaka Marie‐Aleth Lacaille‐Dubois 《Helvetica chimica acta》2015,98(5):611-617
Two new triterpene glycosides, 1 and 2 , together with three known ones, were isolated from roots of Acanthophyllum laxiusculum Schiman ‐Czeika . The structures of the new compounds were established by extensive 1D‐ and 2D‐NMR spectroscopic experiments and MS analyses as 23‐O‐β‐D ‐galactopyranosylgypsogenic acid 28‐O‐{β‐D ‐glucopyranosyl‐(1→2)‐6‐O‐[4‐carboxy‐3‐hydroxy‐3‐methyl‐1‐oxobutyl]‐β‐D ‐glucopyranosyl‐(1→6)}‐[β‐D ‐glucopyranosyl‐(1→3)]‐β‐D ‐galactopyranosyl ester ( 1 ) and gypsogenic acid 28‐O‐{β‐D ‐glucopyranosyl‐(1→2)‐6‐O‐[4‐carboxy‐3‐hydroxy‐3‐methyl‐1‐oxobutyl]‐β‐D ‐glucopyranosyl‐(1→6)}‐[β‐D ‐glucopyranosyl‐(1→3)]‐β‐D ‐galactopyranosyl ester ( 2 ). 相似文献
5.
He‐Shui Yu Bai‐Ping Ma Xin‐Bo Song Li‐Ping Kang Tao Zhang Jing Fu Yang Zhao Cheng‐Qi Xiong Da‐Wei Tan Li‐Juan Zhang Jie Zhang Kate Yu 《Helvetica chimica acta》2010,93(6):1086-1092
Two new spirostanol saponins, kingianoside I ( 1 ) and kingianoside K ( 2 ), corresponding to (3β,23S,25R)‐23‐hydroxy‐12‐oxospirost‐5‐en‐3‐yl 4‐O‐β‐D ‐glucopyranosyl‐β‐D ‐galactopyranoside ( 1 ) and (3β,25R)‐7‐oxospirost‐5‐en‐3‐yl α‐L ‐arabinofuranosyl‐(1→4)‐[6‐deoxy‐α‐L ‐mannopyranosyl‐(1→2)]‐β‐D ‐glucopyranoside ( 2 ), along with 13 known compounds, daucosterol, (25R)‐kingianoside G, (25RS)‐kingianoside A, pratioside D1, (25RS)‐pratioside D1, (25S)‐kingianoside C, kingianoside C, ginsenoside Rb1, saponins Tb and Pb, dioscin, gracillin, and saponin Pa, were isolated from the processed rhizomes of Polygonatum kingianum. The structures of the new compounds were elucidated by detailed spectroscopic analyses, including 1D‐ and 2D‐NMR techniques, and chemical methods. Compound 2 contains a novel unusual spirostanol saponin aglycone. Ginsenoside Rb1 and saponin Tb were isolated for the first time from the genus Polygonatum. The 13 known compounds were detected for the first time in the processed Polygonatum kingianum. 相似文献
6.
Hui Zhang Yan‐Fang Su Feng‐Ying Yang Ze‐Qing Zhao Xiu‐Mei Gao 《Helvetica chimica acta》2014,97(12):1652-1665
Six steroidal saponins, including five spirostanol glycosides, 1 – 5 , and one furostanol glycoside 1‐sulfonate, 6 , previously unknown in nature, together with three known compounds, 7 – 9 , were isolated from dried roots and rhizomes of Helleborus thibetanus. Their structures were elucidated by extensive 1D‐ and 2D‐NMR experiments, along with IR and HR‐ESI‐MS data, as well as the results of acid hydrolysis. Compounds 1 – 5 possessed a C(25)?C(27) bond and were glycosylated at HO? C(1), which was unusual in steroidal saponins. 相似文献
7.
8.
