共查询到20条相似文献,搜索用时 15 毫秒
1.
Rémy Bertrand Teponno Azefack Léon Tapondjou Hyun Ju‐Jung Jung‐Hwan Nam Pierre Tane Hee‐Juhn Park 《Helvetica chimica acta》2007,90(8):1599-1605
From the bulbils of Dioscorea bulbifera L. var. sativa, three new clerodane diterpenoids, bafoudiosbulbin C (=methyl (2β,8α,12S)‐17‐oxo‐2,19 : 8,19 : 12,17 : 15,16‐tetraepoxycleroda‐3,13(16), 14‐triene‐18‐carboxylate; 1 ), bafoudiosbulbin D (=methyl (2β,6β,12R)‐17,19‐dioxo‐2,19 : 6,17 : 8,12 : 15,16‐tetraepoxycleroda‐13(16),14‐diene‐18‐carboxylate; 2 ), and bafoudiosbulbin E (=methyl (2β,3α,4α,6β,12R)‐17,19‐dioxo‐2,19 : 3,4 : 6,17 : 8,12 : 15,16‐pentaepoxycleroda‐13(16),14‐diene‐18‐carboxylate; 3 ) were isolated, together with the known compounds bafoudiosbulbins A and B, 3‐O‐β‐D ‐glucopyranosyl‐β‐sitosterol, and 6′‐stearoyl‐3‐O‐β‐D ‐glucopyranosyl‐β‐sitosterol. Their structures were established by high‐field NMR techniques (1H,1H‐COSY, 13C‐DEPT, HSQC, HMBC, and NOESY), MS analyses, as well as by comparison of their spectral data with those of related compounds. 相似文献
2.
Three new neo‐clerodane diterpenoids, barbatellarines C–E ( 1 – 3 ), were isolated from the CHCl3‐soluble fraction of the aerial part of Scutellaria barbata. Their chemical structures were elucidated by detailed analysis of NMR and MS data. Compounds 1 and 2 were C(13) epimers, which was confirmed by an NOE difference experiment and the NOESY spectrum. The relative configuration was determined on the basis of the 1H‐NMR J‐value and NOE data, while the absolute configuration of the previously isolated analogue, barbatellarine B ( 4 ), as a representative member of the group, was assigned by CD analysis. 相似文献
3.
Rui‐Jie Hou Fu‐Lin Yan Hai‐Yang Zhang Yi‐Xiao Bai Ming‐Ming Ding 《Helvetica chimica acta》2012,95(7):1175-1180
Two new ent‐kaurene diterpenoids, 15α,20‐dihydroxy‐6,7‐seco‐entkaur‐16‐ene‐7,1α(6,11α)‐diolide ( 1 ), 6β‐butyroxy‐3β‐hydroxy‐6,7‐seco‐6,20‐epoxy‐7,1α‐olide‐entkaur‐16‐en‐15‐one ( 2 ), together with 25 known compounds, 3 – 27 , were isolated from the leaves of Isodon japonicus. Their structures were established by spectroscopic methods, including 2D‐NMR techniques. 相似文献
4.
Two new clerodane‐based furanoid diterpenoids, tinosagittones A and B ( 1 and 2 , resp.), were isolated from the roots of Tinospora sagittata, together with five known diterpenoids, i.e., columbin ( 3 ), its glucoside palmatoside C ( 4 ), isocolumbin ( 5 ), 6‐hydroxycolumbin ( 6 ), and tinophylloloside ( 7 ). Their structures were established by mass spectrometry and spectroscopic methods, especially 2D‐NMR techniques. 相似文献
5.
Zheng‐Hong Pan Jin‐Tang Cheng Juan He Yuan‐Yuan Wang Li‐Yan Peng Gang Xu Wei‐Bang Sun Qin‐Shi Zhao 《Helvetica chimica acta》2011,94(3):417-422
Three new clerodane diterpenoids, splendidins A–C ( 1 – 3 , resp.), were isolated from Salvia splendens, together with six known ones. Their structures were elucidated by extensive spectroscopic analysis. Splendidin C ( 3 ) was the first diterpenoid glucoside reported from this plant. These compounds were evaluated for their cytotoxic activity; however, none of them were cytotoxic. 相似文献
6.
