共查询到20条相似文献,搜索用时 390 毫秒
1.
Yulian Volovenko Tatyana Volovnenko Kirill Popov 《Journal of heterocyclic chemistry》2007,44(6):1413-1419
A synthesis of N‐alkyl‐4‐chloro‐1H‐benzo[c][1,2]thiazine‐3‐carbaldehyde‐2,2‐dioxides is described. Reactivity of new β‐chloroaldehydes is investigated, a number of novel benzo[c][1,2]thiazine derivatives are synthesized and characterized using 1H, 13C‐NMR, MS and elemental analysis. 相似文献
2.
Brahim Bennani Bouchra Filali Baba Najib Ben Larbi Abdelatif Boukir Abdelali Kerbal Mostafa Mimouni Taibi Ben Hadda Bartosz Trzaskowski Abraham F. Jalbout 《Journal of heterocyclic chemistry》2007,44(3):711-716
A series of seven new 2′,3′,4′‐substituted spiro[isothiochromene‐3,5′‐isoxazolidin]‐4(1H)‐ones ( 7‐13 ) has been prepared in the reaction of benzylidene(phenyl)azane oxide ( 5 ) or benzylidene(methyl)azane oxide ( 6 ) with (3Z)‐3‐(4‐substituted‐benzylidene)‐1H‐isothio‐ chromen‐4(3H)‐one ( 1‐4 ). The reaction occurs by a 1,3‐dipolar cycloaddition mechanism that leads to the regiospecific formation of various spiroisoxazolidines ( 7‐13 ). 相似文献
3.
P. K. Roychowdhuary Sangeeta Mehrotra Sugandh Srivastava K. K. Upadhay Rakesh K. Mishra Ajit Kumar Shalini Upadhyay 《Journal of heterocyclic chemistry》2008,45(3):741-744
A series of 4‐thiazolidinones having triazinethione moieties have been synthesized by the systematic chemical modification of S‐benzylmercapto‐1‐aryl‐4‐(4‐methoxyphenyl)‐1,6‐dihydro‐1,3,5‐triazine‐6‐thione. 相似文献
4.
Two methods for the preparation of N‐methyl‐4‐(methylthio)thieno[2,3‐d]pyrimidinium salts 6a,b and 13a,b are described. Treatment of 6a,b and/or 13a,b with active methylene compounds such as malononitrile and ethyl cyanoacetate in the presence of sodium methoxide caused nucleophilic addition followed by elimination of methanethiol, giving the corresponding N‐methyl‐4‐ylidenethieno[2,3‐d]‐pyrimidines 7a,b, 8a,b, 14a,b and 15a,b . 相似文献
5.
Helio G. Bonacorso Alexandre P. Wentz Rogério V. Lourega Cleber A. Cechinel Tatiana S. Moraes Alex F. C. Flores Nilo Zanatta Marcos A. P. Martins 《Journal of heterocyclic chemistry》2007,44(1):233-236
The regiospecific synthesis of a new series of eight 3‐alkyl(aryl)‐5‐hydroxy‐5‐trichloromethyl‐4,5‐dihydro‐1H‐1‐tosylpyrazoles is reported. The 1‐p‐tosyl‐2‐pyrazolines were obtained from the cyclocondensation reaction of 4‐alkyl(aryl)‐4‐alkoxy‐1,1,1‐trichloroalk‐3‐en‐2‐ones, [where alkyl = H, Me and aryl = ‐C6H5, 4‐CH3C6H4, 4‐OCH3C6H4, 4‐FC6H4, 4‐ClC6H4, 4‐BrC6H4,] with p‐tosylhydrazine in 64 to 92 % yields, employing anhydrous toluene at reflux or diethyl ether at room temperature as the reaction condition. 相似文献
6.
Vladimir T. Abaev Fatima A. Tsiunchik Alexander V. Butin Andrey V. Gutnov 《Journal of heterocyclic chemistry》2008,45(2):475-481
A new simple synthetic approach to 2,4‐difuryl‐4H‐3,1‐benzothiazines from 2‐isothiocyanoaryldifuryl‐methanes in the presence of acidic catalyst is described. This rearrangement is a new example of furan ring migration reaction resulting from intramolecular attack with electrophilic carbon. 相似文献
7.