Nabil Semmar Miyamoto Tomofumi Yassine Mrabet Marie‐Aleth Lacaille‐Dubois 《Helvetica chimica acta》2010,93(5):870-876
Two new tridesmosidic glycosides of (3β,6α,16β,20R,24S)‐20,24‐epoxycycloartane‐3,6,16,25‐tetrol (=cycloastragenol), armatosides I and II ( 1 and 2 , resp.), were isolated from the roots of Astragalus armatus (Fabaceae) as well as the known bidesmosidic glycosides of cycloastragenol, trigonoside II ( 3 ) and trojanoside H ( 4 ). Their structures were elucidated as (3β,6α,16β,20R,24S)‐3‐O‐(2,3‐di‐O‐acetyl‐β‐D ‐xylopyranosyl)‐20,24‐epoxy‐25‐O‐β‐D ‐glucopyranosyl‐6‐O‐β‐D ‐xylopyranosylcycloartane‐3,6,16,25‐tetrol ( 1 ), and (3β,6α,16β,20R,24S)‐3‐O‐(2‐O‐acetyl‐β‐D ‐xylopyranosyl)‐20,24‐epoxy‐25‐O‐β‐D ‐glucopyranosyl‐6‐O‐β‐D ‐xylopyranosylcycloartane‐3,6,16,25‐tetrol ( 2 ). These structures were established by extensive NMR and MS analyses and by comparison with literature data. 相似文献
9.
Chang‐Ling Duan Yu‐Juan Li Peng Li Yong Jiang Jian‐Xun Liu Peng‐Fei Tu 《Helvetica chimica acta》2010,93(2):227-232
Three new steroidal saponins, (25R)‐ruscogenin‐3‐yl α‐L ‐rhamnopyranosyl‐(1→2)‐[β‐D ‐xylopyranosyl‐(1→4)]‐β‐D ‐glucopyranoside ( 1 ), diosgenin‐3‐yl 2‐O‐acetyl‐α‐L ‐rhamnopyranosyl‐(1→2)‐[β‐D ‐xylopyranosyl‐(1→4)]‐β‐D ‐glucopyranoside ( 2 ), and pennogenin‐3‐yl 2‐O‐acetyl‐α‐L ‐rhamnopyranosyl‐(1→2)‐[β‐D ‐xylopyranosyl‐(1→4)]‐β‐D ‐glucopyranoside ( 3 ) were isolated from the fibrous roots of Ophiopogon japonicus (Thunb .) Ker‐Gawl . Their structures were determined by spectroscopic methods including IR, HR‐ESI‐MS, and 1D‐ and 2D‐NMR. All of these three steroidal saponins exhibited weak cytotoxicities against Hela and Hep2 cell lines. 相似文献
10.
Jong Eel Park Kyeong Wan Woo Sang Un Choi Je Hyun Lee Kang Ro Lee 《Helvetica chimica acta》2014,97(1):56-63
Two new spirostane‐steroidal saponins, bletilnoside A ( 1 ) and bletilnoside B ( 2 ), together with five known compounds, 3 – 7 , were isolated from the roots of Bletilla striata (Thunb .) Reichb . F. The structures of the new compounds were determined based on their 1D‐ and 2D‐NMR spectral data. The isolated compounds 1 – 7 were tested for cytotoxicity against four human tumor cells (A549, SK‐OV‐3, SK‐MEL‐2, and HCT15) in vitro using a sulforhodamin B bioassay, and compounds 1, 2 , and 5 showed significant cytotoxicities against all tested tumor cell lines with IC50 values ranging from 3.98±0.16 to 12.10±0.40 μM . 相似文献
11.