Hai‐Yang Liu Hong‐Ping He Suo Gao Chang‐Xiang Chen Yue‐Mao Shen Xiao‐Jiang Hao 《Helvetica chimica acta》2006,89(5):1017-1022
Two new diterpenoids, pedunculatic acid A (= (4R,5α,7α)‐7‐ethoxy‐9β,13β‐dioxyabiet‐8(14)‐en‐18‐oic acid; 1 ) and pedunculatic acid B (= (4S,5α,12β)‐8β,14β‐epoxy‐12‐hydroxy‐11‐oxototaran‐19‐oic acid; 2 ), together with three known sesquiterpenoids, were isolated from the Chinese medicinal herb Callicarpa pedunculata R. Brown . Their structures were elucidated by spectroscopic analyses, including 1D‐ and 2D‐NMR, and by high‐resolution mass spectrometry. 相似文献
7.
Two new abietane diterpenoids, named 17‐hydroxyteuvincenone G ( 1 ) and 17‐hydroxyteuvincen‐5(6)‐enone G ( 2 ), together with four known diterpenoids, were isolated from the stems of Clerodendrum kaichianum P. S. Hsu . Their structures were elucidated by extensive NMR and MS analyses, and by comparison with literature data. The new compounds showed significant cytotoxicities against the HL‐60 and A‐549 tumor cell lines. 相似文献
8.
Min Zhang Yang‐Wen Ou Xue‐Xiang Chen Yong Cao Yong Kuang Zhu‐Qing Gong Sheng Peng Yun‐Jiao Chen 《Helvetica chimica acta》2011,94(10):1820-1824
A further chemical investigation of the plant Rubus corchorifolius L. f., collected in Hunan Province, afforded two new ent‐kauranoids 6 and 7 . Their structures were elucidated by various spectroscopic methods. 相似文献
9.
Xian Li Wei‐Lie Xiao Sheng‐Xiong Huang Zhi‐Ying Weng Yun‐Heng Shen Quan‐Bin Han Han‐Dong Sun 《Helvetica chimica acta》2006,89(6):1181-1186
Two new ent‐kaurane‐derived diterpene derivatives, phyllostacins A ( 1 ) and B ( 2 ), were isolated from the aerial parts of Isodon phyllostachys, together with two known compounds, irroratin A ( 3 ) and serrin B ( 4 ). Both 1 and 2 were found to be present as diastereoisomers. In the case of 1 , the corresponding diastereoisomeric diacetates 5 and 6 were prepared and separated. The structures of the new compounds were elucidated by extensive 1D‐ and 2D‐NMR spectroscopic methods, in combination with MS experiments. In (D5)pyridine solution, the two epimers of 1 are present in equal amounts, but in CDCl3 or CD3OD, the (S)‐epimer predominates in the mixture of hemiacetals. 相似文献
10.
Xian Li Zhi‐Ying Weng Yong Li Jian‐Xin Pu Sheng‐Xiong Huang Wei‐Lie Xiao Han‐Dong Sun 《Helvetica chimica acta》2008,91(6):1130-1136
Phytochemical investigation of the medicinal plant Isodon phyllostachys led to the isolation of four new ent‐kaurane diterpenoids, phyllostacins F–I ( 1 – 4 , resp.), together with 11 known compounds, rosthorin A ( 5 ), rabdoternin C ( 6 ), enmenol ( 7 ), oridonin ( 8 ), lasiocarpanin ( 9 ), xerophilusin B ( 10 ), ponicidin ( 11 ), macrocalin B ( 12 ), phyllostachysin A ( 13 ), sculponeatin C ( 14 ), and macrocalyxoformin E ( 15 ). The structures of the new compounds were established by spectroscopic methods, including extensive 1D‐ and 2D‐NMR analyses. Compounds 1, 2, 7, 10 , and 13 were evaluated for their inhibitory activity against K562 and HepG2 cell lines. 相似文献
11.
Hai‐Liang Xin Yan‐Feng Xu Yin‐Huan Hou Ya‐Ni Zhang Xiao‐Qiang Yue Jin‐Cai Lu Chang‐Quan Ling 《Helvetica chimica acta》2008,91(11):2075-2080
Two novel triterpenoids, (2α,3α)‐3‐{[4‐O‐(β‐D ‐glucopyranosyl)‐β‐D ‐xylopyranosyl]oxy}‐2,23‐dihydroxy‐30‐methoxy‐30‐oxoolean‐12‐en‐28‐oic acid ( 1 ) and (2α,3α)‐2,23,30‐trihydroxy‐3‐[(β‐D ‐xylopyranosyl)oxy]olean‐12‐en‐28‐oic acid ( 2 ) were isolated from Portulaca oleracea L., and they both showed weak cytotoxic activity assayed with the MTT method. 相似文献
12.