Yoshihisa Kurasawa Masami Nakamura Hiroaki Ashida Mitsunori Masuda Eisuke Kaji Yoshihisa Okamoto Ho Sik Kim 《Journal of heterocyclic chemistry》2007,44(6):1231-1234
The reaction of 7‐chloro‐1‐methylpyridazino[3,4‐b]quinoxalin‐4(1H)‐ones 3a‐5a with sodium methylthiolate gave 1‐methyl‐7‐methylsulfanylpyridazino[3,4‐b]quinoxalin‐4(1H)‐ones 8a‐c , whose reaction with m‐chloroperbenzoic acid afforded the 7‐methanesulfonyl‐1‐methylpyridazino[3,4‐b]‐quinoxalin‐4(1H)‐ones 9a‐c , respectively. The above substituent change at the 7‐position resulted in the activity alteration to microorganisms. 相似文献
8.
Monika Gupta 《Journal of heterocyclic chemistry》2007,44(5):1023-1027
5‐Aryl‐3,4‐diamino‐1,2,4‐triazoles 5 on treatment with β‐chlorocinnamaldehydes 7 in the presence of catalytic amount of p‐TsOH and N,N‐dimethylformamide as an energy transfer medium under microwave irradiation and as solvent with oil‐bath heating at 80 °C affords novel 3,6‐diaryl‐5H‐[1,2,4]triazolo[4,3‐b]‐1,2,4]triazepines 8 . The structures of the synthesized compounds were established on the basis of 1H NMR, IR, mass spectral data and elemental analysis. 相似文献
9.
Avijit Banerji Pizush Kanti Biswas Debasish Bandyopadhyay Maya Gupta Thierry Prangé Alain Neuman 《Journal of heterocyclic chemistry》2007,44(1):137-143
Investigation of cycloadditions of C‐aryl‐N‐(4‐chlorophenyl)nitrones to N‐cinnamoyl piperidines was carried out. Two diastereoisomeric and one regioisomeric cycloadducts, and in some cases ring‐opened compounds were characterized by spectroscopic and X‐ray data. Molecular modelling was carried out for conformational studies. 相似文献
10.
Gurusamy Ravindran Shanmugam Muthusubramanian Sanguvan Selvaraj Subbu Perumal 《Journal of heterocyclic chemistry》2007,44(1):133-136
Several hitherto unknown 3,5,7‐triaryl‐5,6‐dihydro‐4H‐1,2,5‐triazepines have been synthesised by cyclocondensation of N,N‐bis(phenacyl)anilines with hydrazine hydrate in ethanol or ethyleneglycol under reflux condition. Increased yields were obtained in the presence of p‐toluenesulfonic acid compared to the uncatalysed reaction. 相似文献
11.
Ahmad S. Shawali Hamdi M. Hassaneen Nabil Kh. Shurrab 《Journal of heterocyclic chemistry》2008,45(6):1825-1829
A novel series of 2,4‐disubstituted‐1,2,4‐triazolo[1,5‐a]quinazolin‐5(4H)‐ones were prepared by Dimroth rearrangement of their respective isomers namely 1,4‐disubstituted‐[1,2,4]triazolo[4,3‐a]‐quinazolin‐5(4H)‐ones. The latter were prepared via new synthetic strategy based on 1,5‐elecrocyclization of the respective N‐(4‐oxo‐3‐phenylquinazolin‐2‐yl)nitrilimines. 相似文献
12.
13.
P. Haranath V. Sreedhar Kumar C. Suresh Reddy C. Naga Raju C. Devendranath Reddy 《Journal of heterocyclic chemistry》2007,44(2):369-373
Substituted benzoxazaphosphorin 2‐yl ureas were synthesized by reacting 2‐(4‐fluoro‐phenylamino)‐methylphenol (4) with different carbamidophosphoric acid dichlorides (3) in the presence of triethylamine in dry toluene at 45‐50 °C and characterized by spectral data. These compounds were found to possess good antimicrobial activity. 相似文献
14.
A simple one‐step method for preparation of novel 1,3,4‐triaryl‐3,4‐dihydropyrimidin‐2(1H)‐ones has been developed by reaction of aromatic isocyanates with β‐arylamino‐1‐phenylpropan‐1‐ones in refluxing toluene in the presence of KHSO4 and HCl. 相似文献
15.
Leonor Y. Vargas Méndez Vladimir V. Kouznetsov 《Journal of heterocyclic chemistry》2008,45(3):927-930
New diverse N‐aryl‐N‐[1‐furyl(thienyl)but‐3‐enyl]amines (homoallylamines) or 2‐(N‐arylmethylamino)‐2‐furyl(thienyl)acetonitriles (α‐aminonitriles) were easily prepared in good to excellent yields by an indium‐mediated Barbier‐type reaction between N‐hetarylaldimines and allyl bromide in MeOH or a direct three component reaction between anilines, hetaryl aldehydes and trimethylsilyl cyanide in the presence of a catalytic amount of molecular iodine at room temperature, respectively. The entire set of amines was characterized by IR, 1H and 13C NMR spectroscopy. 相似文献
16.