Three new dammarane‐type triterpene saponins, 1 – 3 , together with three known compounds, 4 – 6 , were isolated from the aerial parts of Gynostemma pentaphyllum (Thunb.) Makino . By means of chemical and spectroscopic methods, their structures were established as (20S)‐3β,20,21‐trihydroxydammara‐23,25‐diene 3‐O‐[α‐L ‐rhamnopyranosyl‐(1→2)] [β‐D ‐xylopyranosyl‐(1→3)]‐β‐D ‐glucopyranosyl‐21‐O‐β‐D ‐glucopyranoside ( 1 ), (20R,23R)‐3β,20‐dihydroxy‐19‐oxodammar‐24‐en‐21‐oic acid 21,23‐lactone 3‐O‐[α‐L ‐rhamnopyranosyl‐(1→2)] [β‐D ‐xylopyranosyl‐(1→3)]‐α‐L ‐arabinopyranoside ( 2 ), and (21S,23S)‐3β,20ξ,21,26‐tetrahydroxy‐19‐oxo‐21,23‐epoxydammar‐24‐ene 3‐O‐[α‐L ‐rhamnopyranosyl‐(1→2)] [β‐D ‐xylopyranosyl‐(1→3)]‐α‐L ‐arabinopyranoside ( 3 ). 相似文献
12.
Xu‐Ran Lu Xiao‐Min Wang Zhi‐Min Wang Xiao‐Qing Chen Man‐Yuan Wang Mu‐Xin Gong 《Helvetica chimica acta》2015,98(2):245-252
Two new hederagenin‐type saponins, staunoside G ( 1 ) and staunoside H ( 2 ), along with twelve known triterpenoid saponins, were isolated from stems of Stauntonia obovatifoliola Hayata ssp. intermedia. Their structures were determined by analysis of HR‐EI‐MS, and 1D‐ and 2D‐NMR data, and comparison with those in literature. The two new compounds showed moderate cytotoxicities against three tumor cells, i.e., A549 (lung carcinoma), 4T1 (mammary carcinoma), and HeLa (cervical carcinoma). 相似文献
13.
14.
Two new triterpene saponins, named hippophosides E and F ( 1 and 2 , resp.), together with two known compounds, were isolated from the seed residue of Hippophae rhamnoides L. Their structures were elucidated on the basis of chemical and spectral analysis, including 1D‐ and 2D‐NMR and HR‐MS experiments, and by comparison with literature data. 相似文献
15.
Two novel noroleanane saponins, tubeimoside A ( 1 ) and tubeimoside B ( 2 ), and a new dammarane triterpene saponin, tubeimoside C ( 3 ), together with two known compounds, 4 and 5 , were isolated from the bulbs of Bolbostemma paniculatum (Maxim .) Franquet . Compound 4 was found in this genus for the first time. Based on spectroscopic methods, including IR, NMR (DEPT, COSY, HMQC, HMBC, and TOCSY), and MS experiments, and chemical reactions, the structures of the new compounds were elucidated as 3β‐[β‐D ‐glucopyranosyl‐(1→2)‐β‐D ‐glucopyranosyloxy]‐2β,23‐dihydroxy‐28‐norolean‐12‐en‐16‐one ( 1 ), 3β‐[β‐D ‐glucopyranosyl‐(1→2)‐β‐D ‐glucopyranosyloxy]‐2β,23‐dihydroxy‐28‐norolean‐12‐en‐22‐one ( 2 ), (3β,7β)‐7,18,20‐trihydroxydammar‐24‐en‐3‐yl 2‐O‐α‐L ‐arabinopyranosyl‐β‐D ‐glucopyranoside ( 3 ). 相似文献
16.
Two new spirostanol saponins, namely elephanosides G and H ( 1 and 2 , resp.) were isolated from the leaves of Yucca elephantipes (Agavaceae), together with the two known furostanol saponins 3 and 4 and the six known flavonoid O‐ and C‐glycosides 5 – 10 . The new structures were elucidated as (3β,25S)‐spirost‐5‐en‐3‐yl O‐β‐D ‐glucopyranosyl‐(1→3)‐O‐β‐D ‐glucopyranosyl‐(1→4)‐β‐D ‐galactopyranoside ( 1 ) and (3β,5β,25R)‐3‐[(2‐O‐β‐D ‐glucopyranosyl‐β‐D ‐galactopyranosyl)oxy]spirostan‐12‐one ( 2 ) on the basis of detailed spectroscopic analysis and acidic hydrolysis. 相似文献
17.