Two novel abietane diterpenoids, wardinols A and B ( 1 and 2 , resp.), together with five known diterpenoids, 3 – 7 , were isolated from the fruits of Illicium wardii A.C.Sm . Their structures were elucidated on the basis of intensive spectroscopic analysis, including 1D‐ and 2D‐NMR spectroscopy. Wardinol A ( 1 ) is a rare 9,10‐epoxy‐9,10‐secoabietane diterpenoid. All of the isolated compounds were evaluated for their cytotoxicities against three human tumor cell lines, A549, HCT116, and CCRF‐CEM. 相似文献
13.
Ling‐Zhi Li Pin‐Yi Gao Ying Peng Li‐Hui Wang Jing‐Yu Yang Chun‐Fu Wu Yan Zhang Shao‐Jiang Song 《Helvetica chimica acta》2010,93(6):1172-1179
Three new daphnane‐type diterpenoids, genkwanines M–O ( 1 – 3 , resp.), together with seven known daphnane‐type diterpenoids, genkwanines D and H, genkwaine F, genkwadaphnine, yuanhuatine, yuanhuafine, and yuanhuapine ( 4 – 10 , resp.), were isolated from the flower buds of Daphne genkwa during a phytochemical investigation. The structures of the new compounds were elucidated on the basis of spectroscopic analyses, especially 2D‐NMR spectra (HSQC, HMBC, and NOESY). 相似文献
14.
Idowu E. Fadayomi Okiemute R. Johnson-Ajinwo Elisabete Pires James McCullagh Tim D.W. Claridge Nicholas R. Forsyth Wen-Wu Li 《Molecules (Basel, Switzerland)》2021,26(19)
Objectives: The toxicity of chemotherapeutic anticancer drugs is a serious issue in clinics. Drug discovery from edible and medicinal plants represents a promising approach towards finding safer anticancer therapeutics. Justicia insularis T. Anderson (Acanthaceae) is an edible and medicinal plant in Nigeria. This study aims to discover cytotoxic compounds from this rarely explored J. insularis and investigate their underlying mechanism of action. Methods: The cytotoxicity of the plant extract was evaluated in human ovarian cancer cell lines and normal human ovarian surface epithelia (HOE) cells using a sulforhodamine B assay. Bioassay-guided isolation was carried out using column chromatography including HPLC, and the isolated natural products were characterized using GC-MS, LC-HRMS, and 1D/2D NMR techniques. Induction of apoptosis was evaluated using Caspase 3/7, 8, and 9, and Annexin V and PI based flow cytometry assays. SwissADME and SwissTargetPrediction web tools were used to predict the molecular properties and possible protein targets of identified active compounds. Key finding: The two cytotoxic compounds were identified as clerodane diterpenoids: 16(α/β)-hydroxy-cleroda-3,13(14)Z-dien-15,16-olide (1) and 16-oxo-cleroda-3,13(14)E-dien-15-oic acid (2) from the Acanthaceous plant for the first time. Compound 1 was a very abundant compound (0.7% per dry weight of plant material) and was shown to be more potent than compound 2 with IC50 values in the micromolar range against OVCAR-4 and OVCAR-8 cancer cells. Compounds 1 and 2 were less cytotoxic to HOE cell line. Both compounds induced apoptosis by increasing caspase 3/7 activities in a concentration dependent manner. Compound 1 further increased caspase 8 and 9 activities and apoptosis cell populations. Compounds 1 and 2 are both drug like, and compound 1 may target various proteins including a kinase. Conclusions: Clerodane diterpenoids (1 and 2) in J. insularis were identified as cytotoxic to ovarian cancer cells via the induction of apoptosis, providing an abundant and valuable source of hit compounds for the treatment of ovarian cancer. 相似文献
15.
Zhao‐Yuan Wu Hong‐Mei Li Yuan‐Dan Li Hai‐Zhou Li Rong‐Tao Li 《Helvetica chimica acta》2011,94(7):1283-1289
From the fruits of Pieris formosa, four new highly acylated 3,4‐secograyanane diterpenoids, secorhodomollolides E–H ( 1 – 4 , resp.), along with two known ones, secorhodomollolides C and D ( 5 and 6 , resp.), were obtained. Their structures were established mainly by spectroscopic methods, including 1D‐ and 2D‐NMR spectroscopy, and mass spectrometry. 相似文献
16.