A series of pyrrolo[2,3‐d]pyrimidine Mannich bases of type 9, 12, 15 and 16 have been prepared as potential dopamine D4 receptor ligands. The syntheses start from 4‐aminopyrimidin‐6‐one 3 with pyrrole annulations and Mannich reactions with formaldehyde and phenylpiperazines 8 as new amine components. 相似文献
17.
Monika Wujec Agata Siwek Marta Swatko‐Ossor Liliana Mazur Zofia Rzaczynska 《Journal of heterocyclic chemistry》2008,45(6):1893-1896
By the reaction aminomethylation, chloromethylation and acylation of 4‐methyl‐4H‐1,2,4‐triazole‐3‐thiol, 4‐methyl‐1‐substituted‐1H‐1,2,4‐triazole‐5(4H)‐thione 1‐8 were obtained. Molecular structure of the obtained compounds was confirmed by an elemental analysis, IR, 1H NMR and 13C NMR spectra and additionally by X‐ray analysis for 2. Six new compounds 1,2,4‐7 were tested for antibacterial activity against Mycobacterium smegmatis, Mycobacterium phlei and avirulent strain Mycobacterium H37Ra. 相似文献
18.
Ahmet Şener İshak Bildirici İsrafil Tozlu Hasan Genç Kadir Arısoy 《Journal of heterocyclic chemistry》2007,44(5):1077-1081
1,5‐Diphenyl‐1H‐pyrazole‐3,4‐dicarboxylic acid‐4‐ethyl ester 2 , obtained from the 4‐ethoxycarbonyl‐5‐phenyl‐2,3‐furandione 1 and N‐benzylidene‐N′‐phenyl hydrazine, was converted via reactions of its acid chloride 3 with various alcohols or N‐nucleophiles into the corresponding ester 5 or amide derivatives 6 , respectively. In addition, 2 was decarboxylated to give ethyl 1,5‐diphenylpyrazole‐4‐carboxylate 4 . Nitrile 7 derivative of 2 was also obtained by dehydration of 6a in a mixture of SOCl2 and DMF. While cyclocondensation reaction of 2 with hydrazine hydrate leads to the formation of pyrazolo[3,4‐d]pyridazine‐4,7‐dione 8 , the reaction of 3 with anhydrous hydrazine provided a new bis pyrazole derivative 9 . 相似文献
19.
Ganesh R. Jadhav Mohammad U. Shaikh Murlidhar S. Shingare Charansingh H. Gill 《Journal of heterocyclic chemistry》2008,45(5):1287-1291
Synthesis of some novel 2‐{2‐[1‐(3‐substitutedphenyl)‐1H‐1,2, 3‐triazol‐4‐yl‐]ethyl)‐1H‐benzo[d]‐imidazole derivatives, by the condensation of o‐phenylenediamine with 3‐(1‐(3‐substituted‐phenyl)‐1H‐1,2,3‐triazol‐4‐yl) propanoic acid and then subsequent reactions with different substituted alkyl halides as electrophiles are mentioned. The synthesized compounds were characterized by 1H NMR, EI‐MS and IR spectroscopic techniques. 相似文献
20.
Divvela V. N. Srinivasa Rao Ganala Naga Trinadhachari Koilpillai Joseph Prabahar Ramesh Dandala Meenakshisundaram Sivakumaran Andra Naidu 《Journal of heterocyclic chemistry》2007,44(3):663-667
A new industrially viable process for the preparation of 1β‐(N‐tert‐butyl carbamoyl)‐4‐aza‐5α‐androst‐1‐ene‐3‐one, also known by the generic name finasteride ( 6 ) from the new azaandrostane derivatives such as 1β‐(N‐tert‐butyl carbamoyl)‐4‐benzoyl‐4‐aza‐5α‐androstane‐3‐one ( 4 ), 1β‐(N‐tert‐butyl carbamoyl)‐4‐benzoyl‐4‐aza‐5α‐androst‐1‐ene‐3‐one ( 5 ) is reported. In this process, benzoyl group is demonstrated as a novel protecting group for lactamic NH group. The structures of newly prepared compounds were established on the basis of spectral data (IR, 1H‐NMR, and MS). 相似文献