HaiYangLIU ChangXiangCHEN 《中国化学快报》2002,13(7):633-636
Two new C27 steroidal glycosides, named taccaoside A(1) and B(2), were isolated from the traditional Chinese herb Tacca plantaginea. The spectroscopic and chemical evidences revealed their structures to be 26-O-β-D-glucopyranosyl-(25R)-3β,26-dihydroxy furost-5,20-diene-3-O-[α-L-rhamnopyranosyl(1→2)]-[α-L-rhamnopyranosyl(1→3)]-β-D-glucopyranoside(1) and 26-O-β-D-glucopyranosyl-(25R)-3β,26-dihydroxy furost-5,20-diene-3-O-[α-L-rhamnopyranosyl-(1→2)]-[β-D-glucopyranosyl(1→3)-α-L-rhamnopyranosyl(1→3)]-β-D-glucopyranoside(2),respectively. 相似文献
18.
He‐Shui Yu Peng Zou Xin‐Bo Song Li‐Ping Kang Yi‐Xun Liu Xu Pang Jie Zhang Jing Fu Yang Zhao Cheng‐Qi Xiong Da‐Wei Tan Li‐Juan Zhang Bai‐Ping Ma 《Helvetica chimica acta》2011,94(7):1351-1358
A new furostanol saponin, sisalasaponin C ( 1 ), and a new spirostanol saponin, sisalasaponin D ( 2 ), were isolated from the fresh leaves of Agave sisalana, along with three other known steroidal saponins and two stilbenes. Their structures were identified as (3β,5α,6α,22α,25R)‐3,26‐bis[(β‐D ‐glucopyrano‐ syl)oxy]‐22‐hydroxyfurostan‐6‐yl β‐D ‐glucopyranoside ( 1 ), (3β,5α,25R)‐12‐oxospirostan‐3‐yl 6‐deoxy‐α‐L ‐mannopyranosyl‐(1→4)‐β‐D ‐glucopyranosyl‐(1→3)‐[β‐D ‐xylopyranosyl‐(1→3)‐β‐D ‐glucopyranosyl‐(1→2)]‐β‐D ‐glucopyranosyl‐(1→4)‐β‐D ‐galactopyranoside ( 2 ), (3β,5α,6α,22α,25R)‐22‐methoxyfurostane‐3,6,26‐triyl tris‐β‐D ‐glucopyranoside, cantalasaponin‐1, polianthoside D, (E)‐ and (Z)‐2,3,4′,5‐tetrahydroxystilbene 2‐O‐β‐D ‐glucopyranosides. The last three known compounds were isolated from the fresh leaves of Agavaceae for the first time. The structures of the new compounds were elucidated by detailed spectroscopic analysis, including 1D‐ and 2D‐NMR experiments, and chemical techniques. 相似文献
19.
YANG Feng-ying SU Yan-fang ZHANG Xiao TU Guang-zhong GAO Xiu-mei ZHANG Bo-li 《高等学校化学研究》2010,26(5):746-748
A new spirostanol sulfonate, spirost-5,25(27)-dien-1β,3β-diol 1-sulfonate(1), was isolated from the rhi-zomes of Helleborus thibetanus(Ranunculaceae), and the structure was identified on the basis of a detailed spectros-copic analyses, including 2D NMR spectrometry, IR and HRESI-MS. 相似文献
20.
Olaf Kunert BelvotagiVenkatraoAdavi Rao GummadiSridhar Babu Medaboyina Padmavathi BobbalaRavi Kumar RobertMichael Alex Wolfgang Schühly Nebojsa Simic Doris Kühnelt AchantaVenkataNarasimhaAppa Rao 《Helvetica chimica acta》2006,89(2):201-209
New steroidal glycosides, stalagmosides I–V ( 1 – 5 ) and indicosides I and II ( 7 and 8 ), together with the known compounds carumbelloside III, lasianthoside A, and lasianthoside B, were isolated from whole plants of Caralluma stalagmifera and Caralluma indica, respectively. Their structures were elucidated by extensive NMR spectroscopic studies. 相似文献