Ben‐Yin Zhang Huan Wang Xiao‐Dong Luo Zhi‐Zhi Du Jian‐Wei Shen Hai‐Feng Wu Xiao‐Feng Zhang 《Helvetica chimica acta》2012,95(9):1672-1679
Two novel diterpene dimers with a bismagdalenic acid skeleton, bisyinshanic acids A and B ( 1 and 2 , resp.), along with eight known diterpenoids ( 3 – 10 ), were isolated from the roots of Euphorbia yinshanica. Their structures were elucidated on the basis of spectroscopic evidence. 相似文献
17.
Paecilomycines A and B,Novel Diterpenoids,Isolated from Insect‐Pathogenic Fungi Paecilomyces sp. ACCC 37762 下载免费PDF全文
Kun Zhou Xiao‐Ling Zhao Li‐Ping Han Meng‐Meng Cao Chuan Chen Bao‐Zhong Shi Du‐Qiang Luo 《Helvetica chimica acta》2015,98(5):642-649
Two new diterpenoids, named paecilomycine A ( 1 ) and paecilomycine B ( 2 ), including a novel skeleton with a five‐membered lactone ring, together with three known labdane diterpenoids, rel‐(1R,3S,4aS,5R,8aS)‐5‐[(3E)‐4‐carboxy‐3‐methylbut‐3‐en‐1‐yl]decahydro‐3‐hydroxy‐1,4a‐dimethyl‐6‐methylidenenaphthalene‐1‐carboxylic acid ( 3 ), botryosphaerin E ( 4 ), and agathic acid ( 5 ), were isolated from solid culture of the insect pathogenic fungi strain Paecilomyces sp. The structures of all compounds were established on the basis of comprehensive spectroscopic studies. The relative configurations of 1 and 2 were determined by single‐crystal X‐ray diffraction analyses. 相似文献
18.
Hai‐Yang Liu Suo Gao Ying‐Tong Di Chang‐Xiang Chen Yang Lü Li Zhang Qi‐Tai Zheng Xiao‐Jiang Hao 《Helvetica chimica acta》2007,90(7):1386-1390
A novel ent‐atisane lactone, spiramilactone E ( 1 ), was isolated from Spiraea japonica var. acuta Yu . Its structure was elucidated by extensive spectroscopic analyses, and unequivocally confirmed by single‐crystal X‐ray diffraction (Fig. 2). Compound 1 contains a γ‐lactone moiety between the 6‐OH function and C(20), and β‐configuration for the 7‐OH group, in contrast to known related diterpenes previously isolated from the S. japonica complex. 相似文献
19.
Four new diterpenes, cespihypotins W–Z ( 1 – 4 ), having the verticillane skeleton and characterized by an α,β‐unsaturated γ‐hydroxycyclopentanone moiety, and a new eudesmanolide‐type sesquiterpene, cespilactam A ( 5 ), containing an α,β‐unsaturated γ‐lactam residue, were isolated from the AcOEt‐soluble fraction of the Taiwanese soft coral Cespitularia hypotentaculata. The structure and relative configuration of these metabolites was elucidated through extensive interpretation of MS, COSY, HSQC, HMBC, and NOESY experiments and by comparison of their NMR data with those of related compounds. 相似文献
20.
Ahmed M. Mustafa Samih I. Eldahmy Giovanni Caprioli Massimo Bramucci Luana Quassinti Giulio Lupidi 《Natural product research》2020,34(16):2358-2362
Abstract Pulicaria undulata is used as a traditional herbal remedy in Egypt. We used gas chromatography-mass spectrometry for analysis of essential oil of this plant growing wild in Egypt and 64 compounds were identified. The oil was rich in oxygenated monoterpenes (64.0%) and aromatic derivatives (18.8%). The major components were carvacrol (46.5%), xanthoxylin (18.1%) and carvotanacetone (8.7%). The oil of the Egyptian plant showed significant differences from the oil results reported on this species derived from different accessions. Antioxidant activity was performed by FRAP, DPPH and ABTS assays, and the oil demonstrated a powerful antioxidant properties. Furthermore, cytotoxicity was assessed using MTT assay against three cell lines (A375, T98G, HCT116) and the oil showed moderate results with IC50 of 18.53, 40.64 and 22.23?μg/ml; respectively. The oil showed a good anti-acetylcholinesterase activity (IC50?=?139.2?μg/ml) using Ellman method. In conclusion, the studied oil exhibited a peculiar fingerprint and promising biological activities. 相似